Endoluminal vacuum-assisted closure therapy for upper gastrointestinal leak, perforation, and fistula: a case series and literature review
Conclusion: E-VAC devices can effectively help in the removal of the exudate and necrotic tissue around the fistula, promote the proliferation of granulation tissue, and support closure of the fistula. However, further improvements to the device are needed to improve patient comfort and operational safety. (Source: Digestive Diseases)
Source: Digestive Diseases - October 26, 2022 Category: Gastroenterology Source Type: research

Application of CircRNA Circ_0071662 in the diagnosis and prognosis of hepatocellular carcinoma and its response to radiotherapy
Conclusion: Circ_0071662 is decreased in HCC and may serve as a potential biomarke r to improve the diagnosis of HCC. Moreover, decreased Circ_0071662 is likely correlated to the development of redio resistance. (Source: Digestive Diseases)
Source: Digestive Diseases - October 24, 2022 Category: Gastroenterology Source Type: research

The proton pump inhibitors use and COVID-19 from prior to vaccination perspective - a review
Background: The coronavirus infectious disease 2019 (COVID-19) caused by the severe acute respiratory syndrome coronavirus type 2 (SARS-CoV-2) has been a huge challenge affecting, directly or indirectly, human race worldwide. Many COVID-19-related risk factors have been identified. Various drugs, including proton pump inhibitors (PPIs), have been claimed to increase the risk of acquiring or effecting the outcome of COVID-19 prior to the availability of vaccines. The aim of this review is to summarize the uncertain role of PPIs use on the SARS-CoV-2 infection and COVID-19 clinical course, including both some well-establishe...
Source: Digestive Diseases - October 18, 2022 Category: Gastroenterology Source Type: research

Predictive Value of the Hepatic Immune Predictive Index for Patients with Primary Liver Cancer Treated with Immune Checkpoint Inhibitors
Conclusion: Baseline hepatic immune predictive index based on NLR and AFP level is an effective indicator in ICI-treated patients with primary liver cancer. Our findings may help guide the selection and on-treatment strategies for immunotherapies for primary liver cancer patients. (Source: Digestive Diseases)
Source: Digestive Diseases - October 18, 2022 Category: Gastroenterology Source Type: research

CT-defined fat composition as a prognostic marker in gastric adenocarcinoma: a systematic review and meta-analysis.
Background: Computed tomography (CT)-defined fat quantification has been an emergent field of research in oncology. It was shown that this parameter is predictive and prognostic of several clinically relevant factors in several tumor entities. Objective: Our aim was to establish the effect of visceral and subcutaneous fat areas on overall survival (OS), disease-free survival (DFS), and postoperative complications in gastric cancer patients based on a large patient sample. Methods: MEDLINE library, EMBASE and SCOPUS databases were screened for the associations between visceral (VFA) and subcutaneous fat areas (SFA) defined ...
Source: Digestive Diseases - October 13, 2022 Category: Gastroenterology Source Type: research

Effects of Helicobacter pylori therapy on gut microbiota: a systematic review and meta-analysis
Background: Although indications for evaluation and treatment of Helicobacter pylori (H. pylori) infection are broadening to include primary prevention for gastric adenocarcinoma, potential adverse effects on gut microbiota have been raised. We performed a systematic review and meta-analysis to evaluate the effects of H. pylori therapy on gut microbiota. Methods: PubMed, EMBASE, Cochrane Library and Web of Science (to 4/2021) were searched for studies quantitatively evaluating microbiota before and after H. pylori therapy. Meta-analysis was performed to assess early ( (Source: Digestive Diseases)
Source: Digestive Diseases - October 13, 2022 Category: Gastroenterology Source Type: research

Bedside Live-View Capsule Endoscopy in Evaluation of Overt Obscure Gastrointestinal Bleeding: A Pilot Point-of-Care Study
Conclusion: This study utilizing an RN for LVCE interpretation found inter-observer agreement between RN and physician findings. Larger studies are needed to assess whether this RN-physician team approach can translate to improved outcomes. (Source: Digestive Diseases)
Source: Digestive Diseases - September 13, 2022 Category: Gastroenterology Source Type: research

Bedside Live-View Capsule Endoscopy in Evaluation of Overt Obscure Gastrointestinal Bleeding -A Pilot Point of Care Study
Conclusion: This study utilizing an RN for LVCE interpretation found interobserver agreement between RN and physician findings. Larger studies are needed to assess whether this RN-physician team approach can translate to improved outcomes. (Source: Digestive Diseases)
Source: Digestive Diseases - September 13, 2022 Category: Gastroenterology Source Type: research

Liver complications in untreated treatment-ineligible versus treated treatment-eligible patients with hepatitis B
Conclusion: Patients never meeting standard AASLD 2018 criteria for antiviral therapy and never treated had twice the risk of developing cirrhosis and/or HCC when compared to eligible and treated patients. (Source: Digestive Diseases)
Source: Digestive Diseases - September 7, 2022 Category: Gastroenterology Source Type: research

Drug Exposure and Risk of Microscopic Colitis: A Systematic Review and Meta-analysis
Background and objectives: Microscopic Colitis (MC) is a chronic inflammatory bowel disease, characterized by watery diarrhoea, normal radiological and endoscopic appearance. Concern regarding a potential association between drug exposure and MC has recently emerged. We sought to systematically review and summarize the evidence for the potential association. Methods: A systematic review and meta-analysis were performed to evaluate the incidence of MC associated with exposure to drug. The PubMed and Embase databases were searched to identify potential studies for inclusion. Results: Twelve case-control studies were includ...
Source: Digestive Diseases - September 6, 2022 Category: Gastroenterology Source Type: research

Comparison of Safety and Outcomes between Endoscopic and Surgical Resections of Intermediate-risk Primary Gastric Gastrointestinal Stromal Tumors
The objective of this study was to compare the safety and efficacy of endoscopic resection with surgical resection in the treatment of intermediate-risk gastric GISTs, and to further evaluate whether imatinib adjuvant treatment is necessary for resected intermediate-risk gastric GIST by ER. Methods: We retrospectively studied 128 cases for intermediate-risk gastric GISTs that were distributed in endoscopic (n=33) and surgical groups (n=95) at our center between December 2009 to July 2020. We statistically compared the clinical features, pathological reports, perioperative data, and long-term follow-up outcomes. Results: ...
Source: Digestive Diseases - September 5, 2022 Category: Gastroenterology Source Type: research

The application of probe-based confocal laser endomicroscopy as a diagnostic tool in choledochoscopicgallbladder-preserving surgery
Conclusions: Based on our investigation, pCLE can provide the same accuracy as the tranditional pathology in the diagnosis of gallbladder diseases with the additional advantages like noninvasive, real-time, and instancy.This study serves to validate the correlation between CLE and histology. It holds a broad prospect in the application of pCLE as an intraoperative diagnosis in CGPS. (Source: Digestive Diseases)
Source: Digestive Diseases - September 5, 2022 Category: Gastroenterology Source Type: research

Erratum
Dig Dis (Source: Digestive Diseases)
Source: Digestive Diseases - August 29, 2022 Category: Gastroenterology Source Type: research

Effect of a multistrain probiotic on leaky gut in patients with diarrhea-predominant irritable bowel syndrome (IBS-D): a pilot study
Conclusion: The multistrain probiotic tested may reduce intestinal permeability in a considerable proportion of patients and may improve abdominal pain, stool consistency, and quality of life. These results pave the way for larger, placebo-controlled clinical studies. (Source: Digestive Diseases)
Source: Digestive Diseases - August 25, 2022 Category: Gastroenterology Source Type: research

Prevalence and Risk Factors of Gastroesophageal Reflux Disease in Bulgaria: an internet-based survey
Background: The global pooled prevalence of gastroesophageal reflux disease (GORD) is approximately 14% and varies significantly according to the country. More population-based studies are needed in regions lacking epidemiological data on the prevalence of GORD, such as Eastern Europe, particularly Bulgaria. This current study aimed to evaluate the prevalence of GORD in Bulgaria and assess the risk factors associated with this disorder. Methods: An internet-based health survey was sent to Bulgarian adults. Individuals were invited to complete an online questionnaire on general and gastrointestinal (GI) health. The aim of ...
Source: Digestive Diseases - August 16, 2022 Category: Gastroenterology Source Type: research