A retrospective analysis of the efficacy of endoscopic variceal ligation versus endoscopic tissue adhesive injection in the treatment of esophagogastric variceal bleeding
Conclusion: Both EVL and TAI have good therapeutic effects on EVB. Furthermore, owing to its effectiveness in preventing rebleeding, no reduc tion in efficacy and no increase in complications, shortened operative time, smaller and superficial ulcer and smoother wounds, gastric EVL is worthy of further clinical promotion. (Source: Digestive Diseases)
Source: Digestive Diseases - December 8, 2022 Category: Gastroenterology Source Type: research
Inflammatory Bowel Disease Patients ’ Preferences for Subcutaneous Versus Intravenous Therapies: A Mixed Methods Study
Conclusion
While prior SC/IV exposure was a strong predictor for SC/IV preferences, patients’ preferences largely are determined by a variety of other personal factors. The themes we identified could help guide clinicians whe n discussing therapeutic options with their patients and support shared decision making. (Source: Digestive Diseases)
Source: Digestive Diseases - December 7, 2022 Category: Gastroenterology Source Type: research
The prevalence and factors that impact frailty in Inflammatory Bowel disease patients hospitalized in a tertiary hospital in China
This study aims to assess frailty status and explore the impact factors in IBD inpatients.
Methods: A total of 372 IBD inpatients were recruited from July 2021 to November 2021 at Peking Union Medical College Hospital. All the participants were surveyed by face-to-face questionnaires, including demographic characteristics, disease conditions, lifestyle, psychology, social support and frailty. The impact factors of frailty were further assessed by multinomial logistic regression analysis.
Results: The participants ’ median age was 31.00 (Q1: 24.00, Q3: 40.00) years. The overall prevalence of prefrailty and frailty in IB...
Source: Digestive Diseases - December 1, 2022 Category: Gastroenterology Source Type: research
Improvement of symptoms in patients affected by chronic atrophic gastritis using L-cysteine [Acetium ®]
Background:
Chronic Atrophic Gastritis (CAG) alone is a precancerous condition for gastric cancer. Achlorhydria plays an important role in the formation of a class I carcinogen, acetaldehyde. L-cysteine has been claimed to bind acetaldehyde covalently. Symptoms are present in 55% of CAG patients, of whom 70% have upper gastrointestinal (GI) complaints. The aim of this study was to investigate the properties of L-cysteine in the modification of symptom patterns in CAG patients.
Methods:
Consecutive patients with histological diagnosis of CAG (OLGA ≥1 with gastric corpus involvement) were evaluated with serological dete...
Source: Digestive Diseases - November 24, 2022 Category: Gastroenterology Source Type: research
Clinical and Genomic Analysis of Patients With Short Survival After Surgery for Esophageal Squamous Cell Carcinoma
Conclusion: In patients with progressive primary ESCC, the poor postoperative prognosis may be epiphenomenally associated with the CDKN2A loss. (Source: Digestive Diseases)
Source: Digestive Diseases - November 22, 2022 Category: Gastroenterology Source Type: research
Significant differences in IBD care and education across Europe: results of the pan-European VIPER survey
Background:
Inflammatory bowel disease (IBD) care and education might differ around Europe. Therefore, we conducted this European Variation In IBD PracticE suRvey (VIPER) to investigate potential differences between countries.
Methods:
This trainee-initiated survey, run through SurveyMonkey ®, consisted of 47 questions inquiring basic demographics, IBD training, and clinical care. Results were compared according to gross domestic product (GDP) per capita, for which countries were divided into 2 groups (low/high income, according to the World Bank).
Results:
The online survey was comp leted by 1285 participants from 40...
Source: Digestive Diseases - November 21, 2022 Category: Gastroenterology Source Type: research
Influence of artificial intelligence on the adenoma detection rate throughout the day
Conclusion:
AI helps to overcome the decay in adenoma detection over the daytime. This may be attributed to a constant awareness caused by the use of the AI system. (Source: Digestive Diseases)
Source: Digestive Diseases - November 18, 2022 Category: Gastroenterology Source Type: research
Comparison between transpancreatic sphincterotomy and needle-knife precut in difficult cannulation of endoscopic retrograde cholangiopancreatography: an up-to-date meta-analysis and systematic review
Conclusion TPS appears to be associated with a higher cannulation success rate and less bleeding than those with NKP, with equal post-ERCP pancreatitis, perforation, and adverse events rates between TPS and NKP. Further large-scale trials are w arranted to support our findings. (Source: Digestive Diseases)
Source: Digestive Diseases - November 16, 2022 Category: Gastroenterology Source Type: research
Contents Vol. 40, 2022
Dig Dis 2022;40:I –VIII (Source: Digestive Diseases)
Source: Digestive Diseases - November 15, 2022 Category: Gastroenterology Source Type: research
Acknowledgement to Reviewers
Dig Dis 2022;40:839 –840 (Source: Digestive Diseases)
Source: Digestive Diseases - November 15, 2022 Category: Gastroenterology Source Type: research
miR-3682-3p activated by c-Myc aggravates the migration and stemness in hepatocellular carcinoma cells by regulating PTEN/PI3K/AKT/ β-catenin signaling
Conclusion: miR-3682-3p promoted HCC migration and stemness through PTEN/PI3K/AKT/β-catenin signaling, implying that miR-3682-3p might be a promisi ng target for HCC clinical treatment. (Source: Digestive Diseases)
Source: Digestive Diseases - November 10, 2022 Category: Gastroenterology Source Type: research
The Role of Mean Nocturnal Baseline Impedance and Post-Reflux Swallow-Induced Peristaltic Wave Index in the Diagnosis and Treatment of Gastroesophageal Reflux Disease
Background: As living standards improve, more and more people are becoming overweight or obese, which has led to a gradual increase in the incidence of gastroesophageal reflux disease (GERD). Esophageal multichannel intraluminal impedance pH monitoring is a technique widely used in the clinical diagnosis of GERD. Commonly used traditional impedance parameters include acid exposure time, number of reflux episodes, symptom association probability, and symptom index. Recently, mean nocturnal baseline impedance (MNBI) and post-reflux swallow-induced peristaltic wave (PSPW) index have been proposed as novel impedance parameters...
Source: Digestive Diseases - November 7, 2022 Category: Gastroenterology Source Type: research
The Role of Mean Nocturnal Baseline Impedance and Post reflux Swallow-induced Peristaltic Wave Index in the Diagnosis and Treatment of Gastroesophageal Reflux Disease
Background: As living standards improve, more and more people are becoming overweight or obese, which has led to a gradual increase in the incidence of gastroesophageal reflux disease (GERD). Esophageal multi-channel intraluminal impedance pH monitoring is a technique widely used in the clinical diagnosis of GERD. Commonly used traditional impedance parameters include acid exposure time (AET), number of reflux episodes (NRE), symptom association probability (SAP), and symptom index (SI). Recently, mean nocturnal baseline impedance (MNBI) and post reflux swallow-induced peristaltic wave (PSPW) index have been proposed as no...
Source: Digestive Diseases - November 7, 2022 Category: Gastroenterology Source Type: research
Serum CCL2 is associated with visceral adiposity but not fibrosis in patients with Non-alcoholic Fatty Liver Disease (NAFLD).
Conclusion. Circulating CCL2 and FABP2 are associated with NAFLD co-morbidities, but not liver disease progression in patients with NAFLD. (Source: Digestive Diseases)
Source: Digestive Diseases - November 3, 2022 Category: Gastroenterology Source Type: research
Early Monitoring of Response (MORE) to Golimumab Therapy: results of a multicenter, prospective observational trial
Background: The therapeutic goal of clinical remission in patients with moderate to severe ulcerative colitis (UC) is achieved after biological therapy only in 16% to 39%. Individualization of therapeutic intervention would benefit from prediction of early response.
Study objective: The primary objective of our study was to assess golimumab (GLM) trough serum level of ≥ 2.5 μg/mL in combination with a reduction of fecal calprotectin (FC) of ≥ 50% at week 6 compared to baseline to predict clinical response at week 26 after regular GLM intake.
Methods: Patients with moderate to severe active UC and planed GLM treatment...
Source: Digestive Diseases - November 2, 2022 Category: Gastroenterology Source Type: research
