Pretreatment apparent diffusion coefficient cannot predict histopathological features and response to neoadjuvant radiochemotherapy in rectal cancer. A Meta-Analysis
Conclusion: ADC correlates moderately with expression of Ki 67 in RC. ADC cannot discriminate tumor stages, grades and KRAS status in RC. ADC cannot predict therapy response to neoadjuvant radiochemotherapy in RC. (Source: Digestive Diseases)
Source: Digestive Diseases - March 3, 2021 Category: Gastroenterology Source Type: research

Novel Biomarkers in the Diagnosis of Benign and Malignant GI Diseases
Background. Various non-invasive biomarkers have been used in the diagnosis, prognosis and treatment of different gastrointestinal (GI) diseases for years. Novel technological developments and profound perception of molecular processes related to GI diseases over the last decade has allowed researchers to evaluate genetic, epigenetic and many other potential molecular biomarkers in different diseases and clinical settings. Here we present a review of recent most relevant papers in order to summarize major findings on novel biomarkers in the diagnosis of benign and malignant GI diseases. Summary. Genetic variations, non-cod...
Source: Digestive Diseases - February 28, 2021 Category: Gastroenterology Source Type: research

Evaluation of Diarrhea in Patients with COVID-19
Conclusions:The presence of diarrhea should indicate a suspected COVID-19 infection and suggest testing for early diagnosis of the disease. It should be kept in mind that the course of the disease may be more severe in these patients and precautions should als o be taken in terms of fecal transmission during discharge. (Source: Digestive Diseases)
Source: Digestive Diseases - February 28, 2021 Category: Gastroenterology Source Type: research

Eosinophilic esophagitis and achalasia: two distinct nosologic entities or a possible etiopathogenic association?
Background: Despite the fact that researchers have made significant progress in elucidating pathophysiology of esophageal diseases, the understanding of esophageal motility alterations in patients with eosinophilic esophagitis is in its infancy and current published medical literature remains rather scarce on this topic. A growing body of scientific data regarding associations between esophageal motor disorders such as achalasia and eosinophilic esophagitis exists nowadays. Summary: It seems that association of eosinophilic esophagitis and achalasia does not constitute a cause and effect relationship, as it is not clear w...
Source: Digestive Diseases - February 28, 2021 Category: Gastroenterology Source Type: research

Chronic abdominal pain in general practice
Abstract Background and Summary. Chronic abdominal pain is a challenging complaint for both primary care providers and gastroenterologists alike, due to a broad differential diagnosis and sometimes extensive and negative workup. In the absence of red flag features that herald more acute conditions, the majority of patients with chronic abdominal pain have a benign cause or a functional disorder (e.g. Irritable bowel syndrome). The costs associated with a diagnostic workup are an expensive burden to healthcare. A systematic approach for evaluating patients and initiating a management plan are recommended in the primary car...
Source: Digestive Diseases - February 24, 2021 Category: Gastroenterology Source Type: research

Fecal lactoferrin predicts primary non-response to biologic agents in inflammatory bowel disease
Conclusions: In CD and UC patients during induct ion with biologic agents early FL measurements accurately separate clinical responders from those experiencing PNR. The method described here offers several potential advantages over other strategies to assess and manage these patients. (Source: Digestive Diseases)
Source: Digestive Diseases - February 24, 2021 Category: Gastroenterology Source Type: research

Characteristics and Outcomes of Endoscopies Before and During the COVID-19 Pandemic in New York
This study aimed to characterize differences in gastrointestinal endoscopies in the New York metropolitan region before, during, and after the first wave of the pandemic. Methods Across three hospitals, we compared demographics, indications, and yield of endoscopies before and after March 16, 2020, the date on which elective procedures were cancelled, as well as a recovery period for five months after they were resumed. Results A total of 9,401 procedures before and 332 procedures were performed during the first wave. Females comprised 57% and 44% of patients (p (Source: Digestive Diseases)
Source: Digestive Diseases - February 24, 2021 Category: Gastroenterology Source Type: research

Inflammatory cell numbers in the stomach of Japanese subjects with endoscopically normal mucosa without H. pylori infection
Introduction: Since inflammatory cells, such as lymphocytes and plasma cells, normally inhabit the stomach, the border between normal and mild inflammation is difficult to visually determine using the updated Sydney system scale of gastritis. Additionally, eosinophils in the gastric mucosa must be counted to diagnose eosinophilic gastritis. We aimed to determine the normal number of inflammatory cells in patients with endoscopically normal mucosa and without H. pylori infections. Methods: We assessed patients aged 20 –79 years, who had undergone upper gastrointestinal endoscopy at Kawasaki Medical School Hospital be...
Source: Digestive Diseases - February 18, 2021 Category: Gastroenterology Source Type: research

Management of Chronic Diarrhea in Primary Care: The Gastroenterologists Advice
Background: Chronic diarrhea is defined as more than three bowel movements per day, or loose stools, or stool weight> 200 g/d for at least 4 weeks. Accompanying symptoms may include urgency, abdominal pain or cramps. Summary: A number of causes have to be considered, including inflammatory, neoplastic, malabsorptive, infective, vascular and functional gastrointestinal diseases. Other causes include food intolerances, side effects of drugs, or postsurgical conditions. Diarrhea may also be symptom of a systemic disease, like diabetes or hyperthyroidism. Special patient groups, like the very elderly and immunocompromised ...
Source: Digestive Diseases - February 14, 2021 Category: Gastroenterology Source Type: research

Sleep disturbance in Inflammatory Bowel Disease is associated with disease activity and adverse outcome
Conclusion: There is a high prevalence of poor SQ in IBD patients, highlighting the importance of its inclusion in patient reported outcomes. Sleep disturbance seems to have prognostic value in IBD. (Source: Digestive Diseases)
Source: Digestive Diseases - February 14, 2021 Category: Gastroenterology Source Type: research

Efficacy of vonoprazan for refractory reflux esophagitis after esophagectomy
Background: Refractory reflux esophagitis (RRE), unresponsive to conventional proton-pump inhibitors (PPIs) is a complication in esophagectomy with gastric pull-up. Vonoprazan, a novel potassium-competitive acid blocker, has been available in Japan since 2015. Here, we investigated the efficacy of vonoprazan on PPI-resistant RRE after esophagectomy with gastric pull-up. Methods: This was a single-center retrospective study. We used the revised Los Angeles (r-LA) classification based on the Los Angeles (LA) classification and the modified Los Angeles (m-LA) classification to evaluate abnormal forms of mucosal breaks such ...
Source: Digestive Diseases - February 9, 2021 Category: Gastroenterology Source Type: research

Reflux symptoms – functional and structural diseases The approach from the general practitioner (GP)
A primary care management strategy of gastroesophageal reflux disease (GERD) should pay attention to the epidemiology, prevalence and distribution of reflux-like symptoms in the community, to the special characteristics of patients presenting for the first time with reflux symptoms in primary care. General practitioners (GPs) encounter daily challenges to make cost-effective differential diagnostic and therapeutic decisions, avoiding needless and costly investigation or referral. They should provide long-term effective control of symptoms and esophageal healing in a personalized, symptom based, patient-centered and evidenc...
Source: Digestive Diseases - February 8, 2021 Category: Gastroenterology Source Type: research

Reflux symptoms – functional and structural diseases The approach from the GI specialist
The GI specialist has an important role to play in the long-term management of gastroesophageal reflux disease (GERD) patients; to secure a proper diagnosis and the selection of best possible therapeutic strategy. Through intensified information and education the implementation of national and international guidelines can be more effectively processed, whereupon a significant improvements in also cost-effectiveness of the current management will be fostered. Regarding the more specific group of GERD patients, as represented by the so called PPI refractory patients, data have now emerged to guide us into the future. Notewor...
Source: Digestive Diseases - February 8, 2021 Category: Gastroenterology Source Type: research

NASH/liver fibrosis prevalence and incidence of non-liver comorbidities among people with NAFLD and incidence of NAFLD by metabolic comorbidites: Lessons from South Korea
Background: NAFLD incidence, NASH prevalence, NAFLD fibrosis prevalence, incidence of metabolic comorbidities, as well as mortality data in the NAFLD population remain limited. Aims: We used a meta-analytic approach to “stage” NAFLD among the Korean population. Methods: We searched PubMed, Embase, Cochrane Library, and KoreaMed from inception until June 29, 2019 and calculated pooled estimates via random-effects model. Results: We screened 1,485 studies and analyzed 191 eligible studies: 179 (3,556,579 partici pants) for NAFLD prevalence and outcome analysis and 32 (1,089,785 participants) for NAFLD incidence ...
Source: Digestive Diseases - February 2, 2021 Category: Gastroenterology Source Type: research

Association between the frequency of daily tooth brushing and development of nonalcoholic fatty liver disease
Conclusions: Frequent tooth brushing was shown to significantly reduce the risk of developing NAFLD.   (Source: Digestive Diseases)
Source: Digestive Diseases - February 2, 2021 Category: Gastroenterology Source Type: research

Early kidney dysfunction in non-alcoholic fatty liver disease - is transient elastography useful as a screening method?
Conclusion: Significant liver fibrosis is associated with a significant increased risk of EKD in patients with MAFLD, regardless of other comorbidities. Higher levels of LSM, particularly>6.1kPa, alert for timely identification of EKD and associated comorbidities, as well as their control, in order to prevent the development of CKD in the long term. (Source: Digestive Diseases)
Source: Digestive Diseases - January 27, 2021 Category: Gastroenterology Source Type: research

Outcomes of Radiofrequency ablation vs endoscopic surveillance for Barrett's esophagus with low-grade dysplasia: A systematic review and meta-analysis
CONCLUSIONS: Based on our meta-analysis, there was a significant reduction in the risk of progression to HGD or EAC among patients with BE-LGD treated with RFA compared with those undergoing endoscopic surveillance. Endoscopic eradication therapy with RFA should be the preferred management approach for BE-LGD (Source: Digestive Diseases)
Source: Digestive Diseases - January 26, 2021 Category: Gastroenterology Source Type: research

Gastroenterologists attitude regarding medical cannabis for IBD in Israel
Conclusion: The use of MC for IBD patients is commonly encountered. Completely different attitudes regarding this treatment were seen. Age above 50 and female physicians generally had a more positive attitude towards the use of MC. Guidelines and clear recommendations are needed. (Source: Digestive Diseases)
Source: Digestive Diseases - January 26, 2021 Category: Gastroenterology Source Type: research

Unusual Biliary Complication following Christmas Eve dinner
We present a case of a fish bone impacted in the papilla of Vater resulting in dyspepsia and mild elevation in liver function tests, that was subsequently treated endoscopically. Fish bones are one of the most commonly encountered of swallowed foreign bodies. However involvement of the biliary tract, such as the one described by us, represents an extremely rare complication of fish bone ingestion. The diagnosis of a foreign body in the biliary tract can be difficult and early endoscopic or surgical extraction may be required to avoid complications such as biliary stone formation, obstructive jaundice, cholangitis or cholec...
Source: Digestive Diseases - January 21, 2021 Category: Gastroenterology Source Type: research

Sleeve gastrectomy is the most common cause of Gastro-esophageal Reflux Disease in comparison with other bariatric operations
Abstract Introduction GERD is one of the complications of bariatric operations that might affect the quality of life. We aim to perform a retrospective cohort study to determine the incidence of symptomatic GERD following different types of bariatric surgery and which operations are considered a contraindication of GERD. Besides, we are attempting to identify the risk factors of GERD after bariatric surgery. Methods Medical records of 729 patients undergone bariatric operations between January 2010 and June 2019 at Shamir (Assaf Harofeh) Medical Center were reviewed. Results There was a significant difference between...
Source: Digestive Diseases - January 12, 2021 Category: Gastroenterology Source Type: research

Ascitic Fluid Cytokines in Chronic Liver Disease: A Possible Prognostic Tool
Conclusion: Ascitic fluid levels of IL-4, IL-6 and IL-10 are higher in hepatocellular carcinoma patients than patients with cirrhosis alone. Levels of ascitic fluid IL2 and IL10 were proved to be a better prognostic tool than their levels in sera of the same patients. To conclude; patients with cirrhosis may be subjected to scheduale d examination of ascitic fluid cytokine to predect transformation into hepatocellular carcinoma. (Source: Digestive Diseases)
Source: Digestive Diseases - January 12, 2021 Category: Gastroenterology Source Type: research

Delayed Release Phosphatidylcholine is Effective for Treatment of Ulcerative Colitis: A Meta-Analysis
Conclusions: A 30% PC containing lecithin in delayed intestinal release formulation imp roves clinical and endoscopic outcomes, histologic activity and quality of life in patients with ulcerative colitis. For the patients lack of adverse events is an important consideration. (Source: Digestive Diseases)
Source: Digestive Diseases - January 12, 2021 Category: Gastroenterology Source Type: research

Clinical and Endoscopic Characteristics of Chinese Cronkhite-Canada Syndrome Patients: A Retrospective Study of 103 cases
Conclusions: middle-aged and elderly people are the high-risk group; various GI symptoms are observed in Chinese patients; the typical endoscopic finding is multiple small sessile polyps; these GI polyps has a chance of malignant potential. Long-term endoscopic surveillance and follow-up are recommended for the Chinese CCS patients. Key words: Cronkhite-Canada syndrome, Clinical characteristics, Endoscopy (Source: Digestive Diseases)
Source: Digestive Diseases - January 12, 2021 Category: Gastroenterology Source Type: research

Development of an online app to predict post-endoscopic retrograde cholangiopancreatography adverse events using a single center retrospective cohort
Conclusion: Our app may allow an optimization of the patients ’ care, by helping in the process of decision making, not only regarding patient or endoscopist’s selection but also definition of an adequate and tailored surveillance plan after the procedure. (Source: Digestive Diseases)
Source: Digestive Diseases - January 10, 2021 Category: Gastroenterology Source Type: research

Dual Clarithromycin and Metronidazole Resistance is the Main Cause of Failure in Ultimate Helicobacter pylori Eradication
Conclusions: Dual CLA/MET-R w as the main cause of failure in ultimate H. pylori eradication, and 7 days- bismuth quadruple or concomitant regimen would not be suitable for H. pylori eradication in dual CLA/MET-R group. (Source: Digestive Diseases)
Source: Digestive Diseases - January 10, 2021 Category: Gastroenterology Source Type: research

Co-Medication and nutrition in HCC: Potentially preventative strategies in Hepatocellular carcinoma (HCC)
Background: Hepatocellular carcinoma (HCC) is one of the leading causes of cancer-related death worldwide with about 841,000 new cases and 782,000 deaths annually. Given the clearly defined population at risk, mostly patients with liver cirrhosis, prevention of HCC could be highly effective. Summary: Besides regular ultrasound surveillance, numerous publications have suggested protective effects of diverse drugs and nutrients. However, none of those preventive options has made it into clinical routine or practice guidelines. We therefore summarize the current status on preventive effects of drugs such as statins, acetylsa...
Source: Digestive Diseases - January 10, 2021 Category: Gastroenterology Source Type: research

HELICOBACTER PYLORI INFECTION in CHILDREN with CONCURRENT CELIAC DISEASE and TYPE 1 DIABETES MELLITUS
This study aimed to evaluate the association between Hp and concomitant CD+T1DM in children. Methods: In this two-center, case-control study, children who underwent esophago-gastro-duodenoscopy were studied. CD diagnosis was established by favorable histology and serology. Hp infection was confirmed by both histology and the rapid urease test. Patients were divided into three groups as CD only (CDo), CD+T1DM, and non-CD children who underwent endoscopy as controls. Results: Among the 1431 esophago-gastro-duodenoscopies performed, 783 cases were eligible. Overall, 215 cases had CDo (mean age: 9.12 ±4.18 years, 58.1...
Source: Digestive Diseases - January 10, 2021 Category: Gastroenterology Source Type: research

Skeletal muscle depletion: a risk factor for pneumonia following gastric endoscopic submucosal dissection in elderly patients
Conclusions: SMD was not a rare entity in patients aged ≥80 years with gastric neoplasms. SMD was a significant risk factor for pneumonia related to gastric ESD in elderly patients. (Source: Digestive Diseases)
Source: Digestive Diseases - January 10, 2021 Category: Gastroenterology Source Type: research

Humoral immune responses and Hepatitis B Infection
Background- Chronicity or seroclearance of HBV antigens is determined by the host immune responses. Current approaches to treat Hepatitis B (HBV) patients are based on inhibition of replication using different antivirals (nucleoside or nucleotide analogues) as monotherapy or along with immune modulators as combination therapy is being used worldwide for reducing the viral load. Understanding the role of immune cellular therapies with currently available treatments for persistent viral-mediated responses in HBV patients is unexplored. However, the generation of antibodies against a surface (HBs) and envelop (HBe) antigen of...
Source: Digestive Diseases - January 10, 2021 Category: Gastroenterology Source Type: research

Reflux aspiration associated with oesophageal dysmotility but not delayed liquid gastric emptying
Abstract Introduction Severe oesophageal dysmotility is associated with treatment resistant reflux and pulmonary reflux aspiration. Delayed solid gastric emptying (SGE) has been associated with oesophageal dysmotility, however the role of delayed liquid gastric emptying (LGE) in the pathophysiology of sev ere reflux disease remains unknown. The purpose of this study is to examine the relationship between delayed LGE, reflux aspiration and oesophageal dysmotility. Methods Data was extracted from a prospectively populated database of patients with severe treatment resistant gastro-oesophageal reflux disease (GORD). All ...
Source: Digestive Diseases - December 29, 2020 Category: Gastroenterology Source Type: research

Prognostic Significance of ACP5 in Human Gastric Cancer
Conclusions: The expression of ACP5 in GC tissue was significantly higher than that in normal tissues and its overexpression was associated with a poorer prognosis, suggesting its potential roles in preventing and treating GC. (Source: Digestive Diseases)
Source: Digestive Diseases - December 13, 2020 Category: Gastroenterology Source Type: research

Worse Response to Ursodeoxycholic Acid in Primary Biliary Cholangitis Patients with Autoimmune Hepatitis Features
This study was to elucidate the clinical characteristics of PBC patients with features of AIH. Methods: We included patients with diagnostic criteria of PBC. All patients were treated with ursodeoxycholic acid (UDCA) and without immunosuppressive agents for more than one year. The biochemical response was evaluated at one year after treatment of UCDA. Results: Among 432 patients with PBC, 166 (38.4%) patients did not achieve biochemical response within one year of UDCA treatment. Non-responders had lower albumin (ALB) level and higher immunoglobulin G (IgG), alanine transaminase (ALT), alanine aminotransferase (AST), alk...
Source: Digestive Diseases - November 24, 2020 Category: Gastroenterology Source Type: research

LncRNA PMS2L2 downregulates miR-24 through methylation to suppress cell apoptosis in ulcerative colitis
Conclusion: PMS2L2 may downregulate miR-24 via methylation to suppress cell apoptosis in UC. (Source: Digestive Diseases)
Source: Digestive Diseases - November 24, 2020 Category: Gastroenterology Source Type: research

Prevalence of the Metabolic Syndrome in Severely Obese Patients Presenting for Bariatric Surgery
Conclusion: In severely obese patie nts the prevalence of the MS and the number of criteria met was high. However, over 20% of severely obese individuals have no MS and thus may be at lower risk for cardiovascular complications of obesity. It is currently unclear whether treatment strategies with respect to obesity should differ betwe en severely obese individuals with and without the MS. (Source: Digestive Diseases)
Source: Digestive Diseases - November 15, 2020 Category: Gastroenterology Source Type: research

Does perianal disease influence the efficacy of combination therapy in Crohn ’s disease?
Conclusion: In the first year of combination therapy, perianal disease is associated with an 80% decrease in endoscopic and clinical remission rates and higher ratio of disease relapse. (Source: Digestive Diseases)
Source: Digestive Diseases - November 15, 2020 Category: Gastroenterology Source Type: research

Impact of body mass index on complications of gastric endoscopic submucosal dissection
Background: Gastric endoscopic submucosal dissection (ESD) has a high rate of complications. However, it is unclear whether body mass index (BMI) affects ESD complications. We aimed to investigate the impact of BMI on ESD complications. Methods: A total of 7263 patients who underwent gastric ESD were classified into three groups according to the Asia-Pacific classification of BMI: normal (BMI (Source: Digestive Diseases)
Source: Digestive Diseases - November 8, 2020 Category: Gastroenterology Source Type: research

Contents Vol. 38, 2020
Dig Dis 2020;38:I –VI (Source: Digestive Diseases)
Source: Digestive Diseases - November 6, 2020 Category: Gastroenterology Source Type: research

Natural history of cirrhosis: changing trends in etiology over the years
Background and goals: The aims of the present study were to investigate the natural history of cirrhosis and to determine trends in the etiology of cirrhosis. Methods: Between January 2001 and January 2018, a total of 1341 patients had been diagnosed with cirrhosis were included. Results: A total of 898 cirrhotic patients, who were followed for at least six months were included into the analysis. The median age was 54 years. The median Child-Pugh and MELD scores were 7.5 and 11, respectively. Ascites (51%) was the most common causes of decompensation. Chronic viral hepatitis was the most frequent cause of cirrhosis (58%)...
Source: Digestive Diseases - November 2, 2020 Category: Gastroenterology Source Type: research

Real-world comparison of elobixibat and lubiprostone treatment in patients with chronic constipation: A propensity score matched analysis
Introduction: Elobixibat is a new laxative, but its efficacy and adverse events (AEs) are insufficiently examined compared with those of other laxatives. Hence, by propensity score (PS) matching, we compared the effects and AEs between elobixibat and lubiprostone. Methods: We retrospectively analyzed 1887 Japanese patients with chronic constipation (CC) treated at our hospital between October 2013 and April 2020. Enrolled patients were divided into three treatment groups, namely, elobixibat (10 mg daily) (E10 group, n = 293), lubiprostone (24 mcg daily) (L24 group, n = 772), and lubiprostone (48 mcg daily) (L48 group, n =...
Source: Digestive Diseases - November 2, 2020 Category: Gastroenterology Source Type: research

Efficacy of 90y-radioembolization in metastatic colorectal cancer depending on the primary tumor side
Metastatic colorectal cancer (mCRC) is associated with different molecular biology, clinical characteristics and outcome depending on the primary tumor localization. We aimed to evaluate the effectiveness of 90Y-radioembolization (RE) for therapy of colorectal liver metastases depending on the primary tumor side. We performed a retrospective analysis of n=73 patients with mCRC and RE in our university liver center between 2009 and 2018. Patients were stratified according to the primary tumor side (left vs. right hemicolon), treatment response was assessed by the Response Evaluation Criteria in Solid Tumors (RECIST) at fo...
Source: Digestive Diseases - November 2, 2020 Category: Gastroenterology Source Type: research

Helicobacter pylori eradication rates in Slovenia in the period from 2017 to 2019 – data from the European Registry on Helicobacter pylori Management (Hp-EuReg)
Conclusions. Slovenia is a country with (Source: Digestive Diseases)
Source: Digestive Diseases - October 22, 2020 Category: Gastroenterology Source Type: research

Publisher's Note
Dig Dis (Source: Digestive Diseases)
Source: Digestive Diseases - October 19, 2020 Category: Gastroenterology Source Type: research

Mucin secretion in cystic fibrosis – a systematic review
Conclusions Increased expression of MUC5AC in the surface epithelium and of MUC5B in the sub-epithelial glands may be the result of higher secretion rate of mucin into the lumen of the respiratory tract, causing mucus plaque, infection and inflammation. (Source: Digestive Diseases)
Source: Digestive Diseases - October 12, 2020 Category: Gastroenterology Source Type: research

Transversal incision and longitudinal septostomy- "One size does not fit all"
NA (Source: Digestive Diseases)
Source: Digestive Diseases - October 12, 2020 Category: Gastroenterology Source Type: research

COVID-19 and Gastrointestinal Disease: Implications for the Gastroenterologist
Background: COVID-19 was initially considered a respiratory disease but the SARS-CoV-2 virus can lead to serious systemic consequences affecting major organs including the digestive system.Summary: This review brings new clinically important information for the gastroenterologist. This includes: the mechanisms of tissue damage seen with the SARS-CoV-2 virus; the consequences of immunosuppression in patients with inflammatory bowel disease (IBD) and chronic liver disease with the additional risks of decompensation in patients with cirrhosis; the impact of COVID-19 on gastrointestinal emergencies, on gastrointestinal endosco...
Source: Digestive Diseases - October 8, 2020 Category: Gastroenterology Source Type: research

COVID-19 and Gastrointestinal Disease. Implications for the Gastroenterologist
COVID-19 was initially considered to be a respiratory disease but soon after the pandemic established it became clear that the SARS-CoV-2 virus which caused the disease could lead to serious systemic consequences affecting most of the major organs including the digestive tract, liver and pancreas. This review brings together the new information which is clinically relevant to the gastroenterologist including the origins of the disease, mechanisms of tissue damage and how this affects specific patient groups, including those with inflammatory bowel disease, comorbidities and the role of immunosuppression, chronic liver dise...
Source: Digestive Diseases - October 8, 2020 Category: Gastroenterology Source Type: research

Impact of SARS-CoV-2 Infection on patients suffering from Liver Injury
With great interest, we have read the recent article by Olympia E. Anastasioua et al(1), wherein the authors described the effect of SARS-CoV-2 infection on mortality in patients suffering from Mild or severe liver injury. They demonstrated that while the mild liver injury was not associated with worse outcomes in their cohort, a cohort with severe liver injury showed multiple-organ failure and acute vascular events leading to higher mortality(1). (Source: Digestive Diseases)
Source: Digestive Diseases - October 8, 2020 Category: Gastroenterology Source Type: research

COVID-19 and Gastrointestinal Disease: Implications for the Gastroenterolo-gist
COVID-19 was initially considered to be a respiratory disease but soon after the pandemic established it became clear that the SARS-CoV-2 virus which caused the disease could lead to serious systemic consequences affecting most of the major organs including the digestive tract, liver and pancreas. This review brings together the new information which is clinically relevant to the gastroenterologist including the origins of the disease, mechanisms of tissue damage and how this affects specific patient groups, including those with inflammatory bowel disease, comorbidities and the role of immunosuppression, chronic liver dise...
Source: Digestive Diseases - October 8, 2020 Category: Gastroenterology Source Type: research

Response to the letter: Impact of SARS-CoV-2 infection on patients suffering from liver injury
- (Source: Digestive Diseases)
Source: Digestive Diseases - October 8, 2020 Category: Gastroenterology Source Type: research

Evaluation of Ki67 index in endoscopic ultrasound-guided fine needle aspiration samples for the assessment of malignancy risk in gastric gastrointestinal stromal tumors
Background: The risk of malignancy in resected gastrointestinal stromal tumors (GISTs) depends on tumor size, location, and mitotic index. Reportedly, the Ki67 index has a prognostic value in resected GISTs. We aimed to analyze the accuracy of endoscopic ultrasound (EUS)-guided fine needle aspiration (FNA) samples with reference to Ki67 index, using surgical specimens as the gold standard. Methods: Fifty-five patients who underwent EUS-FNA followed by surgical resection for gastric GISTs were retrospectively analyzed. Patients ’ age and sex; tumors’ size and location; mitotic index, cell type, cellularity, ple...
Source: Digestive Diseases - October 4, 2020 Category: Gastroenterology Source Type: research