Single Nucleotide Polymorphisms in MicroRNA-Binding Site of Epidermal Growth Factor Receptor Signaling Pathway and Susceptibility to Esophageal Squamous Cell Carcinoma
Conclusions: Results of these analyses underline the support of the notion that SNPs in microRNA-binding site of EGFR signaling pathway play certain important roles in the susceptibility to ESCC.Dig Dis (Source: Digestive Diseases)
Source: Digestive Diseases - July 3, 2019 Category: Gastroenterology Source Type: research

Hepatocellular Carcinoma Occurrence/Recurrence after Direct-Acting Antivirals for Hepatitis C in Egyptian Cohort: Single-Center Experience
Conclusions: Although HCC occurrence after DAAs was not high, recurrence was apparently high. Pretreatment alpha-fetoprotein is a predictor for de novo HCC. The time between HCC ablation and DAAs was the strongest predictor of recurrence.Dig Dis (Source: Digestive Diseases)
Source: Digestive Diseases - June 19, 2019 Category: Gastroenterology Source Type: research

Furosemide Dose Changes Associated with Furosemide/Tolvaptan Combination Therapy in Patients with Cirrhosis
Conclusion: A combination therapy of tolvaptan and furosemide enabled furosemide dose reductions. Systematic reductions of the furosemide doses can lead to the improvement of renal function.Dig Dis (Source: Digestive Diseases)
Source: Digestive Diseases - June 19, 2019 Category: Gastroenterology Source Type: research

Crohn ’s Disease Patients with Depression Exhibit Alterations in Monocyte/Macrophage Phenotype and Increased Proinflammatory Cytokine Production
Conclusion: Monocytes subpopulation disequilibrium toward intermediate and nonclassic phenotypes and macrophage polarization toward M1 phenotype with increased proinflammatory cytokine release are more likely to be found in CD patients with depressive symptoms.Dig Dis (Source: Digestive Diseases)
Source: Digestive Diseases - June 19, 2019 Category: Gastroenterology Source Type: research

Cirrhosis Is a Predictor of Adverse Events in Endoscopic Ultrasound Fine-Needle Aspiration: A Propensity-Score Analysis
Conclusions: The rate of AEs after EUS fine-needle aspiration is higher in cirrhotic patients, and acute-on-chronic liver failure may represent a serious complication of this procedure.Dig Dis (Source: Digestive Diseases)
Source: Digestive Diseases - June 18, 2019 Category: Gastroenterology Source Type: research

Unusual Etiology for Transaminitis
We report the case of a 37-year-old man who presented to the gastroenterology clinic with abdominal pain and was found to have elevated transaminases. Workup for acute/chronic liver disease was unrevealing. He underwent endoscopic evaluation showing a live pinworm in the colon. He was treated with albendazole with improvement in GI symptoms and resolution of his transaminitis. There are scarce reports in the literature describing pathognomonic, clinical, imaging, and laboratory findings for pinworm infection. Here, we attempt to review the literature for hepatic involvement with an enterobius infection and discuss the find...
Source: Digestive Diseases - June 14, 2019 Category: Gastroenterology Source Type: research

Author Index / Subject Index
Dig Dis 2019;37:422 (Source: Digestive Diseases)
Source: Digestive Diseases - June 6, 2019 Category: Gastroenterology Source Type: research

Prelims
Dig Dis 2019;37:343 –346 (Source: Digestive Diseases)
Source: Digestive Diseases - June 6, 2019 Category: Gastroenterology Source Type: research

Hepatic Encephalopathy Aggravated by Systemic Inflammation
Conclusions: The degree of HE and depression correlated with a proinflammatory cytokine pattern. It suggests that beside ammonia elevation, inflammatory cytokines determine occurrence and severity of hepatic encephalopathies. Thus, it can be defined a preferential therapeutic target.Dig Dis (Source: Digestive Diseases)
Source: Digestive Diseases - June 6, 2019 Category: Gastroenterology Source Type: research

Benefit of Pelvic Floor Physical Therapy in Pediatric Patients with Dyssynergic Defecation Constipation
Conclusion: The new field of pediatric PFPT is a safe and effective intervention for children with dyssynergic defecation causing or contributing to chronic constipation, particularly in  children whose comorbidities include anxiety and low ­muscle tone.Dig Dis (Source: Digestive Diseases)
Source: Digestive Diseases - May 17, 2019 Category: Gastroenterology Source Type: research

Age Affects Clinical Management after Noncurative Endoscopic Submucosal Dissection for Early Gastric Cancer
Conclusions: Despite the fact that almost 80% of super-elderly patients did not undergo additional surgery, the difference of OS between patients with and without additional surgery was not significant only in patients ≥80 years. Therefore, establishment of criteria for selecting treatment methods after noncurative ESD in elderly patients is required.Dig Dis (Source: Digestive Diseases)
Source: Digestive Diseases - May 17, 2019 Category: Gastroenterology Source Type: research

Pancreatic Solid Focal Lesions: Differential Diagnosis between Autoimmune Pancreatitis and Pancreatic Cancer
Conclusion: Diagnosis of early cancer stages, particularly differentiating AIP from PC can be sometimes problematic. IgG4 levels can be slightly elevated also in case of PC. A targeted biopsy of the pancreas is the method of choice in cases suspected from a focal form of AIP and we recommend to prefer it over other modalities, such as, for example, response to steroid therapy.Dig Dis (Source: Digestive Diseases)
Source: Digestive Diseases - May 10, 2019 Category: Gastroenterology Source Type: research

Psoriasis and Inflammatory Bowel Disease
Background: Inflammatory bowel disease (IBD) and psoriasis (PS) are associated conditions. The reason for this association lies in the sharing of predisposition genes and common immunological mechanisms.Summary: This review will focus on the interplay between IBD and PS, with details on prevalence and phenotype of PS in IBD, genetics, pathogenetic pathways, and therapy.Key Messages: Microbiome seems relevant in both conditions: a reduction of beneficial bacteria has been observed. IBD and PS have in common some comorbidities like cardiovascular disease, similar risk of cancer and psychiatric problems. Many biological thera...
Source: Digestive Diseases - May 10, 2019 Category: Gastroenterology Source Type: research

Portal Angiogenesis in Chronic Liver Disease Patients Correlates with Portal Pressure and Collateral Formation
Conclusions: Angiogenesis factors correlated with portal pressure and collateral formation and different patterns of circulating angiogenesis mediators were found in peripheral and portal blood of patients with chronic liver disease. These results support the importance of angiogenic pathways in cirrhosis and portal hypertension and highlight areas for further study to identify clinically useful noninvasive markers of portal pressure and collateral formation.Dig Dis (Source: Digestive Diseases)
Source: Digestive Diseases - May 8, 2019 Category: Gastroenterology Source Type: research

The Diagnosis and Therapy of < b > < i > Helicobacter pylori < /i > < /b > Infection in Hungary: Comparison of Strategies Applied by Family Physicians and Internists
Conclusion: The adherence to the recent recommendations of current guidelines is moderate. There is a need to increase adherence to current recommendations by family physicians and internists.Dig Dis (Source: Digestive Diseases)
Source: Digestive Diseases - May 8, 2019 Category: Gastroenterology Source Type: research

Relationship between Serum Adalimumab Levels and Clinical Outcome in the Treatment of Inflammatory Bowel Disease
Background: Adalimumab (ADA) is an anti-tumor necrosis factor agent that has been shown to be effective in inducing and maintaining remission in adult patients with inflammatory bowel disease. The relationship between the ADA trough levels and clinical efficacy has been demonstrated, but there is variability in the definition of the most suitable range for its clinical applicability.Summary: A review of published studies during the last 5 years on ADA serum levels and its relationship with the clinical outcome was performed. The studies selected included 7 observational studies, a systematic review, a meta-analysis and a p...
Source: Digestive Diseases - May 5, 2019 Category: Gastroenterology Source Type: research

Fecal Microbiota Transplantation for < b > < i > Clostridium difficile < /i > < /b > Infection: A One-Center Experience
Conclusions: Consistent with some previous reports, we found the following: the source of the donor for FMT did not make a difference in recovery: material from nonrelatives was as effective as from close relatives; and the presence of multiple comorbidities did not make a difference in recovery: patients with 2 or more comorbidities did as well as those with one or none.Dig Dis (Source: Digestive Diseases)
Source: Digestive Diseases - May 5, 2019 Category: Gastroenterology Source Type: research

Diet and Inflammatory Bowel Disease: Thoughts on Food, Perceptions and Beliefs
Dig Dis (Source: Digestive Diseases)
Source: Digestive Diseases - May 5, 2019 Category: Gastroenterology Source Type: research

A Surgeon ’s Role in the Management of Early Esophageal, EGJ and Gastric Lesions
Background: Endoscopic mucosal resection and submucosal dissection (ESD) are indicated in a majority of mucosal esophageal, esophagogastric junction and gastric cancers (GC), and selected cases of submucosal cancers as well.Summary: The presence of lymph node metastases in early esophageal cancer (EC) has been proven in up to 50% of ­patients with sm3 cancers treated with surgical resection, and up to 18.5 and 30.5% in sm1 and sm2 cancer respectively. The presence of lymphovascular invasion (LVI), tumor depth #x3e;500 μm and poor tumor differentiation seem to be a common predictor of worse outcomes in literature rep...
Source: Digestive Diseases - April 26, 2019 Category: Gastroenterology Source Type: research

Clinical Profile, Response to Therapy, and Outcome of Children with Primary Intestinal Lymphangiectasia
Conclusion: Presence of chylous ascites suggests severe disease in children with PIL. Majority of PIL children respond to dietary therapy; only 20% need additional therapy. Long-term follow-up is essential to monitor for symptoms relapse and complications.Dig Dis (Source: Digestive Diseases)
Source: Digestive Diseases - April 26, 2019 Category: Gastroenterology Source Type: research

Pancreatic Mass or Cyst? Diagnostic Dilemma
We present a case of a single episode of pancreatitis who underwent EUS for evaluation of possible pancreatic mass leading to a diagnosis of santorinicele and complete pancreatic divisum. We attempt to describe this anomaly, diagnostic approach, and management options.Dig Dis (Source: Digestive Diseases)
Source: Digestive Diseases - April 15, 2019 Category: Gastroenterology Source Type: research

The Rationale and Efficacy of Primary and Secondary Prevention in Adenocarcinomas of the Upper Gastrointestinal Tract
While the primary risk factor for oesophageal adenocarcinoma (OAC) and its precursor lesion Barrett ’s oesophagus (BO) is gastro-oesophageal reflux, the infection withHelicobacter pylori (H. pylori) is the dominant risk factor for gastric cancer. Reduction of reflux by dietary measures and proton pump inhibitors has some merits in OAC prevention, and the chemopreventive effect of Aspirin and statins is being widely investigated; however, improved outcome in OAC occurs primarily as the result of secondary prevention. Early detection of neoplastic lesions in Barrett ’s metaplasia can be achieved by surveillance e...
Source: Digestive Diseases - April 15, 2019 Category: Gastroenterology Source Type: research

Pulley Traction-Assisted Colonic Endoscopic Submucosal Dissection: A Retrospective Case Series
Conclusion: The “pulley” method affords good visibility of the submucosal layer by changing the traction direction in cases that are difficult to manage by conventional traction-assisted ESD.Dig Dis (Source: Digestive Diseases)
Source: Digestive Diseases - April 3, 2019 Category: Gastroenterology Source Type: research

Assessment of Duodenal Adenomas and Strategies for Curative Therapy
Background: The increasing incidence of duodenal neoplasm has underlined different methods of resection depending on the clinical presentation, endoscopic features and histopathology. In this comprehensive review, we systematically describe the current knowledge concerning the diagnosis and management of duodenal adenomas (DAs) and discuss data considering all possible therapeutic approaches.Summary: Among a variety of duodenal lesions, including neuroendocrine tumors and gastrointestinal stromal tumors, DAs present precancerous lesions of the duodenal papilla or non-ampullary region necessitating removal. DAs can occur sp...
Source: Digestive Diseases - March 31, 2019 Category: Gastroenterology Source Type: research

Pancreatic Neuroendocrine Tumours: The Role of Endoscopic Ultrasound Biopsy in Diagnosis and Grading Based on the WHO 2017 Classification
Conclusion: EUS biopsy is an accurate method for the diagnosis and grading of pNETs based on the WHO 2017 Ki-67 labelling scheme.Dig Dis (Source: Digestive Diseases)
Source: Digestive Diseases - March 21, 2019 Category: Gastroenterology Source Type: research

Bowel Preparation for Colonoscopy in Children: 1 Day PEG-3350 with Bisacodyl versus 3 Day Sennosides
Conclusions: The efficacy, safety, and adverse effect profile of 1-day BP with PEG-B regimen was found to be similar to 3-day sennosides regimen, however, the PEG-B regimen had advantages such as short duration, ease of administration, and better patient comfort. Also, high correlation rate between the Boston and Ottawa scales in pediatric patients was remarkable.Dig Dis (Source: Digestive Diseases)
Source: Digestive Diseases - March 7, 2019 Category: Gastroenterology Source Type: research

Appropriate Management of Attenuated Familial Adenomatous Polyposis: Report of a Case and Review of the Literature
We present a case of a 22-year-old female with AFAP who was treated with endoscopic polypectomy and surveilled by annual colonoscopy. Guidelines for AFAP surveillance suggest annual colonoscopy with endoscopic polypectomy in asymptomatic individuals. Indications for immediate surgery include documented or suspected cancer or significant symptoms. Preferred surgical option in AFAP is colectomy and ileo-rectal anastomosis. Surveillance of the AFAP patients should include upper GI endoscopy and duodenoscopy with random biopsies of fundic gland polyps and endoscopic resection of detected adenomas. Annual thyroid ultrasound is ...
Source: Digestive Diseases - March 7, 2019 Category: Gastroenterology Source Type: research

Risk Factors for Low Bone Density in Inflammatory Bowel Disease: Use of Glucocorticoids, Low Body Mass Index, and Smoking
Conclusion: In addition to the generally accepted risk factors for osteoporosis (glucocorticoids, low BMI, smoking), male IBD patients had a trend toward lower BMD. Carrying a mutaticon in NOD2 did not confer a risk for bone loss.Dig Dis (Source: Digestive Diseases)
Source: Digestive Diseases - February 21, 2019 Category: Gastroenterology Source Type: research

Mentality, Career, Mentorship: My Way
Dig Dis (Source: Digestive Diseases)
Source: Digestive Diseases - February 21, 2019 Category: Gastroenterology Source Type: research

General Aspects of Primary Cancer Prevention
Background: Cancer is the second leading cause of death worldwide next to cardiovascular diseases. Despite the advancement in screening, early diagnosis, and development in treatment technology in last several decades, cancer incidence overall, particularly that of gastrointestinal (GI) cancers, is far from being controlled, and is expected to increase worldwide.Summary: Although numerous preclinical and population-based clinical studies have already made important progress in restraining the overall cancer incidence and mortality, the full potential of preventive strategy is still far from being realized, and remains at a...
Source: Digestive Diseases - February 15, 2019 Category: Gastroenterology Source Type: research

Should Focal Nodular Hyperplasia Still be Operated Upon? Analysis of a Case Series
Conclusion: The present study suggests that it is safe to conservatively manage patients with FNH presumed by highly accurate imaging tests. Similar to hepatic hemangiomas, surgery for FNH should be an exception.Dig Dis (Source: Digestive Diseases)
Source: Digestive Diseases - February 14, 2019 Category: Gastroenterology Source Type: research

Single-Dose Linaclotide Is Equal in Efficacy to Polyethylene Glycol for Bowel Preparation Prior to Capsule Endoscopy
Conclusions: Single-dose linaclotide 1 h before capsule endoscopy was equally effective when compared to PEG in terms of visualization and transit time. This trial was registered at ClincialTrials.gov, number NCT02465385.Dig Dis (Source: Digestive Diseases)
Source: Digestive Diseases - February 7, 2019 Category: Gastroenterology Source Type: research

Validation of Tokyo Guideline 2013 as Treatment of Acute Cholecystitis by Real World Data
Conclusions: Despite the recommendations in the TG (2013), emergency cholecystectomy was not needed in any of the present patients with acute cholecystitis. Acute cholecystitis can be successfully treated with ­PTGBA or PTGBD, which are simple procedures with good short- and long-term safety. These procedures are highly recommended for patients with acute cholecystitis, especially in the elderly population.Dig Dis (Source: Digestive Diseases)
Source: Digestive Diseases - February 7, 2019 Category: Gastroenterology Source Type: research

Diabetes Mellitus and Age are Risk Factors of Interval Colon Cancer: A Case-Control Study
Conclusions: Patients with Interval cancer tend to be older and have diabetes. These patient groups should be more carefully or more frequently screened for pre-malignant lesions.Dig Dis (Source: Digestive Diseases)
Source: Digestive Diseases - February 7, 2019 Category: Gastroenterology Source Type: research

Unmet Medical Needs in Ulcerative Colitis: An Expert Group Consensus
Conclusions: These expert group meetings found a number of areas of unmet needs in UC, which is an important first step in tackling them in the future. Future research and development should be focused in these areas for the management of patients with UC.Dig Dis (Source: Digestive Diseases)
Source: Digestive Diseases - February 6, 2019 Category: Gastroenterology Source Type: research

Diagnosis and Management of Pancreatic Adenocarcinoma in the Background of Chronic Pancreatitis: Core Issues
Background: The incidence of pancreatic adenocarcinoma (PDAC) in patients with chronic pancreatitis (CP) is as high as 5%. It is a commonly encountered diagnostic challenge in patients with CP on long-term follow-up.Summary: This review consolidates the existing literature on assessment of PDAC in background of CP, its evaluation through the available investigations, surgical management, and prognostication. Recent change in symptomatology of an otherwise stable CP should raise a suspicion of malignancy. Endoscopic ultrasound (EUS) is more specific and sensitive in establishing the diagnosis of PDAC compared to cross-secti...
Source: Digestive Diseases - January 31, 2019 Category: Gastroenterology Source Type: research

Gastrointestinal Involvement in Patients with Mantle Cell Lymphoma: A Single Center Experience of Eighty-Five Patients
Conclusions: In our single center cohort, we did not find a clinical impact of GI involvement on the clinical course of MCL and no GI complications occurred during chemotherapy in these patients. As most patients were also asymptomatic, these data argue against a routine GI assessment in patients diagnosed with MCL.Dig Dis (Source: Digestive Diseases)
Source: Digestive Diseases - January 27, 2019 Category: Gastroenterology Source Type: research

Can Iodixanol Prevent Post-Endoscopic Retrograde Cholangiopancreatography Pancreatitis? A Prospective, Randomized, Controlled Trial
Conclusions: In conclusion, HOCM may play a role in the development of PEP and in PEP severity grade.Dig Dis (Source: Digestive Diseases)
Source: Digestive Diseases - January 17, 2019 Category: Gastroenterology Source Type: research

Diabetic Retinopathy as a Risk Factor Associated with the Development of Hepatocellular Carcinoma in Nonalcoholic Fatty Liver Disease
Conclusions: Diabetic retinopathy as well as liver fibrosis is a risk factor that associates with the development of HCC in NAFLD patients. Therefore, NAFLD patients with diabetic retinopathy should undergo careful screening for HCC.Dig Dis (Source: Digestive Diseases)
Source: Digestive Diseases - January 13, 2019 Category: Gastroenterology Source Type: research

Dexlansoprazole is Effective in Relieving Heartburn during the Fasting Month of Ramadan
Conclusion: Dexlansoprazole is effective in the treatment of heartburn during Ramadan. Clinicaltrials.gov number: NCT03079050.Dig Dis (Source: Digestive Diseases)
Source: Digestive Diseases - January 13, 2019 Category: Gastroenterology Source Type: research

Positive Response to Tolvaptan Treatment Would Be a Good Prognostic Factor for Cirrhotic Patients with Ascites
Conclusion: Therapeutic response to tolvaptan was associated with longer survival in cirrhosis patients complicated with ascites. These preliminary findings warrant validation and further exploration.Dig Dis (Source: Digestive Diseases)
Source: Digestive Diseases - January 13, 2019 Category: Gastroenterology Source Type: research

Pseudoachalasia as First Manifestation of a Malignancy
We describe a 16-year-old high school student referred for management of achalasia who turned out to have pseudoachalasia due to adenocarcinoma of the cardia. He was cured with preoperative chemotherapy followed by radical surgery. Therapy of pseudoachalasia secondary to neoplasia is directed against the tumor or may be palliative to keep the lumen open. Other causes of pseudoachalasia include esophageal motility disturbances as a paraneoplastic phenomenon (e.g., with small cell lung cancer), post fundoplication or post bariatric surgery, in association with a thoracic aortic aneurysm, or with sarcoidosis or amyloidosis. T...
Source: Digestive Diseases - January 2, 2019 Category: Gastroenterology Source Type: research

Gastroduodenal Symptoms in Inflammatory Bowel Disease Are Correlated with Gastric Emptying and Serum Levels of Active Ghrelin
Background: Inflammatory bowel disease (IBD) is associated with delay in gastric emptying, increase in ghrelin, and decrease in leptin. The aim was to investigate the correlation between gastroduodenal (GD) symptoms, gastric emptying, and serum levels of active ghrelin and leptin in IBD. Twenty-seven IBD patients and 26 healthy volunteers were asked to complete the Porto Alegre Dyspeptic Symptoms Questionnaire. A gastric emptying test for solids was performed using a C13 octanoic acid breath test. During this test, serum samples were collected for measuring active ghrelin and leptin concentrations by radioimmunoassay.Summa...
Source: Digestive Diseases - January 2, 2019 Category: Gastroenterology Source Type: research

Gastro Update Europe 2018
Dig Dis (Source: Digestive Diseases)
Source: Digestive Diseases - January 2, 2019 Category: Gastroenterology Source Type: research

The “Difficult” Colorectal Polyps and Adenomas: Practical Aspects
Background: Colonoscopy is the gold standard for adenoma detection. All endoscopists who perform colonoscopy must by mandate be skilled to perform polypectomy. However, there are significant differences between endoscopists in terms of the polyp detection rate and in the effectiveness of polypectomy.Summary: Most polyps identified can be managed by conventional polypectomy and do not pose a significant challenge for resection to an adequately skilled and trained endoscopist. Up to 15% of polyps may be considered “difficult”, unsuitable for conventional endoscopic removal because of size, morphology, site, or ac...
Source: Digestive Diseases - December 14, 2018 Category: Gastroenterology Source Type: research

Accuracy and Pitfalls in the Assessment of Early Gastrointestinal Lesions
Superficial neoplastic lesions of the digestive tract are usually asymptomatic, and often represent incidental findings on endoscopy. The Paris Classification was developed for the systematic evaluation of superficial lesions of the oesophagus, stomach and colon. The significance of this classification in clinical practice is that it allows the depth of invasion to be estimated. Chromoendoscopy is used to improve the visualization of gastrointestinal lesions. There are 2 types of chromoendoscopy: dye and virtual chromoendoscopy. In addition to chromoendoscopy, advanced endoscopy techniques have great importance in the dete...
Source: Digestive Diseases - December 14, 2018 Category: Gastroenterology Source Type: research

Upregulation of Fibroblast Growth Factor 19 Is Associated with the Initiation of Colorectal Adenoma
Fibroblast growth factor 19 (FGF19) promotes tumor growth in various types of cancer, but its function has not been investigated in the context of colorectal adenoma. Here, we report thatFGF19 expression was greater in colorectal adenoma than in normal tissues, as measured by an enzyme-linked immunosorbent assay, quantitative reverse-transcription PCR and immunohistochemistry.FGF19 expression was also elevated in a subset of human colon cancer cell lines. Moreover, FGF receptor 4 (FGFR4), the cognate receptor forFGF19, was upregulated in colorectal adenoma tissues. Lipid levels and body mass index values strongly correlate...
Source: Digestive Diseases - December 5, 2018 Category: Gastroenterology Source Type: research

Is Liver Ultrasound Useful as Part of the Surveillance Strategy following Potentially Curative Colorectal Cancer Resection?
Conclusion: In an era where cross-sectional imaging of colorectal cancer is commonplace, abdominal ultrasound offers additional benefit to CT as a postoperative imaging adjunct for the detection of hepatic disease recurrence.Dig Dis (Source: Digestive Diseases)
Source: Digestive Diseases - November 22, 2018 Category: Gastroenterology Source Type: research

Novel Magnified Single-Balloon Enteroscopy Enables Observation of Jejunal White Spots Associated with Lymphangiectasia
This report is the first to describe the white villi in a patient with PIL observed clearly using a newly developed magnifying enteroscope. Technological advancements and the accumulation of reported pathological data would further improve our unde rstanding of the pathophysiological aspects of this disease entity, even in the jejunum.Dig Dis (Source: Digestive Diseases)
Source: Digestive Diseases - November 22, 2018 Category: Gastroenterology Source Type: research

Long-Term Effect of Rifaximin with and without Lactulose on the Active Bacterial Assemblages in the Proximal Small Bowel and Faeces in Patients with Minimal Hepatic Encephalopathy
Conclusion: Rifaximin therapy with and without lactulose over a period of 3 months does not affect the bacterial community composition. The improvement of HE with rifaximin is lasting also after the end of treatment and therefore a prolonged effect on microbiota metabolic function is suggested.Dig Dis (Source: Digestive Diseases)
Source: Digestive Diseases - November 14, 2018 Category: Gastroenterology Source Type: research