Impact of body mass index on complications of gastric endoscopic submucosal dissection
Background: Gastric endoscopic submucosal dissection (ESD) has a high rate of complications. However, it is unclear whether body mass index (BMI) affects ESD complications. We aimed to investigate the impact of BMI on ESD complications.
Methods: A total of 7263 patients who underwent gastric ESD were classified into three groups according to the Asia-Pacific classification of BMI: normal (BMI (Source: Digestive Diseases)
Source: Digestive Diseases - November 8, 2020 Category: Gastroenterology Source Type: research
Contents Vol. 38, 2020
Dig Dis 2020;38:I –VI (Source: Digestive Diseases)
Source: Digestive Diseases - November 6, 2020 Category: Gastroenterology Source Type: research
Natural history of cirrhosis: changing trends in etiology over the years
Background and goals: The aims of the present study were to investigate the natural history of cirrhosis and to determine trends in the etiology of cirrhosis.
Methods: Between January 2001 and January 2018, a total of 1341 patients had been diagnosed with cirrhosis were included.
Results: A total of 898 cirrhotic patients, who were followed for at least six months were included into the analysis. The median age was 54 years. The median Child-Pugh and MELD scores were 7.5 and 11, respectively. Ascites (51%) was the most common causes of decompensation. Chronic viral hepatitis was the most frequent cause of cirrhosis (58%)...
Source: Digestive Diseases - November 2, 2020 Category: Gastroenterology Source Type: research
Real-world comparison of elobixibat and lubiprostone treatment in patients with chronic constipation: A propensity score matched analysis
Introduction: Elobixibat is a new laxative, but its efficacy and adverse events (AEs) are insufficiently examined compared with those of other laxatives. Hence, by propensity score (PS) matching, we compared the effects and AEs between elobixibat and lubiprostone.
Methods: We retrospectively analyzed 1887 Japanese patients with chronic constipation (CC) treated at our hospital between October 2013 and April 2020. Enrolled patients were divided into three treatment groups, namely, elobixibat (10 mg daily) (E10 group, n = 293), lubiprostone (24 mcg daily) (L24 group, n = 772), and lubiprostone (48 mcg daily) (L48 group, n =...
Source: Digestive Diseases - November 2, 2020 Category: Gastroenterology Source Type: research
Efficacy of 90y-radioembolization in metastatic colorectal cancer depending on the primary tumor side
Metastatic colorectal cancer (mCRC) is associated with different molecular biology, clinical characteristics and outcome depending on the primary tumor localization. We aimed to evaluate the effectiveness of 90Y-radioembolization (RE) for therapy of colorectal liver metastases depending on the primary tumor side.
We performed a retrospective analysis of n=73 patients with mCRC and RE in our university liver center between 2009 and 2018. Patients were stratified according to the primary tumor side (left vs. right hemicolon), treatment response was assessed by the Response Evaluation Criteria in Solid Tumors (RECIST) at fo...
Source: Digestive Diseases - November 2, 2020 Category: Gastroenterology Source Type: research
Helicobacter pylori eradication rates in Slovenia in the period from 2017 to 2019 – data from the European Registry on Helicobacter pylori Management (Hp-EuReg)
Conclusions. Slovenia is a country with (Source: Digestive Diseases)
Source: Digestive Diseases - October 22, 2020 Category: Gastroenterology Source Type: research
Publisher's Note
Dig Dis (Source: Digestive Diseases)
Source: Digestive Diseases - October 19, 2020 Category: Gastroenterology Source Type: research
Mucin secretion in cystic fibrosis – a systematic review
Conclusions Increased expression of MUC5AC in the surface epithelium and of MUC5B in the sub-epithelial glands may be the result of higher secretion rate of mucin into the lumen of the respiratory tract, causing mucus plaque, infection and inflammation. (Source: Digestive Diseases)
Source: Digestive Diseases - October 12, 2020 Category: Gastroenterology Source Type: research
Transversal incision and longitudinal septostomy- "One size does not fit all"
NA (Source: Digestive Diseases)
Source: Digestive Diseases - October 12, 2020 Category: Gastroenterology Source Type: research
COVID-19 and Gastrointestinal Disease: Implications for the Gastroenterologist
Background: COVID-19 was initially considered a respiratory disease but the SARS-CoV-2 virus can lead to serious systemic consequences affecting major organs including the digestive system.Summary: This review brings new clinically important information for the gastroenterologist. This includes: the mechanisms of tissue damage seen with the SARS-CoV-2 virus; the consequences of immunosuppression in patients with inflammatory bowel disease (IBD) and chronic liver disease with the additional risks of decompensation in patients with cirrhosis; the impact of COVID-19 on gastrointestinal emergencies, on gastrointestinal endosco...
Source: Digestive Diseases - October 8, 2020 Category: Gastroenterology Source Type: research
COVID-19 and Gastrointestinal Disease. Implications for the Gastroenterologist
COVID-19 was initially considered to be a respiratory disease but soon after the pandemic established it became clear that the SARS-CoV-2 virus which caused the disease could lead to serious systemic consequences affecting most of the major organs including the digestive tract, liver and pancreas. This review brings together the new information which is clinically relevant to the gastroenterologist including the origins of the disease, mechanisms of tissue damage and how this affects specific patient groups, including those with inflammatory bowel disease, comorbidities and the role of immunosuppression, chronic liver dise...
Source: Digestive Diseases - October 8, 2020 Category: Gastroenterology Source Type: research
Impact of SARS-CoV-2 Infection on patients suffering from Liver Injury
With great interest, we have read the recent article by Olympia E. Anastasioua et al(1), wherein the authors described the effect of SARS-CoV-2 infection on mortality in patients suffering from Mild or severe liver injury. They demonstrated that while the mild liver injury was not associated with worse outcomes in their cohort, a cohort with severe liver injury showed multiple-organ failure and acute vascular events leading to higher mortality(1). (Source: Digestive Diseases)
Source: Digestive Diseases - October 8, 2020 Category: Gastroenterology Source Type: research
COVID-19 and Gastrointestinal Disease: Implications for the Gastroenterolo-gist
COVID-19 was initially considered to be a respiratory disease but soon after the pandemic established it became clear that the SARS-CoV-2 virus which caused the disease could lead to serious systemic consequences affecting most of the major organs including the digestive tract, liver and pancreas. This review brings together the new information which is clinically relevant to the gastroenterologist including the origins of the disease, mechanisms of tissue damage and how this affects specific patient groups, including those with inflammatory bowel disease, comorbidities and the role of immunosuppression, chronic liver dise...
Source: Digestive Diseases - October 8, 2020 Category: Gastroenterology Source Type: research
Response to the letter: Impact of SARS-CoV-2 infection on patients suffering from liver injury
- (Source: Digestive Diseases)
Source: Digestive Diseases - October 8, 2020 Category: Gastroenterology Source Type: research
Evaluation of Ki67 index in endoscopic ultrasound-guided fine needle aspiration samples for the assessment of malignancy risk in gastric gastrointestinal stromal tumors
Background: The risk of malignancy in resected gastrointestinal stromal tumors (GISTs) depends on tumor size, location, and mitotic index. Reportedly, the Ki67 index has a prognostic value in resected GISTs. We aimed to analyze the accuracy of endoscopic ultrasound (EUS)-guided fine needle aspiration (FNA) samples with reference to Ki67 index, using surgical specimens as the gold standard.
Methods: Fifty-five patients who underwent EUS-FNA followed by surgical resection for gastric GISTs were retrospectively analyzed. Patients ’ age and sex; tumors’ size and location; mitotic index, cell type, cellularity, pleomorphis...
Source: Digestive Diseases - October 4, 2020 Category: Gastroenterology Source Type: research
