Gastro Update Europe 2020
This narrative review summarizes a selection of clinically-important novel gastrointestinal developments, presented and discussed at the virtual Gastro Update Europe 2020.The selected topics, fully referenced, reflect what the distinguished faculty considered of vital importance to be communicated to the astute busy gastro-hep clinician who is eager to stay abreast of important novel developments. Whenever appropriate a personal comment or addition was added to further raise the educational value of this review. Given its narrative character, statements and conclusions are largely expert opinion-based. A full reference lis...
Source: Digestive Diseases - March 23, 2021 Category: Gastroenterology Source Type: research
Meeting Summary - Gastro Update Europe 2020
This narrative review summarizes a selection of clinically-important novel gastrointestinal developments, presented and discussed at the virtual Gastro Update Europe 2020.The selected topics, fully referenced, reflect what the distinguished faculty considered of vital importance to be communicated to the astute busy gastro-hep clinician who is eager to stay abreast of important novel developments. Whenever appropriate a personal comment or addition was added to further raise the educational value of this review. Given its narrative character, statements and conclusions are largely expert opinion-based. A full reference lis...
Source: Digestive Diseases - March 23, 2021 Category: Gastroenterology Source Type: research
Biomarkers in Irritable Bowel Syndrome: biological rationale and diagnostic value
Patients with irritable bowel syndrome (IBS) usually suffer from non-specific and overlapping signs that hamper the diagnostic process. In line with this, biomarkers specific for IBS could be of great benefit for diagnosing and managing patients. In IBS, the need is for apparent distinguishing features linked to the disease that improve diagnosis, differentiate from other organic diseases, and discriminate between IBS subtypes. Some biomarkers are associated with a possible pathophysiologic mechanism of IBS; others are used for differentiating IBS from non-IBS patients. Implementation of IBS biomarkers in everyday clinical...
Source: Digestive Diseases - March 21, 2021 Category: Gastroenterology Source Type: research
Role of peroral endoscopic myotomy in geriatric patients with achalasia: a systematic review and meta-analysis
Background: Peroral endoscopic myotomy (POEM) is a particularly attractive intervention for achalasia. Presently, POEM has been reported to be effective and safe for achalasia in geriatric patients. Herein, this systematic review was conducted to explore the role of POEM in geriatric patients with achalasia.
Method: PubMed, Embase and Cochrane Library were searched to identify studies evaluating the clinical outcome of POEM in geriatric patients with achalasia during January 2009 to October 2020. The primary outcomes were technical and clinical success. Secondary outcomes included postoperative Eckardt score, lower esopha...
Source: Digestive Diseases - March 21, 2021 Category: Gastroenterology Source Type: research
Probiotics in gastrointestinal diseases: all that glitters is not gold
Background: Multiple lines of evidence now support the notion that gut microbiota can contribute to digestive and extra-digestive diseases. The emergence of these observations enabled to postulate a bacteria-centric paradigm upon which to rethink the treatment of many diseases. The goal of therapy should not be to eradicate the flora but to modify it in a way that leads to symptomatic improvement; thus, the interest in the use of probiotics to modulate microbiota composition has increased worldwide in both community and healthcare settings.
Summary: The results of published studies are conflicting for most probiotic strai...
Source: Digestive Diseases - March 21, 2021 Category: Gastroenterology Source Type: research
Establishment and verification of a nomogram for predicting survival in patients with small intestinal gastrointestinal stromal tumors
Conclusion: Our nomogram can effectively predict 3- and 5-year OS and CSS in patients with SI GISTs, and its use can help improve the accuracy of personalized survival prediction and facilitate to provide construct ive therapeutic suggestions. (Source: Digestive Diseases)
Source: Digestive Diseases - March 21, 2021 Category: Gastroenterology Source Type: research
Endoscopic features of superficial esophageal squamous cell carcinoma in patients with very low risk factors (female, non-drinking, and non-smoking): a case-control study
We examined the endoscopic features of superficial esophageal squamous carcinoma in patients with very low risk factors.
Methods: In this single-center case-control study, 666 patients with 666 superficial esophageal squamous carcinoma lesions were divided into 2 groups: those with very low risk factors (very-low-risk group, n = 34) and those with any risk factors (any-risk group, n = 632). After case-control selection at a 1:5 ratio, the very-low-risk group comprised 34 patients and the any-risk group comprised 170 patients. We compared the baseline characteristics, endoscopic findings, and treatment results (including p...
Source: Digestive Diseases - March 21, 2021 Category: Gastroenterology Source Type: research
Endoscopic resection of a large submucosal tumor causing intermittent gastric outlet obstruction using a novel radiofrequency enabled device
Gastric lipomas are rare benign tumors and account for 1-3% of all benign gastric tumors. Majority of the gastric lipomas are asymptomatic and do not demand resection. However, large gastric lipomas may present with upper gastrointestinal bleeding and more rarely gastric outlet obstruction. Traditionally, surgery has been utilized for the management of giant gastric lipomas. More recently, endoscopic techniques are increasingly utilized for the resection of gastric submucosal lesions. Here we describe a case with large gastric lipoma who presented with symptoms suggestive of gastric outlet obstruction. Gastroscopy revealed...
Source: Digestive Diseases - March 14, 2021 Category: Gastroenterology Source Type: research
Characteristics and healthcare costs in the aging hepatitis B population of Japan: A nationwide real-world analysis
Introduction: Advancing age, comorbidity, and financial burden have been observed in chronic hepatitis B (CHB) patients globally. As Japan is leading the world in aging demographics, similar real-world data are urgently needed for its CHB population to inform all stakeholders. Methods: This cross-sectional study characterized the demographics, comorbidities, and healthcare costs of a large Japanese real-world adult ( ≥18 years) CHB patient (ICD-10: B18.1) population from the Medical Data Vision database from 01/01/2012 to 31/12/2016. Comorbidities were identified by ICD-10 codes and the annual point-prevalence and Charls...
Source: Digestive Diseases - March 14, 2021 Category: Gastroenterology Source Type: research
Biliary cannulation in endoscopic retrograde cholangiography: How to tackle the difficult papilla
Background: In the setting of a na ïve papilla, biliary cannulation is a key step in successfully performing endoscopic retrograde cholangiography (ERC). Difficult biliary cannulation (DBC) is associated with an increased risk of post-ERCP-pancreatitis and failure of the whole procedure.
Summary: Recommendations for biliary cannulat ion can be divided in (a) measures to reduce the likelihood of a difficult papilla-situation a priori and (b) rescue techniques in case the endoscopist is actually facing DBC. (a): careful inspection of the papillary anatomy and optimizing its accessibility by scope-positioning is fundamental....
Source: Digestive Diseases - March 7, 2021 Category: Gastroenterology Source Type: research
Pretreatment apparent diffusion coefficient cannot predict histopathological features and response to neoadjuvant radiochemotherapy in rectal cancer.
A Meta-Analysis
Conclusion: ADC correlates moderately with expression of Ki 67 in RC. ADC cannot discriminate tumor stages, grades and KRAS status in RC. ADC cannot predict therapy response to neoadjuvant radiochemotherapy in RC. (Source: Digestive Diseases)
Source: Digestive Diseases - March 3, 2021 Category: Gastroenterology Source Type: research
Novel Biomarkers in the Diagnosis of Benign and Malignant GI Diseases
Background. Various non-invasive biomarkers have been used in the diagnosis, prognosis and treatment of different gastrointestinal (GI) diseases for years. Novel technological developments and profound perception of molecular processes related to GI diseases over the last decade has allowed researchers to evaluate genetic, epigenetic and many other potential molecular biomarkers in different diseases and clinical settings. Here we present a review of recent most relevant papers in order to summarize major findings on novel biomarkers in the diagnosis of benign and malignant GI diseases. Summary. Genetic variations, non-cod...
Source: Digestive Diseases - February 28, 2021 Category: Gastroenterology Source Type: research
Evaluation of Diarrhea in Patients with COVID-19
Conclusions:The presence of diarrhea should indicate a suspected COVID-19 infection and suggest testing for early diagnosis of the disease. It should be kept in mind that the course of the disease may be more severe in these patients and precautions should als o be taken in terms of fecal transmission during discharge. (Source: Digestive Diseases)
Source: Digestive Diseases - February 28, 2021 Category: Gastroenterology Source Type: research
Eosinophilic esophagitis and achalasia: two distinct nosologic entities or a possible etiopathogenic association?
Background: Despite the fact that researchers have made significant progress in elucidating pathophysiology of esophageal diseases, the understanding of esophageal motility alterations in patients with eosinophilic esophagitis is in its infancy and current published medical literature remains rather scarce on this topic. A growing body of scientific data regarding associations between esophageal motor disorders such as achalasia and eosinophilic esophagitis exists nowadays.
Summary: It seems that association of eosinophilic esophagitis and achalasia does not constitute a cause and effect relationship, as it is not clear w...
Source: Digestive Diseases - February 28, 2021 Category: Gastroenterology Source Type: research
Chronic abdominal pain in general practice
Abstract
Background and Summary. Chronic abdominal pain is a challenging complaint for both primary care providers and gastroenterologists alike, due to a broad differential diagnosis and sometimes extensive and negative workup. In the absence of red flag features that herald more acute conditions, the majority of patients with chronic abdominal pain have a benign cause or a functional disorder (e.g. Irritable bowel syndrome). The costs associated with a diagnostic workup are an expensive burden to healthcare. A systematic approach for evaluating patients and initiating a management plan are recommended in the primary car...
Source: Digestive Diseases - February 24, 2021 Category: Gastroenterology Source Type: research
