Osteogenic microenvironment affects palatal development through glycolysis
In this study, we investigated whether there were differences between the palatal shelf mesenchyme at different developmental stages. Our results found that the palatal shelves facilitate proliferation at the early palate stage at mouse embryonic day (E) 13.5 and the tendency towards osteogenesis at E15.5, the late palate development stage. And the osteogenic microenvironment, which was mimicked by osteogenic differentiation medium (OIM), affected the biological properties of MEPM cells when compared to the routine medium. Specifically, MEPM cells showed slower proliferation, shorter S phase, increased apoptosis, and less ...
Source: Differentiation - June 2, 2023 Category: Research Authors: Xia Peng Jing Chen Yijia Wang Xiaotong Wang Xige Zhao Xiaoyu Zheng Zhiwei Wang Dong Yuan Juan Du Source Type: research
Meibomian gland development: Where, when and how?
Differentiation. 2023 May 5:S0301-4681(23)00026-9. doi: 10.1016/j.diff.2023.04.005. Online ahead of print.ABSTRACTThe Meibomian gland (MG) is an indispensable adnexal structure of eye that produces meibum, an important defensive component for maintaining ocular homeostasis. Normal development and maintenance of the MGs is required for ocular health since atrophic MGs and disturbances in composition and/or secretion of meibum result in major ocular pathologies, collectively termed as Meibomian gland dysfunction (MGD). Currently available therapies for MGD merely provide symptomatic relief and do not treat the underlying def...
Source: Differentiation - May 18, 2023 Category: Research Authors: Sudhir Verma Isabel Y Moreno Morgan E Trapp Luis Ramirez Tarsis F Gesteira Vivien J Coulson-Thomas Source Type: research
Meibomian gland development: Where, when and how?
Differentiation. 2023 May 5:S0301-4681(23)00026-9. doi: 10.1016/j.diff.2023.04.005. Online ahead of print.ABSTRACTThe Meibomian gland (MG) is an indispensable adnexal structure of eye that produces meibum, an important defensive component for maintaining ocular homeostasis. Normal development and maintenance of the MGs is required for ocular health since atrophic MGs and disturbances in composition and/or secretion of meibum result in major ocular pathologies, collectively termed as Meibomian gland dysfunction (MGD). Currently available therapies for MGD merely provide symptomatic relief and do not treat the underlying def...
Source: Differentiation - May 18, 2023 Category: Research Authors: Sudhir Verma Isabel Y Moreno Morgan E Trapp Luis Ramirez Tarsis F Gesteira Vivien J Coulson-Thomas Source Type: research
Meibomian gland development: Where, when and how?
Differentiation. 2023 May 5:S0301-4681(23)00026-9. doi: 10.1016/j.diff.2023.04.005. Online ahead of print.ABSTRACTThe Meibomian gland (MG) is an indispensable adnexal structure of eye that produces meibum, an important defensive component for maintaining ocular homeostasis. Normal development and maintenance of the MGs is required for ocular health since atrophic MGs and disturbances in composition and/or secretion of meibum result in major ocular pathologies, collectively termed as Meibomian gland dysfunction (MGD). Currently available therapies for MGD merely provide symptomatic relief and do not treat the underlying def...
Source: Differentiation - May 18, 2023 Category: Research Authors: Sudhir Verma Isabel Y Moreno Morgan E Trapp Luis Ramirez Tarsis F Gesteira Vivien J Coulson-Thomas Source Type: research
Meibomian gland development: Where, when and how?
Differentiation. 2023 May 5:S0301-4681(23)00026-9. doi: 10.1016/j.diff.2023.04.005. Online ahead of print.ABSTRACTThe Meibomian gland (MG) is an indispensable adnexal structure of eye that produces meibum, an important defensive component for maintaining ocular homeostasis. Normal development and maintenance of the MGs is required for ocular health since atrophic MGs and disturbances in composition and/or secretion of meibum result in major ocular pathologies, collectively termed as Meibomian gland dysfunction (MGD). Currently available therapies for MGD merely provide symptomatic relief and do not treat the underlying def...
Source: Differentiation - May 18, 2023 Category: Research Authors: Sudhir Verma Isabel Y Moreno Morgan E Trapp Luis Ramirez Tarsis F Gesteira Vivien J Coulson-Thomas Source Type: research
Meibomian gland development: Where, when and how?
Differentiation. 2023 May 5:S0301-4681(23)00026-9. doi: 10.1016/j.diff.2023.04.005. Online ahead of print.ABSTRACTThe Meibomian gland (MG) is an indispensable adnexal structure of eye that produces meibum, an important defensive component for maintaining ocular homeostasis. Normal development and maintenance of the MGs is required for ocular health since atrophic MGs and disturbances in composition and/or secretion of meibum result in major ocular pathologies, collectively termed as Meibomian gland dysfunction (MGD). Currently available therapies for MGD merely provide symptomatic relief and do not treat the underlying def...
Source: Differentiation - May 18, 2023 Category: Research Authors: Sudhir Verma Isabel Y Moreno Morgan E Trapp Luis Ramirez Tarsis F Gesteira Vivien J Coulson-Thomas Source Type: research
Meibomian gland development: Where, when and how?
Differentiation. 2023 May 5:S0301-4681(23)00026-9. doi: 10.1016/j.diff.2023.04.005. Online ahead of print.ABSTRACTThe Meibomian gland (MG) is an indispensable adnexal structure of eye that produces meibum, an important defensive component for maintaining ocular homeostasis. Normal development and maintenance of the MGs is required for ocular health since atrophic MGs and disturbances in composition and/or secretion of meibum result in major ocular pathologies, collectively termed as Meibomian gland dysfunction (MGD). Currently available therapies for MGD merely provide symptomatic relief and do not treat the underlying def...
Source: Differentiation - May 18, 2023 Category: Research Authors: Sudhir Verma Isabel Y Moreno Morgan E Trapp Luis Ramirez Tarsis F Gesteira Vivien J Coulson-Thomas Source Type: research
Meibomian gland development: Where, when and how?
Differentiation. 2023 May 5:S0301-4681(23)00026-9. doi: 10.1016/j.diff.2023.04.005. Online ahead of print.ABSTRACTThe Meibomian gland (MG) is an indispensable adnexal structure of eye that produces meibum, an important defensive component for maintaining ocular homeostasis. Normal development and maintenance of the MGs is required for ocular health since atrophic MGs and disturbances in composition and/or secretion of meibum result in major ocular pathologies, collectively termed as Meibomian gland dysfunction (MGD). Currently available therapies for MGD merely provide symptomatic relief and do not treat the underlying def...
Source: Differentiation - May 18, 2023 Category: Research Authors: Sudhir Verma Isabel Y Moreno Morgan E Trapp Luis Ramirez Tarsis F Gesteira Vivien J Coulson-Thomas Source Type: research
Meibomian gland development: Where, when and how?
Differentiation. 2023 May 5:S0301-4681(23)00026-9. doi: 10.1016/j.diff.2023.04.005. Online ahead of print.ABSTRACTThe Meibomian gland (MG) is an indispensable adnexal structure of eye that produces meibum, an important defensive component for maintaining ocular homeostasis. Normal development and maintenance of the MGs is required for ocular health since atrophic MGs and disturbances in composition and/or secretion of meibum result in major ocular pathologies, collectively termed as Meibomian gland dysfunction (MGD). Currently available therapies for MGD merely provide symptomatic relief and do not treat the underlying def...
Source: Differentiation - May 18, 2023 Category: Research Authors: Sudhir Verma Isabel Y Moreno Morgan E Trapp Luis Ramirez Tarsis F Gesteira Vivien J Coulson-Thomas Source Type: research
Meibomian gland development: Where, when and how?
Differentiation. 2023 May 5:S0301-4681(23)00026-9. doi: 10.1016/j.diff.2023.04.005. Online ahead of print.ABSTRACTThe Meibomian gland (MG) is an indispensable adnexal structure of eye that produces meibum, an important defensive component for maintaining ocular homeostasis. Normal development and maintenance of the MGs is required for ocular health since atrophic MGs and disturbances in composition and/or secretion of meibum result in major ocular pathologies, collectively termed as Meibomian gland dysfunction (MGD). Currently available therapies for MGD merely provide symptomatic relief and do not treat the underlying def...
Source: Differentiation - May 18, 2023 Category: Research Authors: Sudhir Verma Isabel Y Moreno Morgan E Trapp Luis Ramirez Tarsis F Gesteira Vivien J Coulson-Thomas Source Type: research
Meibomian gland development: Where, when and how?
Differentiation. 2023 May 5:S0301-4681(23)00026-9. doi: 10.1016/j.diff.2023.04.005. Online ahead of print.ABSTRACTThe Meibomian gland (MG) is an indispensable adnexal structure of eye that produces meibum, an important defensive component for maintaining ocular homeostasis. Normal development and maintenance of the MGs is required for ocular health since atrophic MGs and disturbances in composition and/or secretion of meibum result in major ocular pathologies, collectively termed as Meibomian gland dysfunction (MGD). Currently available therapies for MGD merely provide symptomatic relief and do not treat the underlying def...
Source: Differentiation - May 18, 2023 Category: Research Authors: Sudhir Verma Isabel Y Moreno Morgan E Trapp Luis Ramirez Tarsis F Gesteira Vivien J Coulson-Thomas Source Type: research
Disruption of hedgehog signaling leads to hyoid bone dysplasia during embryogenesis
In this study, we treated pregnant ICR mice with the hedgehog pathway inhibitor vismodegib by oral gavage in order to establish a model of hyoid bone dysplasia. Our results indicate that administration of vismodegib at embryonic days 11.5 (E11.5) and E12.5 resulted in the development of hyoid bone dysplasia. We were able to define the critical periods for the induction of hyoid bone deformity through the use of a meticulous temporal resolution. Our findings suggest that the hedgehog pathway plays a crucial role in the early development of the hyoid bone. Additionally, our research has established a novel and easily establi...
Source: Differentiation - May 13, 2023 Category: Research Authors: Yan Guo Xingyu Chen Yongzhen Lai Meng Lu Chengyong Wang Yun Shi Chengyan Ren Weihui Chen Source Type: research
Disruption of hedgehog signaling leads to hyoid bone dysplasia during embryogenesis
In this study, we treated pregnant ICR mice with the hedgehog pathway inhibitor vismodegib by oral gavage in order to establish a model of hyoid bone dysplasia. Our results indicate that administration of vismodegib at embryonic days 11.5 (E11.5) and E12.5 resulted in the development of hyoid bone dysplasia. We were able to define the critical periods for the induction of hyoid bone deformity through the use of a meticulous temporal resolution. Our findings suggest that the hedgehog pathway plays a crucial role in the early development of the hyoid bone. Additionally, our research has established a novel and easily establi...
Source: Differentiation - May 13, 2023 Category: Research Authors: Yan Guo Xingyu Chen Yongzhen Lai Meng Lu Chengyong Wang Yun Shi Chengyan Ren Weihui Chen Source Type: research
Disruption of hedgehog signaling leads to hyoid bone dysplasia during embryogenesis
In this study, we treated pregnant ICR mice with the hedgehog pathway inhibitor vismodegib by oral gavage in order to establish a model of hyoid bone dysplasia. Our results indicate that administration of vismodegib at embryonic days 11.5 (E11.5) and E12.5 resulted in the development of hyoid bone dysplasia. We were able to define the critical periods for the induction of hyoid bone deformity through the use of a meticulous temporal resolution. Our findings suggest that the hedgehog pathway plays a crucial role in the early development of the hyoid bone. Additionally, our research has established a novel and easily establi...
Source: Differentiation - May 13, 2023 Category: Research Authors: Yan Guo Xingyu Chen Yongzhen Lai Meng Lu Chengyong Wang Yun Shi Chengyan Ren Weihui Chen Source Type: research
Disruption of hedgehog signaling leads to hyoid bone dysplasia during embryogenesis
In this study, we treated pregnant ICR mice with the hedgehog pathway inhibitor vismodegib by oral gavage in order to establish a model of hyoid bone dysplasia. Our results indicate that administration of vismodegib at embryonic days 11.5 (E11.5) and E12.5 resulted in the development of hyoid bone dysplasia. We were able to define the critical periods for the induction of hyoid bone deformity through the use of a meticulous temporal resolution. Our findings suggest that the hedgehog pathway plays a crucial role in the early development of the hyoid bone. Additionally, our research has established a novel and easily establi...
Source: Differentiation - May 13, 2023 Category: Research Authors: Yan Guo Xingyu Chen Yongzhen Lai Meng Lu Chengyong Wang Yun Shi Chengyan Ren Weihui Chen Source Type: research
