The role of non-coding RNAs in diabetes-induced osteoporosis
Differentiation. 2023 Aug 22;133:98-108. doi: 10.1016/j.diff.2023.08.002. Online ahead of print.ABSTRACTDiabetes mellitus (DM) and osteoporosis are two major health care problems worldwide. Emerging evidence suggests that DM poses a risk for osteoporosis and can contribute to the development of diabetes-induced osteoporosis (DOP). Interestingly, some epidemiological studies suggest that DOP may be at least partially distinct from those skeletal abnormalities associated with old age or postmenopausal osteoporosis. The increasing number of DM patients who also have DOP calls for a discussion of the pathogenesis of DOP and th...
Source: Differentiation - August 29, 2023 Category: Research Authors: Er-Li Wu Ming Cheng Xin-Jing Zhang Tian-Gang Wu Lei Zhang Source Type: research
The role of non-coding RNAs in diabetes-induced osteoporosis
Differentiation. 2023 Aug 22;133:98-108. doi: 10.1016/j.diff.2023.08.002. Online ahead of print.ABSTRACTDiabetes mellitus (DM) and osteoporosis are two major health care problems worldwide. Emerging evidence suggests that DM poses a risk for osteoporosis and can contribute to the development of diabetes-induced osteoporosis (DOP). Interestingly, some epidemiological studies suggest that DOP may be at least partially distinct from those skeletal abnormalities associated with old age or postmenopausal osteoporosis. The increasing number of DM patients who also have DOP calls for a discussion of the pathogenesis of DOP and th...
Source: Differentiation - August 29, 2023 Category: Research Authors: Er-Li Wu Ming Cheng Xin-Jing Zhang Tian-Gang Wu Lei Zhang Source Type: research
The role of non-coding RNAs in diabetes-induced osteoporosis
Differentiation. 2023 Aug 22;133:98-108. doi: 10.1016/j.diff.2023.08.002. Online ahead of print.ABSTRACTDiabetes mellitus (DM) and osteoporosis are two major health care problems worldwide. Emerging evidence suggests that DM poses a risk for osteoporosis and can contribute to the development of diabetes-induced osteoporosis (DOP). Interestingly, some epidemiological studies suggest that DOP may be at least partially distinct from those skeletal abnormalities associated with old age or postmenopausal osteoporosis. The increasing number of DM patients who also have DOP calls for a discussion of the pathogenesis of DOP and th...
Source: Differentiation - August 29, 2023 Category: Research Authors: Er-Li Wu Ming Cheng Xin-Jing Zhang Tian-Gang Wu Lei Zhang Source Type: research
Inductive effect of SORT1 on odontoblastic differentiation of human dental pulp-derived stem cells
This study investigated the expression of sortilin 1 (SORT1) in cultured human dental pulp-derived stem cells (hDPSCs) and its role in their odontoblastic differentiation. Permanent teeth were extracted from five patients, and the dental pulp was harvested for explant culture. Fluorescence-activated cell sorting was used to analyze the outgrowth of adherent cells and cells that had migrated from the tissue margin. SORT1 expression was detected in hDPSCs simultaneously expressing the mesenchymal stem cell markers CD44 and CD90. The odontoblastic differentiation potential of SORT1-positive hDPSCs was examined via staining fo...
Source: Differentiation - August 14, 2023 Category: Research Authors: Daisuke Omagari Taku Toriumi Hiromasa Tsuda Manabu Hayatsu Keisuke Watanabe Yusuke Mizutami Masaki Honda Yoshikazu Mikami Source Type: research
Inductive effect of SORT1 on odontoblastic differentiation of human dental pulp-derived stem cells
This study investigated the expression of sortilin 1 (SORT1) in cultured human dental pulp-derived stem cells (hDPSCs) and its role in their odontoblastic differentiation. Permanent teeth were extracted from five patients, and the dental pulp was harvested for explant culture. Fluorescence-activated cell sorting was used to analyze the outgrowth of adherent cells and cells that had migrated from the tissue margin. SORT1 expression was detected in hDPSCs simultaneously expressing the mesenchymal stem cell markers CD44 and CD90. The odontoblastic differentiation potential of SORT1-positive hDPSCs was examined via staining fo...
Source: Differentiation - August 14, 2023 Category: Research Authors: Daisuke Omagari Taku Toriumi Hiromasa Tsuda Manabu Hayatsu Keisuke Watanabe Yusuke Mizutami Masaki Honda Yoshikazu Mikami Source Type: research
Inductive effect of SORT1 on odontoblastic differentiation of human dental pulp-derived stem cells
This study investigated the expression of sortilin 1 (SORT1) in cultured human dental pulp-derived stem cells (hDPSCs) and its role in their odontoblastic differentiation. Permanent teeth were extracted from five patients, and the dental pulp was harvested for explant culture. Fluorescence-activated cell sorting was used to analyze the outgrowth of adherent cells and cells that had migrated from the tissue margin. SORT1 expression was detected in hDPSCs simultaneously expressing the mesenchymal stem cell markers CD44 and CD90. The odontoblastic differentiation potential of SORT1-positive hDPSCs was examined via staining fo...
Source: Differentiation - August 14, 2023 Category: Research Authors: Daisuke Omagari Taku Toriumi Hiromasa Tsuda Manabu Hayatsu Keisuke Watanabe Yusuke Mizutami Masaki Honda Yoshikazu Mikami Source Type: research
Inductive effect of SORT1 on odontoblastic differentiation of human dental pulp-derived stem cells
This study investigated the expression of sortilin 1 (SORT1) in cultured human dental pulp-derived stem cells (hDPSCs) and its role in their odontoblastic differentiation. Permanent teeth were extracted from five patients, and the dental pulp was harvested for explant culture. Fluorescence-activated cell sorting was used to analyze the outgrowth of adherent cells and cells that had migrated from the tissue margin. SORT1 expression was detected in hDPSCs simultaneously expressing the mesenchymal stem cell markers CD44 and CD90. The odontoblastic differentiation potential of SORT1-positive hDPSCs was examined via staining fo...
Source: Differentiation - August 14, 2023 Category: Research Authors: Daisuke Omagari Taku Toriumi Hiromasa Tsuda Manabu Hayatsu Keisuke Watanabe Yusuke Mizutami Masaki Honda Yoshikazu Mikami Source Type: research
Inductive effect of SORT1 on odontoblastic differentiation of human dental pulp-derived stem cells
This study investigated the expression of sortilin 1 (SORT1) in cultured human dental pulp-derived stem cells (hDPSCs) and its role in their odontoblastic differentiation. Permanent teeth were extracted from five patients, and the dental pulp was harvested for explant culture. Fluorescence-activated cell sorting was used to analyze the outgrowth of adherent cells and cells that had migrated from the tissue margin. SORT1 expression was detected in hDPSCs simultaneously expressing the mesenchymal stem cell markers CD44 and CD90. The odontoblastic differentiation potential of SORT1-positive hDPSCs was examined via staining fo...
Source: Differentiation - August 14, 2023 Category: Research Authors: Daisuke Omagari Taku Toriumi Hiromasa Tsuda Manabu Hayatsu Keisuke Watanabe Yusuke Mizutami Masaki Honda Yoshikazu Mikami Source Type: research
Inductive effect of SORT1 on odontoblastic differentiation of human dental pulp-derived stem cells
This study investigated the expression of sortilin 1 (SORT1) in cultured human dental pulp-derived stem cells (hDPSCs) and its role in their odontoblastic differentiation. Permanent teeth were extracted from five patients, and the dental pulp was harvested for explant culture. Fluorescence-activated cell sorting was used to analyze the outgrowth of adherent cells and cells that had migrated from the tissue margin. SORT1 expression was detected in hDPSCs simultaneously expressing the mesenchymal stem cell markers CD44 and CD90. The odontoblastic differentiation potential of SORT1-positive hDPSCs was examined via staining fo...
Source: Differentiation - August 14, 2023 Category: Research Authors: Daisuke Omagari Taku Toriumi Hiromasa Tsuda Manabu Hayatsu Keisuke Watanabe Yusuke Mizutami Masaki Honda Yoshikazu Mikami Source Type: research
Inductive effect of SORT1 on odontoblastic differentiation of human dental pulp-derived stem cells
This study investigated the expression of sortilin 1 (SORT1) in cultured human dental pulp-derived stem cells (hDPSCs) and its role in their odontoblastic differentiation. Permanent teeth were extracted from five patients, and the dental pulp was harvested for explant culture. Fluorescence-activated cell sorting was used to analyze the outgrowth of adherent cells and cells that had migrated from the tissue margin. SORT1 expression was detected in hDPSCs simultaneously expressing the mesenchymal stem cell markers CD44 and CD90. The odontoblastic differentiation potential of SORT1-positive hDPSCs was examined via staining fo...
Source: Differentiation - August 14, 2023 Category: Research Authors: Daisuke Omagari Taku Toriumi Hiromasa Tsuda Manabu Hayatsu Keisuke Watanabe Yusuke Mizutami Masaki Honda Yoshikazu Mikami Source Type: research
Inductive effect of SORT1 on odontoblastic differentiation of human dental pulp-derived stem cells
This study investigated the expression of sortilin 1 (SORT1) in cultured human dental pulp-derived stem cells (hDPSCs) and its role in their odontoblastic differentiation. Permanent teeth were extracted from five patients, and the dental pulp was harvested for explant culture. Fluorescence-activated cell sorting was used to analyze the outgrowth of adherent cells and cells that had migrated from the tissue margin. SORT1 expression was detected in hDPSCs simultaneously expressing the mesenchymal stem cell markers CD44 and CD90. The odontoblastic differentiation potential of SORT1-positive hDPSCs was examined via staining fo...
Source: Differentiation - August 14, 2023 Category: Research Authors: Daisuke Omagari Taku Toriumi Hiromasa Tsuda Manabu Hayatsu Keisuke Watanabe Yusuke Mizutami Masaki Honda Yoshikazu Mikami Source Type: research
Inductive effect of SORT1 on odontoblastic differentiation of human dental pulp-derived stem cells
This study investigated the expression of sortilin 1 (SORT1) in cultured human dental pulp-derived stem cells (hDPSCs) and its role in their odontoblastic differentiation. Permanent teeth were extracted from five patients, and the dental pulp was harvested for explant culture. Fluorescence-activated cell sorting was used to analyze the outgrowth of adherent cells and cells that had migrated from the tissue margin. SORT1 expression was detected in hDPSCs simultaneously expressing the mesenchymal stem cell markers CD44 and CD90. The odontoblastic differentiation potential of SORT1-positive hDPSCs was examined via staining fo...
Source: Differentiation - August 14, 2023 Category: Research Authors: Daisuke Omagari Taku Toriumi Hiromasa Tsuda Manabu Hayatsu Keisuke Watanabe Yusuke Mizutami Masaki Honda Yoshikazu Mikami Source Type: research
Inductive effect of SORT1 on odontoblastic differentiation of human dental pulp-derived stem cells
This study investigated the expression of sortilin 1 (SORT1) in cultured human dental pulp-derived stem cells (hDPSCs) and its role in their odontoblastic differentiation. Permanent teeth were extracted from five patients, and the dental pulp was harvested for explant culture. Fluorescence-activated cell sorting was used to analyze the outgrowth of adherent cells and cells that had migrated from the tissue margin. SORT1 expression was detected in hDPSCs simultaneously expressing the mesenchymal stem cell markers CD44 and CD90. The odontoblastic differentiation potential of SORT1-positive hDPSCs was examined via staining fo...
Source: Differentiation - August 14, 2023 Category: Research Authors: Daisuke Omagari Taku Toriumi Hiromasa Tsuda Manabu Hayatsu Keisuke Watanabe Yusuke Mizutami Masaki Honda Yoshikazu Mikami Source Type: research
Inductive effect of SORT1 on odontoblastic differentiation of human dental pulp-derived stem cells
This study investigated the expression of sortilin 1 (SORT1) in cultured human dental pulp-derived stem cells (hDPSCs) and its role in their odontoblastic differentiation. Permanent teeth were extracted from five patients, and the dental pulp was harvested for explant culture. Fluorescence-activated cell sorting was used to analyze the outgrowth of adherent cells and cells that had migrated from the tissue margin. SORT1 expression was detected in hDPSCs simultaneously expressing the mesenchymal stem cell markers CD44 and CD90. The odontoblastic differentiation potential of SORT1-positive hDPSCs was examined via staining fo...
Source: Differentiation - August 14, 2023 Category: Research Authors: Daisuke Omagari Taku Toriumi Hiromasa Tsuda Manabu Hayatsu Keisuke Watanabe Yusuke Mizutami Masaki Honda Yoshikazu Mikami Source Type: research
Stage-specific requirement for m < sup > 6 < /sup > A RNA methylation during cardiac differentiation of pluripotent stem cells
Differentiation. 2023 Jul 13;133:77-87. doi: 10.1016/j.diff.2023.07.001. Online ahead of print.ABSTRACTPrecise spatiotemporal control of gene expression patterns is critical for normal development. Pluripotent stem cells, including embryonic stem cells (ESCs) and induced pluripotent stem cells (iPSCs), with the ability of unlimited self-renewal and differentiation into any cell type, provide a unique tool for understanding the underlying mechanism of development and disease in a dish. N6-methyl-adenosine (m6A) modification is the most extensive internal mRNA modification, which regulates almost all aspects of mRNA metaboli...
Source: Differentiation - July 28, 2023 Category: Research Authors: Shuai Dong Yuetong Sun Chang Liu Yanli Li Shanshan Yu Qi Zhang Yan Xu Source Type: research
