The Rap1 small GTPase affects cell fate or survival and morphogenetic patterning during Drosophila melanogaster eye development
Differentiation. 2023 Jun 27;133:12-24. doi: 10.1016/j.diff.2023.06.001. Online ahead of print.ABSTRACTThe Drosophila melanogaster eye has been instrumental for determining both how cells communicate with one another to determine cell fate, as well as cell morphogenesis and patterning. Here, we describe the effects of the small GTPase Rap1 on the development of multiple cell types in the D. melanogaster eye. Although Rap1 has previously been linked to RTK-Ras-MAPK signaling in eye development, we demonstrate that manipulation of Rap1 activity is modified by increase or decrease of Delta/Notch signaling during several event...
Source: Differentiation - July 12, 2023 Category: Research Authors: Philip P Yost Abdul Al-Nouman Jennifer Curtiss Source Type: research
The Rap1 small GTPase affects cell fate or survival and morphogenetic patterning during Drosophila melanogaster eye development
Differentiation. 2023 Jun 27;133:12-24. doi: 10.1016/j.diff.2023.06.001. Online ahead of print.ABSTRACTThe Drosophila melanogaster eye has been instrumental for determining both how cells communicate with one another to determine cell fate, as well as cell morphogenesis and patterning. Here, we describe the effects of the small GTPase Rap1 on the development of multiple cell types in the D. melanogaster eye. Although Rap1 has previously been linked to RTK-Ras-MAPK signaling in eye development, we demonstrate that manipulation of Rap1 activity is modified by increase or decrease of Delta/Notch signaling during several event...
Source: Differentiation - July 12, 2023 Category: Research Authors: Philip P Yost Abdul Al-Nouman Jennifer Curtiss Source Type: research
Ocular development: A view from the front to the back of the eye
Differentiation. 2023 Jun 29:S0301-4681(23)00040-3. doi: 10.1016/j.diff.2023.06.004. Online ahead of print.NO ABSTRACTPMID:37407417 | DOI:10.1016/j.diff.2023.06.004 (Source: Differentiation)
Source: Differentiation - July 5, 2023 Category: Research Authors: Anna La Torre Peter Lwigale Source Type: research
Ocular development: A view from the front to the back of the eye
Differentiation. 2023 Jun 29:S0301-4681(23)00040-3. doi: 10.1016/j.diff.2023.06.004. Online ahead of print.NO ABSTRACTPMID:37407417 | DOI:10.1016/j.diff.2023.06.004 (Source: Differentiation)
Source: Differentiation - July 5, 2023 Category: Research Authors: Anna La Torre Peter Lwigale Source Type: research
Ocular development: A view from the front to the back of the eye
Differentiation. 2023 Jun 29:S0301-4681(23)00040-3. doi: 10.1016/j.diff.2023.06.004. Online ahead of print.NO ABSTRACTPMID:37407417 | DOI:10.1016/j.diff.2023.06.004 (Source: Differentiation)
Source: Differentiation - July 5, 2023 Category: Research Authors: Anna La Torre Peter Lwigale Source Type: research
Ocular development: A view from the front to the back of the eye
Differentiation. 2023 Jun 29:S0301-4681(23)00040-3. doi: 10.1016/j.diff.2023.06.004. Online ahead of print.NO ABSTRACTPMID:37407417 | DOI:10.1016/j.diff.2023.06.004 (Source: Differentiation)
Source: Differentiation - July 5, 2023 Category: Research Authors: Anna La Torre Peter Lwigale Source Type: research
Ocular development: A view from the front to the back of the eye
Differentiation. 2023 Jun 29:S0301-4681(23)00040-3. doi: 10.1016/j.diff.2023.06.004. Online ahead of print.NO ABSTRACTPMID:37407417 | DOI:10.1016/j.diff.2023.06.004 (Source: Differentiation)
Source: Differentiation - July 5, 2023 Category: Research Authors: Anna La Torre Peter Lwigale Source Type: research
Ocular development: A view from the front to the back of the eye
Differentiation. 2023 Jun 29:S0301-4681(23)00040-3. doi: 10.1016/j.diff.2023.06.004. Online ahead of print.NO ABSTRACTPMID:37407417 | DOI:10.1016/j.diff.2023.06.004 (Source: Differentiation)
Source: Differentiation - July 5, 2023 Category: Research Authors: Anna La Torre Peter Lwigale Source Type: research
Osteogenic microenvironment affects palatal development through glycolysis
In this study, we investigated whether there were differences between the palatal shelf mesenchyme at different developmental stages. Our results found that the palatal shelves facilitate proliferation at the early palate stage at mouse embryonic day (E) 13.5 and the tendency towards osteogenesis at E15.5, the late palate development stage. And the osteogenic microenvironment, which was mimicked by osteogenic differentiation medium (OIM), affected the biological properties of MEPM cells when compared to the routine medium. Specifically, MEPM cells showed slower proliferation, shorter S phase, increased apoptosis, and less ...
Source: Differentiation - June 2, 2023 Category: Research Authors: Xia Peng Jing Chen Yijia Wang Xiaotong Wang Xige Zhao Xiaoyu Zheng Zhiwei Wang Dong Yuan Juan Du Source Type: research
Osteogenic microenvironment affects palatal development through glycolysis
In this study, we investigated whether there were differences between the palatal shelf mesenchyme at different developmental stages. Our results found that the palatal shelves facilitate proliferation at the early palate stage at mouse embryonic day (E) 13.5 and the tendency towards osteogenesis at E15.5, the late palate development stage. And the osteogenic microenvironment, which was mimicked by osteogenic differentiation medium (OIM), affected the biological properties of MEPM cells when compared to the routine medium. Specifically, MEPM cells showed slower proliferation, shorter S phase, increased apoptosis, and less ...
Source: Differentiation - June 2, 2023 Category: Research Authors: Xia Peng Jing Chen Yijia Wang Xiaotong Wang Xige Zhao Xiaoyu Zheng Zhiwei Wang Dong Yuan Juan Du Source Type: research
Osteogenic microenvironment affects palatal development through glycolysis
In this study, we investigated whether there were differences between the palatal shelf mesenchyme at different developmental stages. Our results found that the palatal shelves facilitate proliferation at the early palate stage at mouse embryonic day (E) 13.5 and the tendency towards osteogenesis at E15.5, the late palate development stage. And the osteogenic microenvironment, which was mimicked by osteogenic differentiation medium (OIM), affected the biological properties of MEPM cells when compared to the routine medium. Specifically, MEPM cells showed slower proliferation, shorter S phase, increased apoptosis, and less ...
Source: Differentiation - June 2, 2023 Category: Research Authors: Xia Peng Jing Chen Yijia Wang Xiaotong Wang Xige Zhao Xiaoyu Zheng Zhiwei Wang Dong Yuan Juan Du Source Type: research
Osteogenic microenvironment affects palatal development through glycolysis
In this study, we investigated whether there were differences between the palatal shelf mesenchyme at different developmental stages. Our results found that the palatal shelves facilitate proliferation at the early palate stage at mouse embryonic day (E) 13.5 and the tendency towards osteogenesis at E15.5, the late palate development stage. And the osteogenic microenvironment, which was mimicked by osteogenic differentiation medium (OIM), affected the biological properties of MEPM cells when compared to the routine medium. Specifically, MEPM cells showed slower proliferation, shorter S phase, increased apoptosis, and less ...
Source: Differentiation - June 2, 2023 Category: Research Authors: Xia Peng Jing Chen Yijia Wang Xiaotong Wang Xige Zhao Xiaoyu Zheng Zhiwei Wang Dong Yuan Juan Du Source Type: research
Osteogenic microenvironment affects palatal development through glycolysis
In this study, we investigated whether there were differences between the palatal shelf mesenchyme at different developmental stages. Our results found that the palatal shelves facilitate proliferation at the early palate stage at mouse embryonic day (E) 13.5 and the tendency towards osteogenesis at E15.5, the late palate development stage. And the osteogenic microenvironment, which was mimicked by osteogenic differentiation medium (OIM), affected the biological properties of MEPM cells when compared to the routine medium. Specifically, MEPM cells showed slower proliferation, shorter S phase, increased apoptosis, and less ...
Source: Differentiation - June 2, 2023 Category: Research Authors: Xia Peng Jing Chen Yijia Wang Xiaotong Wang Xige Zhao Xiaoyu Zheng Zhiwei Wang Dong Yuan Juan Du Source Type: research
Osteogenic microenvironment affects palatal development through glycolysis
In this study, we investigated whether there were differences between the palatal shelf mesenchyme at different developmental stages. Our results found that the palatal shelves facilitate proliferation at the early palate stage at mouse embryonic day (E) 13.5 and the tendency towards osteogenesis at E15.5, the late palate development stage. And the osteogenic microenvironment, which was mimicked by osteogenic differentiation medium (OIM), affected the biological properties of MEPM cells when compared to the routine medium. Specifically, MEPM cells showed slower proliferation, shorter S phase, increased apoptosis, and less ...
Source: Differentiation - June 2, 2023 Category: Research Authors: Xia Peng Jing Chen Yijia Wang Xiaotong Wang Xige Zhao Xiaoyu Zheng Zhiwei Wang Dong Yuan Juan Du Source Type: research
Osteogenic microenvironment affects palatal development through glycolysis
In this study, we investigated whether there were differences between the palatal shelf mesenchyme at different developmental stages. Our results found that the palatal shelves facilitate proliferation at the early palate stage at mouse embryonic day (E) 13.5 and the tendency towards osteogenesis at E15.5, the late palate development stage. And the osteogenic microenvironment, which was mimicked by osteogenic differentiation medium (OIM), affected the biological properties of MEPM cells when compared to the routine medium. Specifically, MEPM cells showed slower proliferation, shorter S phase, increased apoptosis, and less ...
Source: Differentiation - June 2, 2023 Category: Research Authors: Xia Peng Jing Chen Yijia Wang Xiaotong Wang Xige Zhao Xiaoyu Zheng Zhiwei Wang Dong Yuan Juan Du Source Type: research
