FGF12: biology and function
Differentiation. 2023 Nov 25:100740. doi: 10.1016/j.diff.2023.100740. Online ahead of print.ABSTRACTFibroblast growth factor 12 (FGF12) belongs to the fibroblast growth factor homologous factors (FHF) subfamily, which is also known as the FGF11 subfamily. The human FGF12 gene is located on chromosome 3 and consists of four introns and five coding exons. Their alternative splicing results in two FGF12 isoforms - the shorter 'b' isoform and the longer 'a' isoform. Structurally, the core domain of FGF12, is highly homologous to that of the other FGF proteins, providing the classical tertiary structure of β-trefoil. FGF12 is ...
Source: Differentiation - December 2, 2023 Category: Research Authors: Martyna Biadun Radoslaw Karelus Daniel Krowarsch Lukasz Opalinski Malgorzata Zakrzewska Source Type: research
FGF12: biology and function
Differentiation. 2023 Nov 25:100740. doi: 10.1016/j.diff.2023.100740. Online ahead of print.ABSTRACTFibroblast growth factor 12 (FGF12) belongs to the fibroblast growth factor homologous factors (FHF) subfamily, which is also known as the FGF11 subfamily. The human FGF12 gene is located on chromosome 3 and consists of four introns and five coding exons. Their alternative splicing results in two FGF12 isoforms - the shorter 'b' isoform and the longer 'a' isoform. Structurally, the core domain of FGF12, is highly homologous to that of the other FGF proteins, providing the classical tertiary structure of β-trefoil. FGF12 is ...
Source: Differentiation - December 2, 2023 Category: Research Authors: Martyna Biadun Radoslaw Karelus Daniel Krowarsch Lukasz Opalinski Malgorzata Zakrzewska Source Type: research
FGF12: biology and function
Differentiation. 2023 Nov 25:100740. doi: 10.1016/j.diff.2023.100740. Online ahead of print.ABSTRACTFibroblast growth factor 12 (FGF12) belongs to the fibroblast growth factor homologous factors (FHF) subfamily, which is also known as the FGF11 subfamily. The human FGF12 gene is located on chromosome 3 and consists of four introns and five coding exons. Their alternative splicing results in two FGF12 isoforms - the shorter 'b' isoform and the longer 'a' isoform. Structurally, the core domain of FGF12, is highly homologous to that of the other FGF proteins, providing the classical tertiary structure of β-trefoil. FGF12 is ...
Source: Differentiation - December 2, 2023 Category: Research Authors: Martyna Biadun Radoslaw Karelus Daniel Krowarsch Lukasz Opalinski Malgorzata Zakrzewska Source Type: research
FGF12: biology and function
Differentiation. 2023 Nov 25:100740. doi: 10.1016/j.diff.2023.100740. Online ahead of print.ABSTRACTFibroblast growth factor 12 (FGF12) belongs to the fibroblast growth factor homologous factors (FHF) subfamily, which is also known as the FGF11 subfamily. The human FGF12 gene is located on chromosome 3 and consists of four introns and five coding exons. Their alternative splicing results in two FGF12 isoforms - the shorter 'b' isoform and the longer 'a' isoform. Structurally, the core domain of FGF12, is highly homologous to that of the other FGF proteins, providing the classical tertiary structure of β-trefoil. FGF12 is ...
Source: Differentiation - December 2, 2023 Category: Research Authors: Martyna Biadun Radoslaw Karelus Daniel Krowarsch Lukasz Opalinski Malgorzata Zakrzewska Source Type: research
FGF12: biology and function
Differentiation. 2023 Nov 25:100740. doi: 10.1016/j.diff.2023.100740. Online ahead of print.ABSTRACTFibroblast growth factor 12 (FGF12) belongs to the fibroblast growth factor homologous factors (FHF) subfamily, which is also known as the FGF11 subfamily. The human FGF12 gene is located on chromosome 3 and consists of four introns and five coding exons. Their alternative splicing results in two FGF12 isoforms - the shorter 'b' isoform and the longer 'a' isoform. Structurally, the core domain of FGF12, is highly homologous to that of the other FGF proteins, providing the classical tertiary structure of β-trefoil. FGF12 is ...
Source: Differentiation - December 2, 2023 Category: Research Authors: Martyna Biadun Radoslaw Karelus Daniel Krowarsch Lukasz Opalinski Malgorzata Zakrzewska Source Type: research
FGF12: biology and function
Differentiation. 2023 Nov 25:100740. doi: 10.1016/j.diff.2023.100740. Online ahead of print.ABSTRACTFibroblast growth factor 12 (FGF12) belongs to the fibroblast growth factor homologous factors (FHF) subfamily, which is also known as the FGF11 subfamily. The human FGF12 gene is located on chromosome 3 and consists of four introns and five coding exons. Their alternative splicing results in two FGF12 isoforms - the shorter 'b' isoform and the longer 'a' isoform. Structurally, the core domain of FGF12, is highly homologous to that of the other FGF proteins, providing the classical tertiary structure of β-trefoil. FGF12 is ...
Source: Differentiation - December 2, 2023 Category: Research Authors: Martyna Biadun Radoslaw Karelus Daniel Krowarsch Lukasz Opalinski Malgorzata Zakrzewska Source Type: research
FGF12: biology and function
Differentiation. 2023 Nov 25:100740. doi: 10.1016/j.diff.2023.100740. Online ahead of print.ABSTRACTFibroblast growth factor 12 (FGF12) belongs to the fibroblast growth factor homologous factors (FHF) subfamily, which is also known as the FGF11 subfamily. The human FGF12 gene is located on chromosome 3 and consists of four introns and five coding exons. Their alternative splicing results in two FGF12 isoforms - the shorter 'b' isoform and the longer 'a' isoform. Structurally, the core domain of FGF12, is highly homologous to that of the other FGF proteins, providing the classical tertiary structure of β-trefoil. FGF12 is ...
Source: Differentiation - December 2, 2023 Category: Research Authors: Martyna Biadun Radoslaw Karelus Daniel Krowarsch Lukasz Opalinski Malgorzata Zakrzewska Source Type: research
FGF12: biology and function
Differentiation. 2023 Nov 25:100740. doi: 10.1016/j.diff.2023.100740. Online ahead of print.ABSTRACTFibroblast growth factor 12 (FGF12) belongs to the fibroblast growth factor homologous factors (FHF) subfamily, which is also known as the FGF11 subfamily. The human FGF12 gene is located on chromosome 3 and consists of four introns and five coding exons. Their alternative splicing results in two FGF12 isoforms - the shorter 'b' isoform and the longer 'a' isoform. Structurally, the core domain of FGF12, is highly homologous to that of the other FGF proteins, providing the classical tertiary structure of β-trefoil. FGF12 is ...
Source: Differentiation - December 2, 2023 Category: Research Authors: Martyna Biadun Radoslaw Karelus Daniel Krowarsch Lukasz Opalinski Malgorzata Zakrzewska Source Type: research
FGF12: biology and function
Differentiation. 2023 Nov 25:100740. doi: 10.1016/j.diff.2023.100740. Online ahead of print.ABSTRACTFibroblast growth factor 12 (FGF12) belongs to the fibroblast growth factor homologous factors (FHF) subfamily, which is also known as the FGF11 subfamily. The human FGF12 gene is located on chromosome 3 and consists of four introns and five coding exons. Their alternative splicing results in two FGF12 isoforms - the shorter 'b' isoform and the longer 'a' isoform. Structurally, the core domain of FGF12, is highly homologous to that of the other FGF proteins, providing the classical tertiary structure of β-trefoil. FGF12 is ...
Source: Differentiation - December 2, 2023 Category: Research Authors: Martyna Biadun Radoslaw Karelus Daniel Krowarsch Lukasz Opalinski Malgorzata Zakrzewska Source Type: research
FGF12: biology and function
Differentiation. 2023 Nov 25:100740. doi: 10.1016/j.diff.2023.100740. Online ahead of print.ABSTRACTFibroblast growth factor 12 (FGF12) belongs to the fibroblast growth factor homologous factors (FHF) subfamily, which is also known as the FGF11 subfamily. The human FGF12 gene is located on chromosome 3 and consists of four introns and five coding exons. Their alternative splicing results in two FGF12 isoforms - the shorter 'b' isoform and the longer 'a' isoform. Structurally, the core domain of FGF12, is highly homologous to that of the other FGF proteins, providing the classical tertiary structure of β-trefoil. FGF12 is ...
Source: Differentiation - December 2, 2023 Category: Research Authors: Martyna Biadun Radoslaw Karelus Daniel Krowarsch Lukasz Opalinski Malgorzata Zakrzewska Source Type: research
Fibroblast growth factor 10
Differentiation. 2023 Nov 25:100741. doi: 10.1016/j.diff.2023.100741. Online ahead of print.ABSTRACTFibroblast growth factor 10 (FGF10) is a major morphoregulatory factor that plays essential signaling roles during vertebrate multiorgan development and homeostasis. FGF10 is predominantly expressed in mesenchymal cells and signals though FGFR2b in adjacent epithelia to regulate branching morphogenesis, stem cell fate, tissue differentiation and proliferation, in addition to autocrine roles. Genetic loss of function analyses have revealed critical requirements for FGF10 signaling during limb, lung, digestive system, ectoderm...
Source: Differentiation - December 1, 2023 Category: Research Authors: Francesca Rochais Robert G Kelly Source Type: research
Fibroblast growth factor 10
Differentiation. 2023 Nov 25:100741. doi: 10.1016/j.diff.2023.100741. Online ahead of print.ABSTRACTFibroblast growth factor 10 (FGF10) is a major morphoregulatory factor that plays essential signaling roles during vertebrate multiorgan development and homeostasis. FGF10 is predominantly expressed in mesenchymal cells and signals though FGFR2b in adjacent epithelia to regulate branching morphogenesis, stem cell fate, tissue differentiation and proliferation, in addition to autocrine roles. Genetic loss of function analyses have revealed critical requirements for FGF10 signaling during limb, lung, digestive system, ectoderm...
Source: Differentiation - December 1, 2023 Category: Research Authors: Francesca Rochais Robert G Kelly Source Type: research
Network analysis of transcriptomic data uncovers molecular signatures and the interplay of mRNAs, lncRNAs, and miRNAs in human embryonic stem cells
Differentiation. 2023 Nov 14:100738. doi: 10.1016/j.diff.2023.11.001. Online ahead of print.ABSTRACTGrowing evidence has shown that besides the protein coding genes, the non-coding elements of the genome are indispensable for maintaining the property of self-renewal in human embryonic stem cells and in cell fate determination. However, the regulatory mechanisms and the landscape of interactions between the coding and non-coding elements is poorly understood. In this work, we used weighted gene co-expression network analysis (WGCNA) on transcriptomic data retrieved from RNA-seq and small RNA-seq experiments and reconstructe...
Source: Differentiation - November 26, 2023 Category: Research Authors: Arindam Ghosh Anup Som Source Type: research
Network analysis of transcriptomic data uncovers molecular signatures and the interplay of mRNAs, lncRNAs, and miRNAs in human embryonic stem cells
Differentiation. 2023 Nov 14:100738. doi: 10.1016/j.diff.2023.11.001. Online ahead of print.ABSTRACTGrowing evidence has shown that besides the protein coding genes, the non-coding elements of the genome are indispensable for maintaining the property of self-renewal in human embryonic stem cells and in cell fate determination. However, the regulatory mechanisms and the landscape of interactions between the coding and non-coding elements is poorly understood. In this work, we used weighted gene co-expression network analysis (WGCNA) on transcriptomic data retrieved from RNA-seq and small RNA-seq experiments and reconstructe...
Source: Differentiation - November 26, 2023 Category: Research Authors: Arindam Ghosh Anup Som Source Type: research
Network analysis of transcriptomic data uncovers molecular signatures and the interplay of mRNAs, lncRNAs, and miRNAs in human embryonic stem cells
Differentiation. 2023 Nov 14:100738. doi: 10.1016/j.diff.2023.11.001. Online ahead of print.ABSTRACTGrowing evidence has shown that besides the protein coding genes, the non-coding elements of the genome are indispensable for maintaining the property of self-renewal in human embryonic stem cells and in cell fate determination. However, the regulatory mechanisms and the landscape of interactions between the coding and non-coding elements is poorly understood. In this work, we used weighted gene co-expression network analysis (WGCNA) on transcriptomic data retrieved from RNA-seq and small RNA-seq experiments and reconstructe...
Source: Differentiation - November 26, 2023 Category: Research Authors: Arindam Ghosh Anup Som Source Type: research
