Network analysis of transcriptomic data uncovers molecular signatures and the interplay of mRNAs, lncRNAs, and miRNAs in human embryonic stem cells
Differentiation. 2023 Nov 14:100738. doi: 10.1016/j.diff.2023.11.001. Online ahead of print.ABSTRACTGrowing evidence has shown that besides the protein coding genes, the non-coding elements of the genome are indispensable for maintaining the property of self-renewal in human embryonic stem cells and in cell fate determination. However, the regulatory mechanisms and the landscape of interactions between the coding and non-coding elements is poorly understood. In this work, we used weighted gene co-expression network analysis (WGCNA) on transcriptomic data retrieved from RNA-seq and small RNA-seq experiments and reconstructe...
Source: Differentiation - November 26, 2023 Category: Research Authors: Arindam Ghosh Anup Som Source Type: research
Fgf18
Differentiation. 2023 Nov 7:100735. doi: 10.1016/j.diff.2023.10.003. Online ahead of print.ABSTRACTFGF18 was discovered in 1998. It is a pleiotropic growth factor that stimulates major signalling pathways involved in cell proliferation and growth, and is involved in the development and homeostasis of many tissues such as bone, lung, and central nervous system. The gene consists of five exons that code for a 207 amino acid glycosylated protein. FGF18 is widely expressed in developing and adult chickens, mice, and humans, being seen in the mesenchyme, brain, skeleton, heart, and lungs. Knockout studies of FGF18 in mice lead ...
Source: Differentiation - November 25, 2023 Category: Research Authors: Michael G E Goldschagg Dorit Hockman Source Type: research
Fgf20
Differentiation. 2023 Nov 7:100737. doi: 10.1016/j.diff.2023.10.005. Online ahead of print.ABSTRACTFibroblast growth factor 20 (FGF20) is a neurotrophic factor and a member of the FGF9 subfamily. It was first identified in Xenopus embryos and was isolated shortly thereafter from the adult rat brain. Its receptors include FGFR4, FGFR3b, FGFR2b and the FGFRc splice forms. In adults it is highly expressed in the brain, while it is expressed in a variety of regions during embryonic development, including the inner ear, heart, hair placodes, mammary buds, dental epithelium and limbs. As a result of its wide-spread expression, F...
Source: Differentiation - November 25, 2023 Category: Research Authors: Justine D Van Greenen Dorit Hockman Source Type: research
Fgf18
Differentiation. 2023 Nov 7:100735. doi: 10.1016/j.diff.2023.10.003. Online ahead of print.ABSTRACTFGF18 was discovered in 1998. It is a pleiotropic growth factor that stimulates major signalling pathways involved in cell proliferation and growth, and is involved in the development and homeostasis of many tissues such as bone, lung, and central nervous system. The gene consists of five exons that code for a 207 amino acid glycosylated protein. FGF18 is widely expressed in developing and adult chickens, mice, and humans, being seen in the mesenchyme, brain, skeleton, heart, and lungs. Knockout studies of FGF18 in mice lead ...
Source: Differentiation - November 25, 2023 Category: Research Authors: Michael G E Goldschagg Dorit Hockman Source Type: research
Fgf20
Differentiation. 2023 Nov 7:100737. doi: 10.1016/j.diff.2023.10.005. Online ahead of print.ABSTRACTFibroblast growth factor 20 (FGF20) is a neurotrophic factor and a member of the FGF9 subfamily. It was first identified in Xenopus embryos and was isolated shortly thereafter from the adult rat brain. Its receptors include FGFR4, FGFR3b, FGFR2b and the FGFRc splice forms. In adults it is highly expressed in the brain, while it is expressed in a variety of regions during embryonic development, including the inner ear, heart, hair placodes, mammary buds, dental epithelium and limbs. As a result of its wide-spread expression, F...
Source: Differentiation - November 25, 2023 Category: Research Authors: Justine D Van Greenen Dorit Hockman Source Type: research
Ovotesticular cords and ovotesticular follicles: New markers in a model of human mixed ovotestis
Differentiation. 2023 Nov 19:100739. doi: 10.1016/j.diff.2023.11.002. Online ahead of print.NO ABSTRACTPMID:38000942 | DOI:10.1016/j.diff.2023.11.002 (Source: Differentiation)
Source: Differentiation - November 24, 2023 Category: Research Authors: Laurence Baskin Mei Cao Sena Askel Yi Li Gerald Cunha Source Type: research
Fgf5
Differentiation. 2023 Nov 7:S0301-4681(23)00075-0. doi: 10.1016/j.diff.2023.10.004. Online ahead of print.ABSTRACTFGF5 functions as a negative regulator of the hair cycle in mammals. It is expressed in the outer root sheath of hair follicles during the late anagen phase of the hair cycle. It functions as a signaling molecule, mediating the transition of the anagen growth phase to catagen regression phase of the hair cycle. Spontaneous and engineered FGF5 mutations in mammalian animal models result in long hair phenotypes. In humans, inherited FGF5 mutations result in trichomegaly (long eyelashes). Knockdown of fgf5 in zebr...
Source: Differentiation - November 13, 2023 Category: Research Authors: Evelyn A Carrion Malcolm M Moses Richard R Behringer Source Type: research
Fgf5
Differentiation. 2023 Nov 7:S0301-4681(23)00075-0. doi: 10.1016/j.diff.2023.10.004. Online ahead of print.ABSTRACTFGF5 functions as a negative regulator of the hair cycle in mammals. It is expressed in the outer root sheath of hair follicles during the late anagen phase of the hair cycle. It functions as a signaling molecule, mediating the transition of the anagen growth phase to catagen regression phase of the hair cycle. Spontaneous and engineered FGF5 mutations in mammalian animal models result in long hair phenotypes. In humans, inherited FGF5 mutations result in trichomegaly (long eyelashes). Knockdown of fgf5 in zebr...
Source: Differentiation - November 13, 2023 Category: Research Authors: Evelyn A Carrion Malcolm M Moses Richard R Behringer Source Type: research
Fgf5
Differentiation. 2023 Nov 7:S0301-4681(23)00075-0. doi: 10.1016/j.diff.2023.10.004. Online ahead of print.ABSTRACTFGF5 functions as a negative regulator of the hair cycle in mammals. It is expressed in the outer root sheath of hair follicles during the late anagen phase of the hair cycle. It functions as a signaling molecule, mediating the transition of the anagen growth phase to catagen regression phase of the hair cycle. Spontaneous and engineered FGF5 mutations in mammalian animal models result in long hair phenotypes. In humans, inherited FGF5 mutations result in trichomegaly (long eyelashes). Knockdown of fgf5 in zebr...
Source: Differentiation - November 13, 2023 Category: Research Authors: Evelyn A Carrion Malcolm M Moses Richard R Behringer Source Type: research
Fgf5
Differentiation. 2023 Nov 7:S0301-4681(23)00075-0. doi: 10.1016/j.diff.2023.10.004. Online ahead of print.ABSTRACTFGF5 functions as a negative regulator of the hair cycle in mammals. It is expressed in the outer root sheath of hair follicles during the late anagen phase of the hair cycle. It functions as a signaling molecule, mediating the transition of the anagen growth phase to catagen regression phase of the hair cycle. Spontaneous and engineered FGF5 mutations in mammalian animal models result in long hair phenotypes. In humans, inherited FGF5 mutations result in trichomegaly (long eyelashes). Knockdown of fgf5 in zebr...
Source: Differentiation - November 13, 2023 Category: Research Authors: Evelyn A Carrion Malcolm M Moses Richard R Behringer Source Type: research
Fgf5
Differentiation. 2023 Nov 7:S0301-4681(23)00075-0. doi: 10.1016/j.diff.2023.10.004. Online ahead of print.ABSTRACTFGF5 functions as a negative regulator of the hair cycle in mammals. It is expressed in the outer root sheath of hair follicles during the late anagen phase of the hair cycle. It functions as a signaling molecule, mediating the transition of the anagen growth phase to catagen regression phase of the hair cycle. Spontaneous and engineered FGF5 mutations in mammalian animal models result in long hair phenotypes. In humans, inherited FGF5 mutations result in trichomegaly (long eyelashes). Knockdown of fgf5 in zebr...
Source: Differentiation - November 13, 2023 Category: Research Authors: Evelyn A Carrion Malcolm M Moses Richard R Behringer Source Type: research
Fgf5
Differentiation. 2023 Nov 7:S0301-4681(23)00075-0. doi: 10.1016/j.diff.2023.10.004. Online ahead of print.ABSTRACTFGF5 functions as a negative regulator of the hair cycle in mammals. It is expressed in the outer root sheath of hair follicles during the late anagen phase of the hair cycle. It functions as a signaling molecule, mediating the transition of the anagen growth phase to catagen regression phase of the hair cycle. Spontaneous and engineered FGF5 mutations in mammalian animal models result in long hair phenotypes. In humans, inherited FGF5 mutations result in trichomegaly (long eyelashes). Knockdown of fgf5 in zebr...
Source: Differentiation - November 13, 2023 Category: Research Authors: Evelyn A Carrion Malcolm M Moses Richard R Behringer Source Type: research
Fgf5
Differentiation. 2023 Nov 7:S0301-4681(23)00075-0. doi: 10.1016/j.diff.2023.10.004. Online ahead of print.ABSTRACTFGF5 functions as a negative regulator of the hair cycle in mammals. It is expressed in the outer root sheath of hair follicles during the late anagen phase of the hair cycle. It functions as a signaling molecule, mediating the transition of the anagen growth phase to catagen regression phase of the hair cycle. Spontaneous and engineered FGF5 mutations in mammalian animal models result in long hair phenotypes. In humans, inherited FGF5 mutations result in trichomegaly (long eyelashes). Knockdown of fgf5 in zebr...
Source: Differentiation - November 13, 2023 Category: Research Authors: Evelyn A Carrion Malcolm M Moses Richard R Behringer Source Type: research
Fgf5
Differentiation. 2023 Nov 7:S0301-4681(23)00075-0. doi: 10.1016/j.diff.2023.10.004. Online ahead of print.ABSTRACTFGF5 functions as a negative regulator of the hair cycle in mammals. It is expressed in the outer root sheath of hair follicles during the late anagen phase of the hair cycle. It functions as a signaling molecule, mediating the transition of the anagen growth phase to catagen regression phase of the hair cycle. Spontaneous and engineered FGF5 mutations in mammalian animal models result in long hair phenotypes. In humans, inherited FGF5 mutations result in trichomegaly (long eyelashes). Knockdown of fgf5 in zebr...
Source: Differentiation - November 13, 2023 Category: Research Authors: Evelyn A Carrion Malcolm M Moses Richard R Behringer Source Type: research
Fgf5
Differentiation. 2023 Nov 7:S0301-4681(23)00075-0. doi: 10.1016/j.diff.2023.10.004. Online ahead of print.ABSTRACTFGF5 functions as a negative regulator of the hair cycle in mammals. It is expressed in the outer root sheath of hair follicles during the late anagen phase of the hair cycle. It functions as a signaling molecule, mediating the transition of the anagen growth phase to catagen regression phase of the hair cycle. Spontaneous and engineered FGF5 mutations in mammalian animal models result in long hair phenotypes. In humans, inherited FGF5 mutations result in trichomegaly (long eyelashes). Knockdown of fgf5 in zebr...
Source: Differentiation - November 13, 2023 Category: Research Authors: Evelyn A Carrion Malcolm M Moses Richard R Behringer Source Type: research
