Fibroblast growth factor 2
Differentiation. 2023 Oct 12:S0301-4681(23)00072-5. doi: 10.1016/j.diff.2023.10.001. Online ahead of print.ABSTRACTFibroblast Growth Factor 2 (FGF2), also known as basic fibroblast growth factor, is a potent stimulator of growth and differentiation in multiple tissues. Its discovery traces back over 50 years ago when it was first isolated from bovine pituitary extracts due to its ability to stimulate fibroblast proliferation. Subsequent studies investigating the genomic structure of FGF2 identified multiple protein isoforms, categorized as the low molecular weight and high molecular weight FGF2. These isoforms arise from a...
Source: Differentiation - October 20, 2023 Category: Research Authors: Audrey Nickle Sebastian Ko Amy E Merrill Source Type: research
Fibroblast growth factor 2
Differentiation. 2023 Oct 12:S0301-4681(23)00072-5. doi: 10.1016/j.diff.2023.10.001. Online ahead of print.ABSTRACTFibroblast Growth Factor 2 (FGF2), also known as basic fibroblast growth factor, is a potent stimulator of growth and differentiation in multiple tissues. Its discovery traces back over 50 years ago when it was first isolated from bovine pituitary extracts due to its ability to stimulate fibroblast proliferation. Subsequent studies investigating the genomic structure of FGF2 identified multiple protein isoforms, categorized as the low molecular weight and high molecular weight FGF2. These isoforms arise from a...
Source: Differentiation - October 20, 2023 Category: Research Authors: Audrey Nickle Sebastian Ko Amy E Merrill Source Type: research
Fibroblast growth factor 2
Differentiation. 2023 Oct 12:S0301-4681(23)00072-5. doi: 10.1016/j.diff.2023.10.001. Online ahead of print.ABSTRACTFibroblast Growth Factor 2 (FGF2), also known as basic fibroblast growth factor, is a potent stimulator of growth and differentiation in multiple tissues. Its discovery traces back over 50 years ago when it was first isolated from bovine pituitary extracts due to its ability to stimulate fibroblast proliferation. Subsequent studies investigating the genomic structure of FGF2 identified multiple protein isoforms, categorized as the low molecular weight and high molecular weight FGF2. These isoforms arise from a...
Source: Differentiation - October 20, 2023 Category: Research Authors: Audrey Nickle Sebastian Ko Amy E Merrill Source Type: research
Fibroblast growth factor 2
Differentiation. 2023 Oct 12:S0301-4681(23)00072-5. doi: 10.1016/j.diff.2023.10.001. Online ahead of print.ABSTRACTFibroblast Growth Factor 2 (FGF2), also known as basic fibroblast growth factor, is a potent stimulator of growth and differentiation in multiple tissues. Its discovery traces back over 50 years ago when it was first isolated from bovine pituitary extracts due to its ability to stimulate fibroblast proliferation. Subsequent studies investigating the genomic structure of FGF2 identified multiple protein isoforms, categorized as the low molecular weight and high molecular weight FGF2. These isoforms arise from a...
Source: Differentiation - October 20, 2023 Category: Research Authors: Audrey Nickle Sebastian Ko Amy E Merrill Source Type: research
Fibroblast growth factor 2
Differentiation. 2023 Oct 12:S0301-4681(23)00072-5. doi: 10.1016/j.diff.2023.10.001. Online ahead of print.ABSTRACTFibroblast Growth Factor 2 (FGF2), also known as basic fibroblast growth factor, is a potent stimulator of growth and differentiation in multiple tissues. Its discovery traces back over 50 years ago when it was first isolated from bovine pituitary extracts due to its ability to stimulate fibroblast proliferation. Subsequent studies investigating the genomic structure of FGF2 identified multiple protein isoforms, categorized as the low molecular weight and high molecular weight FGF2. These isoforms arise from a...
Source: Differentiation - October 20, 2023 Category: Research Authors: Audrey Nickle Sebastian Ko Amy E Merrill Source Type: research
Effects of a Sertoli cell-specific knockout of Connexin43 on maturation and proliferation of postnatal Sertoli cells
In conclusion, deletion of the testicular gap junction protein Cx43 might prevent normal SC maturation and might even alter also the proliferation potential of adult SC.PMID:37839230 | DOI:10.1016/j.diff.2023.09.002 (Source: Differentiation)
Source: Differentiation - October 15, 2023 Category: Research Authors: Hanna H üneke Marion Langeheine Kristina Rode Klaus Jung Adrian Pilatz Daniela Fietz Sabine Kliesch Ralph Brehm Source Type: research
Effects of a Sertoli cell-specific knockout of Connexin43 on maturation and proliferation of postnatal Sertoli cells
In conclusion, deletion of the testicular gap junction protein Cx43 might prevent normal SC maturation and might even alter also the proliferation potential of adult SC.PMID:37839230 | DOI:10.1016/j.diff.2023.09.002 (Source: Differentiation)
Source: Differentiation - October 15, 2023 Category: Research Authors: Hanna H üneke Marion Langeheine Kristina Rode Klaus Jung Adrian Pilatz Daniela Fietz Sabine Kliesch Ralph Brehm Source Type: research
Effects of a Sertoli cell-specific knockout of Connexin43 on maturation and proliferation of postnatal Sertoli cells
In conclusion, deletion of the testicular gap junction protein Cx43 might prevent normal SC maturation and might even alter also the proliferation potential of adult SC.PMID:37839230 | DOI:10.1016/j.diff.2023.09.002 (Source: Differentiation)
Source: Differentiation - October 15, 2023 Category: Research Authors: Hanna H üneke Marion Langeheine Kristina Rode Klaus Jung Adrian Pilatz Daniela Fietz Sabine Kliesch Ralph Brehm Source Type: research
Effects of a Sertoli cell-specific knockout of Connexin43 on maturation and proliferation of postnatal Sertoli cells
In conclusion, deletion of the testicular gap junction protein Cx43 might prevent normal SC maturation and might even alter also the proliferation potential of adult SC.PMID:37839230 | DOI:10.1016/j.diff.2023.09.002 (Source: Differentiation)
Source: Differentiation - October 15, 2023 Category: Research Authors: Hanna H üneke Marion Langeheine Kristina Rode Klaus Jung Adrian Pilatz Daniela Fietz Sabine Kliesch Ralph Brehm Source Type: research
The fundamentals of fibroblast growth factor 9
Differentiation. 2023 Sep 22:S0301-4681(23)00070-1. doi: 10.1016/j.diff.2023.09.004. Online ahead of print.ABSTRACTFibroblast growth factor 9 (FGF9) was first identified during a screen for factors acting on cells of the central nervous system (CNS). Research over the subsequent two decades has revealed this protein to be a critically important and elegantly regulated growth factor. A hallmark control feature is reciprocal compartmentalization, particularly during development, with epithelium as a dominant source and mesenchyme a prime target. This mesenchyme selectivity is accomplished by the high affinity of FGF9 to the ...
Source: Differentiation - October 2, 2023 Category: Research Authors: Hao Yin Sabrina C R Staples J Geoffrey Pickering Source Type: research
The fundamentals of fibroblast growth factor 9
Differentiation. 2023 Sep 22:S0301-4681(23)00070-1. doi: 10.1016/j.diff.2023.09.004. Online ahead of print.ABSTRACTFibroblast growth factor 9 (FGF9) was first identified during a screen for factors acting on cells of the central nervous system (CNS). Research over the subsequent two decades has revealed this protein to be a critically important and elegantly regulated growth factor. A hallmark control feature is reciprocal compartmentalization, particularly during development, with epithelium as a dominant source and mesenchyme a prime target. This mesenchyme selectivity is accomplished by the high affinity of FGF9 to the ...
Source: Differentiation - October 2, 2023 Category: Research Authors: Hao Yin Sabrina C R Staples J Geoffrey Pickering Source Type: research
The fundamentals of fibroblast growth factor 9
Differentiation. 2023 Sep 22:S0301-4681(23)00070-1. doi: 10.1016/j.diff.2023.09.004. Online ahead of print.ABSTRACTFibroblast growth factor 9 (FGF9) was first identified during a screen for factors acting on cells of the central nervous system (CNS). Research over the subsequent two decades has revealed this protein to be a critically important and elegantly regulated growth factor. A hallmark control feature is reciprocal compartmentalization, particularly during development, with epithelium as a dominant source and mesenchyme a prime target. This mesenchyme selectivity is accomplished by the high affinity of FGF9 to the ...
Source: Differentiation - October 2, 2023 Category: Research Authors: Hao Yin Sabrina C R Staples J Geoffrey Pickering Source Type: research
The fundamentals of fibroblast growth factor 9
Differentiation. 2023 Sep 22:S0301-4681(23)00070-1. doi: 10.1016/j.diff.2023.09.004. Online ahead of print.ABSTRACTFibroblast growth factor 9 (FGF9) was first identified during a screen for factors acting on cells of the central nervous system (CNS). Research over the subsequent two decades has revealed this protein to be a critically important and elegantly regulated growth factor. A hallmark control feature is reciprocal compartmentalization, particularly during development, with epithelium as a dominant source and mesenchyme a prime target. This mesenchyme selectivity is accomplished by the high affinity of FGF9 to the ...
Source: Differentiation - October 2, 2023 Category: Research Authors: Hao Yin Sabrina C R Staples J Geoffrey Pickering Source Type: research
The fundamentals of fibroblast growth factor 9
Differentiation. 2023 Sep 22:S0301-4681(23)00070-1. doi: 10.1016/j.diff.2023.09.004. Online ahead of print.ABSTRACTFibroblast growth factor 9 (FGF9) was first identified during a screen for factors acting on cells of the central nervous system (CNS). Research over the subsequent two decades has revealed this protein to be a critically important and elegantly regulated growth factor. A hallmark control feature is reciprocal compartmentalization, particularly during development, with epithelium as a dominant source and mesenchyme a prime target. This mesenchyme selectivity is accomplished by the high affinity of FGF9 to the ...
Source: Differentiation - October 2, 2023 Category: Research Authors: Hao Yin Sabrina C R Staples J Geoffrey Pickering Source Type: research
The fundamentals of fibroblast growth factor 9
Differentiation. 2023 Sep 22:S0301-4681(23)00070-1. doi: 10.1016/j.diff.2023.09.004. Online ahead of print.ABSTRACTFibroblast growth factor 9 (FGF9) was first identified during a screen for factors acting on cells of the central nervous system (CNS). Research over the subsequent two decades has revealed this protein to be a critically important and elegantly regulated growth factor. A hallmark control feature is reciprocal compartmentalization, particularly during development, with epithelium as a dominant source and mesenchyme a prime target. This mesenchyme selectivity is accomplished by the high affinity of FGF9 to the ...
Source: Differentiation - October 2, 2023 Category: Research Authors: Hao Yin Sabrina C R Staples J Geoffrey Pickering Source Type: research
