Ectopic expression of HNF4 α in Het1A cells induces an invasive phenotype
We examined the competitive ability of Het1A cells stably expressing HNF4α or CDX2 and placed in confrontation with unmodified Het1A cells. The key result is that stable expression of HNF4α, but not CDX2, increased the ability of the cells to migrate and push into the unmodified Het1A domain. In this situation the boundary between the cell types is a sharp one, as is normally seen in BO. The experiments were conducted using a variety of extracellular substrates, which all tended to increase the cell migration compared to uncoated plastic. These data provide evidence that HNF4α expression could have a potential role in t...
Source: Differentiation - September 10, 2023 Category: Research Authors: Carmen Grimaldos Rodriguez Ella F Rimmer Benjamin Colleypriest David Tosh Jonathan M W Slack Ute Jungwirth Source Type: research
Ectopic expression of HNF4 α in Het1A cells induces an invasive phenotype
We examined the competitive ability of Het1A cells stably expressing HNF4α or CDX2 and placed in confrontation with unmodified Het1A cells. The key result is that stable expression of HNF4α, but not CDX2, increased the ability of the cells to migrate and push into the unmodified Het1A domain. In this situation the boundary between the cell types is a sharp one, as is normally seen in BO. The experiments were conducted using a variety of extracellular substrates, which all tended to increase the cell migration compared to uncoated plastic. These data provide evidence that HNF4α expression could have a potential role in t...
Source: Differentiation - September 10, 2023 Category: Research Authors: Carmen Grimaldos Rodriguez Ella F Rimmer Benjamin Colleypriest David Tosh Jonathan M W Slack Ute Jungwirth Source Type: research
Ectopic expression of HNF4 α in Het1A cells induces an invasive phenotype
We examined the competitive ability of Het1A cells stably expressing HNF4α or CDX2 and placed in confrontation with unmodified Het1A cells. The key result is that stable expression of HNF4α, but not CDX2, increased the ability of the cells to migrate and push into the unmodified Het1A domain. In this situation the boundary between the cell types is a sharp one, as is normally seen in BO. The experiments were conducted using a variety of extracellular substrates, which all tended to increase the cell migration compared to uncoated plastic. These data provide evidence that HNF4α expression could have a potential role in t...
Source: Differentiation - September 10, 2023 Category: Research Authors: Carmen Grimaldos Rodriguez Ella F Rimmer Benjamin Colleypriest David Tosh Jonathan M W Slack Ute Jungwirth Source Type: research
Ectopic expression of HNF4 α in Het1A cells induces an invasive phenotype
We examined the competitive ability of Het1A cells stably expressing HNF4α or CDX2 and placed in confrontation with unmodified Het1A cells. The key result is that stable expression of HNF4α, but not CDX2, increased the ability of the cells to migrate and push into the unmodified Het1A domain. In this situation the boundary between the cell types is a sharp one, as is normally seen in BO. The experiments were conducted using a variety of extracellular substrates, which all tended to increase the cell migration compared to uncoated plastic. These data provide evidence that HNF4α expression could have a potential role in t...
Source: Differentiation - September 10, 2023 Category: Research Authors: Carmen Grimaldos Rodriguez Ella F Rimmer Benjamin Colleypriest David Tosh Jonathan M W Slack Ute Jungwirth Source Type: research
Ectopic expression of HNF4 α in Het1A cells induces an invasive phenotype
We examined the competitive ability of Het1A cells stably expressing HNF4α or CDX2 and placed in confrontation with unmodified Het1A cells. The key result is that stable expression of HNF4α, but not CDX2, increased the ability of the cells to migrate and push into the unmodified Het1A domain. In this situation the boundary between the cell types is a sharp one, as is normally seen in BO. The experiments were conducted using a variety of extracellular substrates, which all tended to increase the cell migration compared to uncoated plastic. These data provide evidence that HNF4α expression could have a potential role in t...
Source: Differentiation - September 10, 2023 Category: Research Authors: Carmen Grimaldos Rodriguez Ella F Rimmer Benjamin Colleypriest David Tosh Jonathan M W Slack Ute Jungwirth Source Type: research
Ectopic expression of HNF4 α in Het1A cells induces an invasive phenotype
We examined the competitive ability of Het1A cells stably expressing HNF4α or CDX2 and placed in confrontation with unmodified Het1A cells. The key result is that stable expression of HNF4α, but not CDX2, increased the ability of the cells to migrate and push into the unmodified Het1A domain. In this situation the boundary between the cell types is a sharp one, as is normally seen in BO. The experiments were conducted using a variety of extracellular substrates, which all tended to increase the cell migration compared to uncoated plastic. These data provide evidence that HNF4α expression could have a potential role in t...
Source: Differentiation - September 10, 2023 Category: Research Authors: Carmen Grimaldos Rodriguez Ella F Rimmer Benjamin Colleypriest David Tosh Jonathan M W Slack Ute Jungwirth Source Type: research
Ectopic expression of HNF4 α in Het1A cells induces an invasive phenotype
We examined the competitive ability of Het1A cells stably expressing HNF4α or CDX2 and placed in confrontation with unmodified Het1A cells. The key result is that stable expression of HNF4α, but not CDX2, increased the ability of the cells to migrate and push into the unmodified Het1A domain. In this situation the boundary between the cell types is a sharp one, as is normally seen in BO. The experiments were conducted using a variety of extracellular substrates, which all tended to increase the cell migration compared to uncoated plastic. These data provide evidence that HNF4α expression could have a potential role in t...
Source: Differentiation - September 10, 2023 Category: Research Authors: Carmen Grimaldos Rodriguez Ella F Rimmer Benjamin Colleypriest David Tosh Jonathan M W Slack Ute Jungwirth Source Type: research
Ectopic expression of HNF4 α in Het1A cells induces an invasive phenotype
We examined the competitive ability of Het1A cells stably expressing HNF4α or CDX2 and placed in confrontation with unmodified Het1A cells. The key result is that stable expression of HNF4α, but not CDX2, increased the ability of the cells to migrate and push into the unmodified Het1A domain. In this situation the boundary between the cell types is a sharp one, as is normally seen in BO. The experiments were conducted using a variety of extracellular substrates, which all tended to increase the cell migration compared to uncoated plastic. These data provide evidence that HNF4α expression could have a potential role in t...
Source: Differentiation - September 10, 2023 Category: Research Authors: Carmen Grimaldos Rodriguez Ella F Rimmer Benjamin Colleypriest David Tosh Jonathan M W Slack Ute Jungwirth Source Type: research
The role of non-coding RNAs in diabetes-induced osteoporosis
Differentiation. 2023 Aug 22;133:98-108. doi: 10.1016/j.diff.2023.08.002. Online ahead of print.ABSTRACTDiabetes mellitus (DM) and osteoporosis are two major health care problems worldwide. Emerging evidence suggests that DM poses a risk for osteoporosis and can contribute to the development of diabetes-induced osteoporosis (DOP). Interestingly, some epidemiological studies suggest that DOP may be at least partially distinct from those skeletal abnormalities associated with old age or postmenopausal osteoporosis. The increasing number of DM patients who also have DOP calls for a discussion of the pathogenesis of DOP and th...
Source: Differentiation - August 29, 2023 Category: Research Authors: Er-Li Wu Ming Cheng Xin-Jing Zhang Tian-Gang Wu Lei Zhang Source Type: research
The role of non-coding RNAs in diabetes-induced osteoporosis
Differentiation. 2023 Aug 22;133:98-108. doi: 10.1016/j.diff.2023.08.002. Online ahead of print.ABSTRACTDiabetes mellitus (DM) and osteoporosis are two major health care problems worldwide. Emerging evidence suggests that DM poses a risk for osteoporosis and can contribute to the development of diabetes-induced osteoporosis (DOP). Interestingly, some epidemiological studies suggest that DOP may be at least partially distinct from those skeletal abnormalities associated with old age or postmenopausal osteoporosis. The increasing number of DM patients who also have DOP calls for a discussion of the pathogenesis of DOP and th...
Source: Differentiation - August 29, 2023 Category: Research Authors: Er-Li Wu Ming Cheng Xin-Jing Zhang Tian-Gang Wu Lei Zhang Source Type: research
The role of non-coding RNAs in diabetes-induced osteoporosis
Differentiation. 2023 Aug 22;133:98-108. doi: 10.1016/j.diff.2023.08.002. Online ahead of print.ABSTRACTDiabetes mellitus (DM) and osteoporosis are two major health care problems worldwide. Emerging evidence suggests that DM poses a risk for osteoporosis and can contribute to the development of diabetes-induced osteoporosis (DOP). Interestingly, some epidemiological studies suggest that DOP may be at least partially distinct from those skeletal abnormalities associated with old age or postmenopausal osteoporosis. The increasing number of DM patients who also have DOP calls for a discussion of the pathogenesis of DOP and th...
Source: Differentiation - August 29, 2023 Category: Research Authors: Er-Li Wu Ming Cheng Xin-Jing Zhang Tian-Gang Wu Lei Zhang Source Type: research
The role of non-coding RNAs in diabetes-induced osteoporosis
Differentiation. 2023 Aug 22;133:98-108. doi: 10.1016/j.diff.2023.08.002. Online ahead of print.ABSTRACTDiabetes mellitus (DM) and osteoporosis are two major health care problems worldwide. Emerging evidence suggests that DM poses a risk for osteoporosis and can contribute to the development of diabetes-induced osteoporosis (DOP). Interestingly, some epidemiological studies suggest that DOP may be at least partially distinct from those skeletal abnormalities associated with old age or postmenopausal osteoporosis. The increasing number of DM patients who also have DOP calls for a discussion of the pathogenesis of DOP and th...
Source: Differentiation - August 29, 2023 Category: Research Authors: Er-Li Wu Ming Cheng Xin-Jing Zhang Tian-Gang Wu Lei Zhang Source Type: research
The role of non-coding RNAs in diabetes-induced osteoporosis
Differentiation. 2023 Aug 22;133:98-108. doi: 10.1016/j.diff.2023.08.002. Online ahead of print.ABSTRACTDiabetes mellitus (DM) and osteoporosis are two major health care problems worldwide. Emerging evidence suggests that DM poses a risk for osteoporosis and can contribute to the development of diabetes-induced osteoporosis (DOP). Interestingly, some epidemiological studies suggest that DOP may be at least partially distinct from those skeletal abnormalities associated with old age or postmenopausal osteoporosis. The increasing number of DM patients who also have DOP calls for a discussion of the pathogenesis of DOP and th...
Source: Differentiation - August 29, 2023 Category: Research Authors: Er-Li Wu Ming Cheng Xin-Jing Zhang Tian-Gang Wu Lei Zhang Source Type: research
The role of non-coding RNAs in diabetes-induced osteoporosis
Differentiation. 2023 Aug 22;133:98-108. doi: 10.1016/j.diff.2023.08.002. Online ahead of print.ABSTRACTDiabetes mellitus (DM) and osteoporosis are two major health care problems worldwide. Emerging evidence suggests that DM poses a risk for osteoporosis and can contribute to the development of diabetes-induced osteoporosis (DOP). Interestingly, some epidemiological studies suggest that DOP may be at least partially distinct from those skeletal abnormalities associated with old age or postmenopausal osteoporosis. The increasing number of DM patients who also have DOP calls for a discussion of the pathogenesis of DOP and th...
Source: Differentiation - August 29, 2023 Category: Research Authors: Er-Li Wu Ming Cheng Xin-Jing Zhang Tian-Gang Wu Lei Zhang Source Type: research
The role of non-coding RNAs in diabetes-induced osteoporosis
Differentiation. 2023 Aug 22;133:98-108. doi: 10.1016/j.diff.2023.08.002. Online ahead of print.ABSTRACTDiabetes mellitus (DM) and osteoporosis are two major health care problems worldwide. Emerging evidence suggests that DM poses a risk for osteoporosis and can contribute to the development of diabetes-induced osteoporosis (DOP). Interestingly, some epidemiological studies suggest that DOP may be at least partially distinct from those skeletal abnormalities associated with old age or postmenopausal osteoporosis. The increasing number of DM patients who also have DOP calls for a discussion of the pathogenesis of DOP and th...
Source: Differentiation - August 29, 2023 Category: Research Authors: Er-Li Wu Ming Cheng Xin-Jing Zhang Tian-Gang Wu Lei Zhang Source Type: research
