Disruption of hedgehog signaling leads to hyoid bone dysplasia during embryogenesis

In this study, we treated pregnant ICR mice with the hedgehog pathway inhibitor vismodegib by oral gavage in order to establish a model of hyoid bone dysplasia. Our results indicate that administration of vismodegib at embryonic days 11.5 (E11.5) and E12.5 resulted in the development of hyoid bone dysplasia. We were able to define the critical periods for the induction of hyoid bone deformity through the use of a meticulous temporal resolution. Our findings suggest that the hedgehog pathway plays a crucial role in the early development of the hyoid bone. Additionally, our research has established a novel and easily established mouse model of synostosis in the hyoid bone using a commercially available pathway-selective inhibitor.PMID:37178555 | DOI:10.1016/j.diff.2023.05.001

Source: Differentiation - May 13, 2023 Category: Research Authors: Yan Guo Xingyu Chen Yongzhen Lai Meng Lu Chengyong Wang Yun Shi Chengyan Ren Weihui Chen Source Type: research