Design and methodological issues of within-person (split-body) randomized controlled trials evaluating a topical treatment: A systematic review
Conclusion
Our systematic review highlights that despite the publication of the CONSORT checklist extension for WP-RCTs in 2017, this design is rarely used, and when it is, there are methodological and reporting concerns. (Source: Dermatology)
Source: Dermatology - March 29, 2023 Category: Dermatology Source Type: research
Risk of psychiatric disorders in patients with psoriasis prescribed acitretin versus disease-modifying antirheumatic drugs: a nationwide matched cohort study
Background: Acitretin has been linked to the development of psychiatric disturbance.
Objectives: To assess the psychiatric hazards in patients with psoriasis prescribed acitretin compared with those prescribed disease-modifying antirheumatic drugs (DMARDs).
Methods: This is a nationwide matched cohort study. From Taiwan ’s National Health Insurance Research Database, Adult patients with psoriasis between 1997 and 2013 were screened. Patients prescribed acitretin for at least 30 days per year on average (acitretin cohort) were matched 1:2 with those prescribed DMARDs for at least 30 days per year on average (refer ence ...
Source: Dermatology - March 22, 2023 Category: Dermatology Source Type: research
The Global Incidence Rate of Pemphigus Vulgaris: A Systematic Review and Meta-Analysis
Conclusions: Despite the substantial heterogeneity among studies, this meta-analysis revealed the worldwide incidence rate of pemphigus vulgaris for the first time and may assist in assessing global disease burden and promoting health policy. (Source: Dermatology)
Source: Dermatology - March 21, 2023 Category: Dermatology Source Type: research
The global incidence rate of pemphigus vulgaris: a systematic review and meta-analysis
Conclusions: Despite the substantial heterogeneity among studies, this meta-analysis reveale d the worldwide incidence rate of pemphigus vulgaris for the first time and may assist in assessing global disease burden and promoting health policy. (Source: Dermatology)
Source: Dermatology - March 21, 2023 Category: Dermatology Source Type: research
Artificial intelligence for the classification of pigmented skin lesions in populations with skin of colour: A systematic review
Conclusions
While this review provides promising evidence of accurate AI models in skin of color populations, there are still large discrepancies remain in the number of AI models developed in populations with skin of color (particularly Fitzpatrick type IV-VI) and those with largely European ancestry. A lack of publicly available datasets from diverse populations is likely a contributing factor, as is the inadequate reporting of patient-level metadata relating to skin color in training datasets. (Source: Dermatology)
Source: Dermatology - March 21, 2023 Category: Dermatology Source Type: research
Advanced Cutaneous Squamous Cell Carcinoma: Italian Multicentric Retrospective Analysis of Patient Profiles and Therapeutic Approaches
Conclusions: Our study outlines the complex and heterogeneous clinical and therapeutic landscape of aCSCC patients at the beginning of ICI era, highlighting the need of a standardized care for this fragile and high-need patient population.Dermatology (Source: Dermatology)
Source: Dermatology - March 15, 2023 Category: Dermatology Source Type: research
Arthritis Hit Rate in Patients with Psoriasis Referred for Rheumatology Evaluation
Conclusion: In this study, 23.6% of patients with psoriasis with symptoms suggestive of PsA were diagnosed with axial and/or peripheral arthritis following rheumatologic evaluation. Patient-reported swollen joints and dermatologist-assessed swollen joints indicated a high likelihood of peripheral PsA. Additionally, the absence of patient-reported swollen joints indicated a very low probability of establishing a diagnosis of peripheral PsA. (Source: Dermatology)
Source: Dermatology - March 15, 2023 Category: Dermatology Source Type: research
Increased risk of suicide attempt in patients with alopecia areata: a nationwide population-based cohort study
Conclusions: Patients with AA had a significantly higher incidence of suicidal attempts than controls, regardless of concurrent psychiatric illness. Further studies are needed to elucidate the pathophysiology of the association between AA and suicidality. In addition, dermatologists should be aware of the increased suicidality of patients with alopecia areata. (Source: Dermatology)
Source: Dermatology - March 15, 2023 Category: Dermatology Source Type: research
Patients with limited life expectancy are biopsied for keratinocyte cancers at similar frequency to healthy patients
Conclusion: Biopsy frequency is similar or increased in patients with LLE compared with age-matched controls, with increased frequency of complications. Further studies are needed to understand the underlying factors driving these practice patterns. (Source: Dermatology)
Source: Dermatology - March 15, 2023 Category: Dermatology Source Type: research
Differential effects of metformin on immune-mediated and androgen-mediated non-cancer skin diseases in diabetes patients: a retrospective cohort study
Conclusion: Metformin use is associated with a significantly lower risk of immune-mediated skin diseases but a lack of preventive effect on androgen-mediated skin diseases. (Source: Dermatology)
Source: Dermatology - March 15, 2023 Category: Dermatology Source Type: research
