Dermatologic Research Potential of the Observational Health Data Sciences and Informatics (OHDSI) Network
Background: The Observational Health Data Sciences and Informatics (OHDSI) network enables access to billions of deidentified, standardized health records and built-in analytics software for observational health research, with numerous potential applications to dermatology. While the use of the OHDSI has increased steadily over the past several years, review of the literature reveals few studies utilizing OHDSI in dermatology. To our knowledge, the University of Colorado School of Medicine is unique in its use of OHDSI for dermatology big data research.Summary: A PubMed search was conducted in August 2020, followed by a li...
Source: Dermatology - March 18, 2021 Category: Dermatology Source Type: research
MicroRNA-125a Correlates with Decreased Psoriasis Severity and Inflammation and Represses Keratinocyte Proliferation
Conclusion: miR-125a could facilitate the disease monitoring and probably has the potential to be a therapeutic target in psoriasis.Dermatology (Source: Dermatology)
Source: Dermatology - March 18, 2021 Category: Dermatology Source Type: research
Immunoinflammatory Biomarkers in Serum Are Associated with Disease Severity in Atopic Dermatitis
Conclusions: Specific immunoinflammatory biomarkers in the serum, mainly of the Th2 pathway, are correlated with disease severity in patients with AD. Predictive models identified biomarkers associated with disease severity but this finding warrants further investigation.Dermatology (Source: Dermatology)
Source: Dermatology - March 17, 2021 Category: Dermatology Source Type: research
Sonographic Evaluation of Hidradenitis Suppurativa with Smartphone-Linked Portable Ultrasound
Conclusions: We demonstrate the ability of pUS to identify the key sonographic lesions of HS. pUS is a simple and affordable way to integrate HSUS into clinical and research settings, with clear potential benefits to patients.Dermatology (Source: Dermatology)
Source: Dermatology - March 8, 2021 Category: Dermatology Source Type: research
Development and Evaluation of the Psychosocial Adaptation Questionnaire among Patients with Chronic Skin Disease
Conclusions: The 18-item PSAQ-CSD has been confirmed to have good internal consistency reliability and convergent and discriminant validity. It may be a useful tool to evaluate the PSA among patients with CSD and provide a basis for further research.Dermatology (Source: Dermatology)
Source: Dermatology - March 2, 2021 Category: Dermatology Source Type: research
Estimating the Odds of Ulcerative Colitis-Associated Pyoderma Gangrenosum: A Population-Based Case-Control Study
Conclusions: UC increases the odds of developing PG by 15-fold, with the highest probability of developing PG occurring within the first year after the diagnosis of UC. Patients with UC may be advised to avoid additional precipitating factors for the development of PG.Dermatology (Source: Dermatology)
Source: Dermatology - March 1, 2021 Category: Dermatology Source Type: research
A History of Asthma Increases the Risk of Bullous Pemphigoid: Insights from a Large Population-Based Study
Conclusions: Asthma confers a predisposition to the development of BP. Awareness of this association may be of help for physicians managing patients with BP and asthma. Further research is required to elucidate the mechanism underlying this observation.Dermatology (Source: Dermatology)
Source: Dermatology - February 26, 2021 Category: Dermatology Source Type: research
Cutaneous Histoplasmosis in HIV Seronegative Patients: A Clinicopathological Analysis
Conclusion: A primary cutaneous manifestation ofH. capsulatum infection in non-HIV-infected individuals is extremely rare. Fite stain could aid in differentiating the spores ofH. capsulatum from those of other fungi,Cryptococcus andCandida in particular.Dermatology (Source: Dermatology)
Source: Dermatology - February 24, 2021 Category: Dermatology Source Type: research
Prurigo Pigmentosa: Demographics and Characteristics in 14 Caucasian Patients
Conclusions: Our observations indicate that PP is not so rare in Europe as previously thought and is often diagnosed after a long delay. Demographics, clinical characteristics and triggering factors in Caucasian patients are similar to those described in the Asian population. Diagnosis is based on the peculiar recurrent course and distinctive clinicopathological features. Tetracyclines represent the first-line therapy in PP.Dermatology (Source: Dermatology)
Source: Dermatology - February 16, 2021 Category: Dermatology Source Type: research
A Systematic Review on the Impact of Genetic Testing for Familial Melanoma I: Primary and Secondary Preventative Behaviours
Conclusions: Evidence reviewed suggests that genetic testing has a modestly positive impact on preventative behaviour in high-risk individuals. Furthermore, improvements are observed regardless of mutation carrier status, although greater adherence is found in carriers. While additional studies of more diverse cohorts would be needed to inform clinical recommendations, the findings are encouraging and suggest that genetic testing for melanoma has a positive impact on preventative behaviours.Dermatology (Source: Dermatology)
Source: Dermatology - February 15, 2021 Category: Dermatology Source Type: research
Real-Time Confocal Imaging for Hidradenitis Suppurativa: Description of Morphological Aspects and Focus on the Role of Follicular Ostia
Conclusion: In vivo characterization of open comedos and the recognition of microscopic subclinical alterations of HS normal-appearing skin, compared to healthy skin, could add further insights into the definition of biological events leading to HS manifestations, including the dysregulated process of keratinization.Dermatology (Source: Dermatology)
Source: Dermatology - February 15, 2021 Category: Dermatology Source Type: research
The Impact of ANxA6 Gene Polymorphism on the Efficacy of Methotrexate Treatment in Psoriasis Patients
Conclusions: The CC ge notype of ANxA6 (rs11960458) was significantly associated with a better response when compared to those patients with the TT/CT genotype, thus being a potential predictor for the clinical efficacy of MTX.Dermatology (Source: Dermatology)
Source: Dermatology - February 12, 2021 Category: Dermatology Source Type: research
Orofacial Granulomatosis and Crohn Disease: Coincidence or Pattern? A Systematic Review
Background: To systematically review all cases of orofacial granulomatosis (OFG) and evaluate the association between OFG and Crohn disease (CD).Summary: This review was conducted according to PRISMA guidelines and a search of the PubMed, MEDLINE, and Embase databases, and the Cochrane Library in March 2020, using keywords and MeSH terms associated with “orofacial granulomatosis,” “Crohn disease,” and their variants, with no language restrictions and across all age groups. All relevant articles were accessed in full text. Single case reports and articles on sarcoidosis, allergy, ulcerative colitis, and infectious d...
Source: Dermatology - February 12, 2021 Category: Dermatology Source Type: research
Teledermatology in Times of COVID-19 Confinement: Comparing Patients ’ and Physicians’ Satisfaction by the Standardized Brest Teledermatology Questionnaire
The French government imposed the first COVID-19 pandemic lockdown from March 17 until May 11, 2020. Only emergency cases and teledermatology (TD) were allowed in outpatient settings. A standardized questionnaire was developed to compare the satisfaction level of patients and their treating physicians. Our main question was whether the patients would perceive TD as a valid alternative for direct physical face-to-face consultation. Eighty-two patients and their 4 treating dermatologists from one dermatology department participated in the study (43 females, 39 males) with a mean age of 46.6 years (SD ±23.9). The reason for ...
Source: Dermatology - February 10, 2021 Category: Dermatology Source Type: research
Treatment of Pemphigus with Rituximab: Real-Life Experience in a Cohort of 117 Patients in Israel
Conclusion: In a large real-life long-term cohort, rituximab with corticosteroids ± adjuvants induced remission in most patients with pemphigus, with relatively favorable safety. Repeating treatment following relapse or remission failure was beneficial.Dermatology (Source: Dermatology)
Source: Dermatology - February 10, 2021 Category: Dermatology Source Type: research
