Low Concentrations Of Cationic PAMAM Dendrimers Affect Lymphocyte Respiration in In vitro Studies.
CONCLUSION: Based on these in vitro evaluations, we state that cationic PAMAM dendrimers can impair both the morphology and the bioenergetics of human lymphocytes, even when used at low concentrations and in a short time (up to 1 h). However, these results do not imply that similar findings could be possible for in vivo observations. PMID: 28034293 [PubMed - as supplied by publisher] (Source: Current Pharmaceutical Biotechnology)
Source: Current Pharmaceutical Biotechnology - December 29, 2016 Category: Biotechnology Authors: Labieniec-Watala M, Szwed M, Hertel J, Wisnik E Tags: Curr Pharm Biotechnol Source Type: research

Probiotic properties of Lactobacillus fermentum strains isolated from human oral samples and description of their antibacterial activity.
CONCLUSION: These results describe the characteristics of Lactobacillus strains and provides evidences for their possible use as new potential probiotic. In addition, other studies are now warranted to exploit the antibacterial activity of the supernatant LAC 42 and for its complete chemical characterization. PMID: 28034294 [PubMed - as supplied by publisher] (Source: Current Pharmaceutical Biotechnology)
Source: Current Pharmaceutical Biotechnology - December 29, 2016 Category: Biotechnology Authors: Fuochia V, Volti GL, Furneri PM Tags: Curr Pharm Biotechnol Source Type: research

Molecular, Cellular and Pharmaceutical Aspects of Filling Biomaterials During the Management of Extraction Sockets.
Abstract After a tooth extraction both hard and soft tissues undergo dimensional changes. The use of a ridge preservation technique at the moment of the tooth extraction could help could help to prevent the volume loss, thus simplifying the subsequent prosthetic and/or implant therapy. Some studies were conducted in order to examine the biomaterials and the surgical technique used for ridge preservation procedures. Clinical, histological, volumetric and molecular outcomes were registered and analysed in different studies, in order to comprehend the biological events and the consequences of a socket preservation pr...
Source: Current Pharmaceutical Biotechnology - December 23, 2016 Category: Biotechnology Authors: Barone A, Alfonsia F, Borgia V, Iezzi G, Piattelli A, Covani U, Tonelli P Tags: Curr Pharm Biotechnol Source Type: research

Molecular, Cellular and Pharmaceutical Aspects of bone grafting materials and membranes during maxillary sinus-lift procedures. Part 1: A general overview.
Abstract Sinus augmentation procedure has been demonstrated to be a highly predictable treatment in posterior maxilla atrophy. All the surgical interventions in the maxillary region require deep knowledge of anatomy and possible anatomical variations. In this article pre-operative and post- operative assessments of sinus cavity as well as novel approaches to deepen our knowledge of the behavior of bone substitute materials are described. The awareness of the patient's morphologic conditions enables exact planning of invasive surgery and aids to avoid complications. Pre- operative radiologic evaluation of the regio...
Source: Current Pharmaceutical Biotechnology - December 21, 2016 Category: Biotechnology Authors: Piatelli A, Iezzi G, Giuliani A, Mangano C, Manzon L, Degidi M, Iaculli F, Scarano A, Filippone A, Perrotti V Tags: Curr Pharm Biotechnol Source Type: research

Molecular, Cellular and Pharmaceutical Aspects of bone grafting materials and membranes during maxillary sinus-lift procedures. Part 1: A general overview.
Abstract Sinus augmentation procedure has been demonstrated to be a highly predictable treatment in posterior maxilla atrophy. All the surgical interventions in the maxillary region require deep knowledge of anatomy and possible anatomical variations. In this article pre-operative and post- operative assessments of sinus cavity as well as novel approaches to deepen our knowledge of the behavior of bone substitute materials are described. The awareness of the patient's morphologic conditions enables exact planning of invasive surgery and aids to avoid complications. Pre- operative radiologic evaluation of the regio...
Source: Current Pharmaceutical Biotechnology - December 21, 2016 Category: Biotechnology Authors: Piatelli A, Iezzi G, Giuliani A, Mangano C, Manzon L, Degidi M, Iaculli F, Scarano A, Filippone A, Perrotti V Tags: Curr Pharm Biotechnol Source Type: research

Impact of different implant surfaces topographies on peri-implant tissues: an update of current available data on dental implants retrieved from human jaws.
This article also highlighted that most data in humans are difficult to interpret, due to the lack of detailed information about the surfaces found in retrieved implants. Without the definition of the surface characteristics, it is difficult to link exactly surface patterns to specific clinical observations, and all observations remain de facto incomplete. As a conclusion, data from implants retrieved from human jaws are very important for our understanding, but the studies remain scarce and data is fragmentary. This important approach should be improved, completed and developed in the future. PMID: 28003002 [PubMed -...
Source: Current Pharmaceutical Biotechnology - December 21, 2016 Category: Biotechnology Authors: Shibli JA, Pires JT, Piattelli A, Iezzi G, Mangano C, Mangano F, de Souza SL, Gehrke SA, Wang HL, Ehrenfest DD Tags: Curr Pharm Biotechnol Source Type: research

High Hydrostatic Pressure-Assisted Enzymatic Treatment Improves Antioxidant and Anti-inflammatory Properties of Phosvitin.
CONCLUSION: The HHP-EH method could play a promising role in the production of bioactive peptides from hydrolysis-resistant proteins. HHP-assisted PVH may be useful in preparing a potential pharmaceutical with antioxidant and anti-inflammatory properties. PMID: 27981899 [PubMed - as supplied by publisher] (Source: Current Pharmaceutical Biotechnology)
Source: Current Pharmaceutical Biotechnology - December 16, 2016 Category: Biotechnology Authors: Yoo H, Bamdad F, Gujral N, Suh JW, Sunwoo H Tags: Curr Pharm Biotechnol Source Type: research

Molecular, Cellular and Pharmaceutical Aspects of Biomaterials in Dentistry and Oral and Maxillofacial Surgery. An Internationalization of Higher Education and Research Perspective.
ruz M Abstract In dentistry and oral and maxillofacial surgery, the development of implantable biomaterials and the understanding of their molecular, cellular and pharmaceutical aspects are currently major fields of research and education, with a considerable impact on the daily clinical practice and the evolution of therapeutic strategies. In the era of globalized economy of knowledge and science, this scientific domain needs the development of global cooperation and a paradigm evolution in the organizational culture of the dental sciences and related dental industry. Despite political pressure and theoretical ef...
Source: Current Pharmaceutical Biotechnology - December 13, 2016 Category: Biotechnology Authors: Wisniewska LM, Ehrenfest DM, Galindo-Moreno P, Segovia JD, Inchingolo F, Wang HL, Fernándes-Cruz M Tags: Curr Pharm Biotechnol Source Type: research

Antibacterial combination of oleoresin from Copaifera multijuga Hayne and biogenic silver nanoparticles towards Streptococcus agalactiae.
CONCLUSION: These results indicate the potential of copaiba oil, alone or in combination with AgNPbio, for the development of new alternative strategies for controlling GBS infections. PMID: 27978809 [PubMed - as supplied by publisher] (Source: Current Pharmaceutical Biotechnology)
Source: Current Pharmaceutical Biotechnology - December 13, 2016 Category: Biotechnology Authors: Otaguiri ES, Morguette A, Biasi-Garbin RP, Morey AT, Lancheros C, Kian D, Oliveira AG, Kerbauy G, Perugini M, Durán N, Nakamura CV, Veiga Junior VF, Nakazato G, Pinge-Filho P, Yamauchi LM, Yamada-Ogatta SF Tags: Curr Pharm Biotechnol Source Type: research

Molecular and Pharmaceutical Aspects of Novel Methods and Materials for the Prevention of Tooth Structure Loss.
Abstract In the past decade, a range of dental products have appeared which make advertising claims around preventing mineral loss or repairing mineral loss. This review examines the requirements for effective protection of tooth structure, and the evidence around technologies now available for preventing tooth structure loss and repairing demineralized enamel, ranging from tooth surface protection and enhanced fluoride uptake through to calcium compounds, unstabilized amorphous calcium phosphate, tricalcium phosphate, and casein phosphopeptide - amorphous calcium phosphate. PMID: 27928950 [PubMed - as suppli...
Source: Current Pharmaceutical Biotechnology - December 7, 2016 Category: Biotechnology Authors: Walsh LJ Tags: Curr Pharm Biotechnol Source Type: research

Delivery Systems for Antimicrobial Peptides and Proteins: Towards Optimization of Bioavailability and Targeting.
Abstract Antimicrobial peptides (AMPs) and proteins are produced by a wide range of organisms as important elements of their defense mechanisms, forming a large number of antimicrobial compounds that can be used to treat several human infections. The potential for the use of AMPs and antimicrobial proteins in therapeutics is growing, but their application is often limited, due to their poor physical and/or chemical properties. In recent years, several drug delivery systems have been proposed to carry such molecules, in an attempt to overcome the difficulties regarding their properties. However, no review has yet s...
Source: Current Pharmaceutical Biotechnology - December 7, 2016 Category: Biotechnology Authors: Costa JR, Silva NC, Sarmento B, Pintado M Tags: Curr Pharm Biotechnol Source Type: research

Molecular, cellular and pharmaceutical aspects of synthetic hydroxyapatite bone substitutes for oral and maxillofacial grafting.
Abstract Bone grafts are widely used for augmentation procedures in oral and maxillofacial surgery, with autogenous bone being the gold standard. Recently, the focus of research has shifted towards synthetic bone substitutes, as no second surgery is needed and large quantities of graft can easily be provided. Within the broad range of bone substitutes, synthetic hydroxyapatite has drawn much attention, as they are considered to be biocompatible, non-immunogenic, osteoconductive and osteoinductive. Scope of this review is to summarize existing knowledge concerning the molecular, cellular and pharmaceutical aspects ...
Source: Current Pharmaceutical Biotechnology - December 1, 2016 Category: Biotechnology Authors: Goetz W, Papageorgiou SN Tags: Curr Pharm Biotechnol Source Type: research

Molecular, cellular and pharmaceutical aspects of autologous grafts for peri-implant hard and soft tissue defects.
Abstract The lack of supporting hard and soft tissues always prevents the rehabilitation with dental implants. Among various hard and soft tissue augmentation procedures, autologous grafts have been considered to be the gold standard. Autologous mesenchymal stem cells (MSCs) from bone marrow, dental tissue and adipose tissue have been described as promising alternatives for bone regeneration in the field of dental implantation. Mucosal cells, gingival fibroblasts and dental progenitor cells (DPS) can enhance peri-implant soft tissue augmentation and regenerate periodontal tissues around dental implants. Obtained f...
Source: Current Pharmaceutical Biotechnology - December 1, 2016 Category: Biotechnology Authors: Lu J, Hao Y, Zhao W, Lv C, Zou D Tags: Curr Pharm Biotechnol Source Type: research

Molecular, Cellular and Pharmaceutical Aspects of bone grafting materials and membranes during maxillary sinus-lift procedures. Part 2: detailed characteristics of the materials.
Abstract Various grafts or combination of bone substitute materials have been used in sinus lift procedures. Currently, ongoing developments in several disciplines, from molecular biology and chemistry to computer science and engineering, have contributed to the understanding of biological processes leading to bone healing after the use of bone substitute materials (BSBs) and therefore of the behavior of BSBs. The understanding of the properties of each graft enables individual treatment concepts and therefore allows shift from a simple replacement material to the modern concept of an individually created composit...
Source: Current Pharmaceutical Biotechnology - December 1, 2016 Category: Biotechnology Authors: Iezzi G, Piatelli A, Giuliani A, Mangano C, Barone A, Manzon L, Degidi M, Scarano A, Filippone A, Perrotti V Tags: Curr Pharm Biotechnol Source Type: research

A highly polar phytocomplex involving rutin is responsible for the neuromuscular facilitation caused by Casearia sylvestris (gua çatonga).
CONCLUSION: F55-6 apparently caused neurofacilitation by the same mechanism (presynaptic action) as the methanolic fraction since its activity was also inhibited in tetrodotoxin-pretreated preparations. PMID: 27855599 [PubMed - as supplied by publisher] (Source: Current Pharmaceutical Biotechnology)
Source: Current Pharmaceutical Biotechnology - November 17, 2016 Category: Biotechnology Authors: Eh Y, N T, Al F, Ca F, Rvs T, Tj B, Pcp B, Aj C, S H, P P, A SF, Y OF Tags: Curr Pharm Biotechnol Source Type: research

Optimization on Fc for Improvement of Stability and Aggregation Resistance.
Abstract Fc-based therapeutics including therapeutic full-size monoclonal antibodies (mAbs) and Fc-fusion proteins represent fastest-growing market in biopharmaceutical industrial. However, one major challenge during development of Fc-based therapeutics is how to maintain their efficacy in clinic use. Many factors may lead to failure in final marketing. For example, the stability and aggregation resistance might not be high enough for bearing the disadvantages during fermentation, purification, formulation, storage, shipment and other steps in manufacture and sale. Low stability and high aggregation tendency lead ...
Source: Current Pharmaceutical Biotechnology - November 17, 2016 Category: Biotechnology Authors: Chen X, Zeng F, Huang T, Cheng L, Liu H, Gong R Tags: Curr Pharm Biotechnol Source Type: research

IgG Fc Fragment as a Scaffold for Development of Targeted Therapeutics.
Abstract Monoclonal antibodies and Fc fusion proteins have been successful therapeutics in the field of cancer and immune disease. As their pharmacological activity is dependent on the Fc fragment governing their effector functions and long in vivo half-life, the extensive engineering of the Fc for altered binding of its natural ligands that enable these properties has delivered molecules optimized for their therapeutic effect. Recently, the IgG1 Fc region itself and its subunits monomeric Fc fragment, CH2 and monomeric CH3 domain, have been engineered into scaffolds with favorable biophysical properties and a hig...
Source: Current Pharmaceutical Biotechnology - November 14, 2016 Category: Biotechnology Authors: Wozniak-Knopp G, Stadlmayr G, Rueker F Tags: Curr Pharm Biotechnol Source Type: research

Antibiotic release from Calcium Phosphate Materials in oral and maxillofacial surgery: Molecular, Cellular and Pharmaceutical Aspects.
Abstract Calcium phosphate materials (CPM) are widely used in dentistry and maxillofacial surgery. The presence of microbial biofilms and external infections are responsible for the failure of many procedures of dental implants and bone grafts. In an attempt to reduce the percentage of these infectious processes antibiotics have been associated with CPM improving certain conditions. For instance antibiotics administered orally or intravenously have less effect and the blood flow in relation to this is poor near implants and grafts. Tissue engineering (TE) has employed CPM as a local drug delivery vehicle to be mor...
Source: Current Pharmaceutical Biotechnology - November 14, 2016 Category: Biotechnology Authors: Manchon A, Prados-Frutos JC, Rodriguez CR, Goodier CS, Alkhraisat MH, Rojo R, Gonzalez AR, Berlanga A, Cabarcos EL Tags: Curr Pharm Biotechnol Source Type: research

The Effects of Colchicum baytopiorum on Regulatory Genes of Apoptotic and Autophagic Cell Death in HeLa Cells.
CONCLUSION: We suggested that this endemic plant extract seems to be a new promising therapeutic approach in cancer. PMID: 27834133 [PubMed - as supplied by publisher] (Source: Current Pharmaceutical Biotechnology)
Source: Current Pharmaceutical Biotechnology - November 9, 2016 Category: Biotechnology Authors: Özsöylemez ÖD, Öztürk M, Sütlüpinar N, Kayacan S, Tunçdemir M, Özcan G Tags: Curr Pharm Biotechnol Source Type: research

Design, Synthesis, And Evaluation Of Heat Shock Protein 90 Inhibitors In Human Breast Cancer And Its Metastasis.
Tutar Y Abstract In the present study, a series of benzodiazepine derivatives were designed and synthesized as novel heat shock protein 90 (Hsp90) inhibitor for target specific cancer treatment. Their anticancer activities were determined by XTT cell proliferation assay against human breast cancer cell line (MCF-7). Also, we investigated the antiangiogenic effects of the compounds on human vascular endothelium (HUVEC) cell line. In order to determine the anti-proliferative mechanism of the compounds, in silico molecular docking studies were performed between Hsp90 ATPase domain and benzodiazepine derivatives. Furt...
Source: Current Pharmaceutical Biotechnology - October 31, 2016 Category: Biotechnology Authors: Gumus M, Özgür A, Tutar L, Disli A, Koca İ, Tutar Y Tags: Curr Pharm Biotechnol Source Type: research

Glyco-engineering of human IgG-Fc to modulate biologic activities.
Abstract Advances in genetic and protein engineering and the ability to maintain proliferating mammalian cells in vitro, has allowed reverse engineering of antibodies, i.e. generation of antibodies having specificity for self-antigens. Thus, the lethal consequence of horror autotoxicus, anti-self-responses as envisaged by Paul Ehrlich (1854-1915), has been turned to advantage for treatment of multiple disease states. In order to reap these benefits it is essential that, in addition to target specificity, the antibody is customised to deliver appropriate downstream biologic effector activities. Genetic engineering ...
Source: Current Pharmaceutical Biotechnology - October 29, 2016 Category: Biotechnology Authors: Jefferis R Tags: Curr Pharm Biotechnol Source Type: research

Aerosol Delivery Devices For The Treatment Of Adult Patients In Acute And Critical Care.
Abstract Aerosolized medications are commonly used for the treatment of patients with pulmonary diseases in acute care. While there are many drug/device combinations available on the market, new devices have been developed in the past few years. Due to differences in their operation, performance and requirements for proper use, it is important to know how to use these aerosol devices effectively during inhalation therapy both in ambulatory and acute settings. This paper reviews aerosol devices used for the treatment of patients with an emphasis on acute and critical care. PMID: 27804854 [PubMed - as supplied ...
Source: Current Pharmaceutical Biotechnology - October 28, 2016 Category: Biotechnology Authors: Ari A, Fink JB Tags: Curr Pharm Biotechnol Source Type: research

Bio fabrication of silver nanoparticle from Argemone mexicana for the control of Aedes albopictus and their antimicrobial activity.
Abstract Plant synthesized nanoparticles gives rapid control of mosquito larvae of dengue vector, Aedes albopictus. Hence, the present study evaluated AgNPs synthesized from the plant, Argemone mexicana for the control of larvae and these nanoparticle were subjected to analyzed by UV-vis Spectrophotometry, Fourier transform infrared spectroscopy, scanning electron microscopy, and transmission electron microscopy. Furthermore, laboratory evaluation of plant mediated nano-particle was carried out lethal toxicity on Aedes albopictus. The characterization studies confirmed that the spherical shape and size (5-50 nm) o...
Source: Current Pharmaceutical Biotechnology - October 25, 2016 Category: Biotechnology Authors: Kamalakannan S, Ananth S, Murugan K, Kovendan K, Ramar M, Arumugam P, Chandramohan B, Balachandar V Tags: Curr Pharm Biotechnol Source Type: research

Antibacterial Effect of Gallic Acid against Aeromonas Hydrophila and Aeromonas Sobria through Damaging Membrane Integrity.
Abstract In the study, we investigated the antibacterial activity and mechanism of gallic acid against Aeromonas hydrophila and Aeromonas sobria. Gallic acid showed strong antimicrobial activity against the two bacteria. Furthermore, the antibacterial mechanism of gallic acid (0, 3, 6, 12 mM ) was performed by membrane integrity assay and scanning electron microscopy (SEM) assay. The results showed that gallic acid notably increased the released material absorption value at 260, 280 nm and electric conductivity in a dose-dependent manner. Moreover, the SEM assay showed that gallic acid induced severe shrink of bac...
Source: Current Pharmaceutical Biotechnology - October 22, 2016 Category: Biotechnology Authors: Lu J, Wang Z, Ren M, Huang G, Fang B, Bu X, Liu Y, Guan S Tags: Curr Pharm Biotechnol Source Type: research

A New Era for Cancer Target Therapies: Applying Systems Biology and Computer-Aided Drug Design to Cancer Therapies.
Abstract In recent years, many systems biology approaches have been used with various cancers. The materials described here can be used to build bases to discover novel cancer therapy targets in connection with computer-aided drug design (CADD). A deeper understanding of the mechanisms of cancer will provide more choices and correct strategies in the development of multiple target drug therapies, which is quite different from the traditional cancer single target therapy. Targeted therapy is one of the most powerful strategies against cancer and can also be applied to other diseases. Due to the large amount of prog...
Source: Current Pharmaceutical Biotechnology - October 19, 2016 Category: Biotechnology Authors: Wong YH, Chiu CC, Lin CL, Chen TS, Jheng BR, Lee YC, Chen J, Chen BS Tags: Curr Pharm Biotechnol Source Type: research

Evaluation of antioxidant activity of phytol using non- and pre-clinical models.
In conclusion, PHY exerted antioxidant potential in our current non- and preclinical test systems and can be a good candidate for the development of treatments of oxidative stress mediated diseases. PMID: 27774891 [PubMed - as supplied by publisher] (Source: Current Pharmaceutical Biotechnology)
Source: Current Pharmaceutical Biotechnology - October 19, 2016 Category: Biotechnology Authors: Costa JP, Ul-Islam MT, Santos PS, Ferreira PB, Oliveira GL, Alancer MV, Paz MF, Ferreira ÉL, Feitosa CM, Citó AM, Sousa DP, Melo-Cavalcante AA Tags: Curr Pharm Biotechnol Source Type: research

Generation of bispecific antibodies by Fc heterodimerization and their application.
Abstract Bispecific antibodies with binding specificities for two different antigens have prompted a lot of interest into their development and application. Currently, more than ten bispecific antibodies have been clinically validated for the treatment of various diseases, including cancers and inflammatory diseases. Intensive studies in antibody engineering drive the generation of different bispecific antibody formats that differ in size and shape. However, the most prominent formats, such as IgG-single-chain (sc) Fv or dual-variable domain (DVD) IgG, deviating from the natural IgG structure, may lead to manufact...
Source: Current Pharmaceutical Biotechnology - October 18, 2016 Category: Biotechnology Authors: Chen Z, Wang L, Xu T, Wang Q, Kang L, Zhao Q Tags: Curr Pharm Biotechnol Source Type: research

Mechanisms of anorexia cancer cachexia syndrome and potential benefits of traditional medicine and natural herbs.
Abstract Anorexia cancer cachexia syndrome is prevalent in advanced cancer patients, which is featured by anorexia, decreased dietary intake, body weight loss (skeletal muscle mass loss), and unable to be reversed by routine nutritional support therapy. Up to now, the main mechanisms involved in cancer cachexia include excessive systemic inflammation, which is represented by increased plasma levels of IL-1, IL-6, TNF-alpha, tumor-induced factors, such as PIF and LMF. These factors eventually act on orexigenic and anorexigenic neurons located in hypothalamus or protein and lipid metabolism of peripheral tissues, wh...
Source: Current Pharmaceutical Biotechnology - October 18, 2016 Category: Biotechnology Authors: Ming-Hua C, Bao-Hua Z, Lei Y Tags: Curr Pharm Biotechnol Source Type: research

Simultaneous Determination of Cytochrome P450 Oxidation Capacity in Humans: A Review on the Phenotyping Cocktail Approach.
ena A Abstract Intra- and/or inter-individual variability in drug response is mainly a result of either sub-therapeutic or supratherapeutic plasma levels of the active drugs and their metabolites, with this variability mainly being influenced by differences in the rate of drug metabolism. Indeed, drug metabolism is largely determined by genetic polymorphism in the CYP enzymes, which are responsible for approximately 85% of the drug metabolism process. However, this genetic heterogeneity can accurately predict actual drug metabolizing capacity (oxidation phenotype) for some individuals: poor metabolizers (PMs), who...
Source: Current Pharmaceutical Biotechnology - September 26, 2016 Category: Biotechnology Authors: de Andrés F, Llerena A Tags: Curr Pharm Biotechnol Source Type: research

Astaxanthin; a Promising Protector against Gentamicin-Induced Nephrotoxicity in Rats.
The objective of this study was to evaluate the potential protective effect of astaxanthin on the renal damage generated by gentamicin in rats, in an attempt to understand its mechanism of action, which may pave the way for possible therapeutic applications. The daily oral administration of the astaxanthin at a concentration of 50 mg/kg for 15 days to gentamicin (80 mg/kg.b.w) treated rats showed significant decrease (p<0.05) in plasma creatinine, urea, TNF-α as well as plasma and renal MDA and HP. The treatment also resulted in a significant increase in hemoglobin, plasma sodium, potassium, TAS and renal tota...
Source: Current Pharmaceutical Biotechnology - September 22, 2016 Category: Biotechnology Authors: Omar Y, Gobba NA, Hussein MA Tags: Curr Pharm Biotechnol Source Type: research

Editorial (Thematic Issue: Phytochemicals for Human Diseases: An Update).
PMID: 27640643 [PubMed - in process] (Source: Current Pharmaceutical Biotechnology)
Source: Current Pharmaceutical Biotechnology - September 20, 2016 Category: Biotechnology Authors: Nabavi SM, Daglia M Tags: Curr Pharm Biotechnol Source Type: research

An Updated Review of Natural Products Intended to Prevent or Treat Oral Mucositis in Patients Undergoing Radio-Chemotherapy.
Abstract Oral mucositis is a major clinical challenge in oncology and is characterized by pain and inflammation of the mucous membrane surface resulting from radiotherapy for head and neck cancer or from chemotherapeutic agents. Manifestations range from a burning sensation to ulcer formation that affect the patients' quality of life by producing pain and discomfort on swallowing, ultimately leading to malnutrition and dehydration. Due to complications arising from the use of chemical drugs, in recent decades, increasing attention has been paid to natural-based agents. The results from several studies evaluating n...
Source: Current Pharmaceutical Biotechnology - September 20, 2016 Category: Biotechnology Authors: Panahi Y, Saadat A, Shadboorestan A, Ahmadi A Tags: Curr Pharm Biotechnol Source Type: research

Medicinal Plants Used in Iranian Traditional Medicine (ITM) as Contraceptive Agents.
CONCLUSION: Complementary and Alternative Medicine (CAM), particularly herbal remedies have received a lot of attention because of their truly healing properties. Focusing on ITM knowledge, there are various comments based on medicinal plants to reduce unsafe abortions leading to better public health in the society. PMID: 27640645 [PubMed - in process] (Source: Current Pharmaceutical Biotechnology)
Source: Current Pharmaceutical Biotechnology - September 20, 2016 Category: Biotechnology Authors: Sabourian R, Karimpour-Razkenari E, Saeedi M, Bagheri MS, Khanavi M, Sadati N, Akbarzadeh T, Ardekani MR Tags: Curr Pharm Biotechnol Source Type: research

Wound Healing Effects of Curcumin: A Short Review.
Abstract Wound healing is a complex process that consists of several phases that range from coagulation, inflammation, accumulation of radical substances, to proliferation, formation of fibrous tissues and collagen, contraction of wound with formation of granulation tissue and scar. Since antiquity, vegetable substances have been used as phytotherapeutic agents for wound healing, and more recently natural substances of vegetable origin have been studied with the attempt to show their beneficial effect on wound treatment. Curcumin, the most active component of rhizome of Curcuma longa L. (common name: turmeric), ha...
Source: Current Pharmaceutical Biotechnology - September 20, 2016 Category: Biotechnology Authors: Tejada S, Manayi A, Daglia M, Nabavi SF, Sureda A, Hajheydari Z, Gortzi O, Pazoki-Toroudi H, Nabavi SM Tags: Curr Pharm Biotechnol Source Type: research

Harnessing bioinformatics for designing a novel multi-epitope peptide vaccine against breast cancer.
Abstract Breast cancer (BC) remains as one of the important causes of cancer deaths among women globally. Therefore, finding an effective treatment for BC is really needed. Cancer immunotherapy, as an emerging field, has a notable role in BC therapy. Peptide vaccines possess an outstanding role among different strategies in cancer immunotherapy. In vaccine design for cancer, induction of cellular and humoral immune responses should be considered. In the current study, cytolytic T lymphocytes (CTL) epitopes were evoked from human epidermal growth factor receptor (HER2), mucin 1 protein (MUC1), and heparanase antige...
Source: Current Pharmaceutical Biotechnology - September 14, 2016 Category: Biotechnology Authors: Mahmoodi S, Nezafat N, Barzegar A, Negahdaripour M, Nikanfar AR, Zarghami N, Ghasemi Y Tags: Curr Pharm Biotechnol Source Type: research

Evaluation of Paclitaxel Effects in The Pattern of Expression of Survival and Apoptotic Genes Regulators in HeLa Cells.
In this study, the anti-tumor effects of Paclitaxel (PAC) on HeLa cells have been studied in order to determine the cellular and molecular mechanisms of these effects. PAC has been applied to HeLa cells in 6 different doses (3, 7.5, 15, 30, 60, 120 nM) for 48 hours and the IC50 dose MTT method, has been determined with apoptic index (AI) DAPI. Morphological aspects have been demonstrated using light, phase contrast and fluorescent microscopes, additionally activation of Caspase3,7 and 10 have been shown using florescent spectroscopy. RT-PCR and qRT-PCR have been used to evaluate pro/anti-apoptotic gene expression. Accordin...
Source: Current Pharmaceutical Biotechnology - September 14, 2016 Category: Biotechnology Authors: Serbes U, Özsöylemez ÖD, Özcan G Tags: Curr Pharm Biotechnol Source Type: research

Computational Elucidation of Structural Basis for Ligand Binding with Mycobacterium tuberculosis Glucose-1-Phosphate Thymidylyltransferase (RmlA).
Abstract Glucose-1-Phosphate Thymidylyltransferase (RmlA) is one of the enzymes in rhamnose biosynthesis pathway, where rhamnose act as linker of peptidoglycan and arabinogalacton in the cell wall, therefore RmlA is a potential enzyme for the survival of Mycobacterium tuberculosis (Mtb). To go into the depth of the structure for exploring binding regions, homology model of RmlA was built in Prime, Schrodinger v9.2. The model with lowest Discrete Optimized Potential Energy (DOPE) score of -35524.17 kcal/mol and RMSD of 0.1 Å with the template (1H5R_B) was subjected to Molecular Dynamics Simulation (MDS) for 5...
Source: Current Pharmaceutical Biotechnology - September 9, 2016 Category: Biotechnology Authors: Mansuri R, Ansari MY, Rana S, Singh J, Sinha S, Dikhit MR, Sahoo GC, Das P Tags: Curr Pharm Biotechnol Source Type: research

Cytotoxic and Apoptotic Effects of Three Types of Silver-Iron Oxide Binary Hybrid Nanoparticles.
CONCLUSION: Combined properties of silver and magnetic nanoparticles in the binary hybrid nanoparticles, provide a great potential to be exploited in the cancer therapy, where the combination of cytotoxicity and magnetic targeting is desired. PMID: 27604491 [PubMed - as supplied by publisher] (Source: Current Pharmaceutical Biotechnology)
Source: Current Pharmaceutical Biotechnology - September 7, 2016 Category: Biotechnology Authors: Ebrahimi N, Rasoul-Amini S, Niazi A, Erfani N, Moghadam A, Ebrahiminezhad A, Ghasemi Y Tags: Curr Pharm Biotechnol Source Type: research

Opposite effects of two-derived antioxidants from Physalis pubescens L. on hepatocellular carcinoma cell line Malhavu.
This study aimed to identify whether, or not, antioxidants rich in phenols and flavonoids from fruits and calyxes of P. pubescens can be a candidate for the further development of an anti-hepatoma fraction, and if such biological effects coupled with reactive oxygen species (ROS) changes, can provide a direction for subsequent biological action. The effects of calyx-origin (or fruit-origin) total phenol and flavonoid (CTPF or FTPF) from P. pubescens on Malhavu cell viability were evaluated using a counting-kit-8 (CCK-8) method. Morphological characterisation of cells was undertaken and the structures photographed (200 &tim...
Source: Current Pharmaceutical Biotechnology - September 1, 2016 Category: Biotechnology Authors: Wang JJ, Feng XQ, Yu Y, Zhang Z, Du YH, Su RJ, Zhang BQ Tags: Curr Pharm Biotechnol Source Type: research

Resubmission: Fc engineering to improve the function of therapeutic antibodies.
Abstract Monoclonal antibodies are currently the most attractive therapeutic modality in a broad range of disease areas, including infectious diseases, autoimmune diseases, and oncology. Fc engineering is one attractive application to maximize the value or overcome the drawbacks of monoclonal antibodies for therapeutic use. With the Fc region, antibodies bind to several types of receptors, such as Fc gamma receptors, a complement receptor, and a neonatal Fc receptor. Through this interaction with the receptors, antibodies demonstrate unique functions, such as antibody-dependent cellular cytotoxicity, antibody-depe...
Source: Current Pharmaceutical Biotechnology - August 24, 2016 Category: Biotechnology Authors: Mimoto F, Kuramochi T, Katada H, Igawa T, Hattori K Tags: Curr Pharm Biotechnol Source Type: research

New directions for half-life extension of protein therapeutics: the rise of antibody Fc domains and fragments.
Abstract Protein-based therapeutics has become one of the most rapidly growing and successful drug class in the clinic. However, there are still a number of key challenges that need to be addressed before the full therapeutic potential of protein drugs can be realized. Of note, many biologically active proteins have very short in vivo half-lives, a fact that has greatly hindered their clinical applications. Consequently, several different strategies including polyethylene glycol modification and fusion with Fc or albumin have been developed and implemented to prolong the serum half-life of protein therapeutics. He...
Source: Current Pharmaceutical Biotechnology - August 23, 2016 Category: Biotechnology Authors: Wang L, Ying T Tags: Curr Pharm Biotechnol Source Type: research

A review on flavonoids isolated from Cassia species and their biological activity.
Abstract Plants of Cassia genus is a large tropical genus with about 600 species which were widely used as folk medicines in China and India. This genus has been known to possess various biological activity, such as antimicrobial activity, anti-inflammatory activity, antioxidant activity, antimalarial activity, antimutagenic activity, etc. The presented review summarizes the isolated and characterized flavonoids from various Cassia species and their reported biological activity. It will provide reference basis for their further research and development of the Cassia genus. PMID: 27538998 [PubMed - as supplied...
Source: Current Pharmaceutical Biotechnology - August 19, 2016 Category: Biotechnology Authors: Zhao Y, Zhao K, Jiang K, Tao S, Li Y Tags: Curr Pharm Biotechnol Source Type: research

Genotoxic and mutagenic activity of PT-31.
This study investigated genotoxic and mutagenic effects of PT-31 in Swiss mice. For this ten mice (M1:F1) per group were treated with PT-31 intraperitoneally (i.p.) at 0.5, 1.0 and 5.0 mg/kg. The DMSO (0.5%) and 50 mg/kg cyclophosphamide ( i.p.) were taken as negative (NC) and positive controls, respectively. The bone marrow cells were collected after 24 h, while peripheral blood was collected after 30 min, 12 h and 24 h of the treatment for the comet assay. Micronucleus (MN) test was performed only on bone marrow cells collected after 24 h of i.p. treated animals. A hundred cells were considered for the comet assay and qu...
Source: Current Pharmaceutical Biotechnology - August 11, 2016 Category: Biotechnology Authors: Júnior AL, Paz MF, Alencar MV, Islam MT, Ferreir PM, Melo-Cavalcante AA Tags: Curr Pharm Biotechnol Source Type: research

Larvicidal Activity of Steroidal Saponins from Dracaena arborea on Aedes albopictu.
We report about the isolation of steroidal saponins from Dracaena arborea, evidencing their larvicidal activity against A. albopictus by biological essays. In specific, spiroconazole A demonstrated the best larvicidal activity, showing LT50 value of 57.23 hours at 25 ppm. We finally discuss about the value of this finding. PMID: 27455904 [PubMed - as supplied by publisher] (Source: Current Pharmaceutical Biotechnology)
Source: Current Pharmaceutical Biotechnology - July 25, 2016 Category: Biotechnology Authors: Nya PC, Moretti R, Nicoletti M, Calvitti M, Tomassini L Tags: Curr Pharm Biotechnol Source Type: research

Potential Therapeutic Effects of Oleuropein Aglycone in Alzheimer's disease.
eda A Abstract Alzheimer's disease (AD) is an age-associated neurodegenerative amyloid disease and is considered a social and clinical problem the last decades, particularly in the Western countries. Amyloid diseases are characterized by the deposition of typically aggregated protein/peptides in tissues that are associated with brain degeneration and progressive cognitive impairment. The amyloid plaques and neurofibrillary tangles arise as a result of self-assembly into fibrillar material of amyloid-β protein and hyperphosphorylated tau, respectively. Moreover, mounting evidence shows that oxidative and nitro...
Source: Current Pharmaceutical Biotechnology - July 25, 2016 Category: Biotechnology Authors: Martorell M, Forman K, Castro N, Capó X, Tejada S, Sureda A Tags: Curr Pharm Biotechnol Source Type: research

Effect of Red Wine Polyphenols on the Expression of Transthyretin in Murine Choroid Plexus.
Abstract Plasmatic transthyretin may be regarded as a suitable candidate biomarker for the onset, severity, and progression of Alzheimer disease. The aim of the present experimental work was to evaluate the effect of red wine polyphenols (RWPs) on the expression of transthyretin in murine choroid plexus. In contrast to what generally reported in literature for polyphenols, our experimental results indicated a correlation between RWPs assumption and a decrease of transthyretin expression, with a non-dose dependent trend. The present study would point out the attention on the possible pro-oxidant effects of red wine...
Source: Current Pharmaceutical Biotechnology - July 21, 2016 Category: Biotechnology Authors: Tenore GC, Morisco F, Lembo V, Ritieni A Tags: Curr Pharm Biotechnol Source Type: research

Wound Healing Effects of Curcumin: A Short Review.
Abstract Wound healing is a complex process that consists of several phases that range from coagulation, inflammation, accumulation of radical substances, to proliferation, formation of fibrous tissues and collagen, contraction of wound with formation of granulation tissue and scar. Since antiquity, vegetable substances have been used as phytotherapeutic agents for wound healing, and more recently natural substances of vegetable origin have been studied with the attempt to show their beneficial effect on wound treatment. Curcumin, the most active component of rhizome of Curcuma longa L. (common name: turmeric), ha...
Source: Current Pharmaceutical Biotechnology - July 21, 2016 Category: Biotechnology Authors: Tejada S, Manayi A, Daglia M, Nabavi SF, Sureda A, Hajheydari Z, Gortzi O, Pazoki-Toroudi H, Nabavi SM Tags: Curr Pharm Biotechnol Source Type: research

Wound Healing Effect of Curcumin: A Review.
Abstract Wound healing is a complex process that consists of several phases that range from coagulation, inflammation, accumulation of radical substances, to proliferation, formation of fibrous tissues and collagen, contraction of wound with formation of granulation tissue and scar. Since antiquity, vegetable substances have been used as phytotherapeutic agents for wound healing, and more recently natural substances of vegetable origin have been studied with the attempt to show their beneficial effect on wound treatment. Curcumin, the most active component of rhizome of Curcuma longa L. (common name: turmeric), ha...
Source: Current Pharmaceutical Biotechnology - July 21, 2016 Category: Biotechnology Authors: Tejada S, Manayi A, Daglia M, Nabavi SF, Sureda A, Hajheydari Z, Gortzi O, Pazoki-Toroudi H, Nabavi SM Tags: Curr Pharm Biotechnol Source Type: research

Effect of Red Wine Polyphenols on Genic Levels of Transthyretin at Level of Choroid Plexus in a Murine Model.
Abstract Plasmatic transthyretin may be regarded as a suitable candidate biomarker for the onset, severity, and progression of Alzheimer disease. The aim of the present experimental work was to evaluate the effect of red wine polyphenols (RWPs) on the expression of transthyretin in murine choroid plexus. In contrast to what generally reported in literature for polyphenols, our experimental results indicated a correlation between RWPs assumption and a decrease of transthyretin expression, with a non-dose dependent trend. The present study would point out the attention on the possible pro-oxidant effects of red wine...
Source: Current Pharmaceutical Biotechnology - July 21, 2016 Category: Biotechnology Authors: Tenore GC, Morisco F, Lembo V, Ritieni A Tags: Curr Pharm Biotechnol Source Type: research

Cell-based Assay System for Predicting Bone Regeneration in Patient Affected by Aseptic Nonunion and Treated with Platelet Rich Fibrin.
CONCLUSION: BMSC-based assay could be a useful tool to recognize patients who have a low probability to benefit from the use of autologous platelet concentrate to promote the healing of long bone nonunion. PMID: 27439412 [PubMed - as supplied by publisher] (Source: Current Pharmaceutical Biotechnology)
Source: Current Pharmaceutical Biotechnology - July 19, 2016 Category: Biotechnology Authors: Perut F, Dante D, Nicola R, Nicola B, Donatella G Tags: Curr Pharm Biotechnol Source Type: research