New Insights into Pharmaceutical Nanocrystals for the Improved Topical Delivery of Therapeutics in Various Skin Disorders
This article explores the preparation techniques, applications, and recent patents of nanocrystals for treating various skin conditions.PMID:37921127 | DOI:10.2174/0113892010276223231027075527 (Source: Current Pharmaceutical Biotechnology)
Source: Current Pharmaceutical Biotechnology - November 3, 2023 Category: Biotechnology Authors: Vanshita Singh Keshav Bansal Hemant Bhati Meenakshi Bajpai Source Type: research

Pharmacodynamics Research on Danggui-Shaoyao-San through Body Fluid Indexes of Spleen Deficiency-water Dampness Rats using Bioimpedance Technology
CONCLUSIONS: These findings suggest that using bio-impedance technology to measure body fluid indexes can pave a road for further exploring the molecular mechanism of the reason why the blood-activating and disinhibit-water split prescriptions in DSS are both effective in treating spleen deficiency-water dampness rats.PMID:37921128 | DOI:10.2174/0113892010243018231025065109 (Source: Current Pharmaceutical Biotechnology)
Source: Current Pharmaceutical Biotechnology - November 3, 2023 Category: Biotechnology Authors: Ran Chen Mo Yang Can Peng Dengke Yin Yunjing Zhang Fan Xu Source Type: research

The Cutting-edge of CRISPR for Cancer Treatment and its Future Prospects
Curr Pharm Biotechnol. 2023 Oct 25. doi: 10.2174/0113892010258617231020062637. Online ahead of print.ABSTRACTCRISPR (Clustered Regularly Interspaced Short Palindromic Repeats) is a versatile technology that allows precise modification of genes. One of its most promising applications is in cancer treatment. By targeting and editing specific genes involved in cancer development and progression, CRISPR has the potential to become a powerful tool in the fight against cancer. This review aims to assess the recent progress in CRISPR technology for cancer research and to examine the obstacles and potential strategies to address t...
Source: Current Pharmaceutical Biotechnology - November 3, 2023 Category: Biotechnology Authors: Liau Kah Man Ooi An Gie Mah Chian Huey Penny Yong Ling Siik Kee Loo Cheng Ze Tay Ming Yu Jhi Biau Foo Sharina Hamzah Source Type: research

N-acetylcysteine Attenuates Cigarette Smoke-induced Alveolar Epithelial Cell Apoptosis through Reactive Oxygen Species Depletion and Glutathione Replenish In vivo and In vitro
CONCLUSION: Our study confirmed that NAC can attenuate CS-induced AEC apoptosis via alleviating ROS-mediated ER stress and mitochondrial dysfunction pathway, and the mechanism was found to be related to replenishing the cellular GSH content.PMID:37921125 | DOI:10.2174/0113892010257526231019143524 (Source: Current Pharmaceutical Biotechnology)
Source: Current Pharmaceutical Biotechnology - November 3, 2023 Category: Biotechnology Authors: Jie Zhao Mi Han Yange Tian Peng Zhao Xuefang Liu Haoran Dong Suxiang Feng Jiansheng Li Source Type: research

Structure, Function, and Physicochemical Properties of Pore-forming Antimicrobial Peptides
Curr Pharm Biotechnol. 2023 Oct 25. doi: 10.2174/0113892010194428231017051836. Online ahead of print.ABSTRACTAntimicrobial peptides (AMPs), a class of antimicrobial agents, possess considerable potential to treat various microbial ailments. The broad range of activity and rare complete bacterial resistance to AMPs make them ideal candidates for commercial development. These peptides with widely varying compositions and sources share recurrent structural and functional features in mechanisms of action. Studying the mechanisms of AMP activity against bacteria may lead to the development of new antimicrobial agents that are m...
Source: Current Pharmaceutical Biotechnology - November 3, 2023 Category: Biotechnology Authors: Narjes Hosseini Goki Zeinab Amiri Tehranizadeh Mohammad Reza Saberi Bahman Khameneh Bibi Sedigheh Fazly Bazzaz Source Type: research