Overcoming Low Adherence to Chronic Medications by Improving their Effectiveness Using a Personalized Second-generation Digital System
CONCLUSION: Improving clinically meaningful outcome measures and disease parameters may increase adherence and improve patients' response to therapy.PMID:38288794 | DOI:10.2174/0113892010269461240110060035 (Source: Current Pharmaceutical Biotechnology)
Source: Current Pharmaceutical Biotechnology - January 30, 2024 Category: Biotechnology Authors: Areej Bayatra Rima Nasserat Yaron Ilan Source Type: research

Emerging Therapeutic Approaches Targeting Ferroptosis in Cancer: Focus on Immunotherapy and Nanotechnology
Curr Pharm Biotechnol. 2024 Jan 26. doi: 10.2174/0113892010276664231228124157. Online ahead of print.ABSTRACTFerroptosis is a newly discovered form of programmed cell death characterized by iron overload, ROS accumulation, and lipid peroxidation. It is distinguished by unique morphological, biochemical, and genetic features and stands apart from other known regulated cell death mechanisms. Studies have demonstrated a close association between ferroptosis and various cancers, including liver cancer, lung cancer, renal cell carcinoma, colorectal cancer, pancreatic cancer, and ovarian cancer. Inducing ferroptosis has shown pr...
Source: Current Pharmaceutical Biotechnology - January 29, 2024 Category: Biotechnology Authors: Zongchao Yu Zhongcheng Mo Yuan Qiu Hengzhe Lu Biao Zheng Longfei Liu Source Type: research

Extrusion and Co-extrusion: A Technology in Probiotic Encapsulation with Alternative Materials
Curr Pharm Biotechnol. 2024 Jan 24. doi: 10.2174/0113892010264234231219073231. Online ahead of print.ABSTRACTEncapsulation, in particular extrusion and co-extrusion, is a common practice to protect probiotics from the harsh conditions of the digestive tract as well as processing. Hydrocolloids, including proteins and carbohydrates, natural or modified, are a group of ingredients used as the wall material in extrusion. Hydrocolloids, due to their specific properties, can significantly improve the probiotic survivability of the final powder during the microencapsulation process and storage. The present article will discuss t...
Source: Current Pharmaceutical Biotechnology - January 26, 2024 Category: Biotechnology Authors: Aziz Homayouni-Rad Amir M Mortazavian Hadi Pourjafar Saba Kamalledin Moghadam Source Type: research

Recent Approaches on Molecular Markers, Treatment and Novel Drug Delivery System Used for the Management of Colorectal Cancer: A Comprehensive Review
Curr Pharm Biotechnol. 2024 Jan 24. doi: 10.2174/0113892010270975231208113157. Online ahead of print.ABSTRACTColorectal cancer affects 1 in 25 females and 1 in 24 males, making it the third most frequent cancer with over 6,08,030 deaths worldwide, despite advancements in detection and treatments, including surgery, chemotherapeutics, radiotherapy, and immune therapeutics. Novel potential agents have increased survival in acute and chronic disease conditions, with a higher risk of side effects and cost. However, metastatic disease has an insignificant long-term diagnosis, and significant challenges remain due to last-stage ...
Source: Current Pharmaceutical Biotechnology - January 26, 2024 Category: Biotechnology Authors: Sonia Chauhan Sakshi Sharma Source Type: research

The Astonishing Accomplishment of Biological Drug Delivery using Lipid Nanoparticles: An Ubiquitous Review
Curr Pharm Biotechnol. 2024 Jan 23. doi: 10.2174/0113892010268824231122041237. Online ahead of print.ABSTRACTBiotech drugs, including proteins, hormones, enzymes, DNA/RNA therapies, and cell-based treatments, are gaining popularity due to their effectiveness. However, effective delivery systems are needed to overcome administration challenges. Lipid nanoparticles (LNPs) have emerged as promising carriers for various therapies. LNPs are biocompatible, less likely to cause adverse reactions, and can stabilize delicate biological drugs, enhancing their stability and solubility. Scalable and cost-effective manufacturing proces...
Source: Current Pharmaceutical Biotechnology - January 24, 2024 Category: Biotechnology Authors: Devesh Kapoor Shirisha C Chilkapalli Bhupendra G Prajapati Paul Rodriques Ravish Patel Sudarshan Singh Sankha Bhattacharya Source Type: research

The Impact of miR-122 on Cancer
Curr Pharm Biotechnol. 2024 Jan 22. doi: 10.2174/0113892010272106231109065912. Online ahead of print.ABSTRACTMiRNAs are confirmed to be a kind of short and eminently conserved noncoding RNAs, which regulate gene expression at the post-transcriptional level via binding to the 3'- untranslated region (3'-UTR) of targeting multiple target messenger RNAs. Recently, growing evidence stresses the point that they play a crucial role in a variety of pathological processes, including human cancers. Dysregulated miRNAs act as oncogenes or tumor suppressor genes in many cancer types. Among them, we noticed that miR-122 has been widel...
Source: Current Pharmaceutical Biotechnology - January 23, 2024 Category: Biotechnology Authors: Shijie Wu Yiwen Wu Sijun Deng Xiaoyong Lei Xiaoyan Yang Source Type: research

Industrial and Pharmaceutical Applications of Microbial Diversity of Hypersaline Ecology from Lonar Soda Crater
Curr Pharm Biotechnol. 2024 Jan 22. doi: 10.2174/0113892010265978231109085224. Online ahead of print.ABSTRACTThe unidentified geochemical and physiochemical characteristics of Soda Lakes across the globe make it a novel reservoir and bring attention to scientific civic for its conceivable industrial and pharmaceutical applications. In India, in the Maharashtra state, Lonar Lake is a naturally created Soda Lake by a meteorite impact. Phylogenetic data from this lake explored a diverse array of microorganisms like haloalkaliphilic bacteria and Archaea. Previously reported studies postulated the major microbial communities pr...
Source: Current Pharmaceutical Biotechnology - January 23, 2024 Category: Biotechnology Authors: Pradip Bawane Shirish Deshpande Santosh Yele Source Type: research

Obesity and its Relationship with Covid-19: A Review of the Main Pharmaceutical Aspects
Curr Pharm Biotechnol. 2024 Jan 22. doi: 10.2174/0113892010264503231108070917. Online ahead of print.ABSTRACTImportant physiological changes are observed in patients with obesity, such as intestinal permeability, gastric emptying, cardiac output, and hepatic and renal function. These differences can determine variations in the pharmacokinetics of different drugs and can generate different concentrations at the site of action, which can lead to sub therapeutic or toxic concentrations. Understanding the physiological and immunological processes that lead to the clinical manifestations of COVID-19 is essential to correlate ob...
Source: Current Pharmaceutical Biotechnology - January 23, 2024 Category: Biotechnology Authors: Katharine Hodel Ananda Fonseca Islania Barbosa Caio Medina Brenda Alves Carine Maciel Daniel Nascimento Gessualdo Oliveira-Junior Lorena Pedreira Monielly de Souza Ana Leonor Godoy Source Type: research

Systematic Review on Herbal Preparations for Controlling Visceral Hypersensitivity in Functional Gastrointestinal Disorders
CONCLUSION: Considering the positive effects of herbal formulations in VH management, further research on novel herbal and/or herbal/chemical preparations is warranted.PMID:38258770 | DOI:10.2174/0113892010261502231102040149 (Source: Current Pharmaceutical Biotechnology)
Source: Current Pharmaceutical Biotechnology - January 23, 2024 Category: Biotechnology Authors: Naser-Aldin Lashgari Nazanin Momeni Roudsari Saeideh Momtaz Faezeh Niazi Shahraki Nadia Zandi Benyamin Pazoki Mohammad Hosein Farzaei Mehdi Ghasemi Mohammad Abdollahi Amir Hossein Abdolghaffari Source Type: research

Advances in Aerogels Formulations for Pulmonary Targeted Delivery of Therapeutic Agents: Safety, Efficacy and Regulatory Aspects
In conclusion, aerogel-based pulmonary drug delivery systems can be used in biomedicine and non-biomedicine applications for improved sustainability, mechanical properties, biodegradability, and biocompatibility. This covers scaffolds, aerogels, and nanoparticles. Furthermore, biopolymers have been described, including cellulose nanocrystals (CNC) and MXenes. A safety regulatory database is necessary to offer direction on the commercialization potential of aerogelbased formulations. After that, enormous efforts are discovered to be performed to synthesize an effective aerogel, particularly to shorten the drying period, whi...
Source: Current Pharmaceutical Biotechnology - January 22, 2024 Category: Biotechnology Authors: Shristy Verma Pramod Sharma Rishabha Malviya Sanjita Das Source Type: research

Synergistic Effect of Silver Nanoparticles with Antibiotics for Eradication of Pathogenic Biofilms
CONCLUSION: The present findings encourage the development of alternative therapies with high efficacy and low toxicity.PMID:38231054 | DOI:10.2174/0113892010279217240102100405 (Source: Current Pharmaceutical Biotechnology)
Source: Current Pharmaceutical Biotechnology - January 17, 2024 Category: Biotechnology Authors: Majed M Masadeh Zeinab Al-Tal Mai S Khanfar Karem H Alzoubi Salsabeel H Sabi Majd M Massadeh Source Type: research

Simultaneous Determination of Levo-tetrahydropalmatine and Naltrexone in Rat Plasma by LC-MS/MS and its Application in a Pharmacokinetic Study
CONCLUSION: The assay has been used for pharmacokinetic studies of l-THP and naltrexone in the rat.PMID:38213152 | DOI:10.2174/0113892010271975231218074830 (Source: Current Pharmaceutical Biotechnology)
Source: Current Pharmaceutical Biotechnology - January 12, 2024 Category: Biotechnology Authors: Kun Feng Sherwin K B Sy Mingming Yu Zhihua Lv Meixing Yan Source Type: research

Immunohistochemical Expression of the SERPINA3 Protein in Uterine Fibroids
CONCLUSION: This observation sheds new light on the role of this protein in the formation of proliferative changes and suggests that understanding the mechanism of its action may become the basis for the development of new diagnostic and therapeutic tools.PMID:38204235 | DOI:10.2174/0113892010264673231111082438 (Source: Current Pharmaceutical Biotechnology)
Source: Current Pharmaceutical Biotechnology - January 11, 2024 Category: Biotechnology Authors: Mateusz de Mezer Anna Markowska Janina Markowska Monika Krzy ┼╝aniak Beniamin Grabarek Filip Pokusa Jakub ┼╗urawski Source Type: research

Preparation, Swelling, and Drug Release Studies of Chitosan-based Hydrogels for Controlled Delivery of Buspirone Hydrochloride
CONCLUSION: The results showed that the developed chitosan-based hydrogel can be considered one of the most suitable drug carrier systems for the controlled delivery of buspirone.PMID:38204236 | DOI:10.2174/0113892010267638231206164415 (Source: Current Pharmaceutical Biotechnology)
Source: Current Pharmaceutical Biotechnology - January 11, 2024 Category: Biotechnology Authors: Muhammad Suhail Chih-Wun Fang I-Hui Chiu Hamid Ullah I-Ling Lin Ming-Jun Tsai Pao-Chu Wu Source Type: research

Pharmacological Action and Research Progress of Taraxasterol
Curr Pharm Biotechnol. 2024 Jan 4. doi: 10.2174/0113892010276692231220103636. Online ahead of print.ABSTRACTPrimarily sourced from Asteraceae family herbs such as the Dandelion, Taraxasterol is a pentacyclic triterpenoid lauded for its extensive biological functionalities. Its therapeutic potency is demonstrated in various disease models, encompassing enteritis, arthritis, acute hepatic injury, and pneumonia. Scientific literature underscores its anti-inflammatory, antioxidant, and antineoplastic attributes. The primary aim of this study is to thoroughly explore the diseasemodulating mechanisms and effects of taraxasterol....
Source: Current Pharmaceutical Biotechnology - January 5, 2024 Category: Biotechnology Authors: Yu Zhang Ramizu Bin Shaari Mohamad Arif Bin Awang Nawi Akram Bin Hassan Caiyun Cui Source Type: research