The Emerging Roles of Circpvt1 in Cancer Progression
Curr Pharm Biotechnol. 2024 Mar 6. doi: 10.2174/0113892010282141240226112253. Online ahead of print.ABSTRACTCircRNA is stable due to its ring structure and is abundant in humans, which not only exists in various tissues and biofluids steadily but also plays a significant role in the physiology and pathology of human beings. CircPVT1, an endogenous circRNA, has recently been identified from the PVT1 gene located in the cancer risk region 8q24. CircPVT1 is reported to be highly expressed in many different tumors, where it affects tumor cell proliferation, apoptosis, invasion, and migration. We summarize the biosynthesis and ...
Source: Current Pharmaceutical Biotechnology - March 8, 2024 Category: Biotechnology Authors: Shijie Wu Yan Hu Xiaoyong Lei Xiaoyan Yang Source Type: research

The Emerging Roles of Circpvt1 in Cancer Progression
Curr Pharm Biotechnol. 2024 Mar 6. doi: 10.2174/0113892010282141240226112253. Online ahead of print.ABSTRACTCircRNA is stable due to its ring structure and is abundant in humans, which not only exists in various tissues and biofluids steadily but also plays a significant role in the physiology and pathology of human beings. CircPVT1, an endogenous circRNA, has recently been identified from the PVT1 gene located in the cancer risk region 8q24. CircPVT1 is reported to be highly expressed in many different tumors, where it affects tumor cell proliferation, apoptosis, invasion, and migration. We summarize the biosynthesis and ...
Source: Current Pharmaceutical Biotechnology - March 8, 2024 Category: Biotechnology Authors: Shijie Wu Yan Hu Xiaoyong Lei Xiaoyan Yang Source Type: research

Nanotheranostics: A Cutting-Edge Technology for Cancer Management
Curr Pharm Biotechnol. 2024 Mar 4. doi: 10.2174/0113892010285567240222072959. Online ahead of print.ABSTRACTCancer is the second-leading cause of death in the 21st century, where early detection and appropriate therapeutic interventions are two components essential for effective cancer management. Despite the availability of several conventional diagnostics and therapeutic agents, cancer mortality rates are rising due to an increase in the frequency of recurrence and metastasis in cancer patients. Therefore, tremendous efforts have been expended to address this significant clinical issue and improve therapeutic efficacy. I...
Source: Current Pharmaceutical Biotechnology - March 5, 2024 Category: Biotechnology Authors: Shwetapadma Dash Shasank Sekhar Swain Auromira Khuntia Sneha Dutta Sanjeeb Kumar Sahoo Source Type: research

Application of Nanotechnology to Develop Carrageenan-based Films and Coatings as Carriers for Essential Oils
This study is designed based on a review of previous studies. Biopolymer coatings and films are suitable for food and non-food packaging due to their degradability, renewable and edible nature. Edible coatings and films are based on polysaccharides, proteins, and lipids. They confer some beneficial effects on foods, such as improvement of appearance and texture, reducing the amount of moisture loss and oxidation, prevention of the release of gases and control of microbial growth, delaying ripening and adverse changes in color and taste, improvement of nutritional value, and increasing the shelf life of the product. These i...
Source: Current Pharmaceutical Biotechnology - March 5, 2024 Category: Biotechnology Authors: Leila Nikravan Setayesh Zamanpour Mohammad Hashemi Sayed Mahdi Hossaeini Marashi Marashi Seyyed Mohammad Ali Noori Source Type: research

Nanotheranostics: A Cutting-Edge Technology for Cancer Management
Curr Pharm Biotechnol. 2024 Mar 4. doi: 10.2174/0113892010285567240222072959. Online ahead of print.ABSTRACTCancer is the second-leading cause of death in the 21st century, where early detection and appropriate therapeutic interventions are two components essential for effective cancer management. Despite the availability of several conventional diagnostics and therapeutic agents, cancer mortality rates are rising due to an increase in the frequency of recurrence and metastasis in cancer patients. Therefore, tremendous efforts have been expended to address this significant clinical issue and improve therapeutic efficacy. I...
Source: Current Pharmaceutical Biotechnology - March 5, 2024 Category: Biotechnology Authors: Shwetapadma Dash Shasank Sekhar Swain Auromira Khuntia Sneha Dutta Sanjeeb Kumar Sahoo Source Type: research

Application of Nanotechnology to Develop Carrageenan-based Films and Coatings as Carriers for Essential Oils
This study is designed based on a review of previous studies. Biopolymer coatings and films are suitable for food and non-food packaging due to their degradability, renewable and edible nature. Edible coatings and films are based on polysaccharides, proteins, and lipids. They confer some beneficial effects on foods, such as improvement of appearance and texture, reducing the amount of moisture loss and oxidation, prevention of the release of gases and control of microbial growth, delaying ripening and adverse changes in color and taste, improvement of nutritional value, and increasing the shelf life of the product. These i...
Source: Current Pharmaceutical Biotechnology - March 5, 2024 Category: Biotechnology Authors: Leila Nikravan Setayesh Zamanpour Mohammad Hashemi Sayed Mahdi Hossaeini Marashi Marashi Seyyed Mohammad Ali Noori Source Type: research

Nanotheranostics: A Cutting-Edge Technology for Cancer Management
Curr Pharm Biotechnol. 2024 Mar 4. doi: 10.2174/0113892010285567240222072959. Online ahead of print.ABSTRACTCancer is the second-leading cause of death in the 21st century, where early detection and appropriate therapeutic interventions are two components essential for effective cancer management. Despite the availability of several conventional diagnostics and therapeutic agents, cancer mortality rates are rising due to an increase in the frequency of recurrence and metastasis in cancer patients. Therefore, tremendous efforts have been expended to address this significant clinical issue and improve therapeutic efficacy. I...
Source: Current Pharmaceutical Biotechnology - March 5, 2024 Category: Biotechnology Authors: Shwetapadma Dash Shasank Sekhar Swain Auromira Khuntia Sneha Dutta Sanjeeb Kumar Sahoo Source Type: research

Application of Nanotechnology to Develop Carrageenan-based Films and Coatings as Carriers for Essential Oils
This study is designed based on a review of previous studies. Biopolymer coatings and films are suitable for food and non-food packaging due to their degradability, renewable and edible nature. Edible coatings and films are based on polysaccharides, proteins, and lipids. They confer some beneficial effects on foods, such as improvement of appearance and texture, reducing the amount of moisture loss and oxidation, prevention of the release of gases and control of microbial growth, delaying ripening and adverse changes in color and taste, improvement of nutritional value, and increasing the shelf life of the product. These i...
Source: Current Pharmaceutical Biotechnology - March 5, 2024 Category: Biotechnology Authors: Leila Nikravan Setayesh Zamanpour Mohammad Hashemi Sayed Mahdi Hossaeini Marashi Marashi Seyyed Mohammad Ali Noori Source Type: research

Quassinoids from Eurycoma longifolia as Potential Dihydrofolate Reductase Inhibitors: A Computational Study
CONCLUSION: From the analysis, 6-dehydrolongilactone and eurycomalide B are among the twelve compounds that showed great potential as hit-to-lead compounds based on the docking score on DHFR, drug-likeness, and ADMET properties. These results suggest a great potential to pursue validation studies via in vitro and in vivo models.PMID:38425119 | DOI:10.2174/0113892010273336240221101506 (Source: Current Pharmaceutical Biotechnology)
Source: Current Pharmaceutical Biotechnology - March 1, 2024 Category: Biotechnology Authors: Nurhanan Murni Yunos Mohammad Gasem Al-Thiabat Nor Jannah Sallehudin Habibah A Wahab Source Type: research

Quassinoids from Eurycoma longifolia as Potential Dihydrofolate Reductase Inhibitors: A Computational Study
CONCLUSION: From the analysis, 6-dehydrolongilactone and eurycomalide B are among the twelve compounds that showed great potential as hit-to-lead compounds based on the docking score on DHFR, drug-likeness, and ADMET properties. These results suggest a great potential to pursue validation studies via in vitro and in vivo models.PMID:38425119 | DOI:10.2174/0113892010273336240221101506 (Source: Current Pharmaceutical Biotechnology)
Source: Current Pharmaceutical Biotechnology - March 1, 2024 Category: Biotechnology Authors: Nurhanan Murni Yunos Mohammad Gasem Al-Thiabat Nor Jannah Sallehudin Habibah A Wahab Source Type: research

Quassinoids from Eurycoma longifolia as Potential Dihydrofolate Reductase Inhibitors: A Computational Study
CONCLUSION: From the analysis, 6-dehydrolongilactone and eurycomalide B are among the twelve compounds that showed great potential as hit-to-lead compounds based on the docking score on DHFR, drug-likeness, and ADMET properties. These results suggest a great potential to pursue validation studies via in vitro and in vivo models.PMID:38425119 | DOI:10.2174/0113892010273336240221101506 (Source: Current Pharmaceutical Biotechnology)
Source: Current Pharmaceutical Biotechnology - March 1, 2024 Category: Biotechnology Authors: Nurhanan Murni Yunos Mohammad Gasem Al-Thiabat Nor Jannah Sallehudin Habibah A Wahab Source Type: research

Quassinoids from Eurycoma longifolia as Potential Dihydrofolate Reductase Inhibitors: A Computational Study
CONCLUSION: From the analysis, 6-dehydrolongilactone and eurycomalide B are among the twelve compounds that showed great potential as hit-to-lead compounds based on the docking score on DHFR, drug-likeness, and ADMET properties. These results suggest a great potential to pursue validation studies via in vitro and in vivo models.PMID:38425119 | DOI:10.2174/0113892010273336240221101506 (Source: Current Pharmaceutical Biotechnology)
Source: Current Pharmaceutical Biotechnology - March 1, 2024 Category: Biotechnology Authors: Nurhanan Murni Yunos Mohammad Gasem Al-Thiabat Nor Jannah Sallehudin Habibah A Wahab Source Type: research

Non-Receptor Type PTPases and their Role in Controlling Pathways Related to Diabetes and Liver Cancer Signalling
Curr Pharm Biotechnol. 2024 Feb 28. doi: 10.2174/0113892010288624240213072415. Online ahead of print.ABSTRACTThe role of non-receptor type Protein Tyrosine Phosphatase (PTPases) in controlling pathways related to diabetes and Hepatocellular Carcinoma (HCC) is significant. The insulin signal transduction pathway is regulated by the steady-state phosphorylation of tyrosyl residues of the insulin receptor and post-receptor substrates. PTPase has been shown to have a physiological role in the regulation of reversible tyrosine phosphorylation. There are several non-receptor type PTPases. PTPase containing the SH-2 domain (SHP-2...
Source: Current Pharmaceutical Biotechnology - February 29, 2024 Category: Biotechnology Authors: Nidhee Chaudhary Bellam Kiranmayee Source Type: research

The Hepatoprotective Effects of Ginsenoside from Ginseng: A Review of Molecular Mechanisms and Therapeutic Potentials
Curr Pharm Biotechnol. 2024 Feb 28. doi: 10.2174/0113892010291326240214095327. Online ahead of print.ABSTRACTTreatment of hepatic diseases presents a significant challenge due to their diverse nature. Ginsenosides, bioactive compounds derived from the root of Panax ginseng and widely used in traditional Chinese medicine, offer multifaceted protection to various organs in the body. Their versatile effects, including antioxidant, anti-inflammatory, anti-apoptotic and more, make them a promising approach for addressing hepatic disorders. This review explores the intricate molecular mechanisms and properties of ginsenosides in...
Source: Current Pharmaceutical Biotechnology - February 29, 2024 Category: Biotechnology Authors: Seyed Reza Taha Andarz Fazlollahpour-Naghibi Mahdieh Shariat Zadeh Kimia Bagheri Hamed Rahmani Youshanlouei Reza Mosaddeghi-Heris Seyyed Sina Hejazian Amirreza Khalaji Seyedeh Shaghayegh Alavi Payam Fattahi Saba Mehrtabar Source Type: research

In Rheumatoid Arthritis, A Review of ncRNAs Related to NF- κB Signaling Pathways
Curr Pharm Biotechnol. 2024 Feb 27. doi: 10.2174/0113892010262829240214061103. Online ahead of print.ABSTRACTRheumatoid arthritis (RA) is an autoimmune disease with no known cure that results in joint deformities and dysfunction, significantly impacting the quality of life of patients. The abnormal NF-KB signaling pathway in RA has emerged as a crucial research area for the development of RA therapies, with non-coding RNAs (ncRNAs) serving as a potentially meaningful avenue to regulate it. Thus, understanding the role of ncRNAs in RA and the identification of new therapeutic targets have become pressing issues in the fie...
Source: Current Pharmaceutical Biotechnology - February 29, 2024 Category: Biotechnology Authors: Chun-Xia Wang Hsiang-Hung Cheng Mei Luo Jing-Rong Jiang Source Type: research