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Role of Phytoactive-based Nanoformulation for the Treatment of Arthritis
Curr Pharm Biotechnol. 2024 Mar 14. doi: 10.2174/0113892010276916240308082328. Online ahead of print.ABSTRACTJoints and arthritic conditions are among the most dangerous illnesses that humans have ever encountered and it is even more worrying that there is no recognized treatment for arthritis. The researchers looked for safer alternatives, such as herbal medicines, because the traditional treatments used to treat severe joint inflammatory issues have several negative side effects. A ligand-coated nanomedicine can bind to receptors that are overexpressed by cells in chronically inflammatory tissues, increasing its efficacy...
Source: Current Pharmaceutical Biotechnology - March 15, 2024 Category: Biotechnology Authors: Shivendra Kumar Kantrol Kumar Sahu Mohit Agrawal Kuldeep Singh Sunam Saha Source Type: research

Unlocking the Potential of RNA Nanoparticles: A Breakthrough Approach to Overcoming Challenges in Colon Cancer Treatment
Curr Pharm Biotechnol. 2024 Mar 13. doi: 10.2174/0113892010285554240303160500. Online ahead of print.ABSTRACTGlobally, one of the leading causes of cancer-related deaths is colon cancer. As this form of cancer has a tremendous potential to metastasize, effective treatment is complicated and sometimes impossible. Despite the improvement of conventional chemotherapy and the advent of targeted therapies, overcoming multi-drug resistance (MDR) and side effects remain significant challenges. As a therapeutic intervention for targeted gene silencing in cancer, RNA technology shows promise and certain RNA-based formulations are c...
Source: Current Pharmaceutical Biotechnology - March 14, 2024 Category: Biotechnology Authors: Dipanjan Karati Swarupananda Mukherjee Biswajit Basu KevinKumar Garala Ayon Dutta Bhupendra G Prajapati Sankha Bhattacharya Source Type: research

Intestinal Epithelial Cell-specific Knockout of METTL3 Aggravates Intestinal Inflammation in CLP Mice by Weakening the Intestinal Barrier
CONCLUSION: This study reveals a novel mechanism responsible for exacerbated intestinal inflammation orchestrated by METTL3. Particularly, METTL3 null mice displayed decreased ZO- 1 and Claudin-1 expression, which largely hampered intestinal epithelial barrier function, resulting in bacterial and toxin translocation and intestinal immune activation and inflammation against sepsis.PMID:38482615 | DOI:10.2174/0113892010271970240202054245 (Source: Current Pharmaceutical Biotechnology)
Source: Current Pharmaceutical Biotechnology - March 14, 2024 Category: Biotechnology Authors: Hongzhou Shi Jiahui Sun Yaya Sun Junjie Wu Guangqing Jiang Zhaiyue Xu Xin Shi Miao Fang Source Type: research

Nano-delivery of Silibinin Potentiate the Induction of Immunogenic Cell Death (ICD) in Melanoma Cells
CONCLUSION: Our findings showed that the encapsulation of silibinin in polymeric nanocarriers can potentiate the effects of this drug on the induction of apoptosis and ICD in B16F10 melanoma cells.PMID:38482616 | DOI:10.2174/0113892010280336240227062954 (Source: Current Pharmaceutical Biotechnology)
Source: Current Pharmaceutical Biotechnology - March 14, 2024 Category: Biotechnology Authors: Mina Amiri Sevda Jafari Afsaneh Lavasanifar Ommoleila Molavi Soheila Montazersaheb Source Type: research

Biofilm Formation in Mycobacterial Genus; Mechanism of Biofilm Formation and Anti-Mycobacterial Biofilm Agents
Curr Pharm Biotechnol. 2024 Mar 11. doi: 10.2174/0113892010277107240227054933. Online ahead of print.ABSTRACTMycobacterium tuberculosis, Mycobacterium leprae, and non-tuberculous mycobacteria (NTM) are among the most significant human pathogens within the Mycobacterium genus. These pathogens can infect people who come into contact with biomaterials or have chronic illnesses. A characteristic pathogenic trait of mycobacteria is the development of biofilms, which involves several molecules, such as the GroEL1 chaperone, glycopeptidolipids, and shorter-chain mycolic acids. Bacterial behavior is influenced by nutrients, ions, ...
Source: Current Pharmaceutical Biotechnology - March 14, 2024 Category: Biotechnology Authors: Sina Nasrollahian Hassan Pourmoshtagh Sahar Sabour Nahal Hadi Taher Azimi Saeed Soleiman-Meigooni Source Type: research

TP508 Promotes Bone Regeneration on Distraction Osteogenesis via the Activation of Wnt/ β-catenin Signaling Pathway
CONCLUSION: In conclusion, TP508 promotes bone regeneration in DO by activating the Wnt/β- catenin signaling pathway.PMID:38468521 | DOI:10.2174/0113892010289575240306033011 (Source: Current Pharmaceutical Biotechnology)
Source: Current Pharmaceutical Biotechnology - March 12, 2024 Category: Biotechnology Authors: Kehan Li Linan Liu Jingyi Zhang Chenyu Liao Jian Hu Jian Song Source Type: research

Marine Microalgae Schizochytrium sp. S31: Potential Source for New Antimicrobial and Antibiofilm Agent
CONCLUSION: This research emphasizes the potential of Schizochytrium sp. S31 as a natural antibacterial and antibiofilm agent with promising applications in the pharmaceutical sectors. This is the first study to examine the antibacterial activity of Schizochytrium sp. S31 microalgae using broth microdilution, spot plate assays, and the antibiofilm activity by a crystal staining method. The findings of this study show that Schizochytrium sp. S31 has antibacterial and antibiofilm activities against critical bacterial pathogens.PMID:38465428 | DOI:10.2174/0113892010291960240223054911 (Source: Current Pharmaceutical Biotechnology)
Source: Current Pharmaceutical Biotechnology - March 11, 2024 Category: Biotechnology Authors: Doaa Abdullah Hammadi Al-Ogaidi Sevin ç Karaçam Rafig Gurbanov Nurcan Vardar-Yel Source Type: research