Recent Developments in Nanotechnology and Immunotherapy for the Diagnosis and Treatment of Pancreatic Cancer
Curr Pharm Biotechnol. 2024 Feb 23. doi: 10.2174/0113892010284407240212110745. Online ahead of print.ABSTRACTPancreatic cancer kills millions of people worldwide each year and is one of the most prevalent causes of mortality that requires prompt therapy. A large number of people who have pancreatic cancer are detected at an advanced stage, with incurable and drug-resistant tumors. Hence the overall survival rate of pancreatic cancer is less. The advance phase of this cancer is generated because of the expression of the cancer-causing gene, inactivation of the tumorsuppressing gene, and deregulation of molecules in differen...
Source: Current Pharmaceutical Biotechnology - February 28, 2024 Category: Biotechnology Authors: Komal Sindhi Abhishek Kanugo Source Type: research

MFAP5 Strengthened the Stem Cell Features of Non-small Cell Lung Cancer Cells by Regulating the FBW/Sox9 Axis
CONCLUSION: MFAP5 maintained the stem cell features of non-small cell lung cancer cells by modulating FBW7/Sox9 axis.PMID:38415489 | DOI:10.2174/0113892010259632240213091136 (Source: Current Pharmaceutical Biotechnology)
Source: Current Pharmaceutical Biotechnology - February 28, 2024 Category: Biotechnology Authors: Chun Du Zijuan Qi Wei Zhang Source Type: research

An Updated Review on Nanoemulsion: Factory for Food and Drug Delivery
CONCLUSION: The versatility of nanoemulsions makes them ideal for drug delivery, food, and pesticide formulation applications. These products are highly soluble, bioavailable, and targeted, providing significant advantages. More research and development are required to implement nanoemulsion-based products on a commercial scale.PMID:38415490 | DOI:10.2174/0113892010267771240211124950 (Source: Current Pharmaceutical Biotechnology)
Source: Current Pharmaceutical Biotechnology - February 28, 2024 Category: Biotechnology Authors: Virender Kumar Vandana Garg Nakul Saini Navidha Aggarwal Harsh Kumar Davinder Kumar Hitesh Chopra Mohammad Amjad Kamal Harish Dureja Source Type: research

Recent Developments in Nanotechnology and Immunotherapy for the Diagnosis and Treatment of Pancreatic Cancer
Curr Pharm Biotechnol. 2024 Feb 23. doi: 10.2174/0113892010284407240212110745. Online ahead of print.ABSTRACTPancreatic cancer kills millions of people worldwide each year and is one of the most prevalent causes of mortality that requires prompt therapy. A large number of people who have pancreatic cancer are detected at an advanced stage, with incurable and drug-resistant tumors. Hence the overall survival rate of pancreatic cancer is less. The advance phase of this cancer is generated because of the expression of the cancer-causing gene, inactivation of the tumorsuppressing gene, and deregulation of molecules in differen...
Source: Current Pharmaceutical Biotechnology - February 28, 2024 Category: Biotechnology Authors: Komal Sindhi Abhishek Kanugo Source Type: research

MFAP5 Strengthened the Stem Cell Features of Non-small Cell Lung Cancer Cells by Regulating the FBW/Sox9 Axis
CONCLUSION: MFAP5 maintained the stem cell features of non-small cell lung cancer cells by modulating FBW7/Sox9 axis.PMID:38415489 | DOI:10.2174/0113892010259632240213091136 (Source: Current Pharmaceutical Biotechnology)
Source: Current Pharmaceutical Biotechnology - February 28, 2024 Category: Biotechnology Authors: Chun Du Zijuan Qi Wei Zhang Source Type: research

An Updated Review on Nanoemulsion: Factory for Food and Drug Delivery
CONCLUSION: The versatility of nanoemulsions makes them ideal for drug delivery, food, and pesticide formulation applications. These products are highly soluble, bioavailable, and targeted, providing significant advantages. More research and development are required to implement nanoemulsion-based products on a commercial scale.PMID:38415490 | DOI:10.2174/0113892010267771240211124950 (Source: Current Pharmaceutical Biotechnology)
Source: Current Pharmaceutical Biotechnology - February 28, 2024 Category: Biotechnology Authors: Virender Kumar Vandana Garg Nakul Saini Navidha Aggarwal Harsh Kumar Davinder Kumar Hitesh Chopra Mohammad Amjad Kamal Harish Dureja Source Type: research

Diagnosis of Canine Visceral Leishmaniasis by Flow Cytometry Serology using the rMELEISH Multiepitope Antigen Coupled in a Functional Bead
CONCLUSION: The flow cytometry serology through coupling the antigen rMELEISH in functional beads showed high accuracy in diagnosing CVL.PMID:38409720 | DOI:10.2174/0113892010268142231226115140 (Source: Current Pharmaceutical Biotechnology)
Source: Current Pharmaceutical Biotechnology - February 27, 2024 Category: Biotechnology Authors: Henrique Bonif ácio Moura Henrique Gama Ker Luana S Ramos Lais M Nogueira Juliana M Machado Daniel S Dias Rita Ala íde Leandro Rodrigues Mariana Campos da Paz Rafael Gon çalves Teixeira-Neto Alexandre Barbosa Reis Alexsandro S Galdino Eduardo S Silva Source Type: research

Role of Protein Ubiquitination and HIF Signaling in the Evolution of Hypoxic Breast Cancer
Curr Pharm Biotechnol. 2024 Feb 23. doi: 10.2174/0113892010292219240212065544. Online ahead of print.ABSTRACTAlternations in protein ubiquitination along with hypoxia-inducible factor (HIF) signaling contribute to tumorigenesis and breast tumor advancement. Ubiquitination is an impulsive process, which is coordinately governed by E3 ligases and deubiquitinases (DUBs), that have come out as charismatic therapeutic targets. HIF expression, as well as the transcriptional process in malignancies, are frequently elevated, resulting in pitiable clinical outcomes. According to increasing research, multiple E3 ligases, in addition...
Source: Current Pharmaceutical Biotechnology - February 27, 2024 Category: Biotechnology Authors: Suman Kumar Ray Sukhes Mukherjee Source Type: research

Diagnosis of Canine Visceral Leishmaniasis by Flow Cytometry Serology using the rMELEISH Multiepitope Antigen Coupled in a Functional Bead
CONCLUSION: The flow cytometry serology through coupling the antigen rMELEISH in functional beads showed high accuracy in diagnosing CVL.PMID:38409720 | DOI:10.2174/0113892010268142231226115140 (Source: Current Pharmaceutical Biotechnology)
Source: Current Pharmaceutical Biotechnology - February 27, 2024 Category: Biotechnology Authors: Henrique Bonif ácio Moura Henrique Gama Ker Luana S Ramos Lais M Nogueira Juliana M Machado Daniel S Dias Rita Ala íde Leandro Rodrigues Mariana Campos da Paz Rafael Gon çalves Teixeira-Neto Alexandre Barbosa Reis Alexsandro S Galdino Eduardo S Silva Source Type: research

Role of Protein Ubiquitination and HIF Signaling in the Evolution of Hypoxic Breast Cancer
Curr Pharm Biotechnol. 2024 Feb 23. doi: 10.2174/0113892010292219240212065544. Online ahead of print.ABSTRACTAlternations in protein ubiquitination along with hypoxia-inducible factor (HIF) signaling contribute to tumorigenesis and breast tumor advancement. Ubiquitination is an impulsive process, which is coordinately governed by E3 ligases and deubiquitinases (DUBs), that have come out as charismatic therapeutic targets. HIF expression, as well as the transcriptional process in malignancies, are frequently elevated, resulting in pitiable clinical outcomes. According to increasing research, multiple E3 ligases, in addition...
Source: Current Pharmaceutical Biotechnology - February 27, 2024 Category: Biotechnology Authors: Suman Kumar Ray Sukhes Mukherjee Source Type: research

Anti-seizure Effects and Mechanisms of Berberine: A Systematic Review
CONCLUSION: BBR indicated promising anti-seizure effects with remarkable antioxidant, antiinflammatory, anti-apoptotic, and neuroprotective activity. Future studies should be based on well-designed clinical trial studies that are integrated with new methods related to increasing bioavailability.PMID:38385486 | DOI:10.2174/0113892010283237240107121749 (Source: Current Pharmaceutical Biotechnology)
Source: Current Pharmaceutical Biotechnology - February 22, 2024 Category: Biotechnology Authors: Nahid Jivad Saeid Heidari-Soureshjani Hesamaldin Bagheri Catherine Mt Sherwin Sahar Rostamian Source Type: research

Anti-seizure Effects and Mechanisms of Berberine: A Systematic Review
CONCLUSION: BBR indicated promising anti-seizure effects with remarkable antioxidant, antiinflammatory, anti-apoptotic, and neuroprotective activity. Future studies should be based on well-designed clinical trial studies that are integrated with new methods related to increasing bioavailability.PMID:38385486 | DOI:10.2174/0113892010283237240107121749 (Source: Current Pharmaceutical Biotechnology)
Source: Current Pharmaceutical Biotechnology - February 22, 2024 Category: Biotechnology Authors: Nahid Jivad Saeid Heidari-Soureshjani Hesamaldin Bagheri Catherine Mt Sherwin Sahar Rostamian Source Type: research

Anti-seizure Effects and Mechanisms of Berberine: A Systematic Review
CONCLUSION: BBR indicated promising anti-seizure effects with remarkable antioxidant, antiinflammatory, anti-apoptotic, and neuroprotective activity. Future studies should be based on well-designed clinical trial studies that are integrated with new methods related to increasing bioavailability.PMID:38385486 | DOI:10.2174/0113892010283237240107121749 (Source: Current Pharmaceutical Biotechnology)
Source: Current Pharmaceutical Biotechnology - February 22, 2024 Category: Biotechnology Authors: Nahid Jivad Saeid Heidari-Soureshjani Hesamaldin Bagheri Catherine Mt Sherwin Sahar Rostamian Source Type: research

Anti-seizure Effects and Mechanisms of Berberine: A Systematic Review
CONCLUSION: BBR indicated promising anti-seizure effects with remarkable antioxidant, antiinflammatory, anti-apoptotic, and neuroprotective activity. Future studies should be based on well-designed clinical trial studies that are integrated with new methods related to increasing bioavailability.PMID:38385486 | DOI:10.2174/0113892010283237240107121749 (Source: Current Pharmaceutical Biotechnology)
Source: Current Pharmaceutical Biotechnology - February 22, 2024 Category: Biotechnology Authors: Nahid Jivad Saeid Heidari-Soureshjani Hesamaldin Bagheri Catherine Mt Sherwin Sahar Rostamian Source Type: research

Icariin Attenuates Human Renal Tubular Epithelial Cell Senescence by Targeting PAK2 via miR-23b-3p
CONCLUSION: miR-23b-3p and PAK2 form a signaling axis that regulates RTEC senescence upon urine exosome stimulation. Icariin can increase the resistance of RTECs against senescence via miR-23b-3p/PAK2. Our findings shed light on the mechanism of the clinical effects of icariin on renal diseases, which can be exploited to develop effective drugs targeting RTEC senescence in the future.PMID:38375837 | DOI:10.2174/0113892010276372231129105022 (Source: Current Pharmaceutical Biotechnology)
Source: Current Pharmaceutical Biotechnology - February 20, 2024 Category: Biotechnology Authors: Suqin Zhang Yanbin Li Qiuyue Wang Source Type: research