LncRNA LINC00466 Promotes the Progression of Breast Cancer via miR-4731-5p/EPHA2 Pathway
Conclusion: LINC00466 promoted BC development via mediating the miR-4731-5p/EPHA2 axis, which has the potential value as a promising therapeutic target in BC.PMID:38726776 | DOI:10.2174/0113892010290582240419051056 (Source: Current Pharmaceutical Biotechnology)
Source: Current Pharmaceutical Biotechnology - May 10, 2024 Category: Biotechnology Authors: Xue Han Fan Shi Shujun Guo Yao Li Hongtao Wang Chuanwang Song Shiwu Wu Source Type: research

LncRNA LINC00466 Promotes the Progression of Breast Cancer via miR-4731-5p/EPHA2 Pathway
Conclusion: LINC00466 promoted BC development via mediating the miR-4731-5p/EPHA2 axis, which has the potential value as a promising therapeutic target in BC.PMID:38726776 | DOI:10.2174/0113892010290582240419051056 (Source: Current Pharmaceutical Biotechnology)
Source: Current Pharmaceutical Biotechnology - May 10, 2024 Category: Biotechnology Authors: Xue Han Fan Shi Shujun Guo Yao Li Hongtao Wang Chuanwang Song Shiwu Wu Source Type: research

LncRNA LINC00466 Promotes the Progression of Breast Cancer via miR-4731-5p/EPHA2 Pathway
Conclusion: LINC00466 promoted BC development via mediating the miR-4731-5p/EPHA2 axis, which has the potential value as a promising therapeutic target in BC.PMID:38726776 | DOI:10.2174/0113892010290582240419051056 (Source: Current Pharmaceutical Biotechnology)
Source: Current Pharmaceutical Biotechnology - May 10, 2024 Category: Biotechnology Authors: Xue Han Fan Shi Shujun Guo Yao Li Hongtao Wang Chuanwang Song Shiwu Wu Source Type: research

Emerging Natural Therapies for the Treatment of Inflammatory Bowel Disease
Curr Pharm Biotechnol. 2024 Apr 22. doi: 10.2174/0113892010293150240415143650. Online ahead of print.ABSTRACTThe term "inflammatory bowel disease," which includes Crohn's disease (CD) and ulcerative colitis (UC), refers to a chronic inflammatory condition of the digestive system. There are many different treatment options, such as corticosteroids, biologics, 5-aminosalicylate, and immune-suppressants, but none of them can maintain the disease remission for a longer period, which is the ultimate goal of treatment. Furthermore, they have numerous serious side effects like nephrotoxicity, infertility, congestive heart failure...
Source: Current Pharmaceutical Biotechnology - May 8, 2024 Category: Biotechnology Authors: Monika Joshi Manju Pandey Ravi Shankar Akash Ved Source Type: research

Nanotechnology Integrated Innovative Drug Delivery and Therapy for Cancer
Curr Pharm Biotechnol. 2024 Apr 22. doi: 10.2174/0113892010279483240417050548. Online ahead of print.ABSTRACTCancer remains a significant global health challenge, necessitating innovative approaches to enhance the efficacy and specificity of therapeutic interventions while minimizing adverse effects on healthy tissues. Nanotechnology has emerged as a promising avenue in cancer treatment, offering novel strategies for targeted drug delivery. Nanoparticles, liposomes, and polymer-based systems have played pivotal roles in revolutionizing cancer therapy. Nanotechnology possesses unique physicochemical properties, enabling eff...
Source: Current Pharmaceutical Biotechnology - May 8, 2024 Category: Biotechnology Authors: Romulo R Macadangdang Rutvi Agrawal Bharat Bhushan Akash Garg Kuldeep Singh Shivendra Kumar Atul Kumar Source Type: research

Fisetin from Dietary Supplement to a Drug Candidate: An Assessment of Potential - A Review
Curr Pharm Biotechnol. 2024 Apr 22. doi: 10.2174/0113892010304479240415074928. Online ahead of print.ABSTRACTFisetin is a bioactive compound found in numerous fruits and vegetables, including strawberries, apples, grapes, persimmon, cucumber, onion, etc. The compound is also wellknown for its neurotrophic, anti-inflammatory, anti-carcinogenic, anti-diabetic, and other healthpromoting properties. Although there is increasing agreement that it has therapeutic properties, its poor water solubility, high lipophilicity, and lower oral bioavailability make it difficult to use clinically. Extensive research has attempted to overc...
Source: Current Pharmaceutical Biotechnology - May 8, 2024 Category: Biotechnology Authors: Mohd Aamir Mirza Santwana Padhi Sradhanjali Mohapatra Syed Mahmood Zeenat Iqbal Source Type: research

Emerging Natural Therapies for the Treatment of Inflammatory Bowel Disease
Curr Pharm Biotechnol. 2024 Apr 22. doi: 10.2174/0113892010293150240415143650. Online ahead of print.ABSTRACTThe term "inflammatory bowel disease," which includes Crohn's disease (CD) and ulcerative colitis (UC), refers to a chronic inflammatory condition of the digestive system. There are many different treatment options, such as corticosteroids, biologics, 5-aminosalicylate, and immune-suppressants, but none of them can maintain the disease remission for a longer period, which is the ultimate goal of treatment. Furthermore, they have numerous serious side effects like nephrotoxicity, infertility, congestive heart failure...
Source: Current Pharmaceutical Biotechnology - May 8, 2024 Category: Biotechnology Authors: Monika Joshi Manju Pandey Ravi Shankar Akash Ved Source Type: research

Nanotechnology Integrated Innovative Drug Delivery and Therapy for Cancer
Curr Pharm Biotechnol. 2024 Apr 22. doi: 10.2174/0113892010279483240417050548. Online ahead of print.ABSTRACTCancer remains a significant global health challenge, necessitating innovative approaches to enhance the efficacy and specificity of therapeutic interventions while minimizing adverse effects on healthy tissues. Nanotechnology has emerged as a promising avenue in cancer treatment, offering novel strategies for targeted drug delivery. Nanoparticles, liposomes, and polymer-based systems have played pivotal roles in revolutionizing cancer therapy. Nanotechnology possesses unique physicochemical properties, enabling eff...
Source: Current Pharmaceutical Biotechnology - May 8, 2024 Category: Biotechnology Authors: Romulo R Macadangdang Rutvi Agrawal Bharat Bhushan Akash Garg Kuldeep Singh Shivendra Kumar Atul Kumar Source Type: research

Fisetin from Dietary Supplement to a Drug Candidate: An Assessment of Potential - A Review
Curr Pharm Biotechnol. 2024 Apr 22. doi: 10.2174/0113892010304479240415074928. Online ahead of print.ABSTRACTFisetin is a bioactive compound found in numerous fruits and vegetables, including strawberries, apples, grapes, persimmon, cucumber, onion, etc. The compound is also wellknown for its neurotrophic, anti-inflammatory, anti-carcinogenic, anti-diabetic, and other healthpromoting properties. Although there is increasing agreement that it has therapeutic properties, its poor water solubility, high lipophilicity, and lower oral bioavailability make it difficult to use clinically. Extensive research has attempted to overc...
Source: Current Pharmaceutical Biotechnology - May 8, 2024 Category: Biotechnology Authors: Mohd Aamir Mirza Santwana Padhi Sradhanjali Mohapatra Syed Mahmood Zeenat Iqbal Source Type: research

Nanotechnology-Powered Meningitis Therapies: Lipid Nanoparticles Lead the Way
Curr Pharm Biotechnol. 2024 May 3. doi: 10.2174/0113892010303028240429073144. Online ahead of print.ABSTRACTThe meninges serve as a protective layer, and the fluid around the brain and spinal cord can become inflamed, known as meningitis. Lipid-based pharmaceutical formulations, by their high lipophilicity, can negotiate the Blood-Brain Barrier (BBB). The current mode of treatment of meningitis is mainly through antibiotics, which, at best, is partially effective. The success of antibiotic therapy depends on several factors, for example, the difficulty of reaching the infection site, maintaining proper concentrations of th...
Source: Current Pharmaceutical Biotechnology - May 6, 2024 Category: Biotechnology Authors: Dipanjan Karati Swarupananda Mukherjee Susmita Paul Suchana Das Bhupendra Prajapati Ravish J Patel Sajal Kumar Jha Source Type: research

Nanotechnology-Powered Meningitis Therapies: Lipid Nanoparticles Lead the Way
Curr Pharm Biotechnol. 2024 May 3. doi: 10.2174/0113892010303028240429073144. Online ahead of print.ABSTRACTThe meninges serve as a protective layer, and the fluid around the brain and spinal cord can become inflamed, known as meningitis. Lipid-based pharmaceutical formulations, by their high lipophilicity, can negotiate the Blood-Brain Barrier (BBB). The current mode of treatment of meningitis is mainly through antibiotics, which, at best, is partially effective. The success of antibiotic therapy depends on several factors, for example, the difficulty of reaching the infection site, maintaining proper concentrations of th...
Source: Current Pharmaceutical Biotechnology - May 6, 2024 Category: Biotechnology Authors: Dipanjan Karati Swarupananda Mukherjee Susmita Paul Suchana Das Bhupendra Prajapati Ravish J Patel Sajal Kumar Jha Source Type: research

Optimization of Phloretin-loaded Nanospanlastics for Targeting of FAS/SREBP1c/AMPK/ OB-Rb Signaling Pathway in HFD-induced Obesity
CONCLUSIONS: Administration of PTN-NSLs significantly attenuated the levels of glycemic, oxidative stress, and inflammatory biomarkers. The biochemical and PCR findings are aided by histological investigations. Also, the present findings imply that PTN-NSLs might be a promising pharmacological tool for the treatment of obesity-related diseases.PMID:38698746 | DOI:10.2174/0113892010278684240105115516 (Source: Current Pharmaceutical Biotechnology)
Source: Current Pharmaceutical Biotechnology - May 3, 2024 Category: Biotechnology Authors: Mohamed Alamir Mohammed Abdalla Hussein Heba M Aboud Mohamed H Khedr Mohamed I Zanaty Source Type: research

Optimization of Phloretin-loaded Nanospanlastics for Targeting of FAS/SREBP1c/AMPK/ OB-Rb Signaling Pathway in HFD-induced Obesity
CONCLUSIONS: Administration of PTN-NSLs significantly attenuated the levels of glycemic, oxidative stress, and inflammatory biomarkers. The biochemical and PCR findings are aided by histological investigations. Also, the present findings imply that PTN-NSLs might be a promising pharmacological tool for the treatment of obesity-related diseases.PMID:38698746 | DOI:10.2174/0113892010278684240105115516 (Source: Current Pharmaceutical Biotechnology)
Source: Current Pharmaceutical Biotechnology - May 3, 2024 Category: Biotechnology Authors: Mohamed Alamir Mohammed Abdalla Hussein Heba M Aboud Mohamed H Khedr Mohamed I Zanaty Source Type: research

Optimization of Phloretin-loaded Nanospanlastics for Targeting of FAS/SREBP1c/AMPK/ OB-Rb Signaling Pathway in HFD-induced Obesity
CONCLUSIONS: Administration of PTN-NSLs significantly attenuated the levels of glycemic, oxidative stress, and inflammatory biomarkers. The biochemical and PCR findings are aided by histological investigations. Also, the present findings imply that PTN-NSLs might be a promising pharmacological tool for the treatment of obesity-related diseases.PMID:38698746 | DOI:10.2174/0113892010278684240105115516 (Source: Current Pharmaceutical Biotechnology)
Source: Current Pharmaceutical Biotechnology - May 3, 2024 Category: Biotechnology Authors: Mohamed Alamir Mohammed Abdalla Hussein Heba M Aboud Mohamed H Khedr Mohamed I Zanaty Source Type: research

DHA and Cancer: The Uncharted Territory of Nutritional Oncology
Curr Pharm Biotechnol. 2024 Apr 26. doi: 10.2174/0113892010305256240422110943. Online ahead of print.NO ABSTRACTPMID:38676504 | DOI:10.2174/0113892010305256240422110943 (Source: Current Pharmaceutical Biotechnology)
Source: Current Pharmaceutical Biotechnology - April 27, 2024 Category: Biotechnology Authors: Devank Shekho Abhishek Chauhan Ritika Mishra Ankit Awasthi Source Type: research