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Insulin Analogs and the Mode of Insulin Delivery: Recent Advances and Challenges
Curr Pharm Biotechnol. 2024 Apr 2. doi: 10.2174/0113892010287216240324050651. Online ahead of print.ABSTRACTDiabetes is a medical condition associated with impaired glucose regulation caused either due to insufficient insulin production or resistance to insulin (Type 2 diabetes, gestational diabetes) or the absence of insulin through the selective killing of beta cells in the pancreas (Type 1 diabetes). Irregular insulin production leads to various health complications. To prevent such complications, patients must adhere to medical recommendations before availing of any advanced insulin therapy(ies), considered productive ...
Source: Current Pharmaceutical Biotechnology - April 3, 2024 Category: Biotechnology Authors: Medha Bhagi Jasmine Kaur Arti Dhar Audesh Bhat Source Type: research

Nanoemulsions a Delivery System in the Making for Tumor Targeting Therapeutics: Evaluation and Characterization to Meet Clinical Challenges
Curr Pharm Biotechnol. 2024 Apr 2. doi: 10.2174/0113892010290622240322080633. Online ahead of print.ABSTRACTCancer is a complex disease characterized by the uncontrolled and unregulated growth of cells followed by invasion and proliferation from the site of origin to other sites of the body. Conventional chemotherapy largely kills rapidly expanding and dividing cancer cells by impairing DNA synthesis and mitosis. It is associated with various types of adverse effects ranging from simple nausea and appetite loss to serious ones like bone marrow depression and compromised immunity etc., due to their non-selectivity and inabi...
Source: Current Pharmaceutical Biotechnology - April 3, 2024 Category: Biotechnology Authors: Ravi Shankar Prabhat Kumar Upadhyay Manish Kumar Source Type: research

Revolutionizing Wound Healing: Unleashing Nanostructured Lipid Carriers Embodied with Herbal Medicinal Plant
Curr Pharm Biotechnol. 2024 Apr 1. doi: 10.2174/0113892010287720240322060706. Online ahead of print.ABSTRACTWound healing is crucial for maintaining skin integrity and preventing complications from external threats. Various plants, such as Achillea millefolium, Aloe vera, Curcuma longa, Calendula officinalis, Camellia sinensis, Azadirachta indica, and Plantago, have demonstrated wound healing capabilities and have been used in herbal medicine for wound care. NLCs are second-generation lipid nanoparticles, blending solid and liquid lipids to improve medication loading and limit leakage. NLCs have been used in various applic...
Source: Current Pharmaceutical Biotechnology - April 3, 2024 Category: Biotechnology Authors: Aditya Jain Shikha Yadav Javed Khan Source Type: research

A Comprehensive Review on Nanoparticles as Drug Delivery System and Their Role for Management of Hypertension
Curr Pharm Biotechnol. 2024 Apr 2. doi: 10.2174/0113892010291414240322112508. Online ahead of print.ABSTRACTThe current global epidemic of hypertension is not a disease in and of itself but rather a significant risk factor for serious cardiovascular conditions such as peripheral artery disease, heart failure, myocardial infarction, and stroke. Although many medications that work through various mechanisms of action are available on the market in conventional formulations to treat hypertension, these medications face significant difficulties with their bioavailability, dosing, and associated side effects, which significantl...
Source: Current Pharmaceutical Biotechnology - April 3, 2024 Category: Biotechnology Authors: None Prerna Dinesh Chandra Bhatt Khalid Basir Mir Vikash Kumar Sandeep Rathor Source Type: research

Potential Serotonin 5-HT2A Receptor Agonist of Psychoactive Components of Silene undulata Aiton: LC-MS/MS, ADMET, and Molecular Docking Studies
CONCLUSION: These findings provide insights into the potential therapeutic benefits of S. undulata, supporting its traditional use as a psychoactive plant. This study investigated the chemical constituents and potential serotonergic agonist activity of S. undulata for the first time. While promising, further research is necessary to uncover additional medicinal properties associated with the identified phytochemical components.PMID:38561607 | DOI:10.2174/0113892010299804240324140017 (Source: Current Pharmaceutical Biotechnology)
Source: Current Pharmaceutical Biotechnology - April 1, 2024 Category: Biotechnology Authors: Maram B Alhawarri Suleiman Olimat Source Type: research

Protective Effects of Curcumin and Nanomicelle Curcumin on Chlorpyrifos-induced Oxidative Damage and Inflammation in the Uterus, Ovary and Brain of Rats
CONCLUSION: Our findings indicated that CUR and NMC could be effective in alleviating CPFinduced reproductive toxicity.PMID:38561608 | DOI:10.2174/0113892010297408240319073735 (Source: Current Pharmaceutical Biotechnology)
Source: Current Pharmaceutical Biotechnology - April 1, 2024 Category: Biotechnology Authors: Maryam Nazarian Hamed Aramjoo Babak Roshanravan Saeed Samarghandian Tahereh Farkhondeh Source Type: research

The Neem Limonoid Nimbolide Modulates Key Components of the DNA Damage Response Signalling in Cellular and Animal Models of Oral Squamous Cell Carcinoma
CONCLUSIONS: This study provides compelling evidence that nimbolide functions as a DDR inhibitor in cellular and hamster OSCC models and as a DDR activator in the PDX model primarily by targeting ATM. Small molecules like nimbolide that modulate DDR are of immense benefit in cancer therapy. The study has also unveiled p-ATM as a promising biomarker of tumour progression in human OSCCs.PMID:38561609 | DOI:10.2174/0113892010291998240321074920 (Source: Current Pharmaceutical Biotechnology)
Source: Current Pharmaceutical Biotechnology - April 1, 2024 Category: Biotechnology Authors: Soundararajan Arvindh Manashi Priyadarshini Abdul Basit Baba Veeran Veeravarmal Rajakishore Mishra Rupesh Dash Siddavaram Nagini Source Type: research

Noncoding RNA Lipotherapeutics: A Promising Breakthrough in Pulmonary Hypertension Treatment
In conclusion, ncRNA lipotherapeutics delivered via LNPs offer a transformative approach to treating PH, potentially leading to more effective management and improved patient outcomes in the future. However, continued research and clinical trials are necessary to fully realize their therapeutic potential in the field of PH treatment.PMID:38561610 | DOI:10.2174/0113892010302590240321073509 (Source: Current Pharmaceutical Biotechnology)
Source: Current Pharmaceutical Biotechnology - April 1, 2024 Category: Biotechnology Authors: Xuanyi Hu Xinxin Lv Lingzhu Zhang Shan-Shan Li Xin Jin Source Type: research

Targeted Drug Delivery to ACE2+ Cells Using Engineered Extracellular Vesicles: A Potential Therapeutic Approach for COVID-19
CONCLUSION: These findings indicate promising opportunities for engineered EVs as a novel nanomedicine carrier, offering valuable insights for therapeutic strategies against COVID-19 and other diseases.PMID:38551053 | DOI:10.2174/0113892010282251240324123038 (Source: Current Pharmaceutical Biotechnology)
Source: Current Pharmaceutical Biotechnology - March 29, 2024 Category: Biotechnology Authors: Yao Zhang Sheng-Jiao Song Jin He Zhuo-Hua Zhao Ke Zhang Yuan Zhang Xing Li Source Type: research

Research Strategy for Short-Peptide Fusion Inhibitors Based on 6-HB Core Structure against HIV-1: A Review
Curr Pharm Biotechnol. 2024 Mar 28. doi: 10.2174/0113892010297943240325040448. Online ahead of print.ABSTRACTAcquired Immune Deficiency Syndrome (AIDS) is a devastating infectious disease caused by the Human Immunodeficiency Virus type 1 (HIV-1). Enfuvirtide(T20) is the first HIV-1 fusion inhibitor for marketing, which plays an important role in AIDS treatment. However, in the clinical application process, T20 has several drawbacks, such as a high level of development of drug resistance, a short half-life in vivo, and rapid renal clearance, which severely limits the clinical application. Therefore, the development of novel...
Source: Current Pharmaceutical Biotechnology - March 29, 2024 Category: Biotechnology Authors: Guodong Liang Yan Huang Yanbai Tang Lu Ga Caixia Huo Yuheng Ma Yan Zhao Heiya Na Zhao Meng Source Type: research