Single Nucleotide Polymorphisms [SNPs] in the Shadows: Uncovering their Function in Non-Coding Region of Esophageal Cancer
Curr Pharm Biotechnol. 2024 Jan 15. doi: 10.2174/0113892010265004231116092802. Online ahead of print.ABSTRACTEsophageal cancer is a complex disease influenced by genetic and environmental factors. Single nucleotide polymorphisms [SNPs] in non-coding regions of the genome have emerged as crucial contributors to esophageal cancer susceptibility. This review provides a comprehensive overview of the role of SNPs in non-coding regions and their association with esophageal cancer. The accumulation of SNPs in the genome has been implicated in esophageal cancer risk. Various studies have identified specific locations in the genome...
Source: Current Pharmaceutical Biotechnology - February 4, 2024 Category: Biotechnology Authors: Surovi Saikia Humzah Postwala Vishnu Prabhu Athilingam Aparna A V Vijaya Padma Partha P Kalita Mehul Chorawala Bhupendra Prajapati Source Type: research

Essential Oils of Some Potential Medicinal Plants and Their Wound Healing Activities
Curr Pharm Biotechnol. 2024 Jan 2. doi: 10.2174/0113892010282605231218064053. Online ahead of print.ABSTRACTThe wound has been recognised as a deep cut or tearing of the epidermis, which is also referred to as trauma and harm to the body tissues. Healing of wounds requires a coordinated series of cellular processes, including cell attraction, proliferation, differentiation, and angiogenesis. These processes involve interactions between various cells, such as macrophages, endothelial cells, keratinocytes, fibroblasts, growth hormones, and proteases. The outcome of wounds can be fatal if not treated properly, resulting in ch...
Source: Current Pharmaceutical Biotechnology - February 4, 2024 Category: Biotechnology Authors: Shiv Bahadur Sana Fatima Source Type: research

Recent Insight into Herbal Bioactives-Based Novel Approaches for Chronic Intestinal Inflammatory Disorders Therapy
Curr Pharm Biotechnol. 2024 Jan 2. doi: 10.2174/0113892010282432231222060355. Online ahead of print.ABSTRACTInflammatory bowel disease (IBD) is a life-threatening complex disease. It causes chronic intestinal inflammation in GIT. IBD significantly affects people's lifestyles and carries a high risk of colon cancer. IBD involves the rectum, ileum, and colon, with clinical manifestations of bloody stools, weight loss, diarrhea, and abdominal pain. The prevalence of inflammatory disease is increasing dramatically worldwide. Over 16 million people are affected annually in India, with an economic burden of $6.8- $8.8 billion fo...
Source: Current Pharmaceutical Biotechnology - February 4, 2024 Category: Biotechnology Authors: Ranjit K Harwansh Sonia Chauhan Rohitas Deshmukh Rupa Mazumder Source Type: research

Effects and Mechanisms of Fisetin Against Ischemia-reperfusion Injuries: A Systematic Review
CONCLUSION: Fisetin, by antioxidant, anti-inflammatory, mitochondrial protection, promoting autophagy, and anti-apoptotic properties, can reduce cell injury due to myocardial, cerebral renal, and hepatic IRIs without any significant side effects.PMID:38310454 | DOI:10.2174/0113892010281821240102105415 (Source: Current Pharmaceutical Biotechnology)
Source: Current Pharmaceutical Biotechnology - February 4, 2024 Category: Biotechnology Authors: Omid-Ali Adeli Saeid Heidari-Soureshjani Sahar Rostamian Zahra Azadegan-Dehkordi Armin Khaghani Source Type: research

The Gut Microbiota and Major Depressive Disorder: Current Understanding and Novel Therapeutic Strategies
Curr Pharm Biotechnol. 2024 Jan 29. doi: 10.2174/0113892010281892240116081031. Online ahead of print.ABSTRACTMajor depressive disorder (MDD) is a common neuropsychiatric challenge that primarily targets young females. MDD as a global disorder has a multifactorial etiology related to the environment and genetic background. A balanced gut microbiota is one of the most important environmental factors involved in human physiological health. The interaction of gut microbiota components and metabolic products with the hypothalamic-pituitary-adrenal system and immune mediators can reverse depression phenotypes in vulnerable indiv...
Source: Current Pharmaceutical Biotechnology - January 30, 2024 Category: Biotechnology Authors: Mohaddeseh Bahmani Saba Mehrtabar Ali Jafarizadeh Sevda Zoghi Fatemah Sadeghpour Heravi Amin Abbasi Sarvin Sanaie Sama Rahnemayan Hamed Ebrahimzadeh Leylabadlo Source Type: research

Hydrogel Breakthroughs in Biomedicine: Recent Advances and Implications
The objective of this review is to present a succinct summary of the latest advancements in the utilization of hydrogels for diverse biomedical applications, with a particular focus on their revolutionary impact in augmenting the delivery of drugs, tissue engineering, along with diagnostic methodologies. Using a meticulous examination of current literary works, this review systematically scrutinizes the nascent patterns in applying hydrogels for biomedical progress, condensing crucial discoveries to offer a comprehensive outlook on their ever-changing importance. The analysis presents compelling evidence regarding the grow...
Source: Current Pharmaceutical Biotechnology - January 30, 2024 Category: Biotechnology Authors: Ravi K Mittal Raghav Mishra Rehan Uddin Vikram Sharma Source Type: research

Recent Advances in Pharmaceutical Design: Unleashing the Potential of Novel Therapeutics
Curr Pharm Biotechnol. 2024 Jan 29. doi: 10.2174/0113892010275850240102105033. Online ahead of print.ABSTRACTPharmaceutical design has made significant advancements in recent years, leading to the development of novel therapeutics with unprecedented efficacy and safety profiles. This review highlights the potential of these innovations to revolutionize healthcare and improve patient outcomes. The application of cutting-edge technologies like artificial intelligence, machine learning, and data mining in drug discovery and design has made it easier to find potential drug candidates. Combining big data and omics has led to th...
Source: Current Pharmaceutical Biotechnology - January 30, 2024 Category: Biotechnology Authors: Ram Narayan Prajapati Bharat Bhushan Kuldeep Singh Himansu Chopra Shivendra Kumar Mehak Agrawal Devender Pathak Dilip Kumar Chanchal None Laxmikant Source Type: research

Overcoming Low Adherence to Chronic Medications by Improving their Effectiveness Using a Personalized Second-generation Digital System
CONCLUSION: Improving clinically meaningful outcome measures and disease parameters may increase adherence and improve patients' response to therapy.PMID:38288794 | DOI:10.2174/0113892010269461240110060035 (Source: Current Pharmaceutical Biotechnology)
Source: Current Pharmaceutical Biotechnology - January 30, 2024 Category: Biotechnology Authors: Areej Bayatra Rima Nasserat Yaron Ilan Source Type: research

Emerging Therapeutic Approaches Targeting Ferroptosis in Cancer: Focus on Immunotherapy and Nanotechnology
Curr Pharm Biotechnol. 2024 Jan 26. doi: 10.2174/0113892010276664231228124157. Online ahead of print.ABSTRACTFerroptosis is a newly discovered form of programmed cell death characterized by iron overload, ROS accumulation, and lipid peroxidation. It is distinguished by unique morphological, biochemical, and genetic features and stands apart from other known regulated cell death mechanisms. Studies have demonstrated a close association between ferroptosis and various cancers, including liver cancer, lung cancer, renal cell carcinoma, colorectal cancer, pancreatic cancer, and ovarian cancer. Inducing ferroptosis has shown pr...
Source: Current Pharmaceutical Biotechnology - January 29, 2024 Category: Biotechnology Authors: Zongchao Yu Zhongcheng Mo Yuan Qiu Hengzhe Lu Biao Zheng Longfei Liu Source Type: research

Extrusion and Co-extrusion: A Technology in Probiotic Encapsulation with Alternative Materials
Curr Pharm Biotechnol. 2024 Jan 24. doi: 10.2174/0113892010264234231219073231. Online ahead of print.ABSTRACTEncapsulation, in particular extrusion and co-extrusion, is a common practice to protect probiotics from the harsh conditions of the digestive tract as well as processing. Hydrocolloids, including proteins and carbohydrates, natural or modified, are a group of ingredients used as the wall material in extrusion. Hydrocolloids, due to their specific properties, can significantly improve the probiotic survivability of the final powder during the microencapsulation process and storage. The present article will discuss t...
Source: Current Pharmaceutical Biotechnology - January 26, 2024 Category: Biotechnology Authors: Aziz Homayouni-Rad Amir M Mortazavian Hadi Pourjafar Saba Kamalledin Moghadam Source Type: research

Recent Approaches on Molecular Markers, Treatment and Novel Drug Delivery System Used for the Management of Colorectal Cancer: A Comprehensive Review
Curr Pharm Biotechnol. 2024 Jan 24. doi: 10.2174/0113892010270975231208113157. Online ahead of print.ABSTRACTColorectal cancer affects 1 in 25 females and 1 in 24 males, making it the third most frequent cancer with over 6,08,030 deaths worldwide, despite advancements in detection and treatments, including surgery, chemotherapeutics, radiotherapy, and immune therapeutics. Novel potential agents have increased survival in acute and chronic disease conditions, with a higher risk of side effects and cost. However, metastatic disease has an insignificant long-term diagnosis, and significant challenges remain due to last-stage ...
Source: Current Pharmaceutical Biotechnology - January 26, 2024 Category: Biotechnology Authors: Sonia Chauhan Sakshi Sharma Source Type: research

The Astonishing Accomplishment of Biological Drug Delivery using Lipid Nanoparticles: An Ubiquitous Review
Curr Pharm Biotechnol. 2024 Jan 23. doi: 10.2174/0113892010268824231122041237. Online ahead of print.ABSTRACTBiotech drugs, including proteins, hormones, enzymes, DNA/RNA therapies, and cell-based treatments, are gaining popularity due to their effectiveness. However, effective delivery systems are needed to overcome administration challenges. Lipid nanoparticles (LNPs) have emerged as promising carriers for various therapies. LNPs are biocompatible, less likely to cause adverse reactions, and can stabilize delicate biological drugs, enhancing their stability and solubility. Scalable and cost-effective manufacturing proces...
Source: Current Pharmaceutical Biotechnology - January 24, 2024 Category: Biotechnology Authors: Devesh Kapoor Shirisha C Chilkapalli Bhupendra G Prajapati Paul Rodriques Ravish Patel Sudarshan Singh Sankha Bhattacharya Source Type: research

The Impact of miR-122 on Cancer
Curr Pharm Biotechnol. 2024 Jan 22. doi: 10.2174/0113892010272106231109065912. Online ahead of print.ABSTRACTMiRNAs are confirmed to be a kind of short and eminently conserved noncoding RNAs, which regulate gene expression at the post-transcriptional level via binding to the 3'- untranslated region (3'-UTR) of targeting multiple target messenger RNAs. Recently, growing evidence stresses the point that they play a crucial role in a variety of pathological processes, including human cancers. Dysregulated miRNAs act as oncogenes or tumor suppressor genes in many cancer types. Among them, we noticed that miR-122 has been widel...
Source: Current Pharmaceutical Biotechnology - January 23, 2024 Category: Biotechnology Authors: Shijie Wu Yiwen Wu Sijun Deng Xiaoyong Lei Xiaoyan Yang Source Type: research

Industrial and Pharmaceutical Applications of Microbial Diversity of Hypersaline Ecology from Lonar Soda Crater
Curr Pharm Biotechnol. 2024 Jan 22. doi: 10.2174/0113892010265978231109085224. Online ahead of print.ABSTRACTThe unidentified geochemical and physiochemical characteristics of Soda Lakes across the globe make it a novel reservoir and bring attention to scientific civic for its conceivable industrial and pharmaceutical applications. In India, in the Maharashtra state, Lonar Lake is a naturally created Soda Lake by a meteorite impact. Phylogenetic data from this lake explored a diverse array of microorganisms like haloalkaliphilic bacteria and Archaea. Previously reported studies postulated the major microbial communities pr...
Source: Current Pharmaceutical Biotechnology - January 23, 2024 Category: Biotechnology Authors: Pradip Bawane Shirish Deshpande Santosh Yele Source Type: research

Obesity and its Relationship with Covid-19: A Review of the Main Pharmaceutical Aspects
Curr Pharm Biotechnol. 2024 Jan 22. doi: 10.2174/0113892010264503231108070917. Online ahead of print.ABSTRACTImportant physiological changes are observed in patients with obesity, such as intestinal permeability, gastric emptying, cardiac output, and hepatic and renal function. These differences can determine variations in the pharmacokinetics of different drugs and can generate different concentrations at the site of action, which can lead to sub therapeutic or toxic concentrations. Understanding the physiological and immunological processes that lead to the clinical manifestations of COVID-19 is essential to correlate ob...
Source: Current Pharmaceutical Biotechnology - January 23, 2024 Category: Biotechnology Authors: Katharine Hodel Ananda Fonseca Islania Barbosa Caio Medina Brenda Alves Carine Maciel Daniel Nascimento Gessualdo Oliveira-Junior Lorena Pedreira Monielly de Souza Ana Leonor Godoy Source Type: research