Enhancement in Biological Availability of Vitamins by Nano-engineering and its Applications: An Update
Curr Pharm Biotechnol. 2023 Nov 2. doi: 10.2174/0113892010251234231025085759. Online ahead of print.ABSTRACTVitamin nano-engineering has been accomplished by synthesizing various nanostructures to improve their stability, bioavailability, shelf life, and functioning. This review provides a detailed description of recent advances in the art of encapsulation with high efficiency through the use of practical and logistic nano-engineering techniques such as nanofibres, nanogels, nanobeads, nanotubes, nanoparticles, nanoliposomes, and many other nanostructures. To demonstrate the interaction of molecules with nano-forms, the bi...
Source: Current Pharmaceutical Biotechnology - November 8, 2023 Category: Biotechnology Authors: Sadhna Mishra Shalini Sahani Shikha Pandhi Arvind Kumar Dipendra Kumar Mahato Pradeep Kumar Kaustubh Chandrakant Khaire Ashutosh Rai Source Type: research

Insights into the Mechanism of Osteoporosis and the Available Treatment Options
Curr Pharm Biotechnol. 2023 Nov 2. doi: 10.2174/0113892010273783231027073117. Online ahead of print.ABSTRACTOsteoporosis, one of the most prevalent bone illnesses, majorly affects postmenopausal women and men over 50 years of age. Osteoporosis is associated with an increased susceptibility to fragility fractures and can result in persistent pain and significant impairment in affected individuals. The primary method for diagnosing osteoporosis involves the assessment of bone mineral density (BMD) through the utilisation of dual energy x-ray absorptiometry (DEXA). The integration of a fracture risk assessment algorithm with ...
Source: Current Pharmaceutical Biotechnology - November 8, 2023 Category: Biotechnology Authors: Rajeshwari Muniyasamy I Manjubala Source Type: research

Enhancement in Biological Availability of Vitamins by Nano-engineering and its Applications: An Update
Curr Pharm Biotechnol. 2023 Nov 2. doi: 10.2174/0113892010251234231025085759. Online ahead of print.ABSTRACTVitamin nano-engineering has been accomplished by synthesizing various nanostructures to improve their stability, bioavailability, shelf life, and functioning. This review provides a detailed description of recent advances in the art of encapsulation with high efficiency through the use of practical and logistic nano-engineering techniques such as nanofibres, nanogels, nanobeads, nanotubes, nanoparticles, nanoliposomes, and many other nanostructures. To demonstrate the interaction of molecules with nano-forms, the bi...
Source: Current Pharmaceutical Biotechnology - November 8, 2023 Category: Biotechnology Authors: Sadhna Mishra Shalini Sahani Shikha Pandhi Arvind Kumar Dipendra Kumar Mahato Pradeep Kumar Kaustubh Chandrakant Khaire Ashutosh Rai Source Type: research

Insights into the Mechanism of Osteoporosis and the Available Treatment Options
Curr Pharm Biotechnol. 2023 Nov 2. doi: 10.2174/0113892010273783231027073117. Online ahead of print.ABSTRACTOsteoporosis, one of the most prevalent bone illnesses, majorly affects postmenopausal women and men over 50 years of age. Osteoporosis is associated with an increased susceptibility to fragility fractures and can result in persistent pain and significant impairment in affected individuals. The primary method for diagnosing osteoporosis involves the assessment of bone mineral density (BMD) through the utilisation of dual energy x-ray absorptiometry (DEXA). The integration of a fracture risk assessment algorithm with ...
Source: Current Pharmaceutical Biotechnology - November 8, 2023 Category: Biotechnology Authors: Rajeshwari Muniyasamy I Manjubala Source Type: research

Enhancement in Biological Availability of Vitamins by Nano-engineering and its Applications: An Update
Curr Pharm Biotechnol. 2023 Nov 2. doi: 10.2174/0113892010251234231025085759. Online ahead of print.ABSTRACTVitamin nano-engineering has been accomplished by synthesizing various nanostructures to improve their stability, bioavailability, shelf life, and functioning. This review provides a detailed description of recent advances in the art of encapsulation with high efficiency through the use of practical and logistic nano-engineering techniques such as nanofibres, nanogels, nanobeads, nanotubes, nanoparticles, nanoliposomes, and many other nanostructures. To demonstrate the interaction of molecules with nano-forms, the bi...
Source: Current Pharmaceutical Biotechnology - November 8, 2023 Category: Biotechnology Authors: Sadhna Mishra Shalini Sahani Shikha Pandhi Arvind Kumar Dipendra Kumar Mahato Pradeep Kumar Kaustubh Chandrakant Khaire Ashutosh Rai Source Type: research

Insights into the Mechanism of Osteoporosis and the Available Treatment Options
Curr Pharm Biotechnol. 2023 Nov 2. doi: 10.2174/0113892010273783231027073117. Online ahead of print.ABSTRACTOsteoporosis, one of the most prevalent bone illnesses, majorly affects postmenopausal women and men over 50 years of age. Osteoporosis is associated with an increased susceptibility to fragility fractures and can result in persistent pain and significant impairment in affected individuals. The primary method for diagnosing osteoporosis involves the assessment of bone mineral density (BMD) through the utilisation of dual energy x-ray absorptiometry (DEXA). The integration of a fracture risk assessment algorithm with ...
Source: Current Pharmaceutical Biotechnology - November 8, 2023 Category: Biotechnology Authors: Rajeshwari Muniyasamy I Manjubala Source Type: research

Cubosomes: An Emerging and Promising Drug Delivery System for Enhancing Cancer Therapy
Curr Pharm Biotechnol. 2023 Oct 27. doi: 10.2174/0113892010257937231025065352. Online ahead of print.ABSTRACTCancer and other diseases can be treated with cubosomes, which are lyotropic nonlamellar liquid crystalline nanoparticles (LCNs). These cubosomes can potentially be a highly versatile carrier with theranostic efficacy, as they can be ingested, applied topically, or injected intravenously. Recent years have seen substantial progress in the synthesis, characterization, regulation of drug release patterns, and target selectivity of loaded anticancer bioactive compounds. However, its use in clinical settings has been sl...
Source: Current Pharmaceutical Biotechnology - November 6, 2023 Category: Biotechnology Authors: Smita Singh Kapil Sachan Suryakant Verma Nidhi Singh Pranjal Kumar Singh Source Type: research

Cubosomes: An Emerging and Promising Drug Delivery System for Enhancing Cancer Therapy
Curr Pharm Biotechnol. 2023 Oct 27. doi: 10.2174/0113892010257937231025065352. Online ahead of print.ABSTRACTCancer and other diseases can be treated with cubosomes, which are lyotropic nonlamellar liquid crystalline nanoparticles (LCNs). These cubosomes can potentially be a highly versatile carrier with theranostic efficacy, as they can be ingested, applied topically, or injected intravenously. Recent years have seen substantial progress in the synthesis, characterization, regulation of drug release patterns, and target selectivity of loaded anticancer bioactive compounds. However, its use in clinical settings has been sl...
Source: Current Pharmaceutical Biotechnology - November 6, 2023 Category: Biotechnology Authors: Smita Singh Kapil Sachan Suryakant Verma Nidhi Singh Pranjal Kumar Singh Source Type: research

N-acetylcysteine Attenuates Cigarette Smoke-induced Alveolar Epithelial Cell Apoptosis through Reactive Oxygen Species Depletion and Glutathione Replenish In vivo and In vitro
CONCLUSION: Our study confirmed that NAC can attenuate CS-induced AEC apoptosis via alleviating ROS-mediated ER stress and mitochondrial dysfunction pathway, and the mechanism was found to be related to replenishing the cellular GSH content.PMID:37921125 | DOI:10.2174/0113892010257526231019143524 (Source: Current Pharmaceutical Biotechnology)
Source: Current Pharmaceutical Biotechnology - November 3, 2023 Category: Biotechnology Authors: Jie Zhao Mi Han Yange Tian Peng Zhao Xuefang Liu Haoran Dong Suxiang Feng Jiansheng Li Source Type: research

Structure, Function, and Physicochemical Properties of Pore-forming Antimicrobial Peptides
Curr Pharm Biotechnol. 2023 Oct 25. doi: 10.2174/0113892010194428231017051836. Online ahead of print.ABSTRACTAntimicrobial peptides (AMPs), a class of antimicrobial agents, possess considerable potential to treat various microbial ailments. The broad range of activity and rare complete bacterial resistance to AMPs make them ideal candidates for commercial development. These peptides with widely varying compositions and sources share recurrent structural and functional features in mechanisms of action. Studying the mechanisms of AMP activity against bacteria may lead to the development of new antimicrobial agents that are m...
Source: Current Pharmaceutical Biotechnology - November 3, 2023 Category: Biotechnology Authors: Narjes Hosseini Goki Zeinab Amiri Tehranizadeh Mohammad Reza Saberi Bahman Khameneh Bibi Sedigheh Fazly Bazzaz Source Type: research

New Insights into Pharmaceutical Nanocrystals for the Improved Topical Delivery of Therapeutics in Various Skin Disorders
This article explores the preparation techniques, applications, and recent patents of nanocrystals for treating various skin conditions.PMID:37921127 | DOI:10.2174/0113892010276223231027075527 (Source: Current Pharmaceutical Biotechnology)
Source: Current Pharmaceutical Biotechnology - November 3, 2023 Category: Biotechnology Authors: Vanshita Singh Keshav Bansal Hemant Bhati Meenakshi Bajpai Source Type: research

Pharmacodynamics Research on Danggui-Shaoyao-San through Body Fluid Indexes of Spleen Deficiency-water Dampness Rats using Bioimpedance Technology
CONCLUSIONS: These findings suggest that using bio-impedance technology to measure body fluid indexes can pave a road for further exploring the molecular mechanism of the reason why the blood-activating and disinhibit-water split prescriptions in DSS are both effective in treating spleen deficiency-water dampness rats.PMID:37921128 | DOI:10.2174/0113892010243018231025065109 (Source: Current Pharmaceutical Biotechnology)
Source: Current Pharmaceutical Biotechnology - November 3, 2023 Category: Biotechnology Authors: Ran Chen Mo Yang Can Peng Dengke Yin Yunjing Zhang Fan Xu Source Type: research

The Cutting-edge of CRISPR for Cancer Treatment and its Future Prospects
Curr Pharm Biotechnol. 2023 Oct 25. doi: 10.2174/0113892010258617231020062637. Online ahead of print.ABSTRACTCRISPR (Clustered Regularly Interspaced Short Palindromic Repeats) is a versatile technology that allows precise modification of genes. One of its most promising applications is in cancer treatment. By targeting and editing specific genes involved in cancer development and progression, CRISPR has the potential to become a powerful tool in the fight against cancer. This review aims to assess the recent progress in CRISPR technology for cancer research and to examine the obstacles and potential strategies to address t...
Source: Current Pharmaceutical Biotechnology - November 3, 2023 Category: Biotechnology Authors: Liau Kah Man Ooi An Gie Mah Chian Huey Penny Yong Ling Siik Kee Loo Cheng Ze Tay Ming Yu Jhi Biau Foo Sharina Hamzah Source Type: research

N-acetylcysteine Attenuates Cigarette Smoke-induced Alveolar Epithelial Cell Apoptosis through Reactive Oxygen Species Depletion and Glutathione Replenish In vivo and In vitro
CONCLUSION: Our study confirmed that NAC can attenuate CS-induced AEC apoptosis via alleviating ROS-mediated ER stress and mitochondrial dysfunction pathway, and the mechanism was found to be related to replenishing the cellular GSH content.PMID:37921125 | DOI:10.2174/0113892010257526231019143524 (Source: Current Pharmaceutical Biotechnology)
Source: Current Pharmaceutical Biotechnology - November 3, 2023 Category: Biotechnology Authors: Jie Zhao Mi Han Yange Tian Peng Zhao Xuefang Liu Haoran Dong Suxiang Feng Jiansheng Li Source Type: research

Structure, Function, and Physicochemical Properties of Pore-forming Antimicrobial Peptides
Curr Pharm Biotechnol. 2023 Oct 25. doi: 10.2174/0113892010194428231017051836. Online ahead of print.ABSTRACTAntimicrobial peptides (AMPs), a class of antimicrobial agents, possess considerable potential to treat various microbial ailments. The broad range of activity and rare complete bacterial resistance to AMPs make them ideal candidates for commercial development. These peptides with widely varying compositions and sources share recurrent structural and functional features in mechanisms of action. Studying the mechanisms of AMP activity against bacteria may lead to the development of new antimicrobial agents that are m...
Source: Current Pharmaceutical Biotechnology - November 3, 2023 Category: Biotechnology Authors: Narjes Hosseini Goki Zeinab Amiri Tehranizadeh Mohammad Reza Saberi Bahman Khameneh Bibi Sedigheh Fazly Bazzaz Source Type: research