Micrornas in Anticancer Drugs Hepatotoxicity: From Pathogenic Mechanism and Early Diagnosis to Therapeutic Targeting by Natural Products
Curr Pharm Biotechnol. 2024 Jan 4. doi: 10.2174/0113892010282155231222071903. Online ahead of print.ABSTRACTPatients receiving cancer therapies experience severe adverse effects, including hepatotoxicity, even at therapeutic doses. Consequently, monitoring patients on cancer therapy for hepatic functioning is necessary to avoid permanent liver damage. Several pathways of anticancer drug-induced hepatotoxicity involve microRNAs (miRNAs) via targeting mRNAs. These short and non-coding RNAs undergo rapid modulation in non-targeted organs due to cancer therapy insults. Recently, there has been an interest for miRNAs as useful ...
Source: Current Pharmaceutical Biotechnology - January 5, 2024 Category: Biotechnology Authors: Hebatallah Husseini Atteia Source Type: research

Recent Advances in the Preparation of Protein/peptide Microspheres by Solvent Evaporation Method
Curr Pharm Biotechnol. 2024 Jan 4. doi: 10.2174/0113892010261032231214115415. Online ahead of print.ABSTRACTProtein/peptide drugs are extensively used to treat various chronic and serious diseases. The short half-life in vivo of protein and peptide as therapeutics drug limit the realization of complete effects. Encapsulating drugs in microspheres can slow the speed of drug release and prolong the efficacy of drugs. The solvent evaporation method is widely used to prepare protein/peptide microspheres because of its facile operation and minimal equipment requirements. This method has several challenges in the lower encapsula...
Source: Current Pharmaceutical Biotechnology - January 5, 2024 Category: Biotechnology Authors: Huayan Sun Weiwei Luo Xiaowu Huang Source Type: research

Pharmacological Action and Research Progress of Taraxasterol
Curr Pharm Biotechnol. 2024 Jan 4. doi: 10.2174/0113892010276692231220103636. Online ahead of print.ABSTRACTPrimarily sourced from Asteraceae family herbs such as the Dandelion, Taraxasterol is a pentacyclic triterpenoid lauded for its extensive biological functionalities. Its therapeutic potency is demonstrated in various disease models, encompassing enteritis, arthritis, acute hepatic injury, and pneumonia. Scientific literature underscores its anti-inflammatory, antioxidant, and antineoplastic attributes. The primary aim of this study is to thoroughly explore the diseasemodulating mechanisms and effects of taraxasterol....
Source: Current Pharmaceutical Biotechnology - January 5, 2024 Category: Biotechnology Authors: Yu Zhang Ramizu Bin Shaari Mohamad Arif Bin Awang Nawi Akram Bin Hassan Caiyun Cui Source Type: research

Micrornas in Anticancer Drugs Hepatotoxicity: From Pathogenic Mechanism and Early Diagnosis to Therapeutic Targeting by Natural Products
Curr Pharm Biotechnol. 2024 Jan 4. doi: 10.2174/0113892010282155231222071903. Online ahead of print.ABSTRACTPatients receiving cancer therapies experience severe adverse effects, including hepatotoxicity, even at therapeutic doses. Consequently, monitoring patients on cancer therapy for hepatic functioning is necessary to avoid permanent liver damage. Several pathways of anticancer drug-induced hepatotoxicity involve microRNAs (miRNAs) via targeting mRNAs. These short and non-coding RNAs undergo rapid modulation in non-targeted organs due to cancer therapy insults. Recently, there has been an interest for miRNAs as useful ...
Source: Current Pharmaceutical Biotechnology - January 5, 2024 Category: Biotechnology Authors: Hebatallah Husseini Atteia Source Type: research

Recent Advances in the Preparation of Protein/peptide Microspheres by Solvent Evaporation Method
Curr Pharm Biotechnol. 2024 Jan 4. doi: 10.2174/0113892010261032231214115415. Online ahead of print.ABSTRACTProtein/peptide drugs are extensively used to treat various chronic and serious diseases. The short half-life in vivo of protein and peptide as therapeutics drug limit the realization of complete effects. Encapsulating drugs in microspheres can slow the speed of drug release and prolong the efficacy of drugs. The solvent evaporation method is widely used to prepare protein/peptide microspheres because of its facile operation and minimal equipment requirements. This method has several challenges in the lower encapsula...
Source: Current Pharmaceutical Biotechnology - January 5, 2024 Category: Biotechnology Authors: Huayan Sun Weiwei Luo Xiaowu Huang Source Type: research

Pharmacological Action and Research Progress of Taraxasterol
Curr Pharm Biotechnol. 2024 Jan 4. doi: 10.2174/0113892010276692231220103636. Online ahead of print.ABSTRACTPrimarily sourced from Asteraceae family herbs such as the Dandelion, Taraxasterol is a pentacyclic triterpenoid lauded for its extensive biological functionalities. Its therapeutic potency is demonstrated in various disease models, encompassing enteritis, arthritis, acute hepatic injury, and pneumonia. Scientific literature underscores its anti-inflammatory, antioxidant, and antineoplastic attributes. The primary aim of this study is to thoroughly explore the diseasemodulating mechanisms and effects of taraxasterol....
Source: Current Pharmaceutical Biotechnology - January 5, 2024 Category: Biotechnology Authors: Yu Zhang Ramizu Bin Shaari Mohamad Arif Bin Awang Nawi Akram Bin Hassan Caiyun Cui Source Type: research

Micrornas in Anticancer Drugs Hepatotoxicity: From Pathogenic Mechanism and Early Diagnosis to Therapeutic Targeting by Natural Products
Curr Pharm Biotechnol. 2024 Jan 4. doi: 10.2174/0113892010282155231222071903. Online ahead of print.ABSTRACTPatients receiving cancer therapies experience severe adverse effects, including hepatotoxicity, even at therapeutic doses. Consequently, monitoring patients on cancer therapy for hepatic functioning is necessary to avoid permanent liver damage. Several pathways of anticancer drug-induced hepatotoxicity involve microRNAs (miRNAs) via targeting mRNAs. These short and non-coding RNAs undergo rapid modulation in non-targeted organs due to cancer therapy insults. Recently, there has been an interest for miRNAs as useful ...
Source: Current Pharmaceutical Biotechnology - January 5, 2024 Category: Biotechnology Authors: Hebatallah Husseini Atteia Source Type: research

Recent Advances in the Preparation of Protein/peptide Microspheres by Solvent Evaporation Method
Curr Pharm Biotechnol. 2024 Jan 4. doi: 10.2174/0113892010261032231214115415. Online ahead of print.ABSTRACTProtein/peptide drugs are extensively used to treat various chronic and serious diseases. The short half-life in vivo of protein and peptide as therapeutics drug limit the realization of complete effects. Encapsulating drugs in microspheres can slow the speed of drug release and prolong the efficacy of drugs. The solvent evaporation method is widely used to prepare protein/peptide microspheres because of its facile operation and minimal equipment requirements. This method has several challenges in the lower encapsula...
Source: Current Pharmaceutical Biotechnology - January 5, 2024 Category: Biotechnology Authors: Huayan Sun Weiwei Luo Xiaowu Huang Source Type: research

Pharmacological Action and Research Progress of Taraxasterol
Curr Pharm Biotechnol. 2024 Jan 4. doi: 10.2174/0113892010276692231220103636. Online ahead of print.ABSTRACTPrimarily sourced from Asteraceae family herbs such as the Dandelion, Taraxasterol is a pentacyclic triterpenoid lauded for its extensive biological functionalities. Its therapeutic potency is demonstrated in various disease models, encompassing enteritis, arthritis, acute hepatic injury, and pneumonia. Scientific literature underscores its anti-inflammatory, antioxidant, and antineoplastic attributes. The primary aim of this study is to thoroughly explore the diseasemodulating mechanisms and effects of taraxasterol....
Source: Current Pharmaceutical Biotechnology - January 5, 2024 Category: Biotechnology Authors: Yu Zhang Ramizu Bin Shaari Mohamad Arif Bin Awang Nawi Akram Bin Hassan Caiyun Cui Source Type: research

Micrornas in Anticancer Drugs Hepatotoxicity: From Pathogenic Mechanism and Early Diagnosis to Therapeutic Targeting by Natural Products
Curr Pharm Biotechnol. 2024 Jan 4. doi: 10.2174/0113892010282155231222071903. Online ahead of print.ABSTRACTPatients receiving cancer therapies experience severe adverse effects, including hepatotoxicity, even at therapeutic doses. Consequently, monitoring patients on cancer therapy for hepatic functioning is necessary to avoid permanent liver damage. Several pathways of anticancer drug-induced hepatotoxicity involve microRNAs (miRNAs) via targeting mRNAs. These short and non-coding RNAs undergo rapid modulation in non-targeted organs due to cancer therapy insults. Recently, there has been an interest for miRNAs as useful ...
Source: Current Pharmaceutical Biotechnology - January 5, 2024 Category: Biotechnology Authors: Hebatallah Husseini Atteia Source Type: research

Recent Advances in the Preparation of Protein/peptide Microspheres by Solvent Evaporation Method
Curr Pharm Biotechnol. 2024 Jan 4. doi: 10.2174/0113892010261032231214115415. Online ahead of print.ABSTRACTProtein/peptide drugs are extensively used to treat various chronic and serious diseases. The short half-life in vivo of protein and peptide as therapeutics drug limit the realization of complete effects. Encapsulating drugs in microspheres can slow the speed of drug release and prolong the efficacy of drugs. The solvent evaporation method is widely used to prepare protein/peptide microspheres because of its facile operation and minimal equipment requirements. This method has several challenges in the lower encapsula...
Source: Current Pharmaceutical Biotechnology - January 5, 2024 Category: Biotechnology Authors: Huayan Sun Weiwei Luo Xiaowu Huang Source Type: research

Pharmacological Action and Research Progress of Taraxasterol
Curr Pharm Biotechnol. 2024 Jan 4. doi: 10.2174/0113892010276692231220103636. Online ahead of print.ABSTRACTPrimarily sourced from Asteraceae family herbs such as the Dandelion, Taraxasterol is a pentacyclic triterpenoid lauded for its extensive biological functionalities. Its therapeutic potency is demonstrated in various disease models, encompassing enteritis, arthritis, acute hepatic injury, and pneumonia. Scientific literature underscores its anti-inflammatory, antioxidant, and antineoplastic attributes. The primary aim of this study is to thoroughly explore the diseasemodulating mechanisms and effects of taraxasterol....
Source: Current Pharmaceutical Biotechnology - January 5, 2024 Category: Biotechnology Authors: Yu Zhang Ramizu Bin Shaari Mohamad Arif Bin Awang Nawi Akram Bin Hassan Caiyun Cui Source Type: research

Micrornas in Anticancer Drugs Hepatotoxicity: From Pathogenic Mechanism and Early Diagnosis to Therapeutic Targeting by Natural Products
Curr Pharm Biotechnol. 2024 Jan 4. doi: 10.2174/0113892010282155231222071903. Online ahead of print.ABSTRACTPatients receiving cancer therapies experience severe adverse effects, including hepatotoxicity, even at therapeutic doses. Consequently, monitoring patients on cancer therapy for hepatic functioning is necessary to avoid permanent liver damage. Several pathways of anticancer drug-induced hepatotoxicity involve microRNAs (miRNAs) via targeting mRNAs. These short and non-coding RNAs undergo rapid modulation in non-targeted organs due to cancer therapy insults. Recently, there has been an interest for miRNAs as useful ...
Source: Current Pharmaceutical Biotechnology - January 5, 2024 Category: Biotechnology Authors: Hebatallah Husseini Atteia Source Type: research

Recent Advances in the Preparation of Protein/peptide Microspheres by Solvent Evaporation Method
Curr Pharm Biotechnol. 2024 Jan 4. doi: 10.2174/0113892010261032231214115415. Online ahead of print.ABSTRACTProtein/peptide drugs are extensively used to treat various chronic and serious diseases. The short half-life in vivo of protein and peptide as therapeutics drug limit the realization of complete effects. Encapsulating drugs in microspheres can slow the speed of drug release and prolong the efficacy of drugs. The solvent evaporation method is widely used to prepare protein/peptide microspheres because of its facile operation and minimal equipment requirements. This method has several challenges in the lower encapsula...
Source: Current Pharmaceutical Biotechnology - January 5, 2024 Category: Biotechnology Authors: Huayan Sun Weiwei Luo Xiaowu Huang Source Type: research

Potential Impact of Bioactive Compounds as NLRP3 Inflammasome Inhibitors: An Update
Curr Pharm Biotechnol. 2024 Jan 1. doi: 10.2174/0113892010276859231125165251. Online ahead of print.ABSTRACTThe inflammasome NLRP3 comprises a caspase recruitment domain, a pyrin domain containing receptor 3, an apoptosis-linked protein like a speck containing a procaspase-1, and an attached nucleotide domain leucine abundant repeat. There are a wide variety of stimuli that can activate the inflammasome NLRP3. When activated, the protein NLRP3 appoints the adapter protein ASC. Adapter ASC protein then recruits the procaspase-1 protein, which causes the procaspase- 1 protein to be cleaved and activated, which induces cytoki...
Source: Current Pharmaceutical Biotechnology - January 4, 2024 Category: Biotechnology Authors: Sonia Singh Shiwangi Sharma Himanshu Sharma Source Type: research