Histone deacetylase 3 deletion in alveolar type 2 epithelial cells prevents bleomycin-induced pulmonary fibrosis
Epithelial mesenchymal transformation (EMT) in alveolar type 2 epithelial cells (AT2) is closely associated with pulmonary fibrosis (PF). Histone deacetylase 3 (HDAC3) is an important enzyme that regulates pro... (Source: Clinical Epigenetics)
Source: Clinical Epigenetics - November 11, 2023 Category: Research Authors: Rui Xiong, Boxin Geng, Wenyang Jiang, Yong Hu, Zhaoyu Hu, Bo Hao, Ning Li and Qing Geng Tags: Research Source Type: research
DNA methylation sites in early adulthood characterised by pubertal timing and development: a twin study
Puberty is a highly heritable and variable trait, with environmental factors having a role in its eventual timing and development. Early and late pubertal onset are both associated with various diseases develo... (Source: Clinical Epigenetics)
Source: Clinical Epigenetics - November 10, 2023 Category: Research Authors: Emir Sehovic, Stephanie M. Zellers, Markus K. Youssef, Aino Heikkinen, Jaakko Kaprio and Miina Ollikainen Tags: Research Source Type: research
Tazemetostat decreases β-catenin and CD13 protein expression in HEPG-2 and Hepatitis B virus-transfected HEPG-2 with decreased cell viability
Hepatocellular carcinoma (HCC) is one of the global health concerns. Hepatitis B virus (HBV) is one of the major causes of HCC. Poor clinical outcome of HCC patients is attributed to a small population of canc... (Source: Clinical Epigenetics)
Source: Clinical Epigenetics - November 8, 2023 Category: Research Authors: Mohamed N. Amin, Yousra M. El-Far, Mohammed El-Mowafy and Abdelaziz Elgaml Tags: Research Source Type: research
Upregulation of RSPO3 via targeted promoter DNA demethylation inhibits the progression of cholangiocarcinoma
Cholangiocarcinoma (CCA) refers to a collection of malignant tumors that develop from the biliary epithelium. Extensive clinical evidence and epidemiological observations indicate a concerning increase in both... (Source: Clinical Epigenetics)
Source: Clinical Epigenetics - November 7, 2023 Category: Research Authors: Guanhua Wu, Da Wang, Fei Xiong, Wenzheng Liu, Qi Wang, Junsheng Chen, Bing Wang and Yongjun Chen Tags: Research Source Type: research
Abnormal expression of PRKAG2-AS results in dysfunction of cardiomyocytes through regulating PRKAG2 transcription by interacting with PPARG
In this study, we investigated the role of the lncRNA PRKAG2-AS, w... (Source: Clinical Epigenetics)
Source: Clinical Epigenetics - November 7, 2023 Category: Research Authors: Xiao-Wei Song, Ting Su, Bo Li, Yun-Jie Huang, Wen-Xia He, Li-Li Jiang, Chang-Jin Li, Song-Qun Huang, Song-Hua Li, Zhi-Fu Guo, Hong Wu and Bi-Li Zhang Tags: Research Source Type: research
Retraction Note: Dissecting the role of novel EZH2 inhibitors in primary glioblastoma cell cultures: effects on proliferation, epithelialmesenchymal transition, migration, and on the pro-inflammatory phenotype
(Source: Clinical Epigenetics)
Source: Clinical Epigenetics - November 7, 2023 Category: Research Authors: Giulia Stazi, Ludovica Taglieri, Alice Nicolai, Annalisa Romanelli, Rossella Fioravanti, Stefania Morrone, Manuela Sabatino, Rino Ragno, Samanta Taurone, Marcella Nebbioso, Raffaella Carletti, Marco Artico, Sergio Valente, Susanna Scarpa and Antonello Mai Tags: Retraction Note Source Type: research
Epigenetics insights from perceived facial aging
Facial aging is the most visible manifestation of aging. People desire to look younger than others of the same chronological age. Hence, perceived age is often used as a visible marker of aging, while biologic... (Source: Clinical Epigenetics)
Source: Clinical Epigenetics - November 3, 2023 Category: Research Authors: Klemo Vladimir, Marija Majda Peri šić, Mario Štorga, Ali Mostashari and Raya Khanin Tags: Research Source Type: research
Herbal medicine formula Huazhuo Tiaozhi granule ameliorates dyslipidaemia via regulating histone lactylation and miR-155-5p biogenesis
Huazhuo Tiaozhi granule (HTG) is a herbal medicine formula widely used in clinical practice for hypolipidaemic effects. However, the molecular mechanisms underlying dyslipidaemia treatment have not been well e... (Source: Clinical Epigenetics)
Source: Clinical Epigenetics - November 2, 2023 Category: Research Authors: Xiangjun Yin, Min Li, Yongzhi Wang, Guifang Zhao, Tao Yang, Yuqing Zhang, Jianbo Guo, Tiantian Meng, Ruolin Du, Honglin Li, Zhe Wang, Jian Zhang and Qingyong He Tags: Research Source Type: research
Profound DNA methylomic differences between single- and multi-fraction alpha irradiations of lung fibroblasts
Alpha ( α)-radiation is a ubiquitous environmental agent with epigenotoxic effects. Human exposure to α-radiation at potentially harmful levels can occur repetitively over the long term via inhalation of natura... (Source: Clinical Epigenetics)
Source: Clinical Epigenetics - October 27, 2023 Category: Research Authors: Marilyn N. Vera-Chang, John M. Danforth, Marilyne Stuart, Aaron A. Goodarzi, Marjorie Brand and Richard B. Richardson Tags: Research Source Type: research
Peripheral blood DNA methylation and neuroanatomical responses to HDACi treatment that rescues neurological deficits in a Kabuki syndrome mouse model
Recent findings from studies of mouse models of Mendelian disorders of epigenetic machinery strongly support the potential for postnatal therapies to improve neurobehavioral and cognitive deficits. As several ... (Source: Clinical Epigenetics)
Source: Clinical Epigenetics - October 27, 2023 Category: Research Authors: Sarah Jessica Goodman, Teresa Romeo Luperchio, Jacob Ellegood, Eric Chater-Diehl, Jason P. Lerch, Hans Tomas Bjornsson and Rosanna Weksberg Tags: Research Source Type: research
Multi-tissue epigenetic analysis identifies distinct associations underlying insulin resistance and Alzheimer ’s disease at CPT1A locus
Insulin resistance (IR) is a major risk factor for Alzheimer ’s disease (AD) dementia. The mechanisms by which IR predisposes to AD are not well-understood. Epigenetic studies may help identify molecular signat... (Source: Clinical Epigenetics)
Source: Clinical Epigenetics - October 27, 2023 Category: Research Authors: Chlo é Sarnowski, Tianxiao Huan, Yiyi Ma, Roby Joehanes, Alexa Beiser, Charles S. DeCarli, Nancy L. Heard-Costa, Daniel Levy, Honghuang Lin, Ching-Ti Liu, Chunyu Liu, James B. Meigs, Claudia L. Satizabal, Jose C. Florez, Marie-France Hivert, Josée Dupui Tags: Research Source Type: research
Predictive value of DNA methylation patterns in AML patients treated with an azacytidine containing induction regimen
Acute myeloid leukemia (AML) is a heterogeneous disease with a poor prognosis. Dysregulation of the epigenetic machinery is a significant contributor to disease development. Some AML patients benefit from trea... (Source: Clinical Epigenetics)
Source: Clinical Epigenetics - October 26, 2023 Category: Research Authors: Maximilian Schmutz, Manuela Zucknick, Richard F. Schlenk, Daniel Mertens, Axel Benner, Dieter Weichenhan, Oliver M ücke, Konstanze Döhner, Christoph Plass, Lars Bullinger and Rainer Claus Tags: Research Source Type: research
N6-methyladenosine methylation in kidney injury
Multiple mechanisms are involved in kidney damage, among which the role of epigenetic modifications in the occurrence and development of kidney diseases is constantly being revealed. However, N6-methyladenosin... (Source: Clinical Epigenetics)
Source: Clinical Epigenetics - October 21, 2023 Category: Research Authors: Qimeng Wang, Xiaoting Fan, Qinghao Sheng, Meilin Yang, Ping Zhou, Shangwei Lu, Ying Gao, Zhijuan Kong, Ning Shen, Zhimei Lv and Rong Wang Tags: Review Source Type: research
Further refinement of the differentially methylated distant lung-specific FOXF1 enhancer in a neonate with alveolar capillary dysplasia
Heterozygous SNVs or CNV deletions involving the FOXF1 gene, or its distant enhancer, are causative for 80 –90% of cases of alveolar capillary dysplasia with misalignment of pulmonary veins. Recently, we proposed ... (Source: Clinical Epigenetics)
Source: Clinical Epigenetics - October 21, 2023 Category: Research Authors: Przemyslaw Szafranski, Rijutha P. Garimella, Haresh Mani, Ryan Hartman, Gail Deutsch, Alan Silk, Alan Benheim and Pawe ł Stankiewicz Tags: Research Source Type: research
Metabolomic biomarkers of habitual B vitamin intakes unveil novel differentially methylated positions in the human epigenome
B vitamins such as folate (B9), B6, and B12 are key in one carbon metabolism, which generates methyl donors for DNA methylation. Several studies have linked differential methylation to self-reported intakes of... (Source: Clinical Epigenetics)
Source: Clinical Epigenetics - October 19, 2023 Category: Research Authors: Ricardo Costeira, Laila Evangelista, Rory Wilson, Xinyu Yan, Fabian Hellbach, Lucy Sinke, Colette Christiansen, Sergio Villica ña, Olatz M. Masachs, Pei-Chien Tsai, Massimo Mangino, Cristina Menni, Sarah E. Berry, Marian Beekman, Diana van Heemst, P. Eli Tags: Research Source Type: research
