Kidney-specific methylation patterns correlate with kidney function and are lost upon kidney disease progression
Chronological and biological age correlate with DNA methylation levels at specific sites in the genome. Linear combinations of multiple methylation sites, termed epigenetic clocks, can inform us the chronologi... (Source: Clinical Epigenetics)
Source: Clinical Epigenetics - February 12, 2024 Category: Research Authors: Naor Sagy, Noa Meyrom, Pazit Beckerman, Oren Pleniceanu and Daniel Z. Bar Tags: Research Source Type: research
Molecular map of disulfidptosis-related genes in lung adenocarcinoma: the perspective toward immune microenvironment and prognosis
Disulfidptosis is a recently discovered form of programmed cell death that could impact cancer development. Nevertheless, the prognostic significance of disulfidptosis-related genes (DRGs) in lung adenocarcino... (Source: Clinical Epigenetics)
Source: Clinical Epigenetics - February 11, 2024 Category: Research Authors: Fangchao Zhao, Lei Su, Xuefeng Wang, Jiusong Luan, Xin Zhang, Yishuai Li, Shujun Li and Ling Hu Tags: Research Source Type: research
Tissue of origin prediction for cancer of unknown primary using a targeted methylation sequencing panel
Cancer of unknown primary (CUP) is a group of rare malignancies with poor prognosis and unidentifiable tissue-of-origin. Distinct DNA methylation patterns in different tissues and cancer types enable the ident... (Source: Clinical Epigenetics)
Source: Clinical Epigenetics - February 9, 2024 Category: Research Authors: Miaomiao Sun, Bo Xu, Chao Chen, Youjie Zhu, Xiaomo Li and Kuisheng Chen Tags: Research Source Type: research
The interaction between DNA methylation and tumor immune microenvironment: from the laboratory to clinical applications
DNA methylation is a pivotal epigenetic modification that affects gene expression. Tumor immune microenvironment (TIME) comprises diverse immune cells and stromal components, creating a complex landscape that ... (Source: Clinical Epigenetics)
Source: Clinical Epigenetics - February 8, 2024 Category: Research Authors: Daoqi Zhu, Siying Zeng, Chao Su, Jingjun Li, Yiwen Xuan, Yongkai Lin, Enwu Xu and Qin Fan Tags: Review Source Type: research
Self-control is associated with health-relevant disparities in buccal DNA-methylation measures of biological aging in older adults
Self-control is a personality dimension that is associated with better physical health and a longer lifespan. Here, we examined (1) whether self-control is associated with buccal and saliva DNA-methylation (DN... (Source: Clinical Epigenetics)
Source: Clinical Epigenetics - February 8, 2024 Category: Research Authors: Y. E. Willems, A. deSteiguer, P. T. Tanksley, L. Vinnik, D. Fraemke, A. Okbay, D. Richter, G. G. Wagner, R. Hertwig, P. Koellinger, E. M. Tucker-Drob, K. P. Harden and Laurel Raffington Tags: Research Source Type: research
Correction: A transgenic mice model of retinopathy of cblG ‑type inherited disorder of one‑carbon metabolism highlights epigenome‑wide alterations related to cone photoreceptor cells development and retinal metabolism
(Source: Clinical Epigenetics)
Source: Clinical Epigenetics - February 8, 2024 Category: Research Authors: Karim Matmat, Jean-Baptiste Conart, Paul-Henri Graindorge, Sandra El Kouche, Ziad Hassan, Youssef Siblini, R émy Umoret, Ramia Safar, Okan Baspinar, Aurélie Robert, Jean-Marc Alberto, Abderrahim Oussalah, Sébastien Hergalant, David Coelho, Jean-Louis G Tags: Correction Source Type: research
Per-cell histone acetylation is associated with terminal differentiation in human T cells
Epigenetic remodeling at effector gene loci has been reported to be critical in regulating T cell differentiation and function. However, efforts to investigate underlying epigenetic mechanisms that control T c... (Source: Clinical Epigenetics)
Source: Clinical Epigenetics - February 6, 2024 Category: Research Authors: Cheng Yang, You Li, Yaqiu Hu, Qian Li, Yinghua Lan and Yongguo Li Tags: Research Source Type: research
Epigenetics of prenatal stress in humans: the current research landscape
Fetal exposure to prenatal stress can have significant consequences on short- and long-term health. Epigenetic mechanisms, especially DNA methylation (DNAm), are a possible process how these adverse environmen... (Source: Clinical Epigenetics)
Source: Clinical Epigenetics - February 2, 2024 Category: Research Authors: Linda Dieckmann and Darina Czamara Tags: Review Source Type: research
Identification of DNA methylation biomarkers for evaluating cardiovascular disease risk from epigenome profiles altered by low-dose ionizing radiation
Environmental exposure, medical diagnostic and therapeutic applications, and industrial utilization of radionuclides have prompted a growing focus on the risks associated with low-dose radiation ( (Source: Clinical Epigenetics)
Source: Clinical Epigenetics - February 1, 2024 Category: Research Authors: Jihye Park, Hae-June Lee, Yu Kyeong Han, Keunsoo Kang and Joo Mi Yi Tags: Research Source Type: research
METTL3 promotes osteoblast ribosome biogenesis and alleviates periodontitis
Periodontitis is a highly prevalent oral disease characterized by bacterium-induced periodontal inflammation and alveolar bone destruction. Osteoblast function is impaired in periodontitis with a global proteo... (Source: Clinical Epigenetics)
Source: Clinical Epigenetics - January 24, 2024 Category: Research Authors: Yiwen Zhang, Yiping Kong, Wenjie Zhang, Jinlin He, Zhanqi Zhang, Yongjie Cai, Yiqing Zhao and Qiong Xu Tags: Research Source Type: research
The predictive value of BTG1 for the response of newly diagnosed acute myeloid leukemia to decitabine
This study aimed to identify markers for predicting t... (Source: Clinical Epigenetics)
Source: Clinical Epigenetics - January 22, 2024 Category: Research Authors: Yi Li, Xia Mao, Mengyuan Li, Li Li, Xiwen Tong and Lifang Huang Tags: Research Source Type: research
MethScore as a new comprehensive DNA methylation-based value refining the prognosis in acute myeloid leukemia
Changes in DNA methylation are common events in the pathogenesis of acute myeloid leukemia (AML) and have been repeatedly reported as associated with prognosis. However, studies integrating these numerous and ... (Source: Clinical Epigenetics)
Source: Clinical Epigenetics - January 22, 2024 Category: Research Authors: Šárka Šestáková, Cyril Šálek, Dávid Kundrát, Ela Cerovská, Jan Vydra, Ivana Ježíšková, Adam Folta, Jiří Mayer, Petr Cetkovský and Hana Remešová Tags: Research Source Type: research
Integrative analysis identifies gene signatures mediating the effect of DNA methylation on asthma severity and lung function
DNA methylation (DNAm) changes play a key role in regulating gene expression in asthma. To investigate the role of epigenetics and transcriptomics change in asthma, we used publicly available DNAm (asthmatics, n ... (Source: Clinical Epigenetics)
Source: Clinical Epigenetics - January 20, 2024 Category: Research Authors: Eskezeia Y. Dessie, Lili Ding and Tesfaye B. Mersha Tags: Research Source Type: research
YAP represses intestinal inflammation through epigenetic silencing of JMJD3
Epigenetics plays an important role in the pathogenesis of inflammatory bowel disease (IBD). Some studies have reported that YAP is involved in inflammatory response and can regulate target genes through epige... (Source: Clinical Epigenetics)
Source: Clinical Epigenetics - January 20, 2024 Category: Research Authors: Hua Zhu, Jiali Lu, MingYue Fu, Ping Chen, Yali Yu, Min Chen, Qiu Zhao, Min Wu and Mei Ye Tags: Research Source Type: research
Pancreatic cancer acquires resistance to MAPK pathway inhibition by clonal expansion and adaptive DNA hypermethylation
Pancreatic ductal adenocarcinoma (PDAC) is an aggressive cancer with poor prognosis. It is marked by extraordinary resistance to conventional therapies including chemotherapy and radiation, as well as to essen... (Source: Clinical Epigenetics)
Source: Clinical Epigenetics - January 16, 2024 Category: Research Authors: Laura K. Godfrey, Jan Forster, Sven-Thorsten Liffers, Christopher Schr öder, Johannes Köster, Leonie Henschel, Kerstin U. Ludwig, David Lähnemann, Marija Trajkovic-Arsic, Diana Behrens, Aldo Scarpa, Rita T. Lawlor, Kathrin E. Witzke, Barbara Sitek, Ste Tags: Research Source Type: research
