A quantum physics layer of epigenetics: a hypothesis deduced from charge transfer and chirality-induced spin selectivity of DNA
Epigenetic mechanisms are informational cellular processes instructing normal and diseased phenotypes. They are associated with DNA but without altering the DNA sequence. Whereas chemical processes like DNA me... (Source: Clinical Epigenetics)
Source: Clinical Epigenetics - September 8, 2023 Category: Research Authors: Reiner Siebert, Ole Ammerpohl, Mirko Rossini, Dennis Herb, Sven Rau, Martin B. Plenio, Fedor Jelezko and Joachim Ankerhold Tags: Hypothesis Source Type: research
Altered H3K4me3 profile at the TFAM promoter causes mitochondrial alterations in preadipocytes from first-degree relatives of type 2 diabetics
First-degree relatives of type 2 diabetics (FDR) exhibit a high risk of developing type 2 diabetes (T2D) and feature subcutaneous adipocyte hypertrophy, independent of obesity. In FDR, adipose cell abnormaliti... (Source: Clinical Epigenetics)
Source: Clinical Epigenetics - September 7, 2023 Category: Research Authors: Michele Longo, Federica Zatterale, Rosa Spinelli, Jamal Naderi, Luca Parrillo, Pasqualina Florese, Cecilia Nigro, Alessia Leone, Augusta Moccia, Antonella Desiderio, Gregory A. Raciti, Claudia Miele, Ulf Smith and Francesco Beguinot Tags: Research Source Type: research
Correction: Long-term environmental metal exposure is associated with hypomethylation of CpG sites in NFKB1 and other genes related to oncogenesis
(Source: Clinical Epigenetics)
Source: Clinical Epigenetics - September 5, 2023 Category: Research Authors: Ani Stepanyan, Anna Petrackova, Siras Hakobyan, Jakub Savara, Suren Davitavyan, Eva Kriegova and Arsen Arakelyan Tags: Correction Source Type: research
Evaluation of pediatric epigenetic clocks across multiple tissues
Epigenetic clocks are promising tools for assessing biological age. We assessed the accuracy of pediatric epigenetic clocks in gestational and chronological age determination. (Source: Clinical Epigenetics)
Source: Clinical Epigenetics - September 2, 2023 Category: Research Authors: Fang Fang, Linran Zhou, Wei Perng, Carmen J. Marsit, Anna K. Knight, Andres Cardenas, Max T. Aung, Marie-France Hivert, Izzuddin M. Aris, Jaclyn M. Goodrich, Alicia K. Smith, Abigail Gaylord, Rebecca C. Fry, Emily Oken, George O ’Connor, Douglas M. Rude Tags: Research Source Type: research
Fathers ’ preconception smoking and offspring DNA methylation
Experimental studies suggest that exposures may impact respiratory health across generations via epigenetic changes transmitted specifically through male germ cells. Studies in humans are, however, limited. We... (Source: Clinical Epigenetics)
Source: Clinical Epigenetics - August 31, 2023 Category: Research Authors: Negusse Tadesse Kitaba, Gerd Toril M ørkve Knudsen, Ane Johannessen, Faisal I. Rezwan, Andrei Malinovschi, Anna Oudin, Bryndis Benediktsdottir, David Martino, Francisco Javier Callejas González, Leopoldo Palacios Gómez, Mathias Holm, Nils Oskar Jõgi, Tags: Research Source Type: research
Abnormal DNA methylation analysis of leucine-rich glioma-inactivated 1 antibody encephalitis reveals novel methylation-driven genes related to prognostic and clinical features
Aberrant DNA methylation occurs commonly during pathogenesis of neuroimmunological diseases and is of clinical value in various encephalitis subtypes. However, knowledge of the impact of DNA methylation change... (Source: Clinical Epigenetics)
Source: Clinical Epigenetics - August 29, 2023 Category: Research Authors: Shan Qiao, Quanye Sun, Haiyun Li, Jie Yin, Aihua Wang and Shanchao Zhang Tags: Research Source Type: research
Association of DNA methylation of vitamin D metabolic pathway related genes with colorectal cancer risk
Vitamin D might have anti-tumor effect, which is affected by the genes related to vitamin D metabolic pathway. Epigenetic mechanism may affect the expression level of vitamin D metabolic pathway related genes,... (Source: Clinical Epigenetics)
Source: Clinical Epigenetics - August 29, 2023 Category: Research Authors: Yi-Fan Wang, Lei Li, Xue-Qing Deng, Yu-Jing Fang and Cai-Xia Zhang Tags: Research Source Type: research
Correction : HTRA1 methylation in peripheral blood as a potential marker for the preclinical detection of stroke: a case –control study and a prospective nested case–control study
(Source: Clinical Epigenetics)
Source: Clinical Epigenetics - August 29, 2023 Category: Research Authors: Chunlan Liu, Mengxia Li, Qiming Yin, Yao Fan, Chong Shen and Rongxi Yang Tags: Correction Source Type: research
Evaluation of the pooled sample method in Infinium MethylationEPIC BeadChip array by comparison with individual samples
The pooled sample method is used in epigenomic research and expression analysis and is a cost-effective screening approach for small amounts of DNA. Evaluation of the pooled sample method in epigenomic studies... (Source: Clinical Epigenetics)
Source: Clinical Epigenetics - August 28, 2023 Category: Research Authors: Shota Nishitani, Takashi X. Fujisawa, Akiko Yao, Shinichiro Takiguchi and Akemi Tomoda Tags: Methodology Source Type: research
Objective and subjective measures of sleep initiation are differentially associated with DNA methylation in adolescents
The onset of puberty is associated with a shift in the circadian timing of sleep, leading to delayed sleep initiation [i.e., later sleep onset time (SOT)] due to later bedtimes and/or longer sleep onset latenc... (Source: Clinical Epigenetics)
Source: Clinical Epigenetics - August 26, 2023 Category: Research Authors: Michael Larsen, Fan He, Yuka Imamura Kawasawa, Arthur Berg, Alexandros N. Vgontzas, Duanping Liao, Edward O. Bixler and Julio Fernandez-Mendoza Tags: Research Source Type: research
Associations between nutrients in one-carbon metabolism and fetal DNA methylation in pregnancies with or without gestational diabetes mellitus
Gestational diabetes mellitus (GDM), characterized by hyperglycemia that develops during pregnancy, increases the risk of fetal macrosomia, childhood obesity and cardiometabolic disorders later in life. This p... (Source: Clinical Epigenetics)
Source: Clinical Epigenetics - August 26, 2023 Category: Research Authors: Isma ’il Kadam, Mudar Dalloul, Jeanette Hausser, Monique Huntley, Lori Hoepner, Lawrence Fordjour, Joan Hittelman, Anjana Saxena, Jia Liu, Itamar D. Futterman, Howard Minkoff and Xinyin Jiang Tags: Research Source Type: research
The inactive X chromosome accumulates widespread epigenetic variability with age
Loss of epigenetic control is a hallmark of aging. Among the most prominent roles of epigenetic mechanisms is the inactivation of one of two copies of the X chromosome in females through DNA methylation. Hence... (Source: Clinical Epigenetics)
Source: Clinical Epigenetics - August 25, 2023 Category: Research Authors: Yunfeng Liu, Lucy Sinke, Thomas H. Jonkman, Roderick C. Slieker, Erik W. van Zwet, Lucia Daxinger and Bastiaan T. Heijmans Tags: Research Source Type: research
CRISPR/dCAS9-mediated DNA demethylation screen identifies functional epigenetic determinants of colorectal cancer
Promoter hypermethylation of tumour suppressor genes is frequently observed during the malignant transformation of colorectal cancer (CRC). However, whether this epigenetic mechanism is functional in cancer or... (Source: Clinical Epigenetics)
Source: Clinical Epigenetics - August 24, 2023 Category: Research Authors: Juan Ram ón Tejedor, Alfonso Peñarroya, Javier Gancedo-Verdejo, Pablo Santamarina-Ojeda, Raúl F. Pérez, Sara López-Tamargo, Ana Díez-Borge, Juan J. Alba-Linares, Nerea González-del-Rey, Rocío G. Urdinguio, Cristina Mangas, Annalisa Roberti, Virgin Tags: Research Source Type: research
Cell-free DNA 5-hydroxymethylcytosine is highly sensitive for MRD assessment in acute myeloid leukemia
Measurable residual disease (MRD) is an important biomarker in acute myeloid leukemia (AML). However, MRD cannot be detected in many patients using current methods. We developed a highly sensitive 5-hydroxymet... (Source: Clinical Epigenetics)
Source: Clinical Epigenetics - August 24, 2023 Category: Research Authors: Jianming Shao, Shilpan Shah, Siddhartha Ganguly, Youli Zu, Chuan He and Zejuan Li Tags: Brief Report Source Type: research
Association between acetaminophen metabolites and CYP2E1 DNA methylation level in neonate cord blood in the Boston Birth Cohort
Acetaminophen is a commonly used medication by pregnant women and is known to cross the placenta. However, little is known about the biological mechanisms that regulate acetaminophen in the developing offsprin... (Source: Clinical Epigenetics)
Source: Clinical Epigenetics - August 18, 2023 Category: Research Authors: Yijun Li, Xiumei Hong, Liming Liang, Xiaobin Wang and Christine Ladd-Acosta Tags: Research Source Type: research
