Association between acetaminophen metabolites and CYP2E1 DNA methylation level in neonate cord blood in the Boston Birth Cohort
Acetaminophen is a commonly used medication by pregnant women and is known to cross the placenta. However, little is known about the biological mechanisms that regulate acetaminophen in the developing offsprin... (Source: Clinical Epigenetics)
Source: Clinical Epigenetics - August 18, 2023 Category: Research Authors: Yijun Li, Xiumei Hong, Liming Liang, Xiaobin Wang and Christine Ladd-Acosta Tags: Research Source Type: research
Cross-platform comparisons for targeted bisulfite sequencing of MGISEQ-2000 and NovaSeq6000
An accurate and reproducible next-generation sequencing platform is essential to identify malignancy-related abnormal DNA methylation changes and translate them into clinical applications including cancer dete... (Source: Clinical Epigenetics)
Source: Clinical Epigenetics - August 14, 2023 Category: Research Authors: Jin Sun, Mingyang Su, Jianhua Ma, Minjie Xu, Chengcheng Ma, Wei Li, Rui Liu, Qiye He and Zhixi Su Tags: Research Source Type: research
Globally elevated levels of histone H3 lysine 9 trimethylation in early infancy are associated with poor growth trajectory in Bangladeshi children
Stunting is a global health problem affecting hundreds of millions of children worldwide and contributing to 45% of deaths in children under the age of five. Current therapeutic interventions have limited effi... (Source: Clinical Epigenetics)
Source: Clinical Epigenetics - August 11, 2023 Category: Research Authors: Kristyna Kupkova, Savera J. Shetty, Marilyn G. Pray-Grant, Patrick A. Grant, Rashidul Haque, William A. Petri Jr. and David T. Auble Tags: Research Source Type: research
Introduction of a multiplex amplicon sequencing assay to quantify DNA methylation in target cytosine markers underlying four selected epigenetic clocks
DNA methylation analysis has proven to be a powerful tool for age assessment. However, the implementation of epigenetic age prediction in diagnostics or routine forensic casework requires appropriate laborator... (Source: Clinical Epigenetics)
Source: Clinical Epigenetics - August 10, 2023 Category: Research Authors: Ewelina Po śpiech, Aleksandra Pisarek, Joanna Rudnicka, Rezvan Noroozi, Michał Boroń, Aleksander Masny, Bożena Wysocka, Kamila Migacz-Gruszka, Dagmara Lisman, Paulina Pruszkowska-Przybylska, Magdalena Kobus, Maria Szargut, Joanna Dowejko, Kamila Stani Tags: Research Source Type: research
Long-term environmental metal exposure is associated with hypomethylation of CpG sites in NFKB1 and other genes related to oncogenesis
Long-term environmental exposure to metals leads to epigenetic changes and may increase risks to human health. The relationship between the type and level of metal exposure and epigenetic changes in subjects e... (Source: Clinical Epigenetics)
Source: Clinical Epigenetics - August 7, 2023 Category: Research Authors: Ani Stepanyan, Anna Petrackova, Siras Hakobyan, Jakub Savara, Suren Davitavyan, Eva Kriegova and Arsen Arakelyan Tags: Research Source Type: research
Global effects of identity and aging on the human sperm methylome
As the average age of fatherhood increases worldwide, so too does the need for understanding effects of aging in male germline cells. Molecular change, including epigenomic alterations, may impact offspring. A... (Source: Clinical Epigenetics)
Source: Clinical Epigenetics - August 7, 2023 Category: Research Authors: Guilherme de Sena Brandine, Kenneth I. Aston, Timothy G. Jenkins and Andrew D. Smith Tags: Research Source Type: research
PAX1 hypomethylation as a prognostic biomarker for radioresistance of cervical cancer
PAX1 gene methylation plays an important role in the development of cervical cancer. However, its prognostic value after radiotherapy for locally advanced cervical cancer is unknown, so this study aimed to invest... (Source: Clinical Epigenetics)
Source: Clinical Epigenetics - August 2, 2023 Category: Research Authors: Xuanxuan Li, Huan Liu, Xue Zhou, Yangying Zhou, Yu Zhang, Yu-Ligh Liou, Manting Zeng and Hong Zhu Tags: Research Source Type: research
Update on histone deacetylase inhibitors in peripheral T-cell lymphoma (PTCL)
Peripheral T-cell lymphomas (PTCLs) are a group of highly aggressive malignancies with generally poor prognoses, and the first-line chemotherapy of PTCL has limited efficacy. Currently, several novel targeted ... (Source: Clinical Epigenetics)
Source: Clinical Epigenetics - August 2, 2023 Category: Research Authors: Guang Lu, Shikai Jin, Suwen Lin, Yuping Gong, Liwen Zhang, Jingwen Yang, Weiwei Mou and Jun Du Tags: Review Source Type: research
DNA methylation as a triage marker for colposcopy referral in HPV-based cervical cancer screening: a systematic review and meta-analysis
Screening plays a key role in secondary prevention of cervical cancer. High-risk human papillomavirus (hrHPV) testing, a highly sensitive test but with limited specificity, has become the gold standard frontli... (Source: Clinical Epigenetics)
Source: Clinical Epigenetics - August 2, 2023 Category: Research Authors: Sofia Salta, Jo ão Lobo, Bruno Magalhães, Rui Henrique and Carmen Jerónimo Tags: Research Source Type: research
DNA hypermethylation driven by DNMT1 and DNMT3A favors tumor immune escape contributing to the aggressiveness of adrenocortical carcinoma
Adrenocortical carcinoma is rare and aggressive endocrine cancer of the adrenal gland. Within adrenocortical carcinoma, a recently described subtype characterized by a CpG island methylator phenotype (CIMP) ha... (Source: Clinical Epigenetics)
Source: Clinical Epigenetics - August 2, 2023 Category: Research Authors: Gwenneg Kerdivel, Floriane Amrouche, Marie-Ange Calmejane, Floriane Carallis, Juliette Hamroune, Constanze Hantel, J érôme Bertherat, Guillaume Assié and Valentina Boeva Tags: Research Source Type: research
DNA methylation and 28-year cardiovascular disease risk in type 1 diabetes: the Epidemiology of Diabetes Complications (EDC) cohort study
The potential for DNA methylation (DNAm) as an early marker for cardiovascular disease (CVD) and how such an association might differ by glycemic exposure has not been examined in type 1 diabetes, a population... (Source: Clinical Epigenetics)
Source: Clinical Epigenetics - August 2, 2023 Category: Research Authors: Rachel G. Miller, Josyf C. Mychaleckyj, Suna Onengut-Gumuscu, Eleanor Feingold, Trevor J. Orchard and Tina Costacou Tags: Research Source Type: research
Hypomethylation of ABCG1 in peripheral blood as a potential marker for the detection of coronary heart disease
Novel molecular biomarkers for the risk assessment and early detection of coronary heart disease (CHD) are urgently needed for disease prevention. Altered methylation of ATP-binding cassette subfamily G member... (Source: Clinical Epigenetics)
Source: Clinical Epigenetics - July 28, 2023 Category: Research Authors: Jialie Jin, Xiaojing Zhao, Chao Zhu, Mengxia Li, Jinxin Wang, Yao Fan, Chunlan Liu, Chong Shen and Rongxi Yang Tags: Research Source Type: research
Genome-wide discovery of circulating cell-free DNA methylation biomarkers for colorectal cancer detection
Colorectal polyp is known a precursor of colorectal cancer (CRC) that holds an increased risk for progression to CRC. Circulating cell-free DNA (cfDNA) methylation has shown favorable performance in the detect... (Source: Clinical Epigenetics)
Source: Clinical Epigenetics - July 27, 2023 Category: Research Authors: Qingxiao Fang, Ziming Yuan, Hanqing Hu, Weiyuan Zhang, Guiyu Wang and Xishan Wang Tags: Research Source Type: research
Circulating NPTX2 methylation as a non-invasive biomarker for prognosis and monitoring of metastatic pancreatic cancer
Pancreatic cancer is the most lethal cancer with a dismal prognosis mainly due to diagnosis at advanced stage and ineffective treatments. CA19-9 levels and computed tomography (CT) imaging are the main standar... (Source: Clinical Epigenetics)
Source: Clinical Epigenetics - July 22, 2023 Category: Research Authors: Mar ía Victoria García-Ortiz, Pablo Cano-Ramírez, Marta Toledano-Fonseca, María Teresa Cano, Elizabeth Inga-Saavedra, Rosa María Rodríguez-Alonso, Silvia Guil-Luna, María Auxiliadora Gómez-España, Antonio Rodríguez-Ariza and Enrique Aranda Tags: Research Source Type: research
Correction: Quantification of hematopoietic stem and progenitor cells by targeted DNA methylation analysis
(Source: Clinical Epigenetics)
Source: Clinical Epigenetics - July 20, 2023 Category: Research Authors: Ledio Bocova, Wouter Hubens, Cordula Engel, Steffen Koschmieder, Edgar Jost and Wolfgang Wagner Tags: Correction Source Type: research
