The spectrum of tuberculosis described as differential DNA methylation patterns in alveolar macrophages and alveolar T cells
Host innate immune cells have been identified as key players in the early eradication of Mycobacterium tuberculosis and in the maintenance of an anti-mycobacterial immune memory, which we and others have shown ar... (Source: Clinical Epigenetics)
Source: Clinical Epigenetics - December 17, 2022 Category: Research Authors: Isabelle Pehrson, Shumaila Sayyab, Jyotirmoy Das, Nina Idh, Jakob Paues, Melissa M éndez-Aranda, César Ugarte-Gil and Maria Lerm Tags: Research Source Type: research
Identification of differentially methylated regions in rare diseases from a single-patient perspective
DNA methylation (5-mC) is being widely recognized as an alternative in the detection of sequence variants in the diagnosis of some rare neurodevelopmental and imprinting disorders. Identification of alteration... (Source: Clinical Epigenetics)
Source: Clinical Epigenetics - December 16, 2022 Category: Research Authors: Robin Grolaux, Alexis Hardy, Catharina Olsen, Sonia Van Dooren, Guillaume Smits and Matthieu Defrance Tags: Research Source Type: research
Comparative analysis of the DNA methylation landscape in CD4, CD8, and B memory lineages
There is considerable evidence that epigenetic mechanisms and DNA methylation are critical drivers of immune cell lineage differentiation and activation. However, there has been limited coordinated investigati... (Source: Clinical Epigenetics)
Source: Clinical Epigenetics - December 15, 2022 Category: Research Authors: Ze Zhang, Rondi Butler, Devin C. Koestler, Shelby Bell-Glenn, Gayathri Warrier, Annette M. Molinaro, Brock C. Christensen, John K. Wiencke, Karl T. Kelsey and Lucas A. Salas Tags: Research Source Type: research
Defining post-acute COVID-19 syndrome (PACS) by an epigenetic biosignature in peripheral blood mononuclear cells
Post-acute COVID-19 syndrome (PACS) has been defined as symptoms persisting after clearance of a COVID-19 infection. We have previously demonstrated that alterations in DNA methylation (DNAm) status persist in... (Source: Clinical Epigenetics)
Source: Clinical Epigenetics - December 14, 2022 Category: Research Authors: Frida Nikesj ö, Shumaila Sayyab, Lovisa Karlsson, Eirini Apostolou, Anders Rosén, Kristofer Hedman and Maria Lerm Tags: Brief Report Source Type: research
LINE-1 hypomethylation is associated with poor outcomes in locoregionally advanced oropharyngeal cancer
Currently, human papillomavirus (HPV) positivity represents a strong prognostic factor for both reduced risk of relapse and improved survival in patients with oropharyngeal squamous cell carcinoma (OPSCC). How... (Source: Clinical Epigenetics)
Source: Clinical Epigenetics - December 12, 2022 Category: Research Authors: Mariateresa Casarotto, Valentina Lupato, Giorgio Giurato, Roberto Guerrieri, Sandro Sulfaro, Annamaria Salvati, Elisa D ’Angelo, Carlo Furlan, Anna Menegaldo, Lorena Baboci, Barbara Montico, Irene Turturici, Riccardo Dolcetti, Salvatore Romeo, Vittorio Tags: Research Source Type: research
Methylation of the serotonin reuptake transporter gene and non-motor symptoms in dystonia patients
Dystonia is a rare movement disorder, in which patients suffer from involuntary twisting movements or abnormal posturing. Next to these motor symptoms, patients have a high prevalence of psychiatric comorbidit... (Source: Clinical Epigenetics)
Source: Clinical Epigenetics - December 11, 2022 Category: Research Authors: Elze R. Timmers, Torsten Pl ösch, Marenka Smit, Ingrid H. Hof, Rikst Nynke Verkaik-Schakel, Marina A. J. Tijssen, Tom J. de Koning and Klary E. Niezen-Koning Tags: Research Source Type: research
The emerging role of epigenetic regulation in the progression of silicosis
Silicosis is one of the most severe occupational diseases worldwide and is characterized by silicon nodules and diffuse pulmonary fibrosis. However, specific treatments for silicosis are still lacking at prese... (Source: Clinical Epigenetics)
Source: Clinical Epigenetics - December 9, 2022 Category: Research Authors: Haoyu Yin, Yujia Xie, Pei Gu, Wei Li, Yingdie Zhang, Yuxin Yao, Weihong Chen and Jixuan Ma Tags: Review Source Type: research
Quantification of DNA methylation for carcinogenic risk estimation in patients with non-alcoholic steatohepatitis
In recent years, non-alcoholic steatohepatitis (NASH) has become the main cause of hepatocellular carcinoma (HCC). As a means of improving the treatment of NASH-related HCCs based on early detection, this stud... (Source: Clinical Epigenetics)
Source: Clinical Epigenetics - December 5, 2022 Category: Research Authors: Junko Kuramoto, Eri Arai, Mao Fujimoto, Ying Tian, Yuriko Yamada, Takuya Yotani, Satomi Makiuchi, Noboru Tsuda, Hidenori Ojima, Moto Fukai, Yosuke Seki, Kazunori Kasama, Nobuaki Funahashi, Haruhide Udagawa, Takao Nammo, Kazuki Yasuda & hellip; Tags: Research Source Type: research
The association of accelerated epigenetic age with all-cause mortality in cardiac catheterization patients as mediated by vascular and cardiometabolic outcomes
Epigenetic age is a DNA methylation-based biomarker of aging that is accurate across the lifespan and a range of cell types. The difference between epigenetic age and chronological age, termed age acceleration... (Source: Clinical Epigenetics)
Source: Clinical Epigenetics - December 3, 2022 Category: Research Authors: Rong Jiang, Elizabeth R. Hauser, Lydia Coulter Kwee, Svati H. Shah, Jessica A. Regan, Janet L. Huebner, Virginia B. Kraus, William E. Kraus and Cavin K. Ward-Caviness Tags: Research Source Type: research
A randomized, phase II trial of oral azacitidine (CC-486) in patients with resected pancreatic adenocarcinoma at high risk for recurrence
Of the only 20% of patients with resectable pancreatic ductal adenocarcinoma (rPDA), cancer recurs in 80% of cases. Epigenetic dysregulation is an early hallmark of cancer cells acquiring metastatic potential,... (Source: Clinical Epigenetics)
Source: Clinical Epigenetics - December 3, 2022 Category: Research Authors: Thatcher R. Heumann, Marina Baretti, Elizabeth A. Sugar, Jennifer N. Durham, Sheila Linden, Tamara Y. Lopez-Vidal, James Leatherman, Leslie Cope, Anup Sharma, Colin D. Weekes, Peter J. O ’Dwyer, Kim A. Reiss, Dulabh K. Monga, Nita Ahuja and Nilofer S. A Tags: Research Source Type: research
Novel blood-based FUT7 DNA methylation is associated with lung cancer: especially for lung squamous cell carcinoma
The death rate of lung cancer (LC) ranks first in the world. Changes of DNA methylation in peripheral blood may be related to malignant tumors. It is necessary to explore blood-based biomarkers of methylation ... (Source: Clinical Epigenetics)
Source: Clinical Epigenetics - December 3, 2022 Category: Research Authors: Yifei Fang, Yunhui Qu, Longtao Ji, Hao Sun, Jiaqi Li, Yutong Zhao, Feifei Liang, Zhi Wang, Jiao Su, Jingjing Liu, Liping Dai and Songyun Ouyang Tags: Research Source Type: research
Increased copy number of imprinted genes in the chromosomal region 20q11-q13.32 is associated with resistance to antitumor agents in cancer cell lines
Parent of origin-specific allelic expression of imprinted genes is epigenetically controlled. In cancer, imprinted genes undergo both genomic and epigenomic alterations, including frequent copy number changes.... (Source: Clinical Epigenetics)
Source: Clinical Epigenetics - December 2, 2022 Category: Research Authors: Julia Krushkal, Suleyman Vural, Travis L. Jensen, George Wright and Yingdong Zhao Tags: Research Source Type: research
Longitudinal monitoring of cell-free DNA methylation in ALK-positive non-small cell lung cancer patients
DNA methylation (5-mC) signals in cell-free DNA (cfDNA) of cancer patients represent promising biomarkers for minimally invasive tumor detection. The high abundance of cancer-associated 5-mC alterations permit... (Source: Clinical Epigenetics)
Source: Clinical Epigenetics - December 2, 2022 Category: Research Authors: Florian Janke, Arlou Kristina Angeles, Anja Lisa Riediger, Simone Bauer, Martin Reck, Albrecht Stenzinger, Marc A. Schneider, Thomas Muley, Michael Thomas, Petros Christopoulos and Holger S ültmann Tags: Research Source Type: research
Incorporation of DNA methylation quantitative trait loci (mQTLs) in epigenome-wide association analysis: application to birthweight effects in neonatal whole blood
Epigenome-wide association studies (EWAS) have helped to define the associations between DNA methylation and many clinicopathologic and developmental traits. Since DNA methylation is affected by genetic variat... (Source: Clinical Epigenetics)
Source: Clinical Epigenetics - December 1, 2022 Category: Research Authors: Shaobo Li, Nicholas Mancuso, Catherine Metayer, Xiaomei Ma, Adam J. de Smith and Joseph L. Wiemels Tags: Research Source Type: research
An explorative epigenome-wide association study of plasma renin and aldosterone concentration in a Ghanaian population: the RODAM study
The epigenetic regulation of the renin –angiotensin–aldosterone system (RAAS) potentially plays a role in the pathophysiology underlying the high burden of hypertension in sub-Saharan Africans (SSA). Here we re... (Source: Clinical Epigenetics)
Source: Clinical Epigenetics - December 1, 2022 Category: Research Authors: Eva L. van der Linden, Adrienne Halley, Karlijn A. C. Meeks, Felix Chilunga, Charles Hayfron-Benjamin, Andrea Venema, Ingrid M. Garrelds, A. H. Jan Danser, Bert-Jan van den Born, Peter Henneman and Charles Agyemang Tags: Research Source Type: research
