DNA methylation age at birth and childhood: performance of epigenetic clocks and characteristics associated with epigenetic age acceleration in the Project Viva cohort
Epigenetic age acceleration (EAA) and epigenetic gestational age acceleration (EGAA) are biomarkers of physiological development and may be affected by the perinatal environment. The aim of this study was to e... (Source: Clinical Epigenetics)
Source: Clinical Epigenetics - April 12, 2023 Category: Research Authors: Anne K. Bozack, Sheryl L. Rifas-Shiman, Diane R. Gold, Zachary M. Laubach, Wei Perng, Marie-France Hivert and Andres Cardenas Tags: Research Source Type: research

Effects of epigenetic age acceleration on kidney function: a Mendelian randomization study
Previous studies have reported cross-sectional associations between measures of epigenetic age acceleration (EAA) and kidney function phenotypes. However, the temporal and potentially causal relationships betw... (Source: Clinical Epigenetics)
Source: Clinical Epigenetics - April 8, 2023 Category: Research Authors: Yang Pan, Xiao Sun, Zhijie Huang, Ruiyuan Zhang, Changwei Li, Amanda H. Anderson, James P. Lash and Tanika N. Kelly Tags: Research Source Type: research

Impact of intrauterine exposure to maternal diabetes on preterm birth: fetal DNA methylation alteration is an important mediator
In utero exposure to diabetes has been shown to contribute to preterm birth, though the underlying biological mechanisms are yet to be fully elucidated. Fetal epigenetic variations established in utero may be ... (Source: Clinical Epigenetics)
Source: Clinical Epigenetics - April 7, 2023 Category: Research Authors: Guoying Wang, Richard Xu, Boyang Zhang, Xiumei Hong, Tami R. Bartell, Colleen Pearson, Liming Liang and Xiaobin Wang Tags: Research Source Type: research

Comprehensive analyses of molecular features, prognostic values, and regulatory functionalities of m6A-modified long non-coding RNAs in lung adenocarcinoma
Lung adenocarcinoma (LUAD) has a high incidence and recurrence rate. N6-methyladenosine (m6A) modification of RNA has become a promising epigenetic marker in tumors. The dysregulation of both RNA m6A levels and m (Source: Clinical Epigenetics)
Source: Clinical Epigenetics - April 7, 2023 Category: Research Authors: Yili Ping, Jingjuan Huang, Jichao Zhu, Zujun Sun, Anquan Shang, Chen Chen, Wenfang Liu and Dong Li Tags: Research Source Type: research

Sperm DNA methylation is predominantly stable in mice offspring born after transplantation of long-term cultured spermatogonial stem cells
Spermatogonial stem cell transplantation (SSCT) is proposed as a fertility therapy for childhood cancer survivors. SSCT starts with cryopreserving a testicular biopsy prior to gonadotoxic treatments such as ca... (Source: Clinical Epigenetics)
Source: Clinical Epigenetics - April 7, 2023 Category: Research Authors: Joana B. Serrano, Nils C. Tabeling, Cindy M. de Winter-Korver, Saskia K. M. van Daalen, Ans M. M. van Pelt and Callista L. Mulder Tags: Research Source Type: research

Neuroglobin plays as tumor suppressor by disrupting the stability of GPR35 in colorectal cancer
The incidence of colorectal cancer (CRC) has increased in recent years. Identification of accurate tumor markers has become the focus of CRC research. Early and frequent DNA methylation tends to occur in cance... (Source: Clinical Epigenetics)
Source: Clinical Epigenetics - April 1, 2023 Category: Research Authors: Qin Xiang, Dishu Zhou, Xinni Xiang, Xin Le, Chaoqun Deng, Ran Sun, Chunhong Li, Huayang Pang, Jin He, Zeze Zheng, Jun Tang, Weiyan Peng, Xi Peng, Xiaoqian He, Fan Wu, Jingfu Qiu & hellip; Tags: Research Source Type: research

DNA methylation age in paired tumor and adjacent normal breast tissue in Chinese women with breast cancer
Few studies have examined epigenetic age acceleration (AA), the difference between DNA methylation (DNAm) predicted age and chronological age, in relation to somatic genomic features in paired cancer and norma... (Source: Clinical Epigenetics)
Source: Clinical Epigenetics - March 30, 2023 Category: Research Authors: Hela Koka, Clara Bodelon, Steve Horvath, Priscilla Ming Yi Lee, Difei Wang, Lei Song, Tongwu Zhang, Amber N. Hurson, Jennifer Lyn Guida, Bin Zhu, Maeve Bailey-Whyte, Feng Wang, Cherry Wu, Koon Ho Tsang, Yee-Kei Tsoi, W. C. Chan & hellip; Tags: Research Source Type: research

DNA methylation and cardiovascular disease in humans: a systematic review and database of known CpG methylation sites
Cardiovascular disease (CVD) is the leading cause of death worldwide and considered one of the most environmentally driven diseases. The role of DNA methylation in response to the individual exposure for the d... (Source: Clinical Epigenetics)
Source: Clinical Epigenetics - March 30, 2023 Category: Research Authors: Mykhailo Krolevets, Vincent ten Cate, J ürgen H. Prochaska, Andreas Schulz, Steffen Rapp, Stefan Tenzer, Miguel A. Andrade-Navarro, Steve Horvath, Christof Niehrs and Philipp S. Wild Tags: Review Source Type: research

Distinguishable DNA methylation defines a cardiac-specific epigenetic clock
The present study investigates whether epigenetic differences emerge in the heart of patients undergoing cardiac surgery for an aortic valvular replacement (AVR) or coronary artery bypass graft (CABG). An algo... (Source: Clinical Epigenetics)
Source: Clinical Epigenetics - March 29, 2023 Category: Research Authors: A. Mongelli, S. Panunzi, M. Nesta, M. Gottardi Zamperla, S. Atlante, V. Barbi, V. Mongiardini, F. Ferraro, S. De Martino, L. Cis, A. Re, S. Maltese, T. Bachetti, M. T. La Rovere, F. Martelli, M. Pesce & hellip; Tags: Research Source Type: research

Clinical characteristics and prognostic significance of DNA methylation regulatory gene mutations in acute myeloid leukemia
DNA methylation is a form of epigenetic modification that regulates gene expression. However, there are limited data on the comprehensive analysis of DNA methylation regulated gene mutations (DMRGM) in acute m... (Source: Clinical Epigenetics)
Source: Clinical Epigenetics - March 29, 2023 Category: Research Authors: Xiaoyan Xu, Hong Wang, Haohao Han, Yifang Yao, Xueqian Li, Jiaqian Qi, Chengsen Cai, Meng Zhou, Yaqiong Tang, Tingting Pan, Ziyan Zhang, Jingyi Yang, Depei Wu and Yue Han Tags: Research Source Type: research

Healthy lifestyle, DNA methylation age acceleration, and incident risk of coronary heart disease
DNA methylation clocks emerged as a tool to determine biological aging and have been related to mortality and age-related diseases. Little is known about the association of DNA methylation age (DNAm age) with ... (Source: Clinical Epigenetics)
Source: Clinical Epigenetics - March 28, 2023 Category: Research Authors: Jiahui Si, Lu Chen, Canqing Yu, Yu Guo, Dianjianyi Sun, Yuanjie Pang, Iona Y. Millwood, Robin G. Walters, Ling Yang, Yiping Chen, Huaidong Du, Shixian Feng, Xiaoming Yang, Daniel Avery, Junshi Chen, Zhengming Chen & hellip; Tags: Research Source Type: research

Sex differences in the intergenerational link between maternal and neonatal whole blood DNA methylation: a genome-wide analysis in 2 birth cohorts
The mother –child inheritance of DNA methylation (DNAm) variations could contribute to the inheritance of disease susceptibility across generations. However, no study has investigated patterns of mother–child a... (Source: Clinical Epigenetics)
Source: Clinical Epigenetics - March 25, 2023 Category: Research Authors: Jie Hu, Xin Xu, Jun Li, Yu Jiang, Xiumei Hong, Kathryn M. Rexrode, Guoying Wang, Frank B. Hu, Hongmei Zhang, Wilfried J. Karmaus, Xiaobin Wang and Liming Liang Tags: Research Source Type: research

Longitudinal DNA methylation profiling of the rectal mucosa identifies cell-specific signatures of disease status, severity and clinical outcomes in ulcerative colitis cell-specific DNA methylation signatures of UC
In peripheral blood, DNA methylation (DNAm) patterns in inflammatory bowel disease patients reflect inflammatory status rather than disease status. Here, we examined DNAm in diseased rectal mucosa from ulcerat... (Source: Clinical Epigenetics)
Source: Clinical Epigenetics - March 24, 2023 Category: Research Authors: Suresh Venkateswaran, Hari K. Somineni, Jason D. Matthews, Varun Kilaru, Jeffrey S. Hyams, Lee A. Denson, Richard Kellamayer, Greg Gibson, David J. Cutler, Karen N. Conneely, Alicia K. Smith and Subra Kugathasan Tags: Research Source Type: research

Mediation effects of DNA methylation and hydroxymethylation on birth outcomes after prenatal per- and polyfluoroalkyl substances (PFAS) exposure in the Michigan mother –infant Pairs cohort
Per- and polyfluoroalkyl substances (PFAS) are chemicals that are resistant to degradation and ubiquitous in our environments. PFAS may impact the developing epigenome, but current human evidence is limited to... (Source: Clinical Epigenetics)
Source: Clinical Epigenetics - March 24, 2023 Category: Research Authors: Rebekah L. Petroff, Raymond G. Cavalcante, Elizabeth S. Langen, Dana C. Dolinoy, Vasantha Padmanabhan and Jaclyn M. Goodrich Tags: Research Source Type: research

DNA methylation patterns at birth predict health outcomes in young adults born very low birthweight
Individuals born very low birthweight (VLBW) are at increased risk of impaired cardiovascular and respiratory function in adulthood. To identify markers to predict future risk for VLBW individuals, we analyzed... (Source: Clinical Epigenetics)
Source: Clinical Epigenetics - March 23, 2023 Category: Research Authors: Vicky A. Cameron, Gregory T. Jones, L. John Horwood, Anna P. Pilbrow, Julia Martin, Chris Frampton, Wendy T. Ip, Richard W. Troughton, Charlotte Greer, Jun Yang, Michael J. Epton, Sarah L. Harris and Brian A. Darlow Tags: Research Source Type: research