Association of nutritional glycaemic indices with global DNA methylation patterns: results from the Moli-sani cohort
High dietary glycaemic index (GI) and load (GL) have been associated with increased risk of various cardiometabolic conditions. Among the molecular potential mechanisms underlying this relationship, DNA methyl... (Source: Clinical Epigenetics)
Source: Clinical Epigenetics - December 28, 2022 Category: Research Authors: Fabrizia Noro, Federica Santonastaso, Annalisa Marotta, Marialaura Bonaccio, Sabatino Orlandi, Alfonsina Tirozzi, Simona Costanzo, Amalia De Curtis, Francesco Gianfagna, Augusto Di Castelnuovo, Furio Brighenti, Chiara Cerletti, Maria Benedetta Donati, Gio Tags: Research Source Type: research
Maintenance of methylation profile in imprinting control regions in human induced pluripotent stem cells
Parental imprinting is an epigenetic mechanism that leads to monoallelic expression of a subset of genes depending on their parental origin. Imprinting disorders (IDs), caused by disturbances of imprinted gene... (Source: Clinical Epigenetics)
Source: Clinical Epigenetics - December 28, 2022 Category: Research Authors: A. Pham, C. Selenou, E. Giabicani, V. Fontaine, S. Marteau, F. Brioude, L. David, D. Mitanchez, M. L. Sobrier and I. Netchine Tags: Research Source Type: research
Circulating cell-free DNA methylation mirrors alterations in cerebral patterns in epilepsy
DNA methylation profiling of circulating cell-free DNA (cfDNA) has rapidly become a promising strategy for biomarker identification and development. The cell-type-specific nature of DNA methylation patterns an... (Source: Clinical Epigenetics)
Source: Clinical Epigenetics - December 28, 2022 Category: Research Authors: Ricardo Martins-Ferreira, B árbara Leal, João Chaves, Laura Ciudad, Raquel Samões, António Martins da Silva, Paulo Pinho Costa and Esteban Ballestar Tags: Research Source Type: research
Altered DNA methylation in estrogen-responsive repetitive sequences of spermatozoa of infertile men with shortened anogenital distance
It has been suggested that antenatal exposure to environmental endocrine disruptors is responsible for adverse trends in male reproductive health, including male infertility, impaired semen quality, cryptorchi... (Source: Clinical Epigenetics)
Source: Clinical Epigenetics - December 26, 2022 Category: Research Authors: Ludwig Stenz, Matthias Beyens, Mark E. Gill, Ariane Paoloni-Giacobino and Christian De Geyter Tags: Research Source Type: research
Genome-wide distribution of histone trimethylation reveals a global impact of bisphenol A on telomeric binding proteins and histone acetyltransferase factors: a pilot study with human and in vitro data
To assess the genetic and epigenetic effects promoted by Bisphenol A (BPA) exposure in adolescent males from the Spanish INMA-Granada birth cohort, and in human cells. (Source: Clinical Epigenetics)
Source: Clinical Epigenetics - December 26, 2022 Category: Research Authors: Shereen Cynthia D ’Cruz, Chunxiang Hao, Martin Labussiere, Vicente Mustieles, Carmen Freire, Louis Legoff, Laura Magnaghi-Jaulin, Alicia Olivas-Martinez, Andrea Rodriguez-Carrillo, Christian Jaulin, Arthur David, Mariana F. Fernandez and Fatima Smagulov Tags: Research Source Type: research
BDNF exon IV promoter methylation and antidepressant action: a complex interplay
BDNF exon IV promoter methylation is a potential biomarker for treatment response to antidepressants in MDD. We have previously shown CpG-87 methylation as a successful biomarker for the prediction of non-resp... (Source: Clinical Epigenetics)
Source: Clinical Epigenetics - December 26, 2022 Category: Research Authors: Hansi Pathak, Anton Borchert, Sara Garaali, Alexandra Burkert and Helge Frieling Tags: Research Source Type: research
Identification of hepatocellular carcinoma subtypes based on PcG-related genes and biological relevance with cancer cells
Hepatocellular carcinoma (HCC) is an extensive heterogeneous disease where epigenetic factors contribute to its pathogenesis. Polycomb group (PcG) proteins are a group of subunits constituting various macro-mo... (Source: Clinical Epigenetics)
Source: Clinical Epigenetics - December 24, 2022 Category: Research Authors: Yunong Fu, Kaibo Yang, Kunjin Wu, Hai Wang, Qinglin Li, Fengping Zhang, Kun Yang, Qing Yao, Xiaohua Ma, Yujie Deng, Jingyao Zhang, Chang Liu and Kai Qu Tags: Research Source Type: research
NAA60 (HAT4): the newly discovered bi-functional Golgi member of the acetyltransferase family
Chromatin structural organization, gene expression and proteostasis are intricately regulated in a wide range of biological processes, both physiological and pathological. Protein acetylation, a major post-tra... (Source: Clinical Epigenetics)
Source: Clinical Epigenetics - December 21, 2022 Category: Research Authors: Federica Donnarumma, Valeria Tucci, Concetta Ambrosino, Lucia Altucci and Vincenzo Carafa Tags: Review Source Type: research
Transient Polycomb activity represses developmental genes in growing oocytes
Non-genetic disease inheritance and offspring phenotype are substantially influenced by germline epigenetic programming, including genomic imprinting. Loss of Polycomb Repressive Complex 2 (PRC2) function in o... (Source: Clinical Epigenetics)
Source: Clinical Epigenetics - December 21, 2022 Category: Research Authors: Ellen G. Jarred, Zhipeng Qu, Tesha Tsai, Ruby Oberin, Sigrid Petautschnig, Heidi Bildsoe, Stephen Pederson, Qing-hua Zhang, Jessica M. Stringer, John Carroll, David K. Gardner, Maarten Van den Buuse, Natalie A. Sims, William T. Gibson, David L. Adelson an Tags: Research Source Type: research
Decreased SUV39H1 at the promoter region leads to increased CREM α and accelerates autoimmune response in CD4+ T cells from patients with systemic lupus erythematosus
Overproduction of cAMP-responsive element modulator α (CREMα) in total T cells from patients with systemic lupus erythematosus (SLE) can inhibit IL-2 and increase IL-17A. These ultimately promote progression o... (Source: Clinical Epigenetics)
Source: Clinical Epigenetics - December 20, 2022 Category: Research Authors: Shuangyan Luo, Huilin Zhang, Yuming Xie, Junke Huang, Danhong Luo and Qing Zhang Tags: Research Source Type: research
DNA methylation patterns associated with konzo in Sub-Saharan Africa
Konzo, a disease characterized by sudden, irreversible spastic paraparesis, affecting up to 10% of the population in some regions of Sub-Saharan Africa during outbreaks, is strongly associated with dietary exp... (Source: Clinical Epigenetics)
Source: Clinical Epigenetics - December 19, 2022 Category: Research Authors: Kristen Kocher, Surajit Bhattacharya, Matthew S. Bramble, Daniel Okitundu-Luwa, Dieudonne Mumba Ngoyi, Desire Tshala-Katumbay and Eric Vilain Tags: Brief Report Source Type: research
Tumor mutation burden involving epigenetic regulatory genes and the RhoA GTPase predicts overall survival in nodal mature T-cell lymphomas
Nodal mature T-cell lymphomas (nMTCL) comprises a heterogeneous group of rare malignancies with aggressive biological behavior and poor prognosis. Epigenetic phenomena, including mutations in genes that contro... (Source: Clinical Epigenetics)
Source: Clinical Epigenetics - December 19, 2022 Category: Research Authors: Lu ís Alberto de Pádua Covas Lage, Hebert Fabrício Culler, Guilherme Carneiro Barreto, Cadiele Oliana Reichert, Débora Levy, Renata de Oliveira Costa, Vanderson Rocha and Juliana Pereira Tags: Brief report Source Type: research
Bariatric surgery-induced weight loss and associated genome-wide DNA-methylation alterations in obese individuals
Obesity is a multifactorial and chronic condition of growing universal concern. It has recently been reported that bariatric surgery is a more successful treatment for severe obesity than other noninvasive int... (Source: Clinical Epigenetics)
Source: Clinical Epigenetics - December 18, 2022 Category: Research Authors: Fazlur Rahman Talukdar, David Israel Escobar Marcillo, Ruhina Shirin Laskar, Alexei Novoloaca, Cyrille Cuenin, Paolo Sbraccia, Lorenza Nistic ò, Valeria Guglielmi, Tarik Gheit, Massimo Tommasino, Eugenia Dogliotti, Paola Fortini and Zdenko Herceg Tags: Research Source Type: research
Epigenetics of type 2 diabetes and diabetes-related outcomes in the Strong Heart Study
The prevalence of type 2 diabetes has dramatically increased in the past years. Increasing evidence supports that blood DNA methylation, the best studied epigenetic mark, is related to diabetes risk. Few prosp... (Source: Clinical Epigenetics)
Source: Clinical Epigenetics - December 18, 2022 Category: Research Authors: Arce Domingo-Relloso, Matthew O. Gribble, Angela L. Riffo-Campos, Karin Haack, Shelley A. Cole, Maria Tellez-Plaza, Jason G. Umans, Amanda M. Fretts, Ying Zhang, M. Daniele Fallin, Ana Navas-Acien and Todd M. Everson Tags: Research Source Type: research
THOR is a targetable epigenetic biomarker with clinical implications in breast cancer
Breast cancer (BC) is the most frequently diagnosed cancer and a leading cause of death among women worldwide. Early BC is potentially curable, but the mortality rates still observed among BC patients demonstr... (Source: Clinical Epigenetics)
Source: Clinical Epigenetics - December 18, 2022 Category: Research Authors: Joana Dias Apol ónio, João S. Dias, Mónica Teotónio Fernandes, Martin Komosa, Tatiana Lipman, Cindy H. Zhang, Ricardo Leão, Donghyun Lee, Nuno Miguel Nunes, Ana-Teresa Maia, José L. Morera, Luis Vicioso, Uri Tabori and Pedro Castelo-Branco Tags: Research Source Type: research
