Decreased SUV39H1 at the promoter region leads to increased CREM α and accelerates autoimmune response in CD4+ T cells from patients with systemic lupus erythematosus

Overproduction of cAMP-responsive element modulator α (CREMα) in total T cells from patients with systemic lupus erythematosus (SLE) can inhibit IL-2 and increase IL-17A. These ultimately promote progression o...

Source: Clinical Epigenetics - December 20, 2022 Category: Research Authors: Shuangyan Luo, Huilin Zhang, Yuming Xie, Junke Huang, Danhong Luo and Qing Zhang Tags: Research Source Type: research