Pharmacological inhibition of human EZH2 can influence a regenerative β-like cell capacity with in vitro insulin release in pancreatic ductal cells
Therapeutic replacement of pancreatic endocrine β-cells is key to improving hyperglycaemia caused by insulin-dependent diabetes . Whilst the pool of ductal progenitors, which give rise to the endocrine cells, ... (Source: Clinical Epigenetics)
Source: Clinical Epigenetics - June 12, 2023 Category: Research Authors: Safiya Naina Marikar, Keith Al-Hasani, Ishant Khurana, Harikrishnan Kaipananickal, Jun Okabe, Scott Maxwell and Assam El-Osta Tags: Research Source Type: research
Buffy coat signatures of breast cancer risk in a prospective cohort study
Epigenetic alterations are a near-universal feature of human malignancy and have been detected in malignant cells as well as in easily accessible specimens such as blood and urine. These findings offer promisi... (Source: Clinical Epigenetics)
Source: Clinical Epigenetics - June 12, 2023 Category: Research Authors: Felicia Fei-Lei Chung, Sandra Gonz ález Maldonado, Amelie Nemc, Liacine Bouaoun, Vincent Cahais, Cyrille Cuenin, Aurelie Salle, Theron Johnson, Bekir Ergüner, Marina Laplana, Paul Datlinger, Jana Jeschke, Elisabete Weiderpass, Vessela Kristensen, Suzett Tags: Research Source Type: research
DNA methylation alterations at RE1-silencing transcription factor binding sites and their flanking regions in cancer
DNA methylation changes, frequent early events in cancer, can modulate the binding of transcription factors. RE1-silencing transcription factor (REST) plays a fundamental role in regulating the expression of n... (Source: Clinical Epigenetics)
Source: Clinical Epigenetics - June 10, 2023 Category: Research Authors: Ana Florencia Vega-Benedetti, Eleonora Loi, Loredana Moi and Patrizia Zavattari Tags: Research Source Type: research
ATHENA: an independently validated autophagy-related epigenetic prognostic prediction model of head and neck squamous cell carcinoma
The majority of these existing prognostic models of head and neck squamous cell carcinoma (HNSCC) have unsatisfactory prediction accuracy since they solely utilize demographic and clinical information. Leverag... (Source: Clinical Epigenetics)
Source: Clinical Epigenetics - June 9, 2023 Category: Research Authors: Ziang Xu, Xinlei Chen, Xiaomeng Song, Xinxin Kong, Jiajin Chen, Yunjie Song, Maojie Xue, Lin Qiu, Mingzhu Geng, Changyue Xue, Wei Zhang and Ruyang Zhang Tags: Research Source Type: research
Epigenetic age acceleration mediates the association between smoking and diabetes-related outcomes
Smoking can lead to the deterioration of lung function and susceptibility to diabetes. Recently, smoking was found to induce DNA methylation (DNAm) changes in some cytosine-phosphate-guanine sites (CpGs). As l... (Source: Clinical Epigenetics)
Source: Clinical Epigenetics - June 3, 2023 Category: Research Authors: Xue-Yong Chang and Wan-Yu Lin Tags: Research Source Type: research
Identifying primary and secondary MLH1 epimutation carriers displaying low-level constitutional MLH1 methylation using droplet digital PCR and genome-wide DNA methylation profiling of colorectal cancers
MLH1 epimutation is characterised by constitutional monoallelic MLH1 promoter hypermethylation, which can cause colorectal cancer (CRC). Tumour molecular profiles of MLH1 epimutation CRCs were used to classify ge... (Source: Clinical Epigenetics)
Source: Clinical Epigenetics - June 3, 2023 Category: Research Authors: Jihoon E. Joo, Khalid Mahmood, Romy Walker, Peter Georgeson, Ida Candiloro, Mark Clendenning, Julia Como, Sharelle Joseland, Susan Preston, Lise Graversen, Mathilda Wilding, Michael Field, Michelle Lemon, Janette Wakeling, Helen Marfan, Rachel Susman & he Tags: Research Source Type: research
Novel insights into systemic sclerosis using a sensitive computational method to analyze whole-genome bisulfite sequencing data
Abnormal DNA methylation is thought to contribute to the onset and progression of systemic sclerosis. Currently, the most comprehensive assay for profiling DNA methylation is whole-genome bisulfite sequencing ... (Source: Clinical Epigenetics)
Source: Clinical Epigenetics - June 3, 2023 Category: Research Authors: Jeffrey C. Y. Yu, Yixiao Zeng, Kaiqiong Zhao, Tianyuan Lu, Kathleen Oros Klein, In és Colmegna, Maximilien Lora, Sahir R. Bhatnagar, Andrew Leask, Celia M. T. Greenwood and Marie Hudson Tags: Research Source Type: research
Genome-wide DNA methylation profiling of HPV-negative leukoplakia and gingivobuccal complex cancers
Gingivobuccal complex oral squamous cell carcinoma (GBC-OSCC) is an aggressive malignancy with high mortality often preceded by premalignant lesions, including leukoplakia. Previous studies have reported genom... (Source: Clinical Epigenetics)
Source: Clinical Epigenetics - May 27, 2023 Category: Research Authors: Mayuri Inchanalkar, Sumana Srivatsa, Srikant Ambatipudi, Priyanka G. Bhosale, Asawari Patil, Alejandro A. Sch äffer, Niko Beerenwinkel and Manoj B. Mahimkar Tags: Research Source Type: research
LEP promoter methylation in the initiation and progression of clonal cytopenia of undetermined significance and myelodysplastic syndrome
Idiopathic non-clonal cytopenia (ICUS) and clonal cytopenia (CCUS) are common in the elderly population. While these entities have similar clinical presentations with peripheral blood cytopenia and less than 1... (Source: Clinical Epigenetics)
Source: Clinical Epigenetics - May 26, 2023 Category: Research Authors: Katja Kaastrup, Linn Gillberg, Stine U. Mikkelsen, Andreas D. Ørskov, Claudia Schöllkopf, Bo K. Mortensen, Bo Porse, Jakob W. Hansen and Kirsten Grønbæk Tags: Research Source Type: research
Histone lysine methyltransferase SMYD3 promotes oral squamous cell carcinoma tumorigenesis via H3K4me3-mediated HMGA2 transcription
Epigenetic dysregulation is essential to the tumorigenesis of oral squamous cell carcinoma (OSCC). SET and MYND domain-containing protein 3 (SMYD3), a histone lysine methyltransferase, is implicated in gene tr... (Source: Clinical Epigenetics)
Source: Clinical Epigenetics - May 26, 2023 Category: Research Authors: Zongcheng Yang, Fen Liu, Zongkai Li, Nianping Liu, Xinfeng Yao, Yu Zhou, Liyu Zhang, Pan Jiang, Honghong Liu, Lingming Kong, Chuandong Lang, Xin Xu, Jihui Jia, Takahito Nakajima, Wenchao Gu, Lixin Zheng & hellip; Tags: Research Source Type: research
Epigenomic profiling of isolated blood cell types reveals highly specific B cell smoking signatures and links to disease risk
Tobacco smoking alters the DNA methylation profiles of immune cells which may underpin some of the pathogenesis of smoking-associated diseases. To link smoking-driven epigenetic effects in specific immune cell... (Source: Clinical Epigenetics)
Source: Clinical Epigenetics - May 25, 2023 Category: Research Authors: Xuting Wang, Michelle R. Campbell, Hye-Youn Cho, Gary S. Pittman, Suzanne N. Martos and Douglas A. Bell Tags: Research Source Type: research
Combined inhibition of histone deacetylase and cytidine deaminase improves epigenetic potency of decitabine in colorectal adenocarcinomas
Targeting the epigenome of cancerous diseases represents an innovative approach, and the DNA methylation inhibitor decitabine is recommended for the treatment of hematological malignancies. Although epigenetic... (Source: Clinical Epigenetics)
Source: Clinical Epigenetics - May 19, 2023 Category: Research Authors: Zijiao Tang, Lu Liu and J ürgen Borlak Tags: Research Source Type: research
Retraction Note: Hypermethylation of the 5 ′ CpG island of the p14ARF flanking exon 1β in human colorectal cancer displaying a restricted pattern of p53 overexpression concomitant with increased MDM2 expression
(Source: Clinical Epigenetics)
Source: Clinical Epigenetics - May 17, 2023 Category: Research Authors: Christine Nyiraneza, Christine Sempoux, Roger Detry, Alex Kartheuser and Karin Dahan Tags: Retraction Note Source Type: research
The role of angiotensin I-converting enzyme gene polymorphism and global DNA methylation in the negative associations between urine di-(2-ethylhexyl) phthalate metabolites and serum adiponectin in a young Taiwanese population
Adiponectin is a key protein produced in adipose tissue, with crucial involvement in multiple metabolic processes. Di-(2-ethylhexyl) phthalate (DEHP), one of the phthalate compounds used as a plasticizer, has ... (Source: Clinical Epigenetics)
Source: Clinical Epigenetics - May 17, 2023 Category: Research Authors: Chien-Yu Lin, Hui-Ling Lee, Ching-Way Chen, Chikang Wang, Fung-Chang Sung and Ta-Chen Su Tags: Research Source Type: research
Short-chain fatty acid-butyric acid ameliorates granulosa cells inflammation through regulating METTL3-mediated N6-methyladenosine modification of FOSL2 in polycystic ovarian syndrome
Polycystic ovary syndrome (PCOS) is an endocrine and metabolic disorder characterized by chronic low-grade inflammation. Previous studies have demonstrated that the gut microbiome can affect the host tissue ce... (Source: Clinical Epigenetics)
Source: Clinical Epigenetics - May 13, 2023 Category: Research Authors: Kailu Liu, Xi He, Jingyu Huang, Simin Yu, Meiting Cui, Mengya Gao, Li Liu, Yu Qian, Ying Xie, Miao Hui, Yanli Hong and Xiaowei Nie Tags: Research Source Type: research
