Single-cell sequencing technology applied to epigenetics for the study of tumor heterogeneity
Previous studies have traditionally attributed the initiation of cancer cells to genetic mutations, considering them as the fundamental drivers of carcinogenesis. However, recent research has shed light on the... (Source: Clinical Epigenetics)
Source: Clinical Epigenetics - October 11, 2023 Category: Research Authors: Yuhua Hu, Feng Shen, Xi Yang, Tingting Han, Zhuowen Long, Jiale Wen, Junxing Huang, Jiangfeng Shen and Qing Guo Tags: Review Source Type: research
Effects of iron homeostasis on epigenetic age acceleration: a two-sample Mendelian randomization study
Epigenetic clocks constructed from DNA methylation patterns have emerged as excellent predictors of aging and aging-related health outcomes. Iron, a crucial element, is meticulously regulated within organisms,... (Source: Clinical Epigenetics)
Source: Clinical Epigenetics - October 7, 2023 Category: Research Authors: Zhihao Wang, Yi Liu, Shuxin Zhang, Yunbo Yuan, Siliang Chen, Wenhao Li, Mingrong Zuo, Yufan Xiang, Tengfei Li, Wanchun Yang, Yuan Yang and Yanhui Liu Tags: Research Source Type: research
A transgenic mice model of retinopathy of cblG-type inherited disorder of one-carbon metabolism highlights epigenome-wide alterations related to cone photoreceptor cells development and retinal metabolism
MTR gene encodes the cytoplasmic enzyme methionine synthase, which plays a pivotal role in the methionine cycle of one-carbon metabolism. This cycle holds a significant importance in generating S-adenosylmethioni... (Source: Clinical Epigenetics)
Source: Clinical Epigenetics - October 5, 2023 Category: Research Authors: Karim Matmat, Jean-Baptiste Conart, Paul-Henri Graindorge, Sandra El Kouche, Ziad Hassan, Youssef Siblini, R émy Umoret, Ramia Safar, Okan Baspinar, Aurélie Robert, Jean-Marc Alberto, Abderrahim Oussalah, David Coelho, Jean-Louis Guéant and Rosa-Maria Tags: Research Source Type: research
Serum methylation of GALNT9, UPF3A, WARS, and LDB2 as noninvasive biomarkers for the early detection of colorectal cancer and advanced adenomas
Early detection has proven to be the most effective strategy to reduce the incidence and mortality of colorectal cancer (CRC). Nevertheless, most current screening programs suffer from low participation rates.... (Source: Clinical Epigenetics)
Source: Clinical Epigenetics - October 4, 2023 Category: Research Authors: Mar ía Gallardo-Gómez, Mar Rodríguez-Girondo, Núria Planell, Sebastian Moran, Luis Bujanda, Ane Etxart, Antoni Castells, Francesc Balaguer, Rodrigo Jover, Manel Esteller, Joaquín Cubiella, David Gómez-Cabrero and Loretta De Chiara Tags: Research Source Type: research
Epigenomic response to albuterol treatment in asthma-relevant airway epithelial cells
Albuterol is the first-line asthma medication used in diverse populations. Although DNA methylation (DNAm) is an epigenetic mechanism involved in asthma and bronchodilator drug response (BDR), no study has ass... (Source: Clinical Epigenetics)
Source: Clinical Epigenetics - October 3, 2023 Category: Research Authors: Javier Perez-Garcia, Maria Pino-Yanes, Elizabeth G. Plender, Jamie L. Everman, Celeste Eng, Nathan D. Jackson, Camille M. Moore, Kenneth B. Beckman, Vivian Medina, Sunita Sharma, Daniel Efrain Winnica, Fernando Holguin, Jos é Rodríguez-Santana, Jesús V Tags: Research Source Type: research
A DNA methylation signature in the stress driver gene Fkbp5 indicates a neuropathic component in chronic pain
Epigenetic changes can bring insight into gene regulatory mechanisms associated with disease pathogenicity, including chronicity and increased vulnerability. To date, we are yet to identify genes sensitive to ... (Source: Clinical Epigenetics)
Source: Clinical Epigenetics - September 30, 2023 Category: Research Authors: Maria Maiar ù, Richard J. Acton, Eva L. Woźniak, Charles A. Mein, Christopher G. Bell and Sandrine M. Géranton Tags: Research Source Type: research
Effect of women ’s fertility and sexual development on epigenetic clock: Mendelian randomization study
In observational studies, women ’s fertility and sexual development traits may have implications for DNA methylation patterns, and pregnancy-related risk factors can also affect maternal DNA methylation pattern... (Source: Clinical Epigenetics)
Source: Clinical Epigenetics - September 28, 2023 Category: Research Authors: Boxin Zhang, Qizhi Yuan, Yining Luan and Jian Xia Tags: Research Source Type: research
METTL3 exerts synergistic effects on m6A methylation and histone modification to regulate the function of VGF in lung adenocarcinoma
Multiple genetic and epigenetic regulatory mechanisms play a vital role in tumorigenesis and development. Understanding the interplay between different epigenetic modifications and its contribution to transcri... (Source: Clinical Epigenetics)
Source: Clinical Epigenetics - September 23, 2023 Category: Research Authors: Kesong Shi, Rula Sa, Le Dou, Yuan Wu, Zhiqiang Dong, Xinyao Fu and Haiquan Yu Tags: Research Source Type: research
The association between prenatal famine, DNA methylation and mental disorders: a systematic review and meta-analysis
Undernutrition in pregnant women is an unfavorable environmental condition that can affect the intrauterine development via epigenetic mechanisms and thus have long-lasting detrimental consequences for the men... (Source: Clinical Epigenetics)
Source: Clinical Epigenetics - September 16, 2023 Category: Research Authors: Heike Eichenauer and Ulrike Ehlert Tags: Review Source Type: research
Evaluation of commercial kits for isolation and bisulfite conversion of circulating cell-free tumor DNA from blood
DNA methylation biomarkers in circulating cell-free DNA (cfDNA) have great clinical potential for cancer management. Most methods for DNA methylation analysis require bisulfite conversion, causing DNA degradat... (Source: Clinical Epigenetics)
Source: Clinical Epigenetics - September 14, 2023 Category: Research Authors: Stine H. Kresse, Sara Brandt-Winge, Heidi Pharo, Bj ørnar T. B. Flatin, Marine Jeanmougin, Hege Marie Vedeld and Guro E. Lind Tags: Research Source Type: research
Crosstalk between DNA methylation and hypoxia in acute myeloid leukaemia
Acute myeloid leukaemia (AML) is a deadly disease characterised by the uncontrolled proliferation of immature myeloid cells within the bone marrow. Altered regulation of DNA methylation is an important epigene... (Source: Clinical Epigenetics)
Source: Clinical Epigenetics - September 13, 2023 Category: Research Authors: Sam Humphries, Danielle R. Bond, Zacary P. Germon, Simon Keely, Anoop K. Enjeti, Matthew D. Dun and Heather J. Lee Tags: Review Source Type: research
Unlocking the potential of targeting histone-modifying enzymes for treating IBD and CRC
Dysregulation of histone modifications has been implicated in the pathogenesis of both inflammatory bowel disease (IBD) and colorectal cancer (CRC). These diseases are characterized by chronic inflammation, an... (Source: Clinical Epigenetics)
Source: Clinical Epigenetics - September 11, 2023 Category: Research Authors: Bing Liang, Yanhong Wang, Jiazhen Xu, Yingchun Shao and Dongming Xing Tags: Review Source Type: research
Degradation of methylation signals in cryopreserved DNA
Blood-based DNA methylation has shown great promise as a biomarker in a wide variety of diseases. Studies of DNA methylation in blood often utilize samples which have been cryopreserved for years or even decad... (Source: Clinical Epigenetics)
Source: Clinical Epigenetics - September 11, 2023 Category: Research Authors: Ning Yuan Lee, Melissa Hum, Guek Peng Tan, Ai Choo Seah, Patricia T. Kin, Ngiap Chuan Tan, Hai-Yang Law and Ann S. G. Lee Tags: Research Source Type: research
Analysis of DNA methylation at birth and in childhood reveals changes associated with season of birth and latitude
Seasonal variations in environmental exposures at birth or during gestation are associated with numerous adult traits and health outcomes later in life. Whether DNA methylation (DNAm) plays a role in the molec... (Source: Clinical Epigenetics)
Source: Clinical Epigenetics - September 11, 2023 Category: Research Authors: Latha Kadalayil, Md. Zahangir Alam, Cory Haley White, Akram Ghantous, Esther Walton, Olena Gruzieva, Simon Kebede Merid, Ashish Kumar, Ritu P. Roy, Olivia Solomon, Karen Huen, Brenda Eskenazi, Peter Rzehak, Veit Grote, Jean-Paul Langhendries, Elvira Verdu Tags: Research Source Type: research
Low levels of circulating methylated IRX3 are related to worse outcome after transcatheter aortic valve implantation in patients with severe aortic stenosis
Aortic stenosis (AS) is one of the most common cardiac diseases and major cause of morbidity and mortality in the elderly. Transcatheter aortic valve implantation (TAVI) is performed in such patients with symp... (Source: Clinical Epigenetics)
Source: Clinical Epigenetics - September 11, 2023 Category: Research Authors: Leon Kanwischer, Xingbo Xu, Afifa Binta Saifuddin, Sabine Maamari, Xiaoying Tan, Fouzi Alnour, Bj örn Tampe, Thomas Meyer, Michael Zeisberg, Gerd Hasenfuss, Miriam Puls and Elisabeth M. Zeisberg Tags: Research Source Type: research
