DNA hypermethylation driven by DNMT1 and DNMT3A favors tumor immune escape contributing to the aggressiveness of adrenocortical carcinoma
Adrenocortical carcinoma is rare and aggressive endocrine cancer of the adrenal gland. Within adrenocortical carcinoma, a recently described subtype characterized by a CpG island methylator phenotype (CIMP) ha... (Source: Clinical Epigenetics)
Source: Clinical Epigenetics - August 2, 2023 Category: Research Authors: Gwenneg Kerdivel, Floriane Amrouche, Marie-Ange Calmejane, Floriane Carallis, Juliette Hamroune, Constanze Hantel, J érôme Bertherat, Guillaume Assié and Valentina Boeva Tags: Research Source Type: research
DNA methylation and 28-year cardiovascular disease risk in type 1 diabetes: the Epidemiology of Diabetes Complications (EDC) cohort study
The potential for DNA methylation (DNAm) as an early marker for cardiovascular disease (CVD) and how such an association might differ by glycemic exposure has not been examined in type 1 diabetes, a population... (Source: Clinical Epigenetics)
Source: Clinical Epigenetics - August 2, 2023 Category: Research Authors: Rachel G. Miller, Josyf C. Mychaleckyj, Suna Onengut-Gumuscu, Eleanor Feingold, Trevor J. Orchard and Tina Costacou Tags: Research Source Type: research
Hypomethylation of ABCG1 in peripheral blood as a potential marker for the detection of coronary heart disease
Novel molecular biomarkers for the risk assessment and early detection of coronary heart disease (CHD) are urgently needed for disease prevention. Altered methylation of ATP-binding cassette subfamily G member... (Source: Clinical Epigenetics)
Source: Clinical Epigenetics - July 28, 2023 Category: Research Authors: Jialie Jin, Xiaojing Zhao, Chao Zhu, Mengxia Li, Jinxin Wang, Yao Fan, Chunlan Liu, Chong Shen and Rongxi Yang Tags: Research Source Type: research
Genome-wide discovery of circulating cell-free DNA methylation biomarkers for colorectal cancer detection
Colorectal polyp is known a precursor of colorectal cancer (CRC) that holds an increased risk for progression to CRC. Circulating cell-free DNA (cfDNA) methylation has shown favorable performance in the detect... (Source: Clinical Epigenetics)
Source: Clinical Epigenetics - July 27, 2023 Category: Research Authors: Qingxiao Fang, Ziming Yuan, Hanqing Hu, Weiyuan Zhang, Guiyu Wang and Xishan Wang Tags: Research Source Type: research
Circulating NPTX2 methylation as a non-invasive biomarker for prognosis and monitoring of metastatic pancreatic cancer
Pancreatic cancer is the most lethal cancer with a dismal prognosis mainly due to diagnosis at advanced stage and ineffective treatments. CA19-9 levels and computed tomography (CT) imaging are the main standar... (Source: Clinical Epigenetics)
Source: Clinical Epigenetics - July 22, 2023 Category: Research Authors: Mar ía Victoria García-Ortiz, Pablo Cano-Ramírez, Marta Toledano-Fonseca, María Teresa Cano, Elizabeth Inga-Saavedra, Rosa María Rodríguez-Alonso, Silvia Guil-Luna, María Auxiliadora Gómez-España, Antonio Rodríguez-Ariza and Enrique Aranda Tags: Research Source Type: research
Correction: Quantification of hematopoietic stem and progenitor cells by targeted DNA methylation analysis
(Source: Clinical Epigenetics)
Source: Clinical Epigenetics - July 20, 2023 Category: Research Authors: Ledio Bocova, Wouter Hubens, Cordula Engel, Steffen Koschmieder, Edgar Jost and Wolfgang Wagner Tags: Correction Source Type: research
Abnormal DNA methylation within genes of the steroidogenesis pathway two years after paediatric critical illness and association with stunted growth in height further in time
Former critically ill children show an epigenetic age deceleration 2 years after paediatric intensive care unit (PICU) admission as compared with normally developing healthy children, with stunted growth in he... (Source: Clinical Epigenetics)
Source: Clinical Epigenetics - July 19, 2023 Category: Research Authors: Ilse Vanhorebeek, Gr égoire Coppens, Fabian Güiza, Inge Derese, Pieter J. Wouters, Koen F. Joosten, Sascha C. Verbruggen and Greet Van den Berghe Tags: Research Source Type: research
Association of immune cell composition with the risk factors and incidence of acute coronary syndrome
Although immune cells are involved in acute coronary syndrome (ACS), few studies have explored the association of incident ACS with the relative immune cell proportions. We aimed to investigate the association... (Source: Clinical Epigenetics)
Source: Clinical Epigenetics - July 17, 2023 Category: Research Authors: Xian Shi, Minghan Qu, Yi Jiang, Ziwei Zhu, Chengguqiu Dai, Minghui Jiang, Lin Ding, Yu Yan, Chaolong Wang, Xiaomin Zhang, Shanshan Cheng and Xingjie Hao Tags: Research Source Type: research
Stability selection enhances feature selection and enables accurate prediction of gestational age using only five DNA methylation sites
DNA methylation (DNAm) is robustly associated with chronological age in children and adults, and gestational age (GA) in newborns. This property has enabled the development of several epigenetic clocks that ca... (Source: Clinical Epigenetics)
Source: Clinical Epigenetics - July 13, 2023 Category: Research Authors: Kristine L. Haftorn, Julia Romanowska, Yunsung Lee, Christian M. Page, Per M. Magnus, Siri E. H åberg, Jon Bohlin, Astanand Jugessur and William R. P. Denault Tags: Research Source Type: research
Efficacy and safety of FDA-approved IDH inhibitors in the treatment of IDH mutated acute myeloid leukemia: a systematic review and meta-analysis
To systematically evaluate the efficacy and safety of FDA-approved isocitrate dehydrogenase (IDH) inhibitors in the treatment of IDH-mutated acute myeloid leukemia (AML). (Source: Clinical Epigenetics)
Source: Clinical Epigenetics - July 11, 2023 Category: Research Authors: Xiu Chen, Hongyun Xing, Xiaolu Xie, Liqiu Kou, Jun Li and Yaling Li Tags: Review Source Type: research
Prenatal delta-9-tetrahydrocannabinol exposure is associated with changes in rhesus macaque DNA methylation enriched for autism genes
With the growing availability of cannabis and the popularization of additional routes of cannabis use beyond smoking, including edibles, the prevalence of cannabis use in pregnancy is rapidly increasing. Howev... (Source: Clinical Epigenetics)
Source: Clinical Epigenetics - July 6, 2023 Category: Research Authors: Lyndsey E. Shorey-Kendrick, Victoria H. J. Roberts, Rahul J. D ’Mello, Elinor L. Sullivan, Susan K. Murphy, Owen J. T. Mccarty, Danny J. Schust, Jason C. Hedges, A. J. Mitchell, Jose Juanito D. Terrobias, Charles A. Easley IV, Eliot R. Spindel and Jamie Tags: Research Source Type: research
Epigenetic marks associated with gestational diabetes mellitus across two time points during pregnancy
In this study, we explored the epige... (Source: Clinical Epigenetics)
Source: Clinical Epigenetics - July 6, 2023 Category: Research Authors: Teresa Linares-Pineda, Nerea Pe ña-Montero, Nicolás Fragoso-Bargas, Carolina Gutiérrez-Repiso, Fuensanta Lima-Rubio, María Suarez-Arana, Antonio Sánchez-Pozo, Francisco J. Tinahones, María Molina-Vega, María José Picón-César, Christine Sommer an Tags: Research Source Type: research
Epigenome-wide methylation analysis of colorectal carcinoma, adenoma and normal tissue reveals novel biomarkers addressing unmet clinical needs
Biomarker discovery in colorectal cancer has mostly focused on methylation patterns in normal and colorectal tumor tissue, but adenomas remain understudied. Therefore, we performed the first epigenome-wide stu... (Source: Clinical Epigenetics)
Source: Clinical Epigenetics - July 6, 2023 Category: Research Authors: Katleen Janssens, Isabelle Neefs, Joe Ibrahim, Anne Schepers, Patrick Pauwels, Marc Peeters, Guy Van Camp and Ken Op de Beeck Tags: Research Source Type: research
CTLA4 DNA methylation is associated with CTLA-4 expression and predicts response to immunotherapy in head and neck squamous cell carcinoma
The majority of patients with recurrent or metastasized head and neck squamous cell carcinoma (HNSCC) do not benefit from immune checkpoint blockade (ICB) while several patients experience severe and persisten... (Source: Clinical Epigenetics)
Source: Clinical Epigenetics - July 6, 2023 Category: Research Authors: Friederike Hoffmann, Alina Franzen, Luka de Vos, Lennert Wuest, Zs ófi Kulcsár, Simon Fietz, Alexander Philippe Maas, Sarah Hollick, Marie Yatou Diop, Jennis Gabrielpillai, Timo Vogt, Pia Kuster, Romina Zarbl, Joern Dietrich, Glen Kristiansen, Peter Bro Tags: Research Source Type: research
FTO-dependent m6A regulates muscle fiber remodeling in an NFATC1 –YTHDF2 dependent manner
Adolescent idiopathic scoliosis (AIS) is characterized by low lean mass without vertebral deformity. The cause-and-effect relationship between scoliosis and paraspinal muscle imbalance has long puzzled researc... (Source: Clinical Epigenetics)
Source: Clinical Epigenetics - July 5, 2023 Category: Research Authors: Wengang Wang, Xueming Du, Ming Luo and Ningning Yang Tags: Research Source Type: research
