Traffic-related air pollution and supplemental folic acid intake in relation to DNA methylation in granulosa cells
Higher exposure to traffic-related air pollution (TRAP) is related to lower fertility, with specific adverse effects on the ovary. Folic acid may attenuate these effects. Our goal was to explore the relation o... (Source: Clinical Epigenetics)
Source: Clinical Epigenetics - May 13, 2023 Category: Research Authors: Audrey J. Gaskins, Robert B. Hood, Jennifer B. Ford, Russ Hauser, Anna K. Knight, Alicia K. Smith and Todd M. Everson Tags: Research Source Type: research
Epigenetic effects of herbal medicine
Epigenetic memory is essential for life that governs the predefined functional features of cells. Recent evidence has indicated that the epigenetic modification provides a potential link to gene expression cha... (Source: Clinical Epigenetics)
Source: Clinical Epigenetics - May 13, 2023 Category: Research Authors: Yu-Yao Wu, Yan-Ming Xu and Andy T. Y. Lau Tags: Review Source Type: research
Capturing sex-specific and hypofertility-linked effects of assisted reproductive technologies on the cord blood DNA methylome
Children conceived through assisted reproduction are at an increased risk for growth and genomic imprinting disorders, often linked to DNA methylation defects. It has been suggested that assisted reproductive ... (Source: Clinical Epigenetics)
Source: Clinical Epigenetics - May 11, 2023 Category: Research Authors: Sophia Rahimi, Xiaojian Shao, Donovan Chan, Jos ée Martel, Anick Bérard, William D. Fraser, Marie-Michelle Simon, Tony Kwan, Guillaume Bourque and Jacquetta Trasler Tags: Research Source Type: research
Differential effect of histone H3.3 depletion on retroviral repression in embryonic stem cells
Integration of retroviruses into the host genome can impair the genomic and epigenomic integrity of the cell. As a defense mechanism, epigenetic modifications on the proviral DNA repress retroviral sequences i... (Source: Clinical Epigenetics)
Source: Clinical Epigenetics - May 11, 2023 Category: Research Authors: Ayellet Tal, Jose David Aguilera, Igor Bren, Carmit Strauss and Sharon Schlesinger Tags: Research Source Type: research
Time to relapse in chronic lymphocytic leukemia and DNA-methylation-based biological age
Chronic lymphocytic leukemia (CLL) is a mature B cell neoplasm with a predilection for older individuals. While previous studies have identified epigenetic signatures associated with CLL, whether age-related D... (Source: Clinical Epigenetics)
Source: Clinical Epigenetics - May 10, 2023 Category: Research Authors: Drew R. Nannini, Rene Cortese, Peter Egwom, Senthilnathan Palaniyandi and Gerhard C. Hildebrandt Tags: Research Source Type: research
CRISPR-Cas9 knockout screen identifies novel treatment targets in childhood high-grade glioma
Brain tumours are the leading cause of cancer-related death in children, and there is no effective treatment. A growing body of evidence points to deregulated epigenetics as a tumour driver, particularly in pa... (Source: Clinical Epigenetics)
Source: Clinical Epigenetics - May 9, 2023 Category: Research Authors: Anna Wenger, Ida Karlsson, Teresia Kling and Helena Car én Tags: Research Source Type: research
Risk assessment of assisted reproductive technology and parental age at childbirth for the development of uniparental disomy-mediated imprinting disorders caused by aneuploid gametes
Our previous study suggested that assisted reproductive technology (ART) may be a possible risk factor for the development of epimutation-mediated imprinting disorders (epi-IDs) for mothers aged ≥ 30 years. Ho... (Source: Clinical Epigenetics)
Source: Clinical Epigenetics - May 6, 2023 Category: Research Authors: Kaori Hara-Isono, Keiko Matsubara, Akie Nakamura, Shinichiro Sano, Takanobu Inoue, Sayaka Kawashima, Tomoko Fuke, Kazuki Yamazawa, Maki Fukami, Tsutomu Ogata and Masayo Kagami Tags: Research Source Type: research
SOCS1 methylation level is associated with prognosis in patients with acute-on-chronic hepatitis B liver failure
Glucocorticoids could greatly improve the prognosis of patients with acute-on-chronic hepatitis B liver failure (ACHBLF). Suppressor of cytokine signaling (SOCS) 1 methylation has been shown to be associated w... (Source: Clinical Epigenetics)
Source: Clinical Epigenetics - May 6, 2023 Category: Research Authors: Feng Li, Ying Zhang, Zhao-Hui Wang, Shuai Gao, Yu-Chen Fan and Kai Wang Tags: Research Source Type: research
E3 ubiquitin ligase RNF180 prevents excessive PCDH10 methylation to suppress the proliferation and metastasis of gastric cancer cells by promoting ubiquitination of DNMT1
Downregulation of certain tumor-suppressor genes (TSGs) by aberrant methylation of CpG islands in the promoter region contributes a great deal to the oncogenesis and progression of several cancers, including g... (Source: Clinical Epigenetics)
Source: Clinical Epigenetics - May 5, 2023 Category: Research Authors: Nannan Zhang, Xiaoliang Gao, Qiangqiang Yuan, Xin Fu, Pengliang Wang, Fenglin Cai, Hui Liu, Jing Zhang, Han Liang, Yongzhan Nie and Jingyu Deng Tags: Research Source Type: research
The impact of epigenetic landscape on ovarian cells in infertile older women undergoing IVF procedures
The constant decline in fertility and older reproductive age is the major cause of low clinical pregnancy rates in industrialised countries. Epigenetic mechanisms impact on proper embryonic development in wome... (Source: Clinical Epigenetics)
Source: Clinical Epigenetics - May 4, 2023 Category: Research Authors: Giulia Sgueglia, Salvatore Longobardi, Domenico Valerio, Maria Rosaria Campitiello, Nicola Colacurci, Cinzia Di Pietro, Rosalia Battaglia, Thomas D ’Hooghe, Lucia Altucci and Carmela Dell’Aversana Tags: Review Source Type: research
Epigenetic priming improves salvage chemotherapy in diffuse large B-cell lymphoma via endogenous retrovirus-induced cGAS-STING activation
Although most patients with diffuse large B-cell lymphoma (DLBCL) achieve complete remission after first-line rituximab-containing immunochemotherapy, up to 40% of patients relapse and require salvage therapy.... (Source: Clinical Epigenetics)
Source: Clinical Epigenetics - May 3, 2023 Category: Research Authors: Jun Liu, Suji Min, Dongchan Kim, Jihyun Park, Eunchae Park, Youngil Koh, Dong-Yeop Shin, Tae Kon Kim, Ja Min Byun, Sung-Soo Yoon and Junshik Hong Tags: Research Source Type: research
Epigenetic reactivation of tumor suppressor genes with CRISPRa technologies as precision therapy for hepatocellular carcinoma
Epigenetic silencing of tumor suppressor genes (TSGs) is a key feature of oncogenesis in hepatocellular carcinoma (HCC). Liver-targeted delivery of CRISPR-activation (CRISPRa) systems makes it possible to expl... (Source: Clinical Epigenetics)
Source: Clinical Epigenetics - April 29, 2023 Category: Research Authors: Agustin Sgro, Joseph Cursons, Charlene Waryah, Eleanor A. Woodward, Momeneh Foroutan, Ruqian Lyu, George C. T. Yeoh, Peter J. Leedman and Pilar Blancafort Tags: Research Source Type: research
A study of using epigenetic modulators to enhance response to pembrolizumab (MK-3475) in microsatellite stable advanced colorectal cancer
Approximately 95% of advanced colorectal cancer patients (CRC) have mismatch repair MMR-proficient (MMRp) tumors, which do not respond to PD1 blockade alone. Preclinical studies have shown that combined histon... (Source: Clinical Epigenetics)
Source: Clinical Epigenetics - April 29, 2023 Category: Research Authors: Marina Baretti, Adrian G. Murphy, Marianna Zahurak, Nicole Gianino, Rose Parkinson, Rosalind Walker, Tamara Y. Lopez-Vidal, Lei Zheng, Gary Rosner, Nita Ahuja, Schalper Kurt and Nilofer S. Azad Tags: Research Source Type: research
Extensive intratumor regional epigenetic heterogeneity in clear cell renal cell carcinoma targets kidney enhancers and is associated with poor outcome
Clear cell renal cell cancer (ccRCC), the 8th leading cause of cancer-related death in the US, is challenging to treat due to high level intratumoral heterogeneity (ITH) and the paucity of druggable driver mut... (Source: Clinical Epigenetics)
Source: Clinical Epigenetics - April 29, 2023 Category: Research Authors: Louis Y. El Khoury, Xiaoyu Pan, Ryan A. Hlady, Ryan T. Wagner, Shafiq Shaikh, Liguo Wang, Mitchell R. Humphreys, Erik P. Castle, Melissa L. Stanton, Thai H. Ho and Keith D. Robertson Tags: Research Source Type: research
Characterization of molecular subtypes based on chromatin regulators and identification of the role of NPAS2 in lung adenocarcinoma
Chromatin regulators (CRs) are critical epigenetic modifiers and have been reported to play critical roles during the progression of various tumors, but their role in lung adenocarcinoma (LUAD) has not been co... (Source: Clinical Epigenetics)
Source: Clinical Epigenetics - April 29, 2023 Category: Research Authors: Yongbiao Huang, Lingyan Xiao, Motuma Yigezu Daba, Duo Xu, Yuan Wang, Long Li, Qian Li, Bo Liu, Wan Qin, Huixian Zhang and Xianglin Yuan Tags: Research Source Type: research
