Overexpression of β-Catenin Decreases the Radiosensitivity of Human Nasopharyngeal Carcinoma CNE-2 Cells
Conclusion:β-catenin overexpression may decrease the radiation sensitivity in NPC CNE-2 cells through activating the downstream transcriptional factors of β-catenin, and reducing G2/M arrest and cell apoptosis.Cell Physiol Biochem 2018;50:1929 –1944 (Source: Cellular Physiology and Biochemistry)
Source: Cellular Physiology and Biochemistry - November 7, 2018 Category: Cytology Source Type: research

Targeting Thioredoxin System with an Organosulfur Compound, Diallyl Trisulfide (DATS), Attenuates Progression and Metastasis of Triple-Negative Breast Cancer (TNBC)
Conclusion: Collectively, this present study indicates that targeting Trx system with DATS may provide a promising strategy for treating metastasis of TNBC.Cell Physiol Biochem 2018;50:1945 –1963 (Source: Cellular Physiology and Biochemistry)
Source: Cellular Physiology and Biochemistry - November 7, 2018 Category: Cytology Source Type: research

Expression Signature and Role of miR-30d-5p in Non-Small Cell Lung Cancer: a Comprehensive Study Based on in Silico Analysis of Public Databases and in Vitro Experiments
Conclusion: In summary, miR-30d-5p expression is decreased in NSCLC, and it might play the role as tumor suppressor in NSCLC by regulating target genes.Cell Physiol Biochem 2018;50:1964 –1987 (Source: Cellular Physiology and Biochemistry)
Source: Cellular Physiology and Biochemistry - November 7, 2018 Category: Cytology Source Type: research

Carbon Monoxide Releasing Molecule 3 Inhibits Osteoclastogenic Differentiation of RAW264.7 Cells by Heme Oxygenase-1
Conclusion: CORM-3 inhibits osteoclastogenic differentiation of RAW264.7 cells via releasing CO. The inhibitory effect is mediated partially by HO-1 pathway. The results suggest the potential application of CORM-3 on some bone defective diseases.Cell Physiol Biochem 2018;50:1988 –2003 (Source: Cellular Physiology and Biochemistry)
Source: Cellular Physiology and Biochemistry - November 7, 2018 Category: Cytology Source Type: research

TPPP3 Promotes Cell Proliferation, Invasion and Tumor Metastasis via STAT3/ Twist1 Pathway in Non-Small-Cell Lung Carcinoma
Conclusion: Overall, this study demonstrates that TPPP3 promotes the metastasis of NSCLC through the STAT3/Twist1 pathway.Cell Physiol Biochem 2018;50:2004 –2016 (Source: Cellular Physiology and Biochemistry)
Source: Cellular Physiology and Biochemistry - November 7, 2018 Category: Cytology Source Type: research

Long Noncoding RNA HOXA-AS2 Promotes Papillary Thyroid Cancer Progression by Regulating miR-520c-3p/S100A4 Pathway
Conclusion: In summary, our results suggested that the HOXA-AS2/miR-520c-3p/S100A4 axis may play an important role in the regulation of PTC progression, which provides us with new insights into understanding the PTC.Cell Physiol Biochem 2018;50:1659 –1672 (Source: Cellular Physiology and Biochemistry)
Source: Cellular Physiology and Biochemistry - November 1, 2018 Category: Cytology Source Type: research

Up-Regulation Thioredoxin Inhibits Advanced Glycation End Products-Induced Neurodegeneration
Conclusion: Up-regulating Trx inhibited neurodegeneration induced by AGEs. The underlying mechanism may be related to inhibit Txnip/mTOR pathway-mediated autophagy.Cell Physiol Biochem 2018;50:1673 –1686 (Source: Cellular Physiology and Biochemistry)
Source: Cellular Physiology and Biochemistry - November 1, 2018 Category: Cytology Source Type: research

Aquaporin-3 Attenuates Oxidative Stress-Induced Nucleus Pulposus Cell Apoptosis Through Regulating the P38 MAPK Pathway
Conclusion: Oxidative damage can significantly downregulate AQP-3 expression. Enhancing AQP-3 expression in NP cells partly attenuates cellular apoptosis through regulating the p38 MAPK pathway under oxidative damage.Cell Physiol Biochem 2018;50:1687 –1697 (Source: Cellular Physiology and Biochemistry)
Source: Cellular Physiology and Biochemistry - November 1, 2018 Category: Cytology Source Type: research

Ghrelin Stimulates Hepatocyte Proliferation via Regulating Cell Cycle Through GSK3 β/Β-Catenin Signaling Pathway
Conclusion: Ghrelin activates GHS-R1a to stimulate hepatocyte proliferation via GSK3/ β-catenin signaling pathway.Cell Physiol Biochem 2018;50:1698 –1710 (Source: Cellular Physiology and Biochemistry)
Source: Cellular Physiology and Biochemistry - November 1, 2018 Category: Cytology Source Type: research

Taurocholate Induces Connective Tissue Growth Factor Expression in Hepatocytes Through ERK-YAP Signaling
Conclusion: Our report provides evidence for the role of conjugated BAs in liver fibrosis and suggests that the production of CTGF/CCN2, induced by conjugated BAs via ERK-YAP axis activation, may be a therapeutic target in cholestasis-induced liver fibrosis.Cell Physiol Biochem 2018;50:1711 –1725 (Source: Cellular Physiology and Biochemistry)
Source: Cellular Physiology and Biochemistry - November 1, 2018 Category: Cytology Source Type: research

Shengmai San Alleviates Diabetic Cardiomyopathy Through Improvement of Mitochondrial Lipid Metabolic Disorder
Conclusion: The results indicate that SMS may alleviate diabetes-induced myocardial hypertrophy and diastolic dysfunction by improving mitochondrial lipid metabolism.Cell Physiol Biochem 2018;50:1726 –1739 (Source: Cellular Physiology and Biochemistry)
Source: Cellular Physiology and Biochemistry - November 1, 2018 Category: Cytology Source Type: research

Salusin- α Inhibits Proliferation and Migration of Vascular Smooth Muscle Cell via Akt/mTOR Signaling
Conclusion: Our data indicate that salusin- α suppresses the development of atherosclerosis by inhibiting VSMC proliferation and migration through the Akt/mTOR pathway.Cell Physiol Biochem 2018;50:1740 –1753 (Source: Cellular Physiology and Biochemistry)
Source: Cellular Physiology and Biochemistry - November 1, 2018 Category: Cytology Source Type: research

Circulating Exosomal miR-17 Inhibits the Induction of Regulatory T Cells via Suppressing TGFBR II Expression in Rheumatoid Arthritis
Conclusion: Our findings imply that altered miRNA expression in RA-exosomes may contribute to the pathogenesis of RA by disrupting the homeostasis of Tregs.Cell Physiol Biochem 2018;50:1754 –1763 (Source: Cellular Physiology and Biochemistry)
Source: Cellular Physiology and Biochemistry - November 1, 2018 Category: Cytology Source Type: research

The Landscape of Non-Coding RNA in an Adult Pig Model of Intrauterine Growth Restriction
Conclusion: Together, this study reveals a multitude of candidate lncRNAs and circRNAs involved in the development of IUGR pigs, which could facilitate further researches on the molecular mechanisms of metabolic syndrome.Cell Physiol Biochem 2018;50:1764 –1778 (Source: Cellular Physiology and Biochemistry)
Source: Cellular Physiology and Biochemistry - November 1, 2018 Category: Cytology Source Type: research

ROS Promote Ox-LDL-Induced Platelet Activation by Up-Regulating Autophagy Through the Inhibition of the PI3K/AKT/mTOR Pathway
Conclusion: Inhibition of ROS production may reduce autophagy to suppress ox-LDL-induced platelet activation by activating PI3K/AKT/mTOR pathway.Cell Physiol Biochem 2018;50:1779 –1793 (Source: Cellular Physiology and Biochemistry)
Source: Cellular Physiology and Biochemistry - November 1, 2018 Category: Cytology Source Type: research