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Aldehyde Dehydrogenase 1 (ALDH1) Promotes the Toxicity of TRAIL in Non-Small Cell Lung Cancer Cells via Post-Transcriptional Regulation of MEK-1 Expression
Conclusion: ALDH1 protein induced MEK-1 mRNA stability and promoted its translation via its 3 ’UTR.Cell Physiol Biochem 2018;51:217 –227 (Source: Cellular Physiology and Biochemistry)
Source: Cellular Physiology and Biochemistry - November 16, 2018 Category: Cytology Source Type: research

Cytoprotective Effects of N-Acetylcysteine on Streptozotocin- Induced Oxidative Stress and Apoptosis in RIN-5F Pancreatic β-Cells
Conclusion: Our results suggest that the cytoprotective action of NAC is mediated via suppression of oxidative stress and apoptosis and restoration of GSH homeostasis and mitochondrial bioenergetics. This study may, thus, help in better understanding the cellular defense mechanisms of pancreatic β-cells against STZ-induced cytotoxicity.Cell Physiol Biochem 2018;51:201 –216 (Source: Cellular Physiology and Biochemistry)
Source: Cellular Physiology and Biochemistry - November 16, 2018 Category: Cytology Source Type: research

Butyrate Modulates Inflammation in Chondrocytes via GPR43 Receptor
Conclusion: Taken together, our data suggest the potential application of sodium butyrate as a novel candidate in a multi-target approach for the treatment of chondrocyte inflammation and cartilage degenerative process.Cell Physiol Biochem 2018;51:228 –243 (Source: Cellular Physiology and Biochemistry)
Source: Cellular Physiology and Biochemistry - November 16, 2018 Category: Cytology Source Type: research

Weighted Gene Correlation Network Analysis (WGCNA) Detected Loss of MAGI2 Promotes Chronic Kidney Disease (CKD) by Podocyte Damage
Conclusion: MAGI2 identified by WGCNA regulates cytoskeletal rearrangement in podocytes, with its loss predisposing to proteinuria and CKD.Cell Physiol Biochem 2018;51:244 –261 (Source: Cellular Physiology and Biochemistry)
Source: Cellular Physiology and Biochemistry - November 16, 2018 Category: Cytology Source Type: research

Increased KIF15 Expression Predicts a Poor Prognosis in Patients with Lung Adenocarcinoma
Conclusion: Our findings show that KIF15 is involved in lung cancer carcinogenesis. KIF15 could therefore serve as a specific prognostic marker for patients with lung adenocarcinoma.Cell Physiol Biochem 2018;51:1 –10 (Source: Cellular Physiology and Biochemistry)
Source: Cellular Physiology and Biochemistry - November 15, 2018 Category: Cytology Source Type: research

Long Non-Coding RNA MALAT1 Protects Human Osteoblasts from Dexamethasone-Induced Injury via Activation of PPM1E-AMPK Signaling
Conclusion: Lnc-MALAT1 protects human osteoblasts from Dex-induced injuries, possibly via activation of Ppm1e-AMPK signaling.Cell Physiol Biochem 2018;51:31 –45 (Source: Cellular Physiology and Biochemistry)
Source: Cellular Physiology and Biochemistry - November 15, 2018 Category: Cytology Source Type: research

MicroRNA-24-3p Attenuates Myocardial Ischemia/Reperfusion Injury by Suppressing RIPK1 Expression in Mice
Conclusion: In conclusion,RIPK1 was upregulated and miR-24-3p was downregulated in a myocardial I/R injury mouse model.RIPK1 could aggravate myocardial I/R injury via the TNF signaling pathway, while miR-24-3p could suppressRIPK1 and therefore exert cardioprotective effects in myocardial I/R injury.Cell Physiol Biochem 2018;51:46 –62 (Source: Cellular Physiology and Biochemistry)
Source: Cellular Physiology and Biochemistry - November 15, 2018 Category: Cytology Source Type: research

Novel Protective Effects of Cistanche Tubulosa Extract Against Low-Luminance Blue Light-Induced Degenerative Retinopathy
Conclusion: CTE is a potential prophylactic agent against BLL-induced phototoxicity.Cell Physiol Biochem 2018;51:63 –79 (Source: Cellular Physiology and Biochemistry)
Source: Cellular Physiology and Biochemistry - November 15, 2018 Category: Cytology Source Type: research

Protective Role of NMDAR for Microwave-Induced Synaptic Plasticity Injuries in Primary Hippocampal Neurons
Conclusion: Microwave radiation caused neuronal synaptic plasticity injuries in primary hippocampal neurons, and NMDARs played protective roles on the damage process.Cell Physiol Biochem 2018;51:97 –112 (Source: Cellular Physiology and Biochemistry)
Source: Cellular Physiology and Biochemistry - November 15, 2018 Category: Cytology Source Type: research

Knockdown of Long Non-Coding RNA XIST Inhibited Doxorubicin Resistance in Colorectal Cancer by Upregulation of miR-124 and Downregulation of SGK1
Conclusion: XIST exerted regulatory function in resistance of DOX possibly through miR-124/SGK1 axis, shedding new light on developing promising therapeutic strategy to overcome chemoresistance in CRC patients.Cell Physiol Biochem 2018;51:113 –128 (Source: Cellular Physiology and Biochemistry)
Source: Cellular Physiology and Biochemistry - November 15, 2018 Category: Cytology Source Type: research

Recovery of miR-139-5p in Ovarian Cancer Reverses Cisplatin Resistance by Targeting C-Jun
Conclusion: Recovery of miR-139-5p suppressed the expression of c-Jun and thus reversed cisplatin-resistance in ovarian cancer.Cell Physiol Biochem 2018;51:129 –141 (Source: Cellular Physiology and Biochemistry)
Source: Cellular Physiology and Biochemistry - November 15, 2018 Category: Cytology Source Type: research

Calcium Supplementation Enhanced Adipogenesis and Improved Glucose Homeostasis Through Activation of Camkii and PI3K/Akt Signaling Pathway in Porcine Bone Marrow Mesenchymal Stem Cells (pBMSCs) and Mice Fed High Fat Diet (HFD)
Conclusion: calcium supplementation enhanced adipogenesis and glucose uptake in pBMSCs, which was coincident with the increased adipocyte number and improved glucose homeostasis in HFD-fed mice, and was associated with activation of CaMKII and PI3K/Akt-FoxO1/AS160 pathways. These data provided a broader understanding of the mechanisms underlying calcium-induced body weight/fat loss and glycemic control.Cell Physiol Biochem 2018;51:154 –172 (Source: Cellular Physiology and Biochemistry)
Source: Cellular Physiology and Biochemistry - November 15, 2018 Category: Cytology Source Type: research

Type III Interferons in Viral Infection and Antiviral Immunity
Interferons (IFNs) can serve as the first line of immune defense against viral infection. The identification of IFN- λs 1, 2, 3 #38; 4 (termed as type III IFNs) has revealed that the antiviral immune response to viruses contains more components than the type I IFNs that have been known for more than 50 years. IFN-λs are IFN-λ1 (IL-29), IFN-λ2 (IL-28a), IFN-λ3 (IL-28b) and IFN-λ4, which resembles IFN-λ3. IFN -λs have type I-IFN-like immune responses and biological activities, but our knowledge of these novel players in the antiviral response is not well established. In this review, we try to describe the current inf...
Source: Cellular Physiology and Biochemistry - November 15, 2018 Category: Cytology Source Type: research

Inhibition of MicroRNA-124 Reduces Cardiomyocyte Apoptosis Following Myocardial Infarction via Targeting STAT3
Conclusion: Taken together, our data demonstrate that downregulation of miR-124 inhibits MI-induced apoptosis through upregulating STAT3, which suggests the therapeutic potential of miR-124 for myocardial infarction.Cell Physiol Biochem 2018;51:186 –200 (Source: Cellular Physiology and Biochemistry)
Source: Cellular Physiology and Biochemistry - November 15, 2018 Category: Cytology Source Type: research

High-Conductance Channel Formation in Yeast Mitochondria is Mediated by F-ATP Synthase e and g Subunits
Conclusion: F-ATP synthase e, g and b subunits create a domain within the membrane that is critical for the generation of the high-conductance channel, thus is a prime candidate for PTP formation. Subunits e and g are only present in eukaryotes and may have evolved to confer this novel function to F-ATP synthase.Cell Physiol Biochem 2018;50:1840 –1855 (Source: Cellular Physiology and Biochemistry)
Source: Cellular Physiology and Biochemistry - November 13, 2018 Category: Cytology Source Type: research