Cellular Physiology and Biochemistry This is an RSS file. You can use it to subscribe to this data in your favourite RSS reader or to display this data on your own website or blog.

Ginsenoside 20(S)-Rg3 Prevents PKM2-Targeting miR-324-5p from H19 Sponging to Antagonize the Warburg Effect in Ovarian Cancer Cells
Conclusion: Our study revealed that 20(S)-Rg3 blocked the competitive inhibition of H19 on miR-324-5p, which enhanced the suppression of miR-324-5p on PKM2 and therefore inhibited the Warburg effect and repressed tumorigenesis. In a word, 20(S)-Rg3 inhibited the Warburg effect in ovarian cancer cells via H19/miR-324-5p/PKM2 pathway.Cell Physiol Biochem 2018;51:1340 –1353 (Source: Cellular Physiology and Biochemistry)
Source: Cellular Physiology and Biochemistry - November 27, 2018 Category: Cytology Source Type: research

Galangin Alleviates Liver Ischemia-Reperfusion Injury in a Rat Model by Mediating the PI3K/AKT Pathway
Conclusion: GA reduced liver I/R injury bothin vivo and vitro and inhibited BRL cell apoptosis. PI3K/AKT signaling have been involved. GA may protect against liver I/R and be a potential therapeutic candidate.Cell Physiol Biochem 2018;51:1354 –1363 (Source: Cellular Physiology and Biochemistry)
Source: Cellular Physiology and Biochemistry - November 27, 2018 Category: Cytology Source Type: research

Long Noncoding RNA FER1L4 Suppresses Tumorigenesis by Regulating the Expression of PTEN Targeting miR-18a-5p in Osteosarcoma
Conclusion: These findings suggest that FER1L4, acting as a competing endogenous RNA (ceRNA) of miR-18a-5p, exerts its anti-cancer role by modulating the expression of PTEN. Thus, FER1L4 may be a novel target for the prevention and treatment of OS.Cell Physiol Biochem 2018;51:1364 –1375 (Source: Cellular Physiology and Biochemistry)
Source: Cellular Physiology and Biochemistry - November 27, 2018 Category: Cytology Source Type: research

Protective Effects of Morus Root Extract (MRE) Against Lipopolysaccharide-Activated RAW264.7 Cells and CCl 4 -Induced Mouse Hepatic Damage
Conclusion: MRE exhibited antiinflammatory and hepatic protective activity.Cell Physiol Biochem 2018;51:1376 –1388 (Source: Cellular Physiology and Biochemistry)
Source: Cellular Physiology and Biochemistry - November 27, 2018 Category: Cytology Source Type: research

Thymosin- β4 Mediates Hepatic Stellate Cell Activation by Interfering with CircRNA-0067835/miR-155/FoxO3 Signaling Pathway
Conclusion: Our experiments showed that circRNA-0067835 regulated liver fibrosis progression by acting as a sponge of miR-155 to promote FOXO3a expression, indicating that circRNA-0067835 may serve as a potential therapeutic target for patients with liver fibrosis.Cell Physiol Biochem 2018;51:1389 –1398 (Source: Cellular Physiology and Biochemistry)
Source: Cellular Physiology and Biochemistry - November 27, 2018 Category: Cytology Source Type: research

Long Non-Coding RNA Urothelial Carcinoma Associated 1 Promotes Proliferation, Migration and Invasion of Osteosarcoma Cells by Regulating microRNA-182
Conclusion: Our research verified that UCA1 exerted oncogenic roles in osteosarcoma cells by regulating miR-182 and TIMP2, as well as PI3K/AKT/GSK3 β and NF-κB pathways.Cell Physiol Biochem 2018;51:1149 –1163 (Source: Cellular Physiology and Biochemistry)
Source: Cellular Physiology and Biochemistry - November 27, 2018 Category: Cytology Source Type: research

EFHB is a Novel Cytosolic Ca 2+ Sensor That Modulates STIM1-SARAF Interaction
Conclusion: Our results indicate that EFHB is a new SOCE regulator that modulates STIM1-SARAF interaction.Cell Physiol Biochem 2018;51:1164 –1178 (Source: Cellular Physiology and Biochemistry)
Source: Cellular Physiology and Biochemistry - November 27, 2018 Category: Cytology Source Type: research

miR-650 Promotes the Metastasis and Epithelial –Mesenchymal Transition of Hepatocellular Carcinoma by Directly Inhibiting LATS2 Expression
Conclusion: In conclusion, the miR-650/LATS2 pathway may serve as a novel prognostic biomarker and an attractive therapeutic target for HCC patients.Cell Physiol Biochem 2018;51:1179 –1192 (Source: Cellular Physiology and Biochemistry)
Source: Cellular Physiology and Biochemistry - November 27, 2018 Category: Cytology Source Type: research

Pro-Angiogenic Activity of Monocytic-Type Myeloid-Derived Suppressor Cells from Balb/C Mice Infected with Echinococcus Granulosus and the Regulatory Role of miRNAs
Conclusion: M-MDSCs have a potential angiogenic role duringE. granulosus infection, and miRNAs may play a role in the immune response and angiogenesis functions of M-MDSCs through regulation of the identified signalling pathways.Cell Physiol Biochem 2018;51:1207 –1220 (Source: Cellular Physiology and Biochemistry)
Source: Cellular Physiology and Biochemistry - November 27, 2018 Category: Cytology Source Type: research

Long Non-Coding RNA XLOC_006753 Promotes the Development of Multidrug Resistance in Gastric Cancer Cells Through the PI3K/AKT/mTOR Signaling Pathway
Conclusion: High expression of XLOC_006753 promoted the development of MDR, which was activated by the PI3K/AKT/mTOR pathway in GC cells.Cell Physiol Biochem 2018;51:1221 –1236 (Source: Cellular Physiology and Biochemistry)
Source: Cellular Physiology and Biochemistry - November 27, 2018 Category: Cytology Source Type: research

miR-135a Protects Dextran Sodium Sulfate-Induced Inflammation in Human Colorectal Cell Lines by Activating STAT3 Signal
Conclusion: Our results indicated that miR-135a alleviated DSS-induced inflammation and activated STAT3 signal in colonic cells. Inhibition of STAT3 reversed the anti-inflammatory function of miR-135a by regulating proinflammatory cytokines. Thus, STAT3 signal might serve, at least in part, as the potential mechanism of miR-135a-mediated anti-inflammatory effect in colonic cells.Cell Physiol Biochem 2018;51:1001 –1012 (Source: Cellular Physiology and Biochemistry)
Source: Cellular Physiology and Biochemistry - November 26, 2018 Category: Cytology Source Type: research

Extracellular Matrix Elasticity Regulates Osteocyte Gap Junction Elongation: Involvement of Paxillin in Intracellular Signal Transduction
Conclusion: This process -from mechanosensing and mechanotransduction to cell function - not only indicates that the effects of mechanical factors on osteocytes can be directly sensed from the cell body, but also indicates the involvement of paxillin transduction.Cell Physiol Biochem 2018;51:1013 –1026 (Source: Cellular Physiology and Biochemistry)
Source: Cellular Physiology and Biochemistry - November 26, 2018 Category: Cytology Source Type: research

The Clinicopathological Significance and Correlative Signaling Pathways of an Autophagy-Related Gene, Ambra1, in Breast Cancer: a Study of 25 Microarray RNA-Seq Datasets and in-House Gene Silencing
Conclusion: These results indicate that the level of Ambra1 up-regulation is clearly related to tumorigenesis and progression of BC, probably via influencing several vital pathways. However, this hypothesis needs to be validated with more in-depth experiments in the future.Cell Physiol Biochem 2018;51:1027 –1040 (Source: Cellular Physiology and Biochemistry)
Source: Cellular Physiology and Biochemistry - November 26, 2018 Category: Cytology Source Type: research

Tumor-Infiltrating Podoplanin + Fibroblasts Predict Worse Outcome in Solid Tumors
Conclusion: Podoplanin+ fibroblast infiltration leads to worse clinical outcome in solid tumors, implicating that it is a valuable prognostic biomarker and targeting it may have a potential for effective treatment.Cell Physiol Biochem 2018;51:1041 –1050 (Source: Cellular Physiology and Biochemistry)
Source: Cellular Physiology and Biochemistry - November 26, 2018 Category: Cytology Source Type: research

Decreased TLR3 in Hyperplastic Adipose Tissue, Blood and Inflamed Adipocytes is Related to Metabolic Inflammation
Conclusion: Functional variations in the expression of TLR found in blood and hypertrophied fat depots, namely decreased TLR3 in lymphocytes and inflamed adipocytes, are linked to metabolic inflammation.Cell Physiol Biochem 2018;51:1051 –1068 (Source: Cellular Physiology and Biochemistry)
Source: Cellular Physiology and Biochemistry - November 26, 2018 Category: Cytology Source Type: research