Cellular Physiology and Biochemistry This is an RSS file. You can use it to subscribe to this data in your favourite RSS reader or to display this data on your own website or blog.

Interleukin-35 Expression in Non-Small Cell Lung Cancer is Associated with Tumor Progression
Conclusion: Our results showed that IL-35 plays an inhibitory role in NSCLC development and function as a novel prognostic indicator and a potential therapeutic target.Cell Physiol Biochem 2018;51:1839 –1851 (Source: Cellular Physiology and Biochemistry)
Source: Cellular Physiology and Biochemistry - November 30, 2018 Category: Cytology Source Type: research

Ciliary Neurotrophic Factor (CNTF) Protects Myocardial Cells from Oxygen Glucose Deprivation (OGD)/Re-Oxygenation via Activation of Akt-Nrf2 Signaling
Conclusion: CNTF activates Akt-Nrf2 signaling to protect myocardial cells from OGDR.Cell Physiol Biochem 2018;51:1852 –1862 (Source: Cellular Physiology and Biochemistry)
Source: Cellular Physiology and Biochemistry - November 30, 2018 Category: Cytology Source Type: research

Cr(VI)-Induced Autophagy Protects L-02 Hepatocytes from Apoptosis Through the ROS-AKT-mTOR Pathway
Conclusion: These findings indicated Cr(VI)-induced autophagy protected L-02 hepatocytes from apoptosis through the ROS-AKT-mTOR pathway.Cell Physiol Biochem 2018;51:1863 –1878 (Source: Cellular Physiology and Biochemistry)
Source: Cellular Physiology and Biochemistry - November 30, 2018 Category: Cytology Source Type: research

Targeting CD44 by CRISPR-Cas9 in Multi-Drug Resistant Osteosarcoma Cells
Conclusion: CD44 silencing could inhibit the development of osteosarcoma migration, invasion, proliferation and ameliorate drug resistance to current treatment in osteosarcoma. This study applies new strategy to target CD44, which may improve the prognosis of osteosarcoma.Cell Physiol Biochem 2018;51:1879 –1893 (Source: Cellular Physiology and Biochemistry)
Source: Cellular Physiology and Biochemistry - November 30, 2018 Category: Cytology Source Type: research

Novel Survivin Inhibitor for Suppressing Pancreatic Cancer Cells Growth via Downregulating Sp1 and Sp3 Transcription Factors
Conclusion: These results show that Cu-TA can serve as an effective survivin inhibitor for inhibiting PaCa cell growth.Cell Physiol Biochem 2018;51:1894 –1907 (Source: Cellular Physiology and Biochemistry)
Source: Cellular Physiology and Biochemistry - November 30, 2018 Category: Cytology Source Type: research

K6PC-5 Activates SphK1-Nrf2 Signaling to Protect Neuronal Cells from Oxygen Glucose Deprivation/Re-Oxygenation
Conclusion: K6PC-5 activates SphK1-Nrf2 signaling to protect neuronal cells from OGDR. K6PC-5 might be a promising neuroprotective strategy for ischemia-reperfusion injuries.Cell Physiol Biochem 2018;51:1908 –1920 (Source: Cellular Physiology and Biochemistry)
Source: Cellular Physiology and Biochemistry - November 30, 2018 Category: Cytology Source Type: research

Targeting P-Glycoprotein: Nelfinavir Reverses Adriamycin Resistance in K562/ADR Cells
Conclusion: NFV inhibited P-gp function, decreased intracellular ATP content, and promoted cell apoptosis in K562/ADR cells, thereby reversing MDR. These findings encourage further animal and clinical MDR studies with a combination therapy consisting of NFV and chemotherapeutic drugs.Cell Physiol Biochem 2018;51:1616 –1631 (Source: Cellular Physiology and Biochemistry)
Source: Cellular Physiology and Biochemistry - November 29, 2018 Category: Cytology Source Type: research

Ectodomain Shedding of RAGE and TLR4 as a Negative Feedback Regulation in High-Mobility Group Box 1-Activated Aortic Endothelial Cells
Conclusion: In response to HMGB1 stimulation, HAECs rapidly undergo ectodomain shedding of RAGE and TLR4, and thereby become insensitive to further HMGB1 stimulation. ADAM17, activated through RAGE-p38 MAPK pathway, is implicated in the ectodomain cleavage of the receptors.Cell Physiol Biochem 2018;51:1632 –1644 (Source: Cellular Physiology and Biochemistry)
Source: Cellular Physiology and Biochemistry - November 29, 2018 Category: Cytology Source Type: research

Involvement of the TLR4/NF- κB Signaling Pathway in the Repair of Esophageal Mucosa Injury in Rats with Gastroesophageal Reflux Disease
Conclusion: The key findings of the current study demonstrate that the inactivation of the TLR4/NF- κB signaling pathway alleviates oxidative stress injury and promotes the repair of esophageal mucosal injury among rats with GERD, highlighting a potential novel GERD mechanism.Cell Physiol Biochem 2018;51:1645 –1657 (Source: Cellular Physiology and Biochemistry)
Source: Cellular Physiology and Biochemistry - November 29, 2018 Category: Cytology Source Type: research

Characterization of the Nucleocytoplasmic Transport Mechanisms of Epstein-Barr Virus BFLF2
Conclusion: These works are of significance for the further study of the functions of BFLF2 during EBV infection, as well as for further insights into the design of new antiviral drug target and vaccine development against EBV.Cell Physiol Biochem 2018;51:1500 –1517 (Source: Cellular Physiology and Biochemistry)
Source: Cellular Physiology and Biochemistry - November 29, 2018 Category: Cytology Source Type: research

Long Non-Coding RNA H19 Acts as an Estrogen Receptor Modulator that is Required for Endocrine Therapy Resistance in ER < sup > + < /sup > Breast Cancer Cells
Conclusion: In endocrine therapy resistant breast cancer cells Fulvestrant is ineffective in decreasing ER α levels. Our data suggest that in the ETR cells,H19 expression acts as an ER modulator and that its levels and subsequently ER α levels can be substantially decreased by blocking Notch and c-MET receptor signaling. Consequently, treating ETR cells with these pharmacological inhibitors helps overcome resistance to Fulvestrant and Tamoxifen.Cell Physiol Biochem 2018;51:1518 –1532 (Source: Cellular Physiology and Biochemistry)
Source: Cellular Physiology and Biochemistry - November 29, 2018 Category: Cytology Source Type: research

Retaining mTeSR1 Medium during Hepatic Differentiation Facilitates Hepatocyte-Like Cell Survival by Decreasing Apoptosis
Conclusion: Retaining 25% mTeSR1 medium during hepatic differentiation has been proposed to increase the percentage of ALB-positive cells and cell survival by decreasing cell apoptosis.Cell Physiol Biochem 2018;51:1533 –1543 (Source: Cellular Physiology and Biochemistry)
Source: Cellular Physiology and Biochemistry - November 29, 2018 Category: Cytology Source Type: research

Spatial Relationship and Functional Relevance of Three Lipid Domain Populations at the Erythrocyte Surface
Conclusion: Lipid domains could contribute to calcium influx and efflux by controlling the membrane distribution and/or the activity of the mechano-activated ion channel Piezo1 and the calcium pump PMCA. Whether this results from lipid domain biophysical properties, the strength of their anchorage to the underlying cytoskeleton and/or their correspondence with inner plasma membrane leaflet lipids remains to be demonstrated.Cell Physiol Biochem 2018;51:1544 –1565 (Source: Cellular Physiology and Biochemistry)
Source: Cellular Physiology and Biochemistry - November 29, 2018 Category: Cytology Source Type: research

Peiminine Inhibits Glioblastoma in Vitro and in Vivo Through Cell Cycle Arrest and Autophagic Flux Blocking
Conclusion: Peiminine inhibits glioblastomain vitro andin vivo via arresting the cell cycle and blocking autophagic flux, suggesting new avenues for GBM therapy.Cell Physiol Biochem 2018;51:1566 –1583 (Source: Cellular Physiology and Biochemistry)
Source: Cellular Physiology and Biochemistry - November 29, 2018 Category: Cytology Source Type: research

miR-155-5p is Negatively Associated with Acute Pancreatitis and Inversely Regulates Pancreatic Acinar Cell Progression by Targeting Rela and Traf3
Conclusion: miR-155-5p inversely regulated AP development through the Rela/Traf3/Ptgs2 signaling pathway.Cell Physiol Biochem 2018;51:1584 –1599 (Source: Cellular Physiology and Biochemistry)
Source: Cellular Physiology and Biochemistry - November 29, 2018 Category: Cytology Source Type: research