Cellular Physiology and Biochemistry This is an RSS file. You can use it to subscribe to this data in your favourite RSS reader or to display this data on your own website or blog.

Development and Characterization of Neutralizing Antibodies Against Zaire Ebolavirus Glycoprotein and Protein 40
Conclusion: The study verifies neutralizing efficacy of anti-GP or anti-VP40 mAb, report promising cocktail of anti-GP and anti-VP40 mAb, or cocktail of two anti-VP40 mAbs. To our knowledge, this is the first account to report the important anti-viral effect of cocktails of anti-GP and anti-VP40 mAbsin vitro.Cell Physiol Biochem 2018;50:1055 –1067 (Source: Cellular Physiology and Biochemistry)
Source: Cellular Physiology and Biochemistry - October 24, 2018 Category: Cytology Source Type: research

Mechanism for the Decision of Ovarian Surface Epithelial Stem Cells to Undergo Neo-Oogenesis or Ovarian Tumorigenesis
The ovary is surrounded by a whitish layer of mesodermally derived ovarian surface epithelium (OSE) that lines the intraembryonic celom and comprises simple squamous to cuboidal to low pseudostratified columnar epithelial cells. Its integrity is maintained by simple desmosomes, incomplete tight junctions, several integrins and cadherins. Recent research has found that ovarian stem cells (OSCs) exist within the OSE and may be responsible for both neo-oogenesis and ovarian cancer during adult life. The factors determining whether OSCs undergo neo-oogenesis or ovarian cancer are of great interest to researchers and clinicians...
Source: Cellular Physiology and Biochemistry - October 18, 2018 Category: Cytology Source Type: research

Gab2 Ablation Reverses the Stemness of HER2-Overexpressing Breast Cancer Cells
Conclusion: This study unveils a potential function of Gab2 in HER2-overexpressing breast cancer cells. Gab2 might be a potential target in the clinical therapy of HER2-overexpressing breast carcinoma.Cell Physiol Biochem 2018;50:52 –65 (Source: Cellular Physiology and Biochemistry)
Source: Cellular Physiology and Biochemistry - October 16, 2018 Category: Cytology Source Type: research

High Glucose Induces VEGF-C Expression via the LPA 1/3 -Akt-ROS-LEDGF Signaling Axis in Human Prostate Cancer PC-3 Cells
Conclusion: These results indicated that hyperglycemia leads to LPA synthesis, and subsequent promoting pathological consequence of PCa. These novel findings could potentially provide new strategies for PCa treatments.Cell Physiol Biochem 2018;50:597 –611 (Source: Cellular Physiology and Biochemistry)
Source: Cellular Physiology and Biochemistry - October 12, 2018 Category: Cytology Source Type: research

Gp91 phox (NOX 2 ) in Activated Microglia Exacerbates Neuronal Damage Induced by Oxygen Glucose Deprivation and Hyperglycemia in an in Vitro Model
Conclusion: Knockdown of gp91phoxsiRNA significantly reduced oxidative stress and the inflammatory response, and alleviated neuronal damage after HG and OGD treatment in a rat neuronal-microglial co-culture model.Cell Physiol Biochem 2018;50:783 –797 (Source: Cellular Physiology and Biochemistry)
Source: Cellular Physiology and Biochemistry - October 12, 2018 Category: Cytology Source Type: research

Comparative Transcriptomic Analysis of Embryo Implantation in Mice and Rats
Conclusion: Our study provides insights into the molecular mechanisms involved in the evolution of embryo implantation.Cell Physiol Biochem 2018;50:668 –678 (Source: Cellular Physiology and Biochemistry)
Source: Cellular Physiology and Biochemistry - October 11, 2018 Category: Cytology Source Type: research

Glucagon-Like Peptide-1 Modulates Cholesterol Homeostasis by Suppressing the miR-19b-Induced Downregulation of ABCA1
Conclusion: GLP-1 may affect cholesterol homeostasis by regulating the expression of miR-19b and ABCA1.Cell Physiol Biochem 2018;50:679 –693 (Source: Cellular Physiology and Biochemistry)
Source: Cellular Physiology and Biochemistry - October 11, 2018 Category: Cytology Source Type: research

Downregulation of NGAL is Required for the Inhibition of Proliferation and the Promotion of Apoptosis of Human Gastric Cancer MGC-803 Cells
Conclusion: NGAL gene silencing inhibits proliferation and promotes apoptosis of MGC-803 cells, which can provide a novel theory for treatment of gastric cancer.Cell Physiol Biochem 2018;50:694 –705 (Source: Cellular Physiology and Biochemistry)
Source: Cellular Physiology and Biochemistry - October 11, 2018 Category: Cytology Source Type: research

High Glucose Promotes Epithelial-Mesenchymal Transition of Uterus Endometrial Cancer Cells by Increasing ER/GLUT4-Mediated VEGF Secretion
Conclusion: These data suggest that HG increases GLUT4 and VEGF/VEGFR expression, further promotes EMT process and accelerates the development of UEC by up-regulating ERCell Physiol Biochem 2018;50:706 –720 (Source: Cellular Physiology and Biochemistry)
Source: Cellular Physiology and Biochemistry - October 11, 2018 Category: Cytology Source Type: research

Radiation Enhances the Epithelial – Mesenchymal Transition of A549 Cells via miR3591-5p/USP33/PPM1A
Conclusion: The present study revealed the critical role of miR-3591-5p/USP33/PPM1A in radiation-induced EMT via TGF- β signaling and may suggest novel radiation sensitise strategies for lung cancer.Cell Physiol Biochem 2018;50:721 –733 (Source: Cellular Physiology and Biochemistry)
Source: Cellular Physiology and Biochemistry - October 11, 2018 Category: Cytology Source Type: research

Combination of Fluoride and SO 2 Induce DNA Damage and Morphological Alterations in Male Rat Kidney
Conclusion: The study manifests that presence of NaF and SO2 will not only induce renal tissue lesions but also impact DNA integrity. In addition, this combined exposure exhibits a synergistic effect, characterizing a dose-dependence and time correlation. These findings may provide novel insights regarding perturbations of DNA damage and its functions as a potential new mechanism, by which cautious interpretation of NaF and SO2 co-exposure evolved in both animals and human beings is necessary.Cell Physiol Biochem 2018;50:734 –744 (Source: Cellular Physiology and Biochemistry)
Source: Cellular Physiology and Biochemistry - October 11, 2018 Category: Cytology Source Type: research

Prostaglandin E1 Inhibited Diabetes-Induced Phenotypic Switching of Vascular Smooth Muscle Cells Through Activating Autophagy
Conclusion: These results demonstrated that PGE1 maintained the phenotype of VSMCs via the AKT/mTOR-dependent autophagy, which prevented diabetes-induced vascular complications.Cell Physiol Biochem 2018;50:745 –756 (Source: Cellular Physiology and Biochemistry)
Source: Cellular Physiology and Biochemistry - October 11, 2018 Category: Cytology Source Type: research

TGF β1-Smad Signaling Pathway Participates in Interleukin-33 Induced Epithelial-to-Mesenchymal Transition of A549 Cells
Conclusion: The TGF β1-smad signaling pathway participates in the IL-33 induced epithelial-to-mesenchymal transition of A549 cells.Cell Physiol Biochem 2018;50:757 –767 (Source: Cellular Physiology and Biochemistry)
Source: Cellular Physiology and Biochemistry - October 11, 2018 Category: Cytology Source Type: research

An Analysis of Relationship Between RAS Mutations and Prognosis of Primary Tumour Resection for Metastatic Colorectal Cancer Patients
Conclusion: We found that wild-type RAS gene was a favorable factor for the asymptomatic unresectable mCRC patients experiencing PTR.Cell Physiol Biochem 2018;50:768 –782 (Source: Cellular Physiology and Biochemistry)
Source: Cellular Physiology and Biochemistry - October 11, 2018 Category: Cytology Source Type: research

AZD5153 Inhibits Prostate Cancer Cell Growth in Vitro and in Vivo
Conclusion: Together, our results indicate a promising therapeutic value of the novel BRD4 inhibitor AZD5153 against prostate cancer cells.Cell Physiol Biochem 2018;50:789 –809 (Source: Cellular Physiology and Biochemistry)
Source: Cellular Physiology and Biochemistry - October 11, 2018 Category: Cytology Source Type: research