Cellular Physiology and Biochemistry This is an RSS file. You can use it to subscribe to this data in your favourite RSS reader or to display this data on your own website or blog.

Baicalein Inhibits Proliferation Activity of Human Colorectal Cancer Cells HCT116 Through Downregulation of Ezrin
Conclusion: Baicalein repressed proliferation of human colorectal cancer cells HCT116 and blocked cell cycle through downregulatingEzrin and upregulating P53 pathway-related proteins.Cell Physiol Biochem 2018;49:2035 –2046 (Source: Cellular Physiology and Biochemistry)
Source: Cellular Physiology and Biochemistry - September 21, 2018 Category: Cytology Source Type: research

Downregulation of MicroRNA-4463 Attenuates High-Glucose- and Hypoxia-Induced Endothelial Cell Injury by Targeting PNUTS
Conclusion: Our results suggest that downregulation of miR-4463 attenuates cell apoptosis by directly enhancing PNUTS expression to promote PTEN nuclear localization, subsequently activating AKT signaling pathway in HUVECs under HG and/ or hypoxic conditions.Cell Physiol Biochem 2018;49:2073 –2087 (Source: Cellular Physiology and Biochemistry)
Source: Cellular Physiology and Biochemistry - September 21, 2018 Category: Cytology Source Type: research

Smad Ubiquitination Regulatory Factor 1 (Smurf1) Promotes Thyroid Cancer Cell Proliferation and Migration via Ubiquitin-Dependent Degradation of Kisspeptin-1
Conclusion: Up-regulation of Smurf1 exerted important roles in thyroid cancer formation and development by promoting thyroid cancer proliferation and metastasis. The ubiquitin-dependent degradation of KISS-1 induced by Smurf1 and the activation of NF- κB signaling pathway might be involved in this process. Smurf1 could be an effective therapy target and biomarker for thyroid cancer treatment.Cell Physiol Biochem 2018;49:2047 –2059 (Source: Cellular Physiology and Biochemistry)
Source: Cellular Physiology and Biochemistry - September 21, 2018 Category: Cytology Source Type: research

Ligustrazine Inhibits Growth, Migration and Invasion of Medulloblastoma Daoy Cells by Up-Regulation of miR-211
Conclusion: LSZ suppressed medulloblastoma Daoy cells by up-regulating miR-211 and further modulating the activations of PI3K/AKT and mTOR signaling pathways.Cell Physiol Biochem 2018;49:2012 –2021 (Source: Cellular Physiology and Biochemistry)
Source: Cellular Physiology and Biochemistry - September 21, 2018 Category: Cytology Source Type: research

Role of miR-148a in Mitigating Hepatic Ischemia-Reperfusion Injury by Repressing the TLR4 Signaling Pathway via Targeting CaMKII α in Vivo and in Vitro 
Conclusion: Taken together, we conclude that miR-148a may mitigate hepatic I/R injury by ameliorating TLR4-mediated inflammationvia targeting CaMKII αin vitro andin vivo.Cell Physiol Biochem 2018;49:2060 –2072 (Source: Cellular Physiology and Biochemistry)
Source: Cellular Physiology and Biochemistry - September 21, 2018 Category: Cytology Source Type: research

Fisetin Protects Against Hepatic Steatosis Through Regulation of the Sirt1/AMPK and Fatty Acid β-Oxidation Signaling Pathway in High-Fat Diet-Induced Obese Mice
Conclusion: This study suggests that fisetin is a potential novel treatment for alleviating hepatic lipid metabolism and improving NAFLD in mice via activation of the sirt1/AMPK and β-oxidation pathway.Cell Physiol Biochem 2018;49:1870 –1884 (Source: Cellular Physiology and Biochemistry)
Source: Cellular Physiology and Biochemistry - September 20, 2018 Category: Cytology Source Type: research

Genipin Reverses HFD-Induced Liver Damage and Inhibits UCP2-Mediated Pyroptosis in Mice
Conclusion: GNP reverses HFD-induced liver damage and inhibits UCP2-mediated pyroptosis. Thus, GNP may serve as a potential therapeutic candidate for NAFLD.Cell Physiol Biochem 2018;49:1885 –1897 (Source: Cellular Physiology and Biochemistry)
Source: Cellular Physiology and Biochemistry - September 20, 2018 Category: Cytology Source Type: research

Sublytic C5b-9 Induces Glomerular Mesangial Cell Apoptosis Through miR-3546/SOX4/Survivin Axis in Rat Thy-1 Nephritis
Conclusion: MiR-3546/ SOX4/survivin axis has a promoting role in the GMC apoptosis triggered by sublytic C5b-9, and our findings may provide a new insight into the pathogenesis of rat Thy-1N and human MsPGN.Cell Physiol Biochem 2018;49:1898 –1917 (Source: Cellular Physiology and Biochemistry)
Source: Cellular Physiology and Biochemistry - September 20, 2018 Category: Cytology Source Type: research

Apelin-13 Administration Protects Against LPS-Induced Acute Lung Injury by Inhibiting NF- κB Pathway and NLRP3 Inflammasome Activation
Conclusion: Taken together, these data suggest that apelin-13 administration ameliorates LPS-induced acute lung injury by suppressing ROS formation, as well as by inhibiting the NF- κB pathway and the activation of the NLRP3 inflammasome in the lungs.Cell Physiol Biochem 2018;49:1918 –1932 (Source: Cellular Physiology and Biochemistry)
Source: Cellular Physiology and Biochemistry - September 20, 2018 Category: Cytology Source Type: research

miR-191 Inhibition Induces Apoptosis Through Reactivating Secreted Frizzled-Related Protein-1 in Cholangiocarcinoma
Conclusion: Taken together, our results demonstrate a novel insight into miR-191 biological function in CCA. Our findings suggest that miR-191 is a potential therapeutic target of CCA treatment.Cell Physiol Biochem 2018;49:1933 –1942 (Source: Cellular Physiology and Biochemistry)
Source: Cellular Physiology and Biochemistry - September 20, 2018 Category: Cytology Source Type: research

Pterostilbene Reduces Acetaminophen-Induced Liver Injury by Activating the Nrf2 Antioxidative Defense System via the AMPK/Akt/GSK3 β Pathway
Conclusion: Our data suggest that Pts protects against APAP-induced toxicity by activating Nrf2 via the AMPK/Akt/GSK3 β pathway.Cell Physiol Biochem 2018;49:1943 –1958 (Source: Cellular Physiology and Biochemistry)
Source: Cellular Physiology and Biochemistry - September 20, 2018 Category: Cytology Source Type: research

Clinical Characteristics and Prognostic Factors of Primary Splenic Angiosarcoma: A Retrospective Clinical Analysis from China
Conclusion: Our large series describes and confirms the characteristics and poor prognosis of Chinese primary splenic angiosarcoma, thus indicating a critical role for early diagnosis and surgical intervention (prior to rupture) in management, and highlights the promising potential of adjuvant chemotherapy for improving the outcome in these cases.Cell Physiol Biochem 2018;49:1959 –1969 (Source: Cellular Physiology and Biochemistry)
Source: Cellular Physiology and Biochemistry - September 20, 2018 Category: Cytology Source Type: research

Fucoidan Inhibits the Proliferation of Leiomyoma Cells and Decreases Extracellular Matrix-Associated Protein Expression
Conclusion: Fucoidan displays anti-proliferation and anti-fibrotic effects and exerts protective effects against ULs development.Cell Physiol Biochem 2018;49:1970 –1986 (Source: Cellular Physiology and Biochemistry)
Source: Cellular Physiology and Biochemistry - September 20, 2018 Category: Cytology Source Type: research

Deletion and Functional Analysis of Hepatitis B Virus X Protein: Evidence for an Effect on Cell Cycle Regulators
Conclusion: The HBx-WT and its mutants play a critical role in the pathogenesis and progression of HCC by modulating cell cycle regulatory proteins.Cell Physiol Biochem 2018;49:1987 –1998 (Source: Cellular Physiology and Biochemistry)
Source: Cellular Physiology and Biochemistry - September 20, 2018 Category: Cytology Source Type: research

Inhibition of Histone Deacetylases Prevents Cardiac Remodeling After Myocardial Infarction by Restoring Autophagosome Processing in Cardiac Fibroblasts
Conclusion: Our results provide evidence that the HDAC inhibitor TSA prevents cardiac remodeling after MI and is dependent on restoring autophagosome processing of cardiac fibroblasts.Cell Physiol Biochem 2018;49:1999 –2011 (Source: Cellular Physiology and Biochemistry)
Source: Cellular Physiology and Biochemistry - September 20, 2018 Category: Cytology Source Type: research