Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie 
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This is an RSS file. You can use it to subscribe to this data in your favourite RSS reader or to display this data on your own website or blog.Corrigendum to " β-Asarone suppresses Wnt/β-catenin signaling to reduce viability, inhibit migration/invasion/adhesion and induce mitochondria-related apoptosis in lung cancer cells" [Biomed. Pharmacother. 106 (2018) 821-830]
Biomed Pharmacother. 2024 Mar 29:116499. doi: 10.1016/j.biopha.2024.116499. Online ahead of print.NO ABSTRACTPMID:38555193 | DOI:10.1016/j.biopha.2024.116499 (Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie)
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - March 30, 2024 Category: Drugs & Pharmacology Authors: Tao-Li Wang Chen-Sheng Ouyang Li-Zhu Lin Source Type: research
Hydrogen sulfide dysfunction in metabolic syndrome-associated vascular complications involves cGMP regulation through soluble guanylyl cyclase persulfidation
In conclusion, our study demonstrates a pivotal role of reduced cGMP levels in impaired vasorelaxation in a murine model of MetS involving an impairment of both H2S and NO signaling. Exogenous H2S supplementation through Erucin represents a promising alternative in MetS therapy, targeting smooth muscle cells and supporting the importance of lifestyle and nutrition in managing MetS.PMID:38552439 | DOI:10.1016/j.biopha.2024.116466 (Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie)
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - March 29, 2024 Category: Drugs & Pharmacology Authors: M Smimmo V Casale G M Casillo E Mitidieri R d'Emmanuele di Villa Bianca I Bello A Schettino R Montanaro V Brancaleone C Indolfi G Cirino A Di Lorenzo M Bucci E Panza V Vellecco Source Type: research
Investigation of prunetrin induced G2/M cell cycle arrest and apoptosis via Akt/mTOR/MAPK pathways in hepatocellular carcinoma cells
Biomed Pharmacother. 2024 Mar 28;174:116483. doi: 10.1016/j.biopha.2024.116483. Online ahead of print.ABSTRACTHepatocellular carcinoma (HCC) stands as a leading cause of mortality, and despite recent advancements in the overall survival rates, the prognosis remains dismal. Prunetin 4-O-glucoside (Prunetrin or PUR), an active compound derived from Prunus sp., was explored for its impact on HepG2 and Huh7 cells. The cytotoxicity assessment revealed a notable reduction in cell viability in both cell lines, while exhibiting non-toxicity towards HaCaT cells. Colony formation studies underscored PUR's inhibitory effect on cell p...
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - March 29, 2024 Category: Drugs & Pharmacology Authors: Abuyaseer Abusaliya Pritam Bhagwan Bhosale Hun Hwan Kim Min Yeong Park Se Hyo Jeong Sijoon Lee Gon Sup Kim Source Type: research
Anti-inflammatory effect and pharmacokinetics of dehydroandrographolide, an active component of Andrographis paniculata, on Poly(I:C)-induced acute lung injury
This study evaluated the anti-inflammatory effects and pharmacokinetics (PK) profile of DAP in ALI mice induced by intratracheal instillation of Poly(I:C) (PIC). The results showed that oral administration of DAP (10-40 mg/kg) effectively suppressed the increase in lung wet-dry weight ratio, total cells, total protein content, accumulation of immune cells, inflammatory cytokines and neutrophil elastase levels in bronchoalveolar lavage fluid of PIC-treated mice. DAP concentrations, determined by an LC-MS/MS method, in plasma after receiving DAP (20 mg/kg) were unchanged compared to those in normal mice. However, DAP concent...
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - March 29, 2024 Category: Drugs & Pharmacology Authors: Yong-Guang Liu Shan-Shan Zhang Su-Wei Jin Tian-Ji Xia Yong-Hong Liao Rui-Le Pan Ming-Zhu Yan Qi Chang Source Type: research
The significant improvement in ovarian PCOS syndrome using hydralazine and alendronate aromatase inhibitor FDA-approved drugs in Wistar rat models
Biomed Pharmacother. 2024 Mar 28;174:116504. doi: 10.1016/j.biopha.2024.116504. Online ahead of print.ABSTRACTPolycystic ovary syndrome (PCOS) is the most common cause of anovulatory infertility. The aim of this study was to investigate the therapeutic potential of vitamin C, glutamine, mesalazine, hydralazine, and alendronate as new drug candidates for the treatment of letrozole-induced PCOS in female Wistar rats. PCOS was induced in rats by intramuscular injection of estradiol valerate (2 mg/kg body weight for 28 days). The rats then received normal saline (PCOS group), letrozole (0.5 mg/kg), vitamin C (100 mg/kg), gluta...
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - March 29, 2024 Category: Drugs & Pharmacology Authors: Soudabeh Kavousipour Fahimeh Koohnavard Behzad Shahbazi Ebrahim Eftekhar Khadijeh Ahmadi Source Type: research
Antioxidants activities of phytochemicals perspective modulation of autophagy and apoptosis to treating cancer
Biomed Pharmacother. 2024 Mar 27;174:116497. doi: 10.1016/j.biopha.2024.116497. Online ahead of print.ABSTRACTThe study of chemicals extracted from natural sources should be encouraged due to the significant number of cancer deaths each year and the financial burden imposed by this disease on society. The causes of almost all cancers involve a combination of lifestyle, environmental factors, and genetic and inherited factors. Modern medicine researchers are increasingly interested in traditional phytochemicals as they hold potential for new bioactive compounds with medical applications. Recent publications have provided ev...
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - March 29, 2024 Category: Drugs & Pharmacology Authors: Kazi Rejvee Ahmed Md Masudur Rahman Md Nahidul Islam Md Maharub Hossain Fahim Md Ataur Rahman Bonglee Kim Source Type: research
Hydrogen sulfide dysfunction in metabolic syndrome-associated vascular complications involves cGMP regulation through soluble guanylyl cyclase persulfidation
In conclusion, our study demonstrates a pivotal role of reduced cGMP levels in impaired vasorelaxation in a murine model of MetS involving an impairment of both H2S and NO signaling. Exogenous H2S supplementation through Erucin represents a promising alternative in MetS therapy, targeting smooth muscle cells and supporting the importance of lifestyle and nutrition in managing MetS.PMID:38552439 | DOI:10.1016/j.biopha.2024.116466 (Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie)
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - March 29, 2024 Category: Drugs & Pharmacology Authors: M Smimmo V Casale G M Casillo E Mitidieri R d'Emmanuele di Villa Bianca I Bello A Schettino R Montanaro V Brancaleone C Indolfi G Cirino A Di Lorenzo M Bucci E Panza V Vellecco Source Type: research
Investigation of prunetrin induced G2/M cell cycle arrest and apoptosis via Akt/mTOR/MAPK pathways in hepatocellular carcinoma cells
Biomed Pharmacother. 2024 Mar 28;174:116483. doi: 10.1016/j.biopha.2024.116483. Online ahead of print.ABSTRACTHepatocellular carcinoma (HCC) stands as a leading cause of mortality, and despite recent advancements in the overall survival rates, the prognosis remains dismal. Prunetin 4-O-glucoside (Prunetrin or PUR), an active compound derived from Prunus sp., was explored for its impact on HepG2 and Huh7 cells. The cytotoxicity assessment revealed a notable reduction in cell viability in both cell lines, while exhibiting non-toxicity towards HaCaT cells. Colony formation studies underscored PUR's inhibitory effect on cell p...
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - March 29, 2024 Category: Drugs & Pharmacology Authors: Abuyaseer Abusaliya Pritam Bhagwan Bhosale Hun Hwan Kim Min Yeong Park Se Hyo Jeong Sijoon Lee Gon Sup Kim Source Type: research
Anti-inflammatory effect and pharmacokinetics of dehydroandrographolide, an active component of Andrographis paniculata, on Poly(I:C)-induced acute lung injury
This study evaluated the anti-inflammatory effects and pharmacokinetics (PK) profile of DAP in ALI mice induced by intratracheal instillation of Poly(I:C) (PIC). The results showed that oral administration of DAP (10-40 mg/kg) effectively suppressed the increase in lung wet-dry weight ratio, total cells, total protein content, accumulation of immune cells, inflammatory cytokines and neutrophil elastase levels in bronchoalveolar lavage fluid of PIC-treated mice. DAP concentrations, determined by an LC-MS/MS method, in plasma after receiving DAP (20 mg/kg) were unchanged compared to those in normal mice. However, DAP concent...
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - March 29, 2024 Category: Drugs & Pharmacology Authors: Yong-Guang Liu Shan-Shan Zhang Su-Wei Jin Tian-Ji Xia Yong-Hong Liao Rui-Le Pan Ming-Zhu Yan Qi Chang Source Type: research
The significant improvement in ovarian PCOS syndrome using hydralazine and alendronate aromatase inhibitor FDA-approved drugs in Wistar rat models
Biomed Pharmacother. 2024 Mar 28;174:116504. doi: 10.1016/j.biopha.2024.116504. Online ahead of print.ABSTRACTPolycystic ovary syndrome (PCOS) is the most common cause of anovulatory infertility. The aim of this study was to investigate the therapeutic potential of vitamin C, glutamine, mesalazine, hydralazine, and alendronate as new drug candidates for the treatment of letrozole-induced PCOS in female Wistar rats. PCOS was induced in rats by intramuscular injection of estradiol valerate (2 mg/kg body weight for 28 days). The rats then received normal saline (PCOS group), letrozole (0.5 mg/kg), vitamin C (100 mg/kg), gluta...
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - March 29, 2024 Category: Drugs & Pharmacology Authors: Soudabeh Kavousipour Fahimeh Koohnavard Behzad Shahbazi Ebrahim Eftekhar Khadijeh Ahmadi Source Type: research
Antioxidants activities of phytochemicals perspective modulation of autophagy and apoptosis to treating cancer
Biomed Pharmacother. 2024 Mar 27;174:116497. doi: 10.1016/j.biopha.2024.116497. Online ahead of print.ABSTRACTThe study of chemicals extracted from natural sources should be encouraged due to the significant number of cancer deaths each year and the financial burden imposed by this disease on society. The causes of almost all cancers involve a combination of lifestyle, environmental factors, and genetic and inherited factors. Modern medicine researchers are increasingly interested in traditional phytochemicals as they hold potential for new bioactive compounds with medical applications. Recent publications have provided ev...
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - March 29, 2024 Category: Drugs & Pharmacology Authors: Kazi Rejvee Ahmed Md Masudur Rahman Md Nahidul Islam Md Maharub Hossain Fahim Md Ataur Rahman Bonglee Kim Source Type: research
MRGPRB2/X2 and the analogous effects of its agonist and antagonist in DSS-induced colitis in mice
Biomed Pharmacother. 2024 Mar 27;174:116471. doi: 10.1016/j.biopha.2024.116471. Online ahead of print.ABSTRACTThe mast cell receptor Mrgprb2, a mouse orthologue of human Mrgprx2, is known as an inflammatory receptor and its elevated expression is associated with various diseases such as ulcerative colitis. We aimed to elucidate the role of Mrgprb2/x2 and the effect of its ligands on a chemically induced murine colitis model. We showed that in Mrgprb2-/- mice, there is a differential regulation of cytokine releases in the blood plasma and severe colonic damages after DSS treatment. Unexpectedly, we demonstrated that known M...
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - March 28, 2024 Category: Drugs & Pharmacology Authors: Karthi Duraisamy Mukesh Kumar Abdullah Nawabjan Emily Kwun Kwan Lo Ming Hui Lin Benjamin Lefranc Elsa Bonnaf é Michel Treilhou Hani El-Nezami J érôme Leprince Billy K C Chow Source Type: research
Treatment with bestatin (the exogenous synthetic inhibitor of metalloproteinases) reduces the activity of metalloproteinase 2 and 12 in the spleen and lung tissues of rats in a model of lipopolysaccharide-induced sepsis
CONCLUSIONS: 1. Bestatin reduces MMP 2 and 12 levels in spleen and lungs. 2. Treatment with bestatin minimizes the effect of LPS.PMID:38547765 | DOI:10.1016/j.biopha.2024.116480 (Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie)
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - March 28, 2024 Category: Drugs & Pharmacology Authors: Barbara Nieradko-Iwanicka Jaros ław Piasecki Andrzej Borz ęcki Source Type: research
Identification of ADME genes polymorphic variants linked to trastuzumab-induced cardiotoxicity in breast cancer patients: Case series of mono-institutional experience
CONCLUSION: Real-world TIC incidence is higher compared to randomized clinical trials and biomarkers with potential predictive value aren't available. Our preliminary data, as proof of concept, could suggest a predictive role of pharmacogenomic approach in the identification of cardiotoxicity risk biomarkers for anti-HER2 treatment.PMID:38547766 | DOI:10.1016/j.biopha.2024.116478 (Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie)
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - March 28, 2024 Category: Drugs & Pharmacology Authors: Nicoletta Staropoli Francesca Scionti Valentina Farenza Federica Falcone Francesco Luciano Maria Renne Maria Teresa Di Martino Domenico Ciliberto Ludovica Tedesco Antonella Crispino Caterina Labanca Maria Cuc è Stefania Esposito Giuseppe Agapito Mario Ca Source Type: research
MRGPRB2/X2 and the analogous effects of its agonist and antagonist in DSS-induced colitis in mice
Biomed Pharmacother. 2024 Mar 27;174:116471. doi: 10.1016/j.biopha.2024.116471. Online ahead of print.ABSTRACTThe mast cell receptor Mrgprb2, a mouse orthologue of human Mrgprx2, is known as an inflammatory receptor and its elevated expression is associated with various diseases such as ulcerative colitis. We aimed to elucidate the role of Mrgprb2/x2 and the effect of its ligands on a chemically induced murine colitis model. We showed that in Mrgprb2-/- mice, there is a differential regulation of cytokine releases in the blood plasma and severe colonic damages after DSS treatment. Unexpectedly, we demonstrated that known M...
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - March 28, 2024 Category: Drugs & Pharmacology Authors: Karthi Duraisamy Mukesh Kumar Abdullah Nawabjan Emily Kwun Kwan Lo Ming Hui Lin Benjamin Lefranc Elsa Bonnaf é Michel Treilhou Hani El-Nezami J érôme Leprince Billy K C Chow Source Type: research
