Identification of ADME genes polymorphic variants linked to trastuzumab-induced cardiotoxicity in breast cancer patients: Case series of mono-institutional experience

CONCLUSION: Real-world TIC incidence is higher compared to randomized clinical trials and biomarkers with potential predictive value aren't available. Our preliminary data, as proof of concept, could suggest a predictive role of pharmacogenomic approach in the identification of cardiotoxicity risk biomarkers for anti-HER2 treatment.PMID:38547766 | DOI:10.1016/j.biopha.2024.116478

Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - March 28, 2024 Category: Drugs & Pharmacology Authors: Nicoletta Staropoli Francesca Scionti Valentina Farenza Federica Falcone Francesco Luciano Maria Renne Maria Teresa Di Martino Domenico Ciliberto Ludovica Tedesco Antonella Crispino Caterina Labanca Maria Cuc è Stefania Esposito Giuseppe Agapito Mario Ca Source Type: research