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The effects of acteoside on locomotor recovery after spinal cord injury - The role of autophagy and apoptosis signaling pathway
Biomed Pharmacother. 2024 Apr 30;175:116607. doi: 10.1016/j.biopha.2024.116607. Online ahead of print.ABSTRACTIn the current study, we investigated the effects of acteoside as a phenylpropanoid glycoside on interaction with neurons to assesses locomotor recovery after spinal cord injury (SCI) in rats by focusing on evaluating the factors involved in autophagy, apoptosis, inflammation and oxidative stress processes. 49 Spargue-Dawley rats were prepared and divided into seven healthy and SCI groups receiving different concentrations of acteoside. After 28 days of disease induction and treatment with acteoside, a BBB score te...
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - May 1, 2024 Category: Drugs & Pharmacology Authors: Shanglong Ning Yang Chen Jia Shao Hui Zhu Zepei Zhang Jun Miao Source Type: research

Interplay of OATP1A/1B/2B1 uptake transporters and ABCB1 and ABCG2 efflux transporters in the handling of bilirubin and drugs
Biomed Pharmacother. 2024 Apr 30;175:116644. doi: 10.1016/j.biopha.2024.116644. Online ahead of print.ABSTRACTTransmembrane drug transporters can be important determinants of the pharmacokinetics, efficacy, and safety profiles of drugs. To investigate the potential cooperative and/or counteracting interplay of OATP1A/1B/2B1 uptake transporters and ABCB1 and ABCG2 efflux transporters in physiology and pharmacology, we generated a new mouse model (Bab12), deficient for Slco1a/1b, Slco2b1, Abcb1a/1b and Abcg2. Bab12 mice were viable and fertile. We compared wild-type, Slco1a/1b/2b1-/-, Abcb1a/1b;Abcg2-/- and Bab12 strains. En...
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - May 1, 2024 Category: Drugs & Pharmacology Authors: Wenlong Li Rolf W Sparidans Yaogeng Wang Margarida L F Martins Dirk R de Waart Olaf van Tellingen Ji-Ying Song Maria C Lebre St éphanie van Hoppe Els Wagenaar Jos H Beijnen Alfred H Schinkel Source Type: research

Early signs of neurodegenerative diseases: Possible mechanisms and targets for Golgi stress
Biomed Pharmacother. 2024 Apr 30;175:116646. doi: 10.1016/j.biopha.2024.116646. Online ahead of print.ABSTRACTThe Golgi apparatus plays a crucial role in mediating the modification, transport, and sorting of intracellular proteins and lipids. The morphological changes occurring in the Golgi apparatus are exceptionally important for maintaining its function. When exposed to external pressure or environmental stimulation, the Golgi apparatus undergoes adaptive changes in both structure and function, which are known as Golgi stress. Although certain signal pathway responses or post-translational modifications have been observ...
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - May 1, 2024 Category: Drugs & Pharmacology Authors: Mengyu Liu Ying Duan Jianru Dong Kaisong Zhang Xin Jin Menglin Gao Huachao Jia Ju Chen Mingyan Liu Minjie Wei Xin Zhong Source Type: research

Ziprasidone triggers inflammasome signaling via PI3K-Akt-mTOR pathway to promote atrial fibrillation
CONCLUSIONS: Our findings suggest ziprasidone induces atrial arrhythmia, potentially through upregulation of the NLRP3 inflammasome and enhancement of reactive oxygen species production via the PI3K/Akt/mTOR pathway.PMID:38692059 | DOI:10.1016/j.biopha.2024.116649 (Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie)
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - May 1, 2024 Category: Drugs & Pharmacology Authors: Ming-Kun Lu Yen-Nien Huo Buh-Yuan Tai Chih-Yuan Lin Hsiang-Yu Yang Chien-Sung Tsai Source Type: research

CaMKII activity and metabolic imbalance-related neurological diseases: Focus on vascular dysfunction, synaptic plasticity, amyloid beta accumulation, and lipid metabolism
Biomed Pharmacother. 2024 Apr 30;175:116688. doi: 10.1016/j.biopha.2024.116688. Online ahead of print.ABSTRACTMetabolic syndrome (MetS) is characterized by insulin resistance, hyperglycemia, excessive fat accumulation and dyslipidemia, and is known to be accompanied by neuropathological symptoms such as memory loss, anxiety, and depression. As the number of MetS patients is rapidly increasing globally, studies on the mechanisms of metabolic imbalance-related neuropathology are emerging as an important issue. Ca2+/calmodulin-dependent kinase II (CaMKII) is the main Ca2+ sensor and contributes to diverse intracellular signal...
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - May 1, 2024 Category: Drugs & Pharmacology Authors: Jeongsik Yong Juhyun Song Source Type: research

The roles of epigenetic regulation in graft-versus-host disease
Biomed Pharmacother. 2024 Apr 30;175:116652. doi: 10.1016/j.biopha.2024.116652. Online ahead of print.ABSTRACTAllogeneic hematopoietic stem cell transplantation (aHSCT) is utilized as a potential curative treatment for various hematologic malignancies. However, graft-versus-host disease (GVHD) post-aHSCT is a severe complication that significantly impacts patients' quality of life and overall survival, becoming a major cause of non-relapse mortality. In recent years, the association between epigenetics and GVHD has garnered increasing attention. Epigenetics focuses on studying mechanisms that affect gene expression without...
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - May 1, 2024 Category: Drugs & Pharmacology Authors: Yimin Wang Qi Liu Lei Deng Xiting Ma Yuling Gong Yifei Wang Fang Zhou Source Type: research

Voltage-gated potassium channel 1.3: A promising molecular target in multiple disease therapy
Biomed Pharmacother. 2024 Apr 30;175:116651. doi: 10.1016/j.biopha.2024.116651. Online ahead of print.ABSTRACTVoltage-gated potassium channel 1.3 (Kv1.3) has emerged as a pivotal player in numerous biological processes and pathological conditions, sparking considerable interest as a potential therapeutic target across various diseases. In this review, we present a comprehensive examination of Kv1.3 channels, highlighting their fundamental characteristics and recent advancements in utilizing Kv1.3 inhibitors for treating autoimmune disorders, neuroinflammation, and cancers. Notably, Kv1.3 is prominently expressed in immune ...
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - May 1, 2024 Category: Drugs & Pharmacology Authors: Sixuan Cheng Dawei Jiang Xiaoli Lan Kun Liu Cheng Fan Source Type: research

Unveiling the promise of PD1/PD-L1: A new dawn in immunotherapy for cholangiocarcinoma
This article seeks to meticulously review the latest studies on PD1/PD-L1 involvement in CCA, delving into their expression profiles, prognostic significance, contribution to oncogenic processes, and their potential clinical utility.PMID:38692063 | DOI:10.1016/j.biopha.2024.116659 (Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie)
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - May 1, 2024 Category: Drugs & Pharmacology Authors: Fei Chen Jian Sheng Xiaoping Li Zhaofeng Gao Siqi Zhao Lingyu Hu Minjie Chen Jianguo Fei Zhengwei Song Source Type: research

DHEA-S, Androstenedione, 17- β-estradiol signature as novel biomarkers for early prediction of risk of malignant pleural mesothelioma linked to asbestos-exposure: A preliminary investigation
In conclusion, this study suggests 17-β-estradiol, DHEA-S, and androstenedione as biomarkers for mesothelioma risk and early diagnosis of mesothelioma in asbestos-exposed individuals, aiding timely intervention and improved care.PMID:38692064 | DOI:10.1016/j.biopha.2024.116662 (Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie)
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - May 1, 2024 Category: Drugs & Pharmacology Authors: Barbara Nuvoli Andrea Sacconi Grazia Bottillo Francesca Sciarra Roberta Libener Antonio Maconi Mariantonia Carosi Giorgio Piperno Eliuccia Mastropasqua Maria Papale Emanuela Camera Rossella Galati Source Type: research

Formyl peptide enhances cancer immunotherapy by activating antitumoral neutrophils, and T cells
Biomed Pharmacother. 2024 Apr 30;175:116670. doi: 10.1016/j.biopha.2024.116670. Online ahead of print.ABSTRACTNeutrophils are heterogeneous and plastic, with the ability to polarize from antitumour to protumour phenotype and modulate tumour microenvironment components. While some advances have been made, the neutrophil-targeting therapy remains underexplored. Activation of formyl peptide receptors (FPRs) by formylated peptides is needed for local control of infection through the recruitment of activated neutrophils while the potential contribution of antitumour activity remains underexplored. Here, we demonstrate that neut...
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - May 1, 2024 Category: Drugs & Pharmacology Authors: Haixia Sun Shuxin Li Qiaoli Wang Chunxiang Luo Lanyi Zhong Guohui Wan Ziqian Li Gexin Zhao Xianzhang Bu Musheng Zeng Guokai Feng Source Type: research

Advancing oral health: Harnessing the potential of chitosan and polyphenols in innovative mouthwash formulation
Biomed Pharmacother. 2024 Apr 30;175:116654. doi: 10.1016/j.biopha.2024.116654. Online ahead of print.ABSTRACTThis paper explores the therapeutic perspectives of polyphenols and chitosan as potential anticancer agents in the mouthwash formulations. Taking into account the high incidence of squamous cell carcinoma (SCC) among oral cancers, this discussion will concentrate on the potential advantages of these compounds in oral care, focusing on their impact on improving oral health and cancer prevention. According to the data, it appears that the mixture of BACs extract and chitosan may increase the efficiency of the apoptos...
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - May 1, 2024 Category: Drugs & Pharmacology Authors: Ma łgorzata Maj Bartosz Tylkowski Piotr Konopka Marta Wo źniak-Budych Katarzyna Staszak Maciej Staszak Łukasz Kaźmierski Anna Bajek Renata Jastrzab Source Type: research

Current status of superoxide dismutase 2 on oral disease progression by supervision of ROS
Biomed Pharmacother. 2024 Apr 29;175:116605. doi: 10.1016/j.biopha.2024.116605. Online ahead of print.ABSTRACTThe recent Global Burden of Disease results have demonstrated that oral diseases are some of the most significant public health challenges facing the world. Owing to its specific localization advantage, superoxide dismutase 2 (SOD2 or MnSOD) has the ability to process the reactive oxygen species (ROS) produced by mitochondrial respiration before anything else, thereby impacting the occurrence and development of diseases. In this review, we summarize the processes of common oral diseases in which SOD2 is involved. S...
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - April 30, 2024 Category: Drugs & Pharmacology Authors: Dian Ding Na Li Yihong Ge Hongle Wu Jinzhao Yu Wei Qiu Fuchun Fang Source Type: research

Seedless black Vitis vinifera polyphenols suppress hepatocellular carcinoma in vitro and in vivo by targeting apoptosis, cancer stem cells, and proliferation
In conclusion, these findings declare that VV polyphenolic fractions, particularly VVF1, could be promising safe anti-HCC agents.PMID:38688169 | DOI:10.1016/j.biopha.2024.116638 (Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie)
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - April 30, 2024 Category: Drugs & Pharmacology Authors: Nadia Z Shaban Walaa A Hegazy Marwa M Abu-Serie Iman M Talaat Olfat M Awad Noha H Habashy Source Type: research

H2AX: A key player in DNA damage response and a promising target for cancer therapy
Biomed Pharmacother. 2024 Apr 29;175:116663. doi: 10.1016/j.biopha.2024.116663. Online ahead of print.ABSTRACTCancer is caused by a complex interaction of factors that interrupt the normal growth and division of cells. At the center of this process is the intricate relationship between DNA damage and the cellular mechanisms responsible for maintaining genomic stability. When DNA damage is not repaired, it can cause genetic mutations that contribute to the initiation and progression of cancer. On the other hand, the DNA damage response system, which involves the phosphorylation of the histone variant H2AX (γH2AX), is cruci...
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - April 30, 2024 Category: Drugs & Pharmacology Authors: Kirti S Prabhu Shilpa Kuttikrishnan Nuha Ahamad Ummu Habeeba Zahwa Mariyam Muhammad Suleman Ajaz A Bhat Shahab Uddin Source Type: research

In vitro study of cold atmospheric plasma-activated liquids inhibits malignant melanoma by affecting macrophage polarization through the ROS/JAK2/STAT1 pathway
This study illustrates that PAL therapy is an effective tumor immunotherapy and expands the scope of tumor immunotherapy. Furthermore, these findings establish a theoretical foundation for potential clinical applications of PAL.PMID:38688171 | DOI:10.1016/j.biopha.2024.116657 (Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie)
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - April 30, 2024 Category: Drugs & Pharmacology Authors: Cheng Chen Shiyun Zhou Xingyu Yang Miaomiao Ren Yongshuang Qi Yiwen Mao Chunjun Yang Source Type: research