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An anti-GD2 aptamer-based bifunctional spherical nucleic acid nanoplatform for synergistic therapy targeting MDM2 for retinoblastoma
This study showed a potent antitumor effect following intravitreal injection of SNAs in Y79 tumor-bearing mice through clinical manifestation and tumor pathological analysis. In hematological analysis and hepatotoxicity assays, SNAs were safer for mice than melphalan, the favored drug for treating RB in clinical practice. Our results illustrated the potential of intravitreally injected SNAs as a precision medicine for treating RB.PMID:38522240 | DOI:10.1016/j.biopha.2024.116437 (Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie)
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - March 24, 2024 Category: Drugs & Pharmacology Authors: Shijing Wang Yan Zhao Fei Yao Pengxue Wei Lan Ma Shaochong Zhang Source Type: research

The effects of Nardosinone on levodopa intervention in the treatment of Parkinson's disease
CONCLUSION: Our findings indicate that Nardosinone and its metabolites might act as a potential adjutant to enhance the efficacy of levodopa via the intestinal flora, thus expanding the therapeutic potential of the combination of Chinese and Western medicine as a treatment method for PD.PMID:38522241 | DOI:10.1016/j.biopha.2024.116448 (Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie)
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - March 24, 2024 Category: Drugs & Pharmacology Authors: Mengmeng Liu Jingwen Xue Yuxin Cao Zhuangzhuang Hao Yuqing Wang Jiayuan Li Tingyue Jiang Jinli Shi Source Type: research

Neuroprotective effects of the salidroside derivative SHPL-49 via the BDNF/TrkB/Gap43 pathway in rats with cerebral ischemia
Biomed Pharmacother. 2024 Mar 22;174:116460. doi: 10.1016/j.biopha.2024.116460. Online ahead of print.ABSTRACTIschemic stroke is a common intravascular disease and one of the leading causes of death and disability. The salidroside derivative SHPL-49, which we previously synthesized, significantly attenuates cerebral ischemic injury in a rat model of permanent middle cerebral artery occlusion. To explore the neuroprotective mechanism of SHPL-49, the effects of SHPL-49 on the expression levels of neurotrophic factors in neurons and microglia and the polarization of microglia were investigated in the present study. SHPL-49 ac...
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - March 23, 2024 Category: Drugs & Pharmacology Authors: Suxin You Zhouyun Ma Pei Zhang Wenwen Xu Changsen Zhan Nina Sang Jiazhen Xu Feiyun Wang Jiange Zhang Source Type: research

A novel combined therapeutic strategy of Nano-EN-IR@Lip mediated photothermal therapy and stem cell inhibition for gastric cancer
In this study, we developed a combined therapeutic strategy of photothermal therapy (PTT) and gastric cancer stem cells (GCSCs) inhibition by successfully synthesizing nanoliposomes loaded with IR780 (photosensitizer) and EN4 (c-Myc inhibitor). The nanocomposites are biocompatible and exhibit superior photoacoustic (PA) imaging properties. Under laser irradiation, IR780-mediated PTT effectively and rapidly killed tumor cells, while EN4 synergistically inhibited the self-renewal and stemness of GCSCs by suppressing the expression and activity of the pluripotent transcription factor c-Myc, preventing the tumor progression of...
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - March 23, 2024 Category: Drugs & Pharmacology Authors: Liping Yang Yan-E Du Fangli Liao Tong Huang Yadong Liu Junzhao Liu Can Wang Zhu Zhan Yang Cao Zhigang Wang Weixian Chen Source Type: research

Harnessing PD-1 cell membrane-coated paclitaxel dimer nanoparticles for potentiated chemoimmunotherapy
Biomed Pharmacother. 2024 Mar 22;174:116482. doi: 10.1016/j.biopha.2024.116482. Online ahead of print.ABSTRACTChemoimmunotherapy has emerged as a promising strategy for improving the efficacy of cancer treatment. Herein, we present PD-1 receptor-presenting membrane-coated paclitaxel dimers nanoparticles (PD-1@PTX2 NPs) for enhanced treatment efficacy. PD-1 cell membrane-cloaked PTX dimer exhibited effective cellular uptake and increased cytotoxicity against cancer cells. PD-1@PTX2 NPs could selectively bind with PD-L1 ligands expressed on breast cancer cells. Our nanoparticles exhibit a remarkable tumor growth inhibition r...
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - March 23, 2024 Category: Drugs & Pharmacology Authors: Nannan Hu Han Xue Ting Zhang Yuxin Fan Fenglin Guo Zhimin Li Mingge Huo Xingang Guan Guofu Chen Source Type: research

The role of miR-155 in urologic malignancies
This article provides a comprehensive review of the significant role played by miR-155 in the development of urologic malignancies. Furthermore, the potential of miR-155 as a biomarker and therapeutic target in urologic malignancies is also discussed.PMID:38520867 | DOI:10.1016/j.biopha.2024.116412 (Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie)
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - March 23, 2024 Category: Drugs & Pharmacology Authors: Maolei Shen Tao Chen Xin Li Shankun Zhao Xinsheng Zhang Liying Zheng Biao Qian Source Type: research

Bioactive compounds from nature: Antioxidants targeting cellular transformation in response to epigenetic perturbations induced by oxidative stress
Biomed Pharmacother. 2024 Mar 22;174:116432. doi: 10.1016/j.biopha.2024.116432. Online ahead of print.ABSTRACTOxidative stress results from a persistent imbalance in oxidation levels that promotes oxidants, playing a crucial role in the early and sustained phases of DNA damage and genomic and epigenetic instability, both of which are intricately linked to the development of tumors. The molecular pathways contributing to carcinogenesis in this context, particularly those related to double-strand and single-strand breaks in DNA, serve as indicators of DNA damage due to oxidation in cancer cases, as well as factors contributi...
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - March 23, 2024 Category: Drugs & Pharmacology Authors: Abdelhakim Bouyahya Saad Bakrim Sara Aboulaghras Kawtar El Kadri Tarik Aanniz Asaad Khalid Ashraf N Abdalla Ahmed A Abdallah Chrismawan Ardianto Long Chiau Ming Nasreddine El Omari Source Type: research

Targeted inhibition of STAT3 (Tyr705) by xanthatin alleviates osteoarthritis progression through the NF- κB signaling pathway
In this study, our objective was to explore the therapeutic effects exerted by XA on OA and the underlying molecular mechanisms. The effects of XA treatment on mouse OA models subjected to destabilization of the medial meniscus using medial collateral ligament transection, as well as on interleukin-1β (IL-1β)-induced mouse chondrocytes, were examined. Histological changes in cartilage and subchondral bone (SCB), as well as changes in the expression levels of osteophytes, cartilage degeneration- and osteoclast differentiation-related factors, and the role of XA-related signaling pathways in human cartilage tissue, were st...
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - March 23, 2024 Category: Drugs & Pharmacology Authors: Yangjun Xu Zhuolin Chen Xuanyuan Lu Jiewen Zheng Xuewen Liu Tan Zhang Wanlei Yang Yu Qian Source Type: research

Unveil the mechanism for EHMT -- A novel triterpenoid inhibits proliferation and induces apoptosis in colon cancer through ROS-mediated JNK signaling pathway
Biomed Pharmacother. 2024 Mar 22;174:116469. doi: 10.1016/j.biopha.2024.116469. Online ahead of print.ABSTRACTColon cancer ranks among the most prevalent malignancies worldwide, trailing only lung and breast cancer in incidence. Despite the availability of numerous therapeutic strategies, the burden of new cases and fatalities remains high in countries undergoing socioeconomic transitions. Natural products offer promising avenues for developing more effective and less toxic anticancer agents, expanding the clinical arsenal. In this investigation, we isolated a triterpenoid, (21 S,23 R,24 R)-21,23-epoxy-24-hydroxy-21-methox...
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - March 23, 2024 Category: Drugs & Pharmacology Authors: Qiushuang Wu Min Song Siyuan Luo Libin Guo Qingwen Zhang Hang Fai Kwok Source Type: research

Controllers of histone methylation-modifying enzymes in gastrointestinal cancers
Biomed Pharmacother. 2024 Mar 22;174:116488. doi: 10.1016/j.biopha.2024.116488. Online ahead of print.ABSTRACTGastrointestinal (GI) cancers have been considered primarily genetic malignancies, caused by a series of progressive genetic alterations. Accumulating evidence shows that histone methylation, an epigenetic modification program, plays an essential role in the different pathological stages of GI cancer progression, such as precancerous lesions, tumorigenesis, and tumor metastasis. Histone methylation-modifying enzymes, including histone methyltransferases (HMTs) and demethylases (HDMs), are the main executor of post-...
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - March 23, 2024 Category: Drugs & Pharmacology Authors: Ling Li Qing Song Jing Zhou Qing Ji Source Type: research

Resveratrol protects against myocardial ischemic injury in obese mice via activating SIRT3/FOXO3a signaling pathway and restoring redox homeostasis
CONCLUSION: Our findings provide important new evidence that supports the daily intake of resveratrol, especially in those overweight or obese, which can robustly decrease the extent of ischemic damage following MI. Our study therefore provides new mechanistic insight and suggests the therapeutic potential of resveratrol as an invaluable drug in the treatment of ischemic heart diseases.PMID:38520872 | DOI:10.1016/j.biopha.2024.116476 (Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie)
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - March 23, 2024 Category: Drugs & Pharmacology Authors: Xi Zhu En Ma Yixuan Ge Meng Yuan Xiaowei Guo Jun Peng Weidong Zhu Dan-Ni Ren Da Wo Source Type: research

Intranasal administration of Escherichia coli Nissle expressing the spike protein of SARS-CoV-2 induces long-term immunization and prevents spike protein-mediated lung injury in mice
Biomed Pharmacother. 2024 Mar 21;174:116441. doi: 10.1016/j.biopha.2024.116441. Online ahead of print.ABSTRACTWhile current anti-Spike protein (SP) vaccines have been pivotal in managing the pandemic, their limitations in delivery, storage, and the inability to provide mucosal immunization (preventing infections) highlight the ongoing necessity for research and innovation. To tackle these constraints, our research group developed a bacterial-based vaccine using a non-pathogenic E. coli Nissle 1917 (EcN) strain genetically modified to express the SARS-CoV-2 spike protein on its surface (EcN-pAIDA1-SP). We intranasally deliv...
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - March 22, 2024 Category: Drugs & Pharmacology Authors: Giovanni Sarnelli Alessandro Del Re Irene Palenca Silvia Basili Franzin Jie Lu Luisa Seguella Aurora Zilli Marcella Pesce Sara Rurgo Giovanni Esposito Walter Sanseverino Giuseppe Esposito Source Type: research

Gut microbiota in neurological diseases: Melatonin plays an important regulatory role
Biomed Pharmacother. 2024 Mar 21;174:116487. doi: 10.1016/j.biopha.2024.116487. Online ahead of print.ABSTRACTMelatonin is a highly conserved molecule produced in the human pineal gland as a hormone. It is known for its essential biological effects, such as antioxidant activity, circadian rhythm regulator, and immunomodulatory effects. The gut is one of the primary known sources of melatonin. The gut microbiota helps produce melatonin from tryptophan, and melatonin has been shown to have a beneficial effect on gut barrier function and microbial population. Dysbiosis of the intestinal microbiota is associated with bacterial...
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - March 22, 2024 Category: Drugs & Pharmacology Authors: Somayeh Ahmadi Mohammad Taghizadieh Elham Mehdizadehfar Alka Hasani Javad Khalili Fard Hadi Feizi Hammed Hamishehkar Masood Ansarin Mina Yekani Mohammad Yousef Memar Source Type: research

Utilizing machine learning to identify nifuroxazide as an inhibitor of ubiquitin-specific protease 21 in a drug repositioning strategy
Biomed Pharmacother. 2024 Mar 21;174:116459. doi: 10.1016/j.biopha.2024.116459. Online ahead of print.ABSTRACTUbiquitin-specific protease (USP), an enzyme catalyzing protein deubiquitination, is involved in biological processes related to metabolic disorders and cancer proliferation. We focused on constructing predictive models tailored to unveil compounds boasting USP21 inhibitory attributes. Six models, Extra Trees Classifier, Random Forest Classifier, LightGBM Classifier, XGBoost Classifier, Bagging Classifier, and a convolutional neural network harnessed from empirical data were selected for the screening process. Thes...
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - March 22, 2024 Category: Drugs & Pharmacology Authors: Jihoon Tak Tan Khanh Nguyen Kyeong Lee Sang Geon Kim Hee-Chul Ahn Source Type: research

Emerging regulatory mechanisms in cardiovascular disease: Ferroptosis
Biomed Pharmacother. 2024 Mar 21;174:116457. doi: 10.1016/j.biopha.2024.116457. Online ahead of print.ABSTRACTFerroptosis, distinct from apoptosis, necrosis, autophagy, and other types of cell death, is a novel iron-dependent regulated cell death characterized by the accumulation of lipid peroxides and redox imbalance with distinct morphological, biochemical, and genetic features. Dysregulation of iron homeostasis, the disruption of antioxidative stress pathways and lipid peroxidation are crucial in ferroptosis. Ferroptosis is involved in the pathogenesis of several cardiovascular diseases, including atherosclerosis, cardi...
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - March 22, 2024 Category: Drugs & Pharmacology Authors: Sijie Jin He Wang Xiaohao Zhang Mengyang Song Bin Liu Wei Sun Source Type: research