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A new frontier in precision medicine: Exploring the role of extracellular vesicles in chronic obstructive pulmonary disease
Biomed Pharmacother. 2024 Mar 20;174:116443. doi: 10.1016/j.biopha.2024.116443. Online ahead of print.ABSTRACTChronic obstructive pulmonary disease (COPD) is a chronic inflammatory airway disease characterized by progressive respiratory difficulties. It has a high incidence and disability rate worldwide. However, currently there is still a lack of highly effective treatment methods for COPD, only symptom relief is possible. Therefore, there is an urgent need to explore new treatment options. Almost all cells can secrete extracellular vesicles (EVs), which participate in many physiological activities by transporting cargoes...
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - March 21, 2024 Category: Drugs & Pharmacology Authors: Zixuan Gou Hongrun Yang Ruijia Wang Shihan Wang Qirui Chen Ziyu Liu Ying Zhang Source Type: research

Dexmedetomidine attenuates lipopolysaccharide-induced renal cell fibrotic phenotypic changes by inhibiting necroinflammation via activating α < sub > 2 < /sub > -adrenoceptor: A combined randomised animal and in vitro study
CONCLUSIONS: Dex reduced EMT following LPS stimulation whilst simultaneously inhibiting pyroptosis and necroptosis via α2-AR activation in the renal tubular cells. The "anti-fibrotic" and cytoprotective properties and its clinical use of Dex need to be further studied.PMID:38513598 | DOI:10.1016/j.biopha.2024.116462 (Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie)
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - March 21, 2024 Category: Drugs & Pharmacology Authors: Qizhe Sun Priyanka Kamath Yibing Sun Min Liang Lingzhi Wu Enqiang Chang Qian Chen Azeem Alam Yi Liu Hailin Zhao Daqing Ma Source Type: research

Innovative gelatin-based micelles with AS1411 aptamer targeting and reduction responsiveness for doxorubicin delivery in tumor therapy
Biomed Pharmacother. 2024 Mar 20;174:116446. doi: 10.1016/j.biopha.2024.116446. Online ahead of print.ABSTRACTHerein, we constructed innovative reduction-sensitive and targeted gelatin-based micelles for doxorubicin (DOX) delivery in tumor therapy. AS1411 aptamer-modified gelatin-ss-tocopherol succinate (AGSST) and the control GSST without AS1411 modification were synthesized and characterized. Antitumor drug DOX-containing AGSST (AGSST-D) and GSST-D nanoparticles were prepared, and their shapes were almost spherical. Reduction-responsive characteristics of DOX release in vitro were revealed in AGSST-D and GSST-D. Compared...
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - March 21, 2024 Category: Drugs & Pharmacology Authors: Jingmou Yu Yifei Zhang Meilin Xu Dengzhao Jiang Wenbo Liu Hongguang Jin Pu Chen Jing Xu Lei Zhang Source Type: research

Smart co-delivery of plasmid DNA and doxorubicin using MCM-chitosan-PEG polymerization functionalized with MUC-1 aptamer against breast cancer
This study introduces an innovative co-delivery approach using the MCM-co-polymerized nanosystem, integrating chitosan and polyethylene glycol, and targeted by the MUC-1 aptamer (MCM@CS@PEG-APT). This system enables simultaneous delivery of the GFP plasmid and doxorubicin (DOX). The synthesis of the nanosystem was thoroughly characterized at each step, including FTIR, XRD, BET, DLS, FE-SEM, and HRTEM analyses. The impact of individual polymers (chitosan and PEG) on payload retardation was compared to the co-polymerized MCM@CS@PEG conjugation. Furthermore, the DOX release mechanism was investigated using various kinetic mod...
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - March 20, 2024 Category: Drugs & Pharmacology Authors: Yasaman Esmaeili Arezou Dabiri Fariba Mashayekhi Ilnaz Rahimmanesh Elham Bidram Saeed Karbasi Mohammad Rafienia Shaghayegh Haghjooy Javanmard Yavuz Nuri Ertas Ali Zarrabi Laleh Shariati Source Type: research

Solid lipid nanoparticles and their application in the treatment of bacterial infectious diseases
Biomed Pharmacother. 2024 Mar 19;174:116433. doi: 10.1016/j.biopha.2024.116433. Online ahead of print.ABSTRACTNano pharmacology is considered an effective, safe, and applicable approach for drug delivery applications. Solid lipid nanoparticle (SLNs) colloids contain biocompatible lipids which are capable of encapsulating and maintaining hydrophilic or hydrophobic drugs in the solid matrix followed by releasing the drug in a sustained manner in the target site. SLNs have more promising potential than other drug delivery systems for various purposes. Nowadays, the SLNs are used as a carrier for antibiotics, chemotherapeutic ...
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - March 20, 2024 Category: Drugs & Pharmacology Authors: Mohammad Reza Arabestani Ashkan Bigham Farideh Kamarehei Mahya Dini Fatemeh Gorjikhah Aref Shariati Seyed Mostafa Hosseini Source Type: research

Mechanistic insights into the potential role of dietary polyphenols and their nanoformulation in the management of Alzheimer's disease
Biomed Pharmacother. 2024 Mar 19;174:116376. doi: 10.1016/j.biopha.2024.116376. Online ahead of print.ABSTRACTAlzheimer's disease (AD) is a very common neurodegenerative disorder associated with memory loss and a progressive decline in cognitive activity. The two major pathophysiological factors responsible for AD are amyloid plaques (comprising amyloid-beta aggregates) and neurofibrillary tangles (consisting of hyperphosphorylated tau protein). Polyphenols, a class of naturally occurring compounds, are immensely beneficial for the treatment or management of various disorders and illnesses. Naturally occurring sources of p...
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - March 20, 2024 Category: Drugs & Pharmacology Authors: Hind Muteb Albadrani Payal Chauhan Sumel Ashique M Arockia Babu Danish Iqbal Abdulmajeed G Almutary Mosleh Mohammad Abomughaid Mehnaz Kamal Ana Cl áudia Paiva-Santos Mohammed Alsaweed Munerah Hamed Punya Sachdeva Saikat Dewanjee Saurabh Kumar Jha Shreesh Source Type: research

CD19 CAR-expressing iPSC-derived NK cells effectively enhance migration and cytotoxicity into glioblastoma by targeting to the pericytes in tumor microenvironment
Biomed Pharmacother. 2024 Mar 19;174:116436. doi: 10.1016/j.biopha.2024.116436. Online ahead of print.ABSTRACTIn cancer immunotherapy, chimeric antigen receptors (CARs) targeting specific antigens have become a powerful tool for cell-based therapy. CAR-natural killer (NK) cells offer selective anticancer lysis with reduced off-tumor toxicity compared to CAR-T cells, which is beneficial in the heterogeneous milieu of solid tumors. In the tumor microenvironment (TME) of glioblastoma (GBM), pericytes not only support tumor growth but also contribute to immune evasion, underscoring their potential as therapeutic targets in GBM...
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - March 20, 2024 Category: Drugs & Pharmacology Authors: Dasom Kong Daekee Kwon Bokyung Moon Da-Hyun Kim Min-Ji Kim Jungju Choi Kyung-Sun Kang Source Type: research

Simple ammonium salt and sigma-1 receptor ligand dipentylammonium provides neuroprotective effects in cell culture and Caenorhabditis elegans models of Alzheimer's disease
Biomed Pharmacother. 2024 Mar 18;173:116455. doi: 10.1016/j.biopha.2024.116455. Online ahead of print.ABSTRACTThe sigma-1 receptor (σ-1R), a chaperone protein located at the mitochondria-associated membrane (MAM) of the endoplasmic reticulum, can interact with and modify the signaling pathways of various proteins, thereby modulating many disease pathologies, including Alzheimer's disease (AD). The σ-1R ligand dipentylammonium (DPA) was analyzed for its anti-AD properties using PC12 cells (in vitro) and Caenorhabditis elegans (in vivo) models along with molecular docking (in silico) analysis. DPA at 1 and 10 µM concentra...
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - March 19, 2024 Category: Drugs & Pharmacology Authors: Mani Iyer Prasanth Kanika Verma Sirikalaya Brimson Tewin Tencomnao James Michael Brimson Source Type: research

The role of amino acid metabolism in autoimmune hepatitis
Biomed Pharmacother. 2024 Mar 18;173:116452. doi: 10.1016/j.biopha.2024.116452. Online ahead of print.ABSTRACTAutoimmune hepatitis (AIH) is an inflammatory chronic liver disease with persistent and recurrent immune-mediated liver injury. The exact cause of AIH is still not fully understood, but it is believed to be primarily due to an abnormal activation of the immune system, leading to autoimmune injury caused by the breakdown of autoimmune tolerance. Although the pathogenesis of AIH remains unclear, recent studies have shown that abnormalities in amino acid metabolism play significant roles in its development. These abno...
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - March 19, 2024 Category: Drugs & Pharmacology Authors: Xiaorong Xiang Qihong Li Jiajia Wan Chao Chen Mengmeng Guo Zhixu He Donghong Wang Xu Zhao Lin Xu Source Type: research

Synergistic effect of cannabidiol with dasatinib on lung cancer by SRC/PI3K/AKT signal pathway
In this study, we explored the combination effect of CBD and dasatinib on A549 cells. CBD in combination with dasatinib could induce significant synergistic apoptosis in vitro (ZIP > 10) and in vivo. The combination of CBD and low-dose dasatinib exhibited antiproliferative and proapoptotic effects through up-regulation of caspase-3 and Bax, and down-regulation of Bcl-2 in A549 cells. The xenograft mouse model suggested that the combination was more efficient and safer. In short, CBD and low-dose dasatinib exhibited a synergistic effect on anticancer by targeting the SRC/PI3K/AKT signaling pathway, suggesting a potential...
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - March 19, 2024 Category: Drugs & Pharmacology Authors: Qianqian Ye Changqin Gui Di Jin Jiazhen Zhang Jing Zhang Na Ma Li Xu Source Type: research

Nrf-2-dependent antioxidant and anti-inflammatory effects underlie the protective effect of esculeoside A against retinal damage in streptozotocin-induced diabetic rats
In conclusion, ESA alleviates retinopathy in T1DM rats by suppressing REDD1-associated degradation and inhibiting the Nrf2/antioxidant axis.PMID:38503237 | DOI:10.1016/j.biopha.2024.116461 (Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie)
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - March 19, 2024 Category: Drugs & Pharmacology Authors: Nasser A Alsabaani Kawther Amawi Samy M Eleawa Wisam Nabeel Ibrahim Walid Aldhaban Ahmad Mohammad Alaraj Badr Alkhalaf Waqas Sami Hisham Alshaikhli Mahmoud A Alkhateeb Source Type: research

α-synuclein regulates Cyclin D1 to promote abnormal initiation of the cell cycle and induce apoptosis in dopamine neurons
In this study, a PD mouse model was induced by stereotactic injection of α-syn into the nucleus, and treated with the cell cycle inhibitor, roscovitine (Rosc). The results demonstrated that Rosc improved behavioral disorders caused by α-syn, increased TH protein expression, inhibited α-syn and p-α-syn protein expression, and reduced the expression levels of G1/S phase cell cycle genes Cyclin D1, Cyclin E, CDK2, CDK4, E2F and pRB. Additionally, Rosc decreased Bax and Caspase-3 expression caused by α-syn, while increasing Bcl-2 protein expression. Meanwhile, we observed that α-syn can influence neuronal cell autophagy ...
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - March 19, 2024 Category: Drugs & Pharmacology Authors: Xiaokang Jia Qiliang Chen Ciyu Yao Tetsuya Asakawa Yuanyuan Zhang Source Type: research

RNA is a pro-apoptotic target of cisplatin in cancer cell lines and C. elegans
Biomed Pharmacother. 2024 Mar 18;173:116450. doi: 10.1016/j.biopha.2024.116450. Online ahead of print.ABSTRACTCisplatin not only targets DNA but also RNA. However, it is largely unknown whether platinated RNA (Pt-RNA) causes apoptosis and thus contributes to the cytotoxic effects of cisplatin. Consequently, cellular RNA was isolated from HepG2 and LS180 cells, exposed to cisplatin, and the resulting Pt-RNA (20 ng Pt/µg RNA) was transfected into these cancer cell lines or used to treat an apoptosis reporter Caenorhabditis elegans (C. elegans) strain (MD701, expressing CED-1::GFP). Cellular and molecular effects of Pt-RNA w...
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - March 19, 2024 Category: Drugs & Pharmacology Authors: Fabian Rose Beate K öberle Sebastian Honnen Cindy Bay J ürgen Burhenne Johanna Weiss Walter E Haefeli Dirk Theile Source Type: research

Cellular senescence in chronic lung diseases from newborns to the elderly: An update literature review
Biomed Pharmacother. 2024 Mar 18;173:116463. doi: 10.1016/j.biopha.2024.116463. Online ahead of print.ABSTRACTThe role of cellular senescence in age-related diseases has been fully recognized. In various age-related-chronic lung diseases, the function of alveolar epithelial cells (AECs) is impaired and alveolar regeneration disorders, especially in bronchopulmonary dysplasia，pulmonary fibrosis (PF), chronic obstructive pulmonary disease (COPD), cancer, etc. Except for age-related-chronic lung diseases, an increasing number of studies are exploring the role of cellular senescence in developmental chronic lung diseases, wh...
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - March 19, 2024 Category: Drugs & Pharmacology Authors: Ziyun Liu Yiqi Zhang Danni Li Jianhua Fu Source Type: research

Revolutionizing osteoarthritis treatment: How mesenchymal stem cells hold the key
Biomed Pharmacother. 2024 Mar 18;173:116458. doi: 10.1016/j.biopha.2024.116458. Online ahead of print.ABSTRACTOsteoarthritis (OA) is a multifaceted disease characterized by imbalances in extracellular matrix metabolism, chondrocyte and synoviocyte senescence, as well as inflammatory responses mediated by macrophages. Although there have been notable advancements in pharmacological and surgical interventions, achieving complete remission of OA remains a formidable challenge, oftentimes accompanied by significant side effects. Mesenchymal stem cells (MSCs) have emerged as a promising avenue for OA treatment, given their abil...
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - March 19, 2024 Category: Drugs & Pharmacology Authors: Ruijiao Tian Shibo Su Yang Yu Siqiang Liang Chuqing Ma Yang Jiao Weihong Xing Ziheng Tian Tongmeng Jiang Juan Wang Source Type: research