Oseltamivir enhances 5-FU sensitivity in esophageal squamous carcinoma with high SPNS1
Biomed Pharmacother. 2024 Mar 8;173:116367. doi: 10.1016/j.biopha.2024.116367. Online ahead of print.ABSTRACTSphingolipid transporter 1 (SPNS1) is a significant differentially expressed gene (DEGs) in esophageal squamous cell carcinoma (ESCC). According to 3 pairs clinic cohorts, transcriptomic (155 pairs of ESCC samples and GSE53624, and proteomic data from PXD021701 including 124 ESCC samples) we found that SPNS1 was significantly higher in ESCC tissues compared to adjacent normal esophagus tissues. ESCC patients with high SPNS1 had a significantly poorer clinical prognosis than those with low SPNS1. Knockdown of SPNS1 s...
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - March 9, 2024 Category: Drugs & Pharmacology Authors: Xin Yang Ye Jiao Yingying Zhang Meng Sun Yingzhen Gao Yan Zhou Heng Xiao Jing Ren Zhinan Zhou Yuanfang Zhai Bin Song Ling Zhang Pengzhou Kong Source Type: research

Bioactivity and mechanism of action of sanguinarine and its derivatives in the past 10 years
Biomed Pharmacother. 2024 Mar 8;173:116406. doi: 10.1016/j.biopha.2024.116406. Online ahead of print.ABSTRACTSanguinarine is a quaternary ammonium benzophenanthine alkaloid found in traditional herbs such as Chelidonium, Corydalis, Sanguinarum, and Borovula. It has been proven to possess broad-spectrum biological activities, such as antitumor, anti-inflammatory, antiosteoporosis, neuroprotective, and antipathogenic microorganism activities. In this paper, recent progress on the biological activity and mechanism of action of sanguinarine and its derivatives over the past ten years is reviewed. The results showed that the bi...
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - March 9, 2024 Category: Drugs & Pharmacology Authors: Le-Jun Huang Jin-Xia Lan Jin-Hua Wang Hao Huang Kuo Lu Zhi-Nuo Zhou Su-Ya Xin Zi-Yun Zhang Jing-Yang Wang Ping Dai Xiao-Mei Chen Wen Hou Source Type: research

Effect of high-dose vitamin C on renal ischemia-reperfusion injury
Biomed Pharmacother. 2024 Mar 8;173:116407. doi: 10.1016/j.biopha.2024.116407. Online ahead of print.ABSTRACTAcute kidney injury frequently occurs after cardiac surgery, and is primarily attributed to renal ischemia-reperfusion (I/R) injury and inflammation from surgery and cardiopulmonary bypass. Vitamin C, an antioxidant that is often depleted in critically ill patients, could potentially mitigate I/R-induced oxidative stress at high doses. We investigated the effectiveness of high-dose vitamin C in preventing I/R-induced renal injury. The ideal time and optimal dosage for administration were determined in a two-phase ex...
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - March 9, 2024 Category: Drugs & Pharmacology Authors: Seo Hee Ko Ji Hae Jun Ju Eun Oh Eunah Shin Young-Lan Kwak Jae-Kwang Shim Source Type: research

Intra-abdominal transplantation of PLGA/PCL/M13 phage electrospun scaffold induces self-assembly of lymphoid tissue-like structure
Biomed Pharmacother. 2024 Mar 8;173:116382. doi: 10.1016/j.biopha.2024.116382. Online ahead of print.ABSTRACTLymphoid organs are the main structural components of the immune system. In the current research, the mixture of poly lactic-co-glycolic acid (PLGA), polycaprolactone (PCL), and M13 phage or its RGD-modified form was used in the construction of a fibrillar scaffold using the electrospinning method. The constructs were transplanted intra-abdominally and examined for the formation of lymphoid-like tissues at different time intervals. The confocal and scanning electron microscopy demonstrate that M13 phage-containing s...
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - March 9, 2024 Category: Drugs & Pharmacology Authors: Zohreh Safari Majid Sadeghizadeh Ahmad Zavaran Hosseini Ali Hazrati Sara Soudi Source Type: research

Antiseizure effects of Lilii Bulbus on pentylenetetrazol kindling-induced seizures in mice: Involvement of Reelin, Netrin-1, and semaphorin
In this study, we investigated the antiseizure effects of a water extract of Lilii Bulbus (WELB) in mouse model of pentylenetetrazol (PTZ)-induced seizure. Mice were injected with PTZ once every 48 h until full kindling was achieved. WELB (100 and 500 mg/kg) was orally administered once daily before PTZ administration and during the kindling process. We found that WELB treatment protected against PTZ-induced low seizure thresholds and high seizure severity. Further, WELB-treated mice showed attenuated PTZ kindling-induced anxiety and memory impairment. Immunostaining and immunoblots showed that hyperactivation and ectopic ...
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - March 9, 2024 Category: Drugs & Pharmacology Authors: Hee Ra Park Mudan Cai Source Type: research

Histone deacetylase 9-mediated phenotypic transformation of vascular smooth muscle cells is a potential target for treating aortic aneurysm/dissection
Biomed Pharmacother. 2024 Mar 8;173:116396. doi: 10.1016/j.biopha.2024.116396. Online ahead of print.ABSTRACTAortic aneurysm/dissection (AAD) is a serious cardiovascular condition characterized by rapid onset and high mortality rates. Currently, no effective drug treatment options are known for AAD. AAD pathogenesis is associated with the phenotypic transformation and abnormal proliferation of vascular smooth muscle cells (VSMCs). However, endogenous factors that contribute to AAD progression remain unclear. We aimed to investigate the role of histone deacetylase 9 (HDAC9) in AAD pathogenesis. HDAC9 expression was consider...
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - March 9, 2024 Category: Drugs & Pharmacology Authors: Zhiqiao Dang Haijie Li Shishan Xue Baowei Shao Yansong Ning Guohai Su Fengquan Zhang Wenqian Yu Shuai Leng Source Type: research

A M1 muscarinic acetylcholine receptor-specific positive allosteric modulator VU0486846 reduces neurogliosis in female Alzheimer's mice
This study sheds light on an additional mechanism through which novel M1 mAChR PAMs exhibit disease-modifying effects by reducing neuroglial activation and underscore the potential of these ligands for the treatment of AD, especially in females.PMID:38460371 | DOI:10.1016/j.biopha.2024.116388 (Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie)
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - March 9, 2024 Category: Drugs & Pharmacology Authors: Khaled S Abd-Elrahman Tash-Lynn L Colson Shaarika Sarasija Stephen S G Ferguson Source Type: research

GSH-activable heterotrimeric nano-prodrug for precise synergistic therapy of TNBC
Biomed Pharmacother. 2024 Mar 8;173:116375. doi: 10.1016/j.biopha.2024.116375. Online ahead of print.ABSTRACTCombination chemotherapy is an effective approach for triple-negative breast cancer (TNBC) therapy, especially when drugs are administered at specific optimal ratios. However, at present, strategies involving precise and controllable ratios based on effective loading and release of drugs are unavailable. Herein, we designed and synthesized a glutathione (GSH)--responsive heterotrimeric prodrug and formulated it with an amphiphilic polymer to obtain nanoparticles (DSSC2 NPs) for precise synergistic chemotherapy of TN...
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - March 9, 2024 Category: Drugs & Pharmacology Authors: Xiaojing Zhang Yansong Chen Jingwei Tang Chen Chen Yanfeng Sun Hao Zhang Mengxiang Qiao Gongsheng Jin Xianfu Liu Source Type: research

Gut microbiome-metabolites axis: A friend or foe to colorectal cancer progression
Biomed Pharmacother. 2024 Mar 8;173:116410. doi: 10.1016/j.biopha.2024.116410. Online ahead of print.ABSTRACTAn expanding corpus of research robustly substantiates the complex interrelation between gut microbiota and the onset, progression, and metastasis of colorectal cancer. Investigations in both animal models and human subjects have consistently underscored the role of gut bacteria in a variety of metabolic activities, driven by dietary intake. These activities include amino acid metabolism, carbohydrate fermentation, and the generation and regulation of bile acids. These metabolic derivatives, in turn, have been ident...
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - March 9, 2024 Category: Drugs & Pharmacology Authors: Hao Wu Wenmeng Ma Yiyao Wang Yuanyuan Wang Xun Sun Qianqian Zheng Source Type: research

Regulation of histone acetylation by garcinol blocks the reconsolidation of heroin-associated memory
Biomed Pharmacother. 2024 Mar 8;173:116414. doi: 10.1016/j.biopha.2024.116414. Online ahead of print.ABSTRACTDrug-associated long-term memories underlie substance use disorders, including heroin use disorder (HUD), which are difficult to eliminate through existing therapies. Addictive memories may become unstable when reexposed to drug-related cues and need to be stabilized again through protein resynthesis. Studies have shown the involvement of histone acetylation in the formation and reconsolidation of long-term drug-associated memory. However, it remains unknown whether and how histone acetyltransferases (HAT), the esse...
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - March 9, 2024 Category: Drugs & Pharmacology Authors: Junzhe Cheng Binbin Wang Hongkun Hu Xinzhu Lin Yuhang Liu Jiang Lin Jinlong Zhang Shuliang Niu Jie Yan Source Type: research

Exosomal ncRNAs: Multifunctional contributors to the immunosuppressive tumor microenvironment of hepatocellular carcinoma
This study discusses the features of exosomal ncRNAs in HCC and how the activation of the exosomes redefines the tumor's immunosuppressive microenvironment, hence facilitating the advancement of HCC. Furthermore, we also explored the potential of exosomal ncRNAs as a viable biological target or natural vehicle for HCC therapy.PMID:38460375 | DOI:10.1016/j.biopha.2024.116409 (Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie)
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - March 9, 2024 Category: Drugs & Pharmacology Authors: Qi Huang Xin Zhong Jing Li Rui Hu Jinyu Yi Jialing Sun Youhua Xu Xiaozhou Zhou Source Type: research

Anti-inflammatory, healing and antiophidic potential of Jatropha mollissima (Pohl) Baill. (Euphorbiaceae): From popular use to pharmaceutical formulation in gel
Biomed Pharmacother. 2024 Mar 7;173:116290. doi: 10.1016/j.biopha.2024.116290. Online ahead of print.ABSTRACTJatropha mollissima (Pohl) Baill. (Euphorbiaceae) is widely used in traditional medicine to treat inflammatory disorders. So, a topical gel containing the hydroethanolic extract of its leaves was developed and evaluated for its anti-inflammatory, wound healing, and antiophidic properties in mice. First, the chemical profile of different parts of the plant was characterized by liquid chromatography coupled to mass spectrometry (LC-MS) using molecular networking. In the leaf extract, 11 compounds were characterized, w...
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - March 8, 2024 Category: Drugs & Pharmacology Authors: J úlia G R Passos Jacyra A S Gomes Jacinthia B Xavier-Santos Fabiana O Yamashita Joelly V Cavalcanti-Cruz Emerson M S Siqueira Vin ícius Barreto Garcia Silvana M Zucolotto Raimundo Fernandes de Araujo-Junior Leandro S Ferreira Arn óbio A Silva-Junior J Source Type: research

PP2A as a potential therapeutic target for breast cancer: Current insights and future perspectives
Biomed Pharmacother. 2024 Mar 7;173:116398. doi: 10.1016/j.biopha.2024.116398. Online ahead of print.ABSTRACTBreast cancer has become the most prevalent malignancy worldwide; however, therapeutic efficacy is far from satisfactory. To alleviate the burden of this disease, it is imperative to discover novel mechanisms and treatment strategies. Protein phosphatase 2 A (PP2A) comprises a family of mammalian serine/threonine phosphatases that regulate many cellular processes. PP2A is dysregulated in several human diseases, including oncological pathologies, and plays a pivotal role in the initiation and progression of tumours. ...
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - March 8, 2024 Category: Drugs & Pharmacology Authors: Yalong Qi Lixi Li Yuhan Wei Fei Ma Source Type: research

Gardenin A treatment attenuates inflammatory markers, synuclein pathology and deficits in tyrosine hydroxylase expression and improves cognitive and motor function in A53T- α-syn mice
Biomed Pharmacother. 2024 Mar 7;173:116370. doi: 10.1016/j.biopha.2024.116370. Online ahead of print.ABSTRACTOxidative stress and neuroinflammation are widespread in the Parkinson's disease (PD) brain and contribute to the synaptic degradation and dopaminergic cell loss that result in cognitive impairment and motor dysfunction. The polymethoxyflavone Gardenin A (GA) has been shown to activate the NRF2-regulated antioxidant pathway and inhibit the NFkB-dependent pro-inflammatory pathway in a Drosophila model of PD. Here, we evaluate the effects of GA on A53T alpha-synuclein overexpressing (A53TSyn) mice. A53TSyn mice were t...
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - March 8, 2024 Category: Drugs & Pharmacology Authors: Wyatt Hack Noah Gladen-Kolarsky Swarnali Chatterjee Qiaoli Liang Urmila Maitra Lukasz Ciesla Nora E Gray Source Type: research

Inhibition of PTPRE suppresses tumor progression and improves sorafenib response in hepatocellular carcinoma
In conclusion, we demonstrated that the PTPRE inhibitors represented a potential therapeutic agent for HCC management.PMID:38458013 | DOI:10.1016/j.biopha.2024.116366 (Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie)
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - March 8, 2024 Category: Drugs & Pharmacology Authors: Renshun Dong Tianci Wang Wei Dong He Zhu Qiumeng Liu Huifang Liang Xiaoping Chen Bixiang Zhang Xuewu Zhang Source Type: research