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Iguratimod inhibits protein citrullination and inflammation by downregulating NBCe2 in patients with rheumatoid arthritis
CONCLUSIONS: Bicarbonate promotes protein citrullination and inflammation in RA via NBCe2, and IGU can downregulate NBCe2.PMID:38636399 | DOI:10.1016/j.biopha.2024.116551 (Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie)
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - April 18, 2024 Category: Drugs & Pharmacology Authors: Tiane Peng Bingtong Li Liqi Bi Fangze Zhang Source Type: research

Tectorigenin protects against cardiac fibrosis in diabetic mice heart via activating the adiponectin receptor 1-mediated AMPK pathway
In conclusion, TEC improves cardiac fibrosis in DCM mice by modulating the AdipoR1/AMPK signaling pathway. These findings suggest that TEC could be an effective therapeutic agent for the treatment of diabetic cardiomyopathy.PMID:38636400 | DOI:10.1016/j.biopha.2024.116589 (Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie)
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - April 18, 2024 Category: Drugs & Pharmacology Authors: Yu-Lan Ma Man Xu Xian-Feng Cen Hong-Liang Qiu Ying-Ying Guo Qi-Zhu Tang Source Type: research

Physical training mitigates alveolar bone and blood enzymatic antioxidants defense impairment induced by binge ethanol consumption in rats
Biomed Pharmacother. 2024 Apr 17;174:116554. doi: 10.1016/j.biopha.2024.116554. Online ahead of print.ABSTRACTWe aimed to investigate the effectiveness of physical training as a protective strategy to mitigate alveolar bone damage and blood antioxidant defense caused by ethanol (EtOH) consumption in a binge-drinking pattern. Male Wistar rats aged approximately 90 days were divided into four groups: control, training, EtOH, and training + EtOH. The physical training protocol was conducted on a treadmill for four consecutive weeks, while the animals in the EtOH group were administered EtOH via orogastric gavage for three con...
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - April 18, 2024 Category: Drugs & Pharmacology Authors: Beatriz Rodrigues Risuenho Peinado Deborah Ribeiro Fraz ão Vict ória Santos Chemelo Jos é Mario Matos-Souza Railson de Oliveira Ferreira Leonardo Oliveira Bittencourt Gabriela de Souza Balbinot Fabr ício Mezzomo Collares Luanna Melo Pereira Fernandes Source Type: research

Interaction of selected alkoxy naringenin oximes with model and bacterial membranes
Biomed Pharmacother. 2024 Apr 16;174:116581. doi: 10.1016/j.biopha.2024.116581. Online ahead of print.ABSTRACTNaringenin is a flavonoid found in many fruits and herbs, most notably in grapefruits. In recent years, this compound and its derivatives have been of great interest due to their high biological activity, including fungicidal and bactericidal effects, also in relation to multidrug-resistant bacteria. Membrane interactions of naringenin oxime (NO) and its 7-O-alkyl (7-alkoxy) derivatives, such as methyl (7MENO), ethyl (7ETNO), isopropyl (7IPNO), n-butyl (7BUNO) and n-pentyl (7PENO) were studied. Thermotropic propert...
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - April 18, 2024 Category: Drugs & Pharmacology Authors: Olga Weso łowska Anna Duda-Madej Maria B łaszczyk Kamila Środa-Pomianek Joanna Koz łowska Miros ław Anioł Source Type: research

Intratumoural delivery of TRAIL mRNA induces colon cancer cell apoptosis
Biomed Pharmacother. 2024 Apr 17;174:116603. doi: 10.1016/j.biopha.2024.116603. Online ahead of print.ABSTRACTNovel strategies in intratumoral injection and emerging immunotherapies have heralded a new era of precise cancer treatments. The affinity of SARS-CoV-2 to ACE2 receptors, a feature which facilitates virulent human infection, is leveraged in this research. Colon cancer cells, with their high ACE2 expression, provide a potentially strategic target for using this SARS-CoV-2 feature. While the highly expression of ACE2 is observed in several cancer types, the idea of using the viral spike protein for targeting colon c...
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - April 18, 2024 Category: Drugs & Pharmacology Authors: Tingxuan Gu Mengqiao Wang Xiaorong Fu Xueli Tian Juanjuan Bi Ning Lu Chen Chen Shijia Yan Ang Li Luyun Wang Xiang Li Kangdong Liu Zigang Dong Source Type: research

Identification of Riluzole derivatives as novel calmodulin inhibitors with neuroprotective activity by a joint synthesis, biosensor, and computational guided strategy
Biomed Pharmacother. 2024 Apr 17;174:116602. doi: 10.1016/j.biopha.2024.116602. Online ahead of print.ABSTRACTThe development of new molecules for the treatment of calmodulin related cardiovascular or neurodegenerative diseases is an interesting goal. In this work, we introduce a novel strategy with four main steps: (1) chemical synthesis of target molecules, (2) Förster Resonance Energy Transfer (FRET) biosensor development and in vitro biological assay of new derivatives, (3) Cheminformatics models development and in vivo activity prediction, and (4) Docking studies. This strategy is illustrated with a case study. First...
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - April 18, 2024 Category: Drugs & Pharmacology Authors: Maider Baltasar-Marchueta Leire Llona Sara M-Alicante Iratxe Barbolla Markel Garcia Ibarluzea Rafael Ramis Ane Miren Salomon Brenda Fundora Ariane Araujo Arantza Muguruza-Montero Eider Nu ñez Scarlett P érez-Olea Christian Villanueva Aritz Leonardo Soni Source Type: research

Effects of mitochondrial dysfunction on cellular function: Role in atherosclerosis
Biomed Pharmacother. 2024 Apr 17;174:116587. doi: 10.1016/j.biopha.2024.116587. Online ahead of print.ABSTRACTAtherosclerosis, an immunoinflammatory disease of medium and large arteries, is associated with life-threatening clinical events, such as acute coronary syndromes and stroke. Chronic inflammation and impaired lipoprotein metabolism are considered to be among the leading causes of atherosclerosis, while numerous risk factors, including arterial hypertension, diabetes mellitus, obesity, and aging, can contribute to the development of the disease. In recent years, emerging evidence has underlined the key role of mitoc...
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - April 18, 2024 Category: Drugs & Pharmacology Authors: Minwen Xu Wenjun Wang Jingpei Cheng Hongen Qu Minjuan Xu Liefeng Wang Source Type: research

Caffeic acid alleviates skeletal muscle atrophy in 5/6 nephrectomy rats through the TLR4/MYD88/NF-kB pathway
Biomed Pharmacother. 2024 Apr 17;174:116556. doi: 10.1016/j.biopha.2024.116556. Online ahead of print.ABSTRACTSkeletal muscle atrophy is a common complication of chronic kidney disease (CKD) that affects the quality of life and prognosis of patients. We aimed to investigate the effects and mechanisms of caffeic acid (CA), a natural phenolic compound, on skeletal muscle atrophy in CKD rats. Male Sprague-Dawley rats underwent 5/6 nephrectomy (NPM) and were treated with CA (20, 40, or 80 mg/kg/day) for 10 weeks. The body and muscle weights, renal function, hemoglobin, and albumin were measured. The histological, molecular, an...
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - April 18, 2024 Category: Drugs & Pharmacology Authors: Jinyue He Zhuoen He Hao Wang Chi Zhang Tingting Pei Shihua Yan Yangtian Yan Fujing Wang Yuchi Chen Ningning Yuan Mingqing Wang Wei Xiao Source Type: research

Re-exploration of immunotherapy targeting EMT of hepatocellular carcinoma: Starting from the NF- κB pathway
This article reviews the progress of immunotherapy in improving EMT development in HCC cells by exploring the mechanism of regulating EMT.PMID:38631143 | DOI:10.1016/j.biopha.2024.116566 (Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie)
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - April 17, 2024 Category: Drugs & Pharmacology Authors: Shuang Wang Yan He Jun Wang En Luo Source Type: research

The novel insights of epithelial-derived exosomes in various fibrotic diseases
Biomed Pharmacother. 2024 Apr 16;174:116591. doi: 10.1016/j.biopha.2024.116591. Online ahead of print.ABSTRACTThe characteristics of fibrosis include the abnormal accumulation of extracellular matrix proteins and abnormal tissue repair caused by injury, infection, and inflammation, leading to a significant increase in organ failure and mortality. Effective and precise treatments are urgently needed to halt and reverse the progression of fibrotic diseases. Exosomes are tiny vesicles derived from endosomes, spanning from 40 to 160 nanometers in diameter, which are expelled into the extracellular matrix environment by various...
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - April 17, 2024 Category: Drugs & Pharmacology Authors: Rifu Wang Yuxin Shi Yonglin Lv Changqing Xie Yanjia Hu Source Type: research

Upregulation of Nrf2 signaling: A key molecular mechanism of Baicalin's neuroprotective action against diabetes-induced cognitive impairment
CONCLUSIONS AND IMPLICATIONS: Bai demonstrates a great therapeutic potential for attenuating DCI. The antioxidant defense and anti-inflammatory actions of Bai were mediated through the KEAP1-Nrf2 axis. These findings advance our understanding of potential treatment approaches for DCI, a common complication associated with diabetes.PMID:38631145 | DOI:10.1016/j.biopha.2024.116579 (Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie)
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - April 17, 2024 Category: Drugs & Pharmacology Authors: Yanfang Zheng Chenxiang Wang Wenjing Liu Jiaying Chen Yibin Sun Dennis Chang Huan Wang Wen Xu Jin-Jian Lu Xian Zhou Mingqing Huang Source Type: research

Hydrangea serrata extract attenuates PM-exacerbated airway inflammation in the CARAS model by modulating the IL-33/ST2/NF- κB signaling pathway
This study was conducted to investigate the efficacy of Hydrangea serrata extract (HSE) in airway inflammation in a mouse model of CARAS exacerbated by PM. In the CARAS mouse model worsened by PM, the airway inflammation improvement effect of HSE was evaluated by analyzing allergic nasal symptoms, changes in inflammatory cells, OVA-specific immunoglobulin (Ig) levels, cytokines, mast cell activation, and histopathological findings of both nasal mucosa and lung tissue. HSE effectively reduced OVA-specific IgE and IgG1 and inhibited the production of T helper type 2 (Th2)-related cytokines such as IL-4 and IL-5. Importantly,...
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - April 17, 2024 Category: Drugs & Pharmacology Authors: Juan Jin Thi Van Nguyen Yuna Jiang Zhen Nan Yu Chang Ho Song So-Young Lee Hee Soon Shin Ok Hee Chai Source Type: research